-
1
-
-
0003964361
-
-
American Cancer Society Accessed March 25, 2009
-
American Cancer Society. Cancer facts and figures. http://www.cancer.org/ downloads/STT/2008CAFFfinalsecured.pdf. Accessed March 25, 2009.
-
Cancer Facts and Figures
-
-
-
2
-
-
20344380924
-
A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer
-
DOI 10.1038/sj.bjc.6602569
-
ML Veronsese W Sun B Giantonio, et al. 2005 A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer Br J Cancer 92 1846 1849 10.1038/sj.bjc.6602569 (Pubitemid 40826131)
-
(2005)
British Journal of Cancer
, vol.92
, Issue.10
, pp. 1846-1849
-
-
Veronese, M.L.1
Sun, W.2
Giantonio, B.3
Berlin, J.4
Shults, J.5
Davis, L.6
Haller, D.G.7
O'Dwyer, P.J.8
-
3
-
-
33646143020
-
Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer
-
10.1038/sj.bjc.6603055 1:CAS:528:DC%2BD28XjsFaksrk%3D 16570047
-
CA Townsley P Major LL Siu, et al. 2006 Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer Br J Cancer 94 1136 1143 10.1038/sj.bjc.6603055 1:CAS:528:DC%2BD28XjsFaksrk%3D 16570047
-
(2006)
Br J Cancer
, vol.94
, pp. 1136-1143
-
-
Townsley, C.A.1
Major, P.2
Siu, L.L.3
-
4
-
-
34547364633
-
-
[prescribing information]. Branchburg, NJ: ImClone Systems Inc; revised November 2008
-
Erbitux (cetuximab) [prescribing information]. Branchburg, NJ: ImClone Systems Inc; revised November 2008.
-
Erbitux (Cetuximab)
-
-
-
5
-
-
84910062552
-
-
[prescribing information]. Thousand Oaks, CA: Amgen Inc.; revised February 2009
-
Vectibix (panitumumab) [prescribing information]. Thousand Oaks, CA: Amgen Inc.; revised February 2009.
-
Vectibix (Panitumumab)
-
-
-
6
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan- refractory metastatic colorectal cancer
-
DOI 10.1056/NEJMoa033025
-
D Cunningham Y Humblet S Siena, et al. 2004 Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer N Engl J Med 351 337 345 10.1056/NEJMoa033025 1:CAS:528:DC%2BD2cXlvFGitbk%3D 15269313 (Pubitemid 38944402)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.4
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
Bets, D.7
Mueser, M.8
Harstrick, A.9
Verslype, C.10
Chau, I.11
Van Cutsem, E.12
-
7
-
-
36148941301
-
Cetuximab for the treatment of colorectal cancer
-
DOI 10.1056/NEJMoa071834
-
DJ Jonker CJ O'Callaghan CS Karapetis, et al. 2007 Cetuximab for the treatment of colorectal cancer N Engl J Med 357 2040 2048 10.1056/NEJMoa071834 1:CAS:528:DC%2BD2sXhtlWis7rI 18003960 (Pubitemid 350106711)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.20
, pp. 2040-2048
-
-
Jonker, D.J.1
O'Callaghan, C.J.2
Karapetis, C.S.3
Zalcberg, J.R.4
Tu, D.5
Au, H.-J.6
Berry, S.R.7
Krahn, M.8
Price, T.9
Simes, R.J.10
Tebbutt, N.C.11
Van Hazel, G.12
Wierzbicki, R.13
Langer, C.14
Moore, M.J.15
-
8
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
-
DOI 10.1200/JCO.2006.08.1620
-
E Van Cutsem M Peeters S Siena, et al. 2007 Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer J Clin Oncol 25 1658 1664 10.1200/JCO.2006.08.1620 17470858 (Pubitemid 46797944)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.13
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
Humblet, Y.4
Hendlisz, A.5
Neyns, B.6
Canon, J.-L.7
Van Laethem, J.-L.8
Maurel, J.9
Richardson, G.10
Wolf, M.11
Amado, R.G.12
-
10
-
-
34247224987
-
Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study
-
DOI 10.1016/S1470-2045(07)70108-0, PII S1470204507701080
-
S Tejpar H Piessevaux K Claes, et al. 2007 Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: A prospective study Lancet Oncol 8 387 394 10.1016/S1470-2045(07)70108-0 1:CAS:528:DC%2BD2sXkslKru70%3D 17466895 (Pubitemid 46621761)
-
(2007)
Lancet Oncology
, vol.8
, Issue.5
, pp. 387-394
-
-
Tejpar, S.1
Piessevaux, H.2
Claes, K.3
Piront, P.4
Hoenderop, J.G.5
Verslype, C.6
Van Cutsem, E.7
-
11
-
-
0037805547
-
RAS oncogenes: The first 30 years
-
DOI 10.1038/nrc1097
-
M Malumbres M Barbacid 2003 RAS oncogenes: The first 30 years Nat Rev Cancer 3 459 465 10.1038/nrc1097 1:CAS:528:DC%2BD3sXktFOnsbs%3D 12778136 (Pubitemid 37328850)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.6
, pp. 459-465
-
-
Malumbres, M.1
Barbacid, M.2
-
12
-
-
33947594129
-
Hyperactive Ras in developmental disorders and cancer
-
DOI 10.1038/nrc2109, PII NRC2109
-
S Schubbert K Shannon G Bollag 2007 Hyperactive Ras in developmental disorders and cancer Nat Rev Cancer 7 295 308 10.1038/nrc2109 1:CAS:528:DC%2BD2sXjtlyhtLs%3D 17384584 (Pubitemid 46480970)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.4
, pp. 295-308
-
-
Schubbert, S.1
Shannon, K.2
Bollag, G.3
-
13
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
10.1158/0008-5472.CAN-06-0191 1:CAS:528:DC%2BD28XjsFSlsb0%3D 16618717
-
A Lievre JB Bachet D Le Corre, et al. 2006 KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer Cancer Res 66 3992 3995 10.1158/0008-5472.CAN-06-0191 1:CAS:528:DC%2BD28XjsFSlsb0%3D 16618717
-
(2006)
Cancer Res
, vol.66
, pp. 3992-3995
-
-
Lievre, A.1
Bachet, J.B.2
Le Corre, D.3
-
14
-
-
34047248571
-
Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
-
DOI 10.1158/0008-5472.CAN-06-4158
-
S Benvenuti A Sartore-Bianchi F Di Nicolantonio, et al. 2007 Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies Cancer Res 67 2643 2648 10.1158/0008-5472.CAN-06-4158 1:CAS:528: DC%2BD2sXivV2ns7w%3D 17363584 (Pubitemid 46548951)
-
(2007)
Cancer Research
, vol.67
, Issue.6
, pp. 2643-2648
-
-
Benvenuti, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
Zanon, C.4
Moroni, M.5
Veronese, S.6
Siena, S.7
Bardelli, A.8
-
15
-
-
40149088765
-
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
-
DOI 10.1093/annonc/mdm496
-
W De Roock H Piessevaux J De Schutter, et al. 2008 KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab Ann Oncol 19 508 515 10.1093/annonc/mdm496 17998284 (Pubitemid 351325672)
-
(2008)
Annals of Oncology
, vol.19
, Issue.3
, pp. 508-515
-
-
De Roock, W.1
Piessevaux, H.2
De Schutter, J.3
Janssens, M.4
De Hertogh, G.5
Personeni, N.6
Biesmans, B.7
Van Laethem, J.-L.8
Peeters, M.9
Humblet, Y.10
Van Cutsem, E.11
Tejpar, S.12
-
16
-
-
39349083477
-
EGFR, HER2 and Kras as predictive factors for cetuximab sensitivity in colorectal cancer
-
G Finocchiaro F Cappuzzo PA Janne, et al. 2007 EGFR, HER2 and Kras as predictive factors for cetuximab sensitivity in colorectal cancer J Clin Oncol 25 168s
-
(2007)
J Clin Oncol
, vol.25
-
-
Finocchiaro, G.1
Cappuzzo, F.2
Janne, P.A.3
-
17
-
-
38649099966
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
-
DOI 10.1200/JCO.2007.12.5906
-
A Lievre JB Bachet V Boige, et al. 2008 KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab J Clin Oncol 26 374 379 10.1200/JCO.2007.12.5906 1:CAS:528: DC%2BD1cXitVGntLc%3D 18202412 (Pubitemid 351171687)
-
(2008)
Journal of Clinical Oncology
, vol.26
, Issue.3
, pp. 374-379
-
-
Lievre, A.1
Bachet, J.-B.2
Boige, V.3
Cayre, A.4
Le Corre, D.5
Buc, E.6
Ychou, M.7
Bouche, O.8
Landi, B.9
Louvet, C.10
Andre, T.11
Bibeau, F.12
Diebold, M.-D.13
Rougier, P.14
Ducreux, M.15
Tomasic, G.16
Emile, J.-F.17
Penault-Llorca, F.18
Laurent-Puig, P.19
-
18
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
DOI 10.1200/JCO.2006.10.5437
-
S Khambata-Ford CR Garrett NJ Meropol, et al. 2007 Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab J Clin Oncol 25 3230 3237 10.1200/JCO.2006.10.5437 1:CAS:528:DC%2BD2sXhtVWqs7rF 17664471 (Pubitemid 47325606)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.22
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
Basik, M.4
Harbison, C.T.5
Wu, S.6
Wong, T.W.7
Huang, X.8
Takimoto, C.H.9
Godwin, A.K.10
Tan, B.R.11
Krishnamurthi, S.S.12
Burris III, H.A.13
Poplin, E.A.14
Hidalgo, M.15
Baselga, J.16
Clark, E.A.17
Mauro, D.J.18
-
19
-
-
44449090596
-
Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone
-
DOI 10.3816/CCC.2008.n.024
-
DJ Freeman T Juan M Reiner, et al. 2008 Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone Clin Colorectal Cancer 7 184 190 10.3816/CCC.2008.n.024 1:CAS:528:DC%2BD1cXnvVCqt78%3D 18621636 (Pubitemid 351758148)
-
(2008)
Clinical Colorectal Cancer
, vol.7
, Issue.3
, pp. 184-190
-
-
Freeman, D.J.1
Juan, T.2
Reiner, M.3
Hecht, J.R.4
Meropol, N.J.5
Berlin, J.6
Mitchell, E.7
Sarosi, I.8
Radinsky, R.9
Amado, R.G.10
-
20
-
-
0027412665
-
Prognostic significance of K-ras mutations in colorectal carcinoma
-
J Benhattar L Losi P Chaubert, et al. 1993 Prognostic significance of K-ras mutations in colorectal carcinoma Gastroenterology 104 1044 1048 1:STN:280:DyaK3s3hs1SisQ%3D%3D 8462792 (Pubitemid 23090756)
-
(1993)
Gastroenterology
, vol.104
, Issue.4
, pp. 1044-1048
-
-
Benhattar, J.1
Losi, L.2
Chaubert, P.3
Givel, J.-C.4
Costa, J.5
-
21
-
-
0030499353
-
K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers
-
1:STN:280:DyaK2s7psVyhuw%3D%3D 9042267
-
JC Lee ST Wang MD Lai, et al. 1996 K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers Anticancer Res 16 3839 3844 1:STN:280:DyaK2s7psVyhuw%3D%3D 9042267
-
(1996)
Anticancer Res
, vol.16
, pp. 3839-3844
-
-
Lee, J.C.1
Wang, S.T.2
Lai, M.D.3
-
22
-
-
51049092984
-
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy
-
10.1158/1078-0432.CCR-07-4906 1:CAS:528:DC%2BD1cXpt1ejtbg%3D 18676755
-
MC Etienne-Grimaldi JL Formento M Francoual, et al. 2008 K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy Clin Cancer Res 14 4830 4835 10.1158/1078-0432.CCR-07- 4906 1:CAS:528:DC%2BD1cXpt1ejtbg%3D 18676755
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4830-4835
-
-
Etienne-Grimaldi, M.C.1
Formento, J.L.2
Francoual, M.3
-
23
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
10.1056/NEJMoa0804385 1:CAS:528:DC%2BD1cXht12nu77J 18946061
-
CS Karapetis S Khambata-Ford DJ Jonker, et al. 2008 K-ras mutations and benefit from cetuximab in advanced colorectal cancer N Engl J Med 359 1757 1765 10.1056/NEJMoa0804385 1:CAS:528:DC%2BD1cXht12nu77J 18946061
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
24
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
10.1200/JCO.2007.14.7116 1:CAS:528:DC%2BD1cXltlWhsrw%3D 18316791
-
RG Amado M Wolf M Peeters, et al. 2008 Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer J Clin Oncol 26 1626 1634 10.1200/JCO.2007.14.7116 1:CAS:528:DC%2BD1cXltlWhsrw%3D 18316791
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
25
-
-
58249093955
-
Results from panitumumab (pmab) regimen evaluation in colorectal cancer to estimate primary response to treatment (PRECEPT): Second-line treatment with pmab and FOLFIRI by tumor KRAS status
-
10.1200/JCO.2008.16.6785
-
AL Cohn DA Smith A Neubauer, et al. 2009 Results from panitumumab (pmab) regimen evaluation in colorectal cancer to estimate primary response to treatment (PRECEPT): Second-line treatment with pmab and FOLFIRI by tumor KRAS status J Clin Oncol 27 184s 10.1200/JCO.2008.16.6785
-
(2009)
J Clin Oncol
, vol.27
-
-
Cohn, A.L.1
Smith, D.A.2
Neubauer, A.3
-
26
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
10.1200/JCO.2008.20.8397 1:CAS:528:DC%2BD1MXjsVCjsrk%3D 19114683
-
C Bokemeyer I Bondarenko A Makhson, et al. 2009 Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer J Clin Oncol 27 663 671 10.1200/JCO.2008.20.8397 1:CAS:528:DC%2BD1MXjsVCjsrk%3D 19114683
-
(2009)
J Clin Oncol
, vol.27
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
-
27
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
10.1056/NEJMoa0805019 19339720
-
E Van Cutsem C-H Kohene E Hitre, et al. 2009 Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer N Engl J Med 360 1408 1417 10.1056/NEJMoa0805019 19339720
-
(2009)
N Engl J Med
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohene, C.-H.2
Hitre, E.3
-
28
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
DOI 10.1016/0092-8674(90)90186-I
-
ER Fearon B Vogelstein 1990 A genetic model for colorectal tumorigenesis Cell 61 759 767 10.1016/0092-8674(90)90186-I 1:CAS:528:DyaK3cXktlyhtrg%3D 2188735 (Pubitemid 20185636)
-
(1990)
Cell
, vol.61
, Issue.5
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
29
-
-
0023748414
-
Genetic alterations during colorectal-tumor development
-
1:STN:280:DyaL1czgt1aqtQ%3D%3D 2841597
-
B Vogelstein ER Fearon SR Hamilton, et al. 1988 Genetic alterations during colorectal-tumor development N Engl J Med 319 525 532 1:STN:280:DyaL1czgt1aqtQ%3D%3D 2841597
-
(1988)
N Engl J Med
, vol.319
, pp. 525-532
-
-
Vogelstein, B.1
Fearon, E.R.2
Hamilton, S.R.3
-
30
-
-
0028822834
-
Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
-
1:CAS:528:DyaK2MXoslWms7Y%3D 7553632
-
J Rak Y Mitsuhashi L Bayko, et al. 1995 Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis Cancer Res 55 4575 4580 1:CAS:528:DyaK2MXoslWms7Y%3D 7553632
-
(1995)
Cancer Res
, vol.55
, pp. 4575-4580
-
-
Rak, J.1
Mitsuhashi, Y.2
Bayko, L.3
-
31
-
-
0035863495
-
K-ras and p16 aberrations confer poor prognosis in human colorectal cancer
-
M Esteller S Gonzalez RA Risques, et al. 2001 K-ras and p16 aberrations confer poor prognosis in human colorectal cancer J Clin Oncol 19 299 304 1:CAS:528:DC%2BD3MXhtVektro%3D 11208819 (Pubitemid 32112840)
-
(2001)
Journal of Clinical Oncology
, vol.19
, Issue.2
, pp. 299-304
-
-
Esteller, M.1
Gonzalez, S.2
Risques, R.A.3
Marcuello, E.4
Mangues, R.5
Germa, J.R.6
Herman, J.G.7
Capella, G.8
Peinado, M.A.9
-
32
-
-
24944525406
-
Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients
-
DOI 10.1200/JCO.2005.04.096
-
JL Westra M Schaapveld H Hollema, et al. 2005 Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients J Clin Oncol 23 5635 5643 10.1200/JCO.2005.04.096 1:CAS:528: DC%2BD2MXhtVersrzN 16110022 (Pubitemid 46300159)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.24
, pp. 5635-5643
-
-
Westra, J.L.1
Schaapveld, M.2
Hollema, H.3
De Boer, J.P.4
Kraak, M.M.J.5
De Jong, D.6
Ter Elst, A.7
Mulder, N.H.8
Buys, C.H.C.M.9
Hofstra, R.M.W.10
Plukker, J.T.M.11
-
33
-
-
0035070638
-
Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer
-
WS Samowitz JA Holden K Curtin, et al. 2001 Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer Am J Pathol 158 1517 1524 1:CAS:528:DC%2BD3MXjtVWht7o%3D 11290569 (Pubitemid 32281315)
-
(2001)
American Journal of Pathology
, vol.158
, Issue.4
, pp. 1517-1524
-
-
Samowitz, W.S.1
Holden, J.A.2
Curtin, K.3
Edwards, S.L.4
Walker, A.R.5
Lin, H.A.6
Robertson, M.A.7
Nichols, M.F.8
Gruenthal, K.M.9
Lynch, B.J.10
Leppert, M.F.11
Slattery, M.L.12
-
34
-
-
77952094011
-
A comparability study of 4 commercial KRAS tests (abstract 1811)
-
San Diego, CA
-
Juan T, Suggs S, Wolf M, et al. A comparability study of 4 commercial KRAS tests (abstract 1811). Paper presented at: 99th AACR Annual Meeting; 2008; San Diego, CA.
-
(2008)
99th AACR Annual Meeting
-
-
Juan, T.1
Suggs, S.2
Wolf, M.3
-
35
-
-
65349189958
-
American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
-
10.1200/JCO.2009.21.9170 19188670
-
CJ Allegra JM Jessup MR Sommerfield, et al. 2009 American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy J Clin Oncol 27 2091 2096 10.1200/JCO.2009.21.9170 19188670
-
(2009)
J Clin Oncol
, vol.27
, pp. 2091-2096
-
-
Allegra, C.J.1
Jessup, J.M.2
Sommerfield, M.R.3
-
36
-
-
54249098184
-
KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: Proposal for an European quality assurance program
-
10.1007/s00428-008-0665-y
-
JH van Krieken A Jung T Kirchner, et al. 2009 KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: Proposal for an European quality assurance program Virchows Arch 453 417 431 10.1007/s00428-008-0665-y
-
(2009)
Virchows Arch
, vol.453
, pp. 417-431
-
-
Van Krieken, J.H.1
Jung, A.2
Kirchner, T.3
-
37
-
-
0032521205
-
Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: A Southwest Oncology Group study
-
DJ Ahnen P Feigl G Quan, et al. 1998 Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: A Southwest Oncology Group study Cancer Res 58 1149 1158 1:CAS:528:DyaK1cXhvV2rsro%3D 9515799 (Pubitemid 28183202)
-
(1998)
Cancer Research
, vol.58
, Issue.6
, pp. 1149-1158
-
-
Ahnen, D.J.1
Feigl, P.2
Quan, G.3
Fenoglio-Preiser, C.4
Lovato, L.C.5
Bunn Jr., P.A.6
Stemmerman, G.7
Wells, J.D.8
Macdonald, J.S.9
Meyskens Jr., F.L.10
-
38
-
-
30644473641
-
Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies
-
DOI 10.1093/annonc/mdi907
-
A Russo V Bazan V Agnese, et al. 2005 Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies Ann Oncol 16 Suppl 4 iv44 iv49 10.1093/annonc/mdi907 15923428 (Pubitemid 43084945)
-
(2005)
Annals of Oncology
, vol.16
, Issue.SUPPL. 4
-
-
Russo, A.1
Bazan, V.2
Agnese, V.3
Rodolico, V.4
Gebbia, N.5
-
39
-
-
0034026701
-
P53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer
-
DOI 10.1016/S0959-8049(00)00036-8, PII S0959804900000368
-
H Bouzourene P Gervaz JP Cerottini, et al. 2000 p53 and K-ras as prognostic factors for Dukes' stage B colorectal cancer Eur J Cancer 36 1008 1015 10.1016/S0959-8049(00)00036-8 1:CAS:528:DC%2BD3cXjsVCqsLk%3D 10885605 (Pubitemid 30316426)
-
(2000)
European Journal of Cancer
, vol.36
, Issue.8
, pp. 1008-1015
-
-
Bouzourene, H.1
Gervaz, P.2
Cerottini, J.-P.3
Benhattar, J.4
Chaubert, P.5
Saraga, E.6
Pampallona, S.7
Bosman, F.T.8
Givel, J.-C.9
-
40
-
-
61449202998
-
The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
-
10.1634/theoncologist.2008-0213 1:CAS:528:DC%2BD1MXjt1Clt7o%3D 19144677
-
HI Hurwitz J Yi W Ince, et al. 2009 The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer Oncologist 14 22 28 10.1634/ theoncologist.2008-0213 1:CAS:528:DC%2BD1MXjt1Clt7o%3D 19144677
-
(2009)
Oncologist
, vol.14
, pp. 22-28
-
-
Hurwitz, H.I.1
Yi, J.2
Ince, W.3
-
41
-
-
72249101664
-
Final STEPP results of prophylactic versus reactive skin toxicity (ST) treatment (tx) for panitumumab (pmab)-related ST in patients (pts) with metastatic colorectal cancer (mCRC)
-
10.1200/JCO.2008.17.0910
-
EP Mitchell M LaCouture H Shearer, et al. 2009 Final STEPP results of prophylactic versus reactive skin toxicity (ST) treatment (tx) for panitumumab (pmab)-related ST in patients (pts) with metastatic colorectal cancer (mCRC) J Clin Oncol 27 805s 10.1200/JCO.2008.17.0910
-
(2009)
J Clin Oncol
, vol.27
-
-
Mitchell, E.P.1
Lacouture, M.2
Shearer, H.3
-
42
-
-
70449528360
-
Cetuximab plus FOLFOX6 or cetuximab plus FOLFIRI as neoadjuvant treatment of nonresectable colorectal liver metastases: A randomized multicenter study (CELIM-study)
-
January 15-17, 2009; San Francisco, CA
-
Folprecht G, Gruenberger T, Hartmann JT, et al. Cetuximab plus FOLFOX6 or cetuximab plus FOLFIRI as neoadjuvant treatment of nonresectable colorectal liver metastases: A randomized multicenter study (CELIM-study). Paper presented at: 2009 Gastrointestinal Cancers Symposium; January 15-17, 2009; San Francisco, CA.
-
2009 Gastrointestinal Cancers Symposium
-
-
Folprecht, G.1
Gruenberger, T.2
Hartmann, J.T.3
-
43
-
-
57149101253
-
Phase III study (PRIME/20050203) of panitumumab (pmab) with FOLFOX compared with FOLFOX alone in patients (pts) with previously untreated metastatic colorectal cancer (mCRC): Pooled safety data
-
S Siena J Tabernero RL Burkes, et al. 2008 Phase III study (PRIME/20050203) of panitumumab (pmab) with FOLFOX compared with FOLFOX alone in patients (pts) with previously untreated metastatic colorectal cancer (mCRC): Pooled safety data J Clin Oncol 26 186s
-
(2008)
J Clin Oncol
, vol.26
-
-
Siena, S.1
Tabernero, J.2
Burkes, R.L.3
-
44
-
-
55249110754
-
Phase III study (20050181) of panitumumab (pmab) with FOLFIRI versus FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC): Pooled safety results
-
M Peeters G Wilson M Ducreux, et al. 2008 Phase III study (20050181) of panitumumab (pmab) with FOLFIRI versus FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC): Pooled safety results J Clin Oncol 26 194s
-
(2008)
J Clin Oncol
, vol.26
-
-
Peeters, M.1
Wilson, G.2
Ducreux, M.3
-
45
-
-
59949102930
-
A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
-
10.1200/JCO.2008.19.8135 1:CAS:528:DC%2BD1MXjsVCjs74%3D 19114685
-
JR Hecht E Mitchell T Chidiac, et al. 2009 A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer J Clin Oncol 27 672 680 10.1200/JCO.2008.19.8135 1:CAS:528:DC%2BD1MXjsVCjs74%3D 19114685
-
(2009)
J Clin Oncol
, vol.27
, pp. 672-680
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
-
46
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
10.1056/NEJMoa0808268 1:CAS:528:DC%2BD1MXhsFyitrw%3D 19196673
-
J Tol M Koopman A Cats, et al. 2009 Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer N Engl J Med 360 563 572 10.1056/NEJMoa0808268 1:CAS:528:DC%2BD1MXhsFyitrw%3D 19196673
-
(2009)
N Engl J Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
-
49
-
-
68749119351
-
KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer
-
10.1038/sj.bjc.6605177 1:CAS:528:DC%2BD1MXpvFyisb0%3D 19603018
-
F Loupakis A Ruzzo C Cremolini, et al. 2009 KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer Br J Cancer 101 715 721 10.1038/sj.bjc.6605177 1:CAS:528:DC%2BD1MXpvFyisb0%3D 19603018
-
(2009)
Br J Cancer
, vol.101
, pp. 715-721
-
-
Loupakis, F.1
Ruzzo, A.2
Cremolini, C.3
-
50
-
-
62449302407
-
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
-
10.1158/0008-5472.CAN-08-2466
-
A Sartore-Bianchi M Martini F Molinari, et al. 2009 PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies Cancer Res 69 7 1857 10.1158/0008-5472.CAN-08-2466
-
(2009)
Cancer Res
, vol.69
, pp. 7-1857
-
-
Sartore-Bianchi, A.1
Martini, M.2
Molinari, F.3
-
51
-
-
57449095367
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
10.1200/JCO.2008.18.0786 1:CAS:528:DC%2BD1MXotFemsA%3D%3D 19001320
-
F Di Nicolantonio M Martini F Molinari, et al. 2008 Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer J Clin Oncol 26 5705 5712 10.1200/JCO.2008.18.0786 1:CAS:528: DC%2BD1MXotFemsA%3D%3D 19001320
-
(2008)
J Clin Oncol
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
-
52
-
-
65649086786
-
PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer
-
10.1158/1078-0432.CCR-08-2961 1:CAS:528:DC%2BD1MXltFOrur0%3D 19366826
-
H Prenen J De Schutter B Jacobs, et al. 2009 PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer Clin Cancer Res 15 3184 3188 10.1158/1078-0432.CCR-08-2961 1:CAS:528:DC%2BD1MXltFOrur0%3D 19366826
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3184-3188
-
-
Prenen, H.1
De Schutter, J.2
Jacobs, B.3
-
53
-
-
72449204284
-
Et al. High epiregulin (EREG) plus K-ras (WT) status as predictors of cetuximab benefit in the treatments of advanced colorectal cancer (ACRC): Results from NCIC CTG CO.17-a phase III trial of cetuximab versus best supportive care (BSC)
-
DJ Jonker C Karapetis C Harbison 2009 et al. High epiregulin (EREG) plus K-ras (WT) status as predictors of cetuximab benefit in the treatments of advanced colorectal cancer (ACRC): Results from NCIC CTG CO.17-a phase III trial of cetuximab versus best supportive care (BSC) J Clin Oncol 27 172s
-
(2009)
J Clin Oncol
, vol.27
-
-
Jonker, D.J.1
Karapetis, C.2
Harbison, C.3
|