메뉴 건너뛰기




Volumn 17, Issue 4, 2010, Pages 1168-1176

KRAS mutation in colon cancer: A marker of resistance to EGFR-I therapy

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; IRINOTECAN; K RAS PROTEIN; PANITUMUMAB;

EID: 77952092038     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-009-0811-z     Document Type: Review
Times cited : (115)

References (53)
  • 1
    • 0003964361 scopus 로고    scopus 로고
    • American Cancer Society Accessed March 25, 2009
    • American Cancer Society. Cancer facts and figures. http://www.cancer.org/ downloads/STT/2008CAFFfinalsecured.pdf. Accessed March 25, 2009.
    • Cancer Facts and Figures
  • 3
    • 33646143020 scopus 로고    scopus 로고
    • Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer
    • 10.1038/sj.bjc.6603055 1:CAS:528:DC%2BD28XjsFaksrk%3D 16570047
    • CA Townsley P Major LL Siu, et al. 2006 Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer Br J Cancer 94 1136 1143 10.1038/sj.bjc.6603055 1:CAS:528:DC%2BD28XjsFaksrk%3D 16570047
    • (2006) Br J Cancer , vol.94 , pp. 1136-1143
    • Townsley, C.A.1    Major, P.2    Siu, L.L.3
  • 4
    • 34547364633 scopus 로고    scopus 로고
    • [prescribing information]. Branchburg, NJ: ImClone Systems Inc; revised November 2008
    • Erbitux (cetuximab) [prescribing information]. Branchburg, NJ: ImClone Systems Inc; revised November 2008.
    • Erbitux (Cetuximab)
  • 5
    • 84910062552 scopus 로고    scopus 로고
    • [prescribing information]. Thousand Oaks, CA: Amgen Inc.; revised February 2009
    • Vectibix (panitumumab) [prescribing information]. Thousand Oaks, CA: Amgen Inc.; revised February 2009.
    • Vectibix (Panitumumab)
  • 10
    • 34247224987 scopus 로고    scopus 로고
    • Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study
    • DOI 10.1016/S1470-2045(07)70108-0, PII S1470204507701080
    • S Tejpar H Piessevaux K Claes, et al. 2007 Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: A prospective study Lancet Oncol 8 387 394 10.1016/S1470-2045(07)70108-0 1:CAS:528:DC%2BD2sXkslKru70%3D 17466895 (Pubitemid 46621761)
    • (2007) Lancet Oncology , vol.8 , Issue.5 , pp. 387-394
    • Tejpar, S.1    Piessevaux, H.2    Claes, K.3    Piront, P.4    Hoenderop, J.G.5    Verslype, C.6    Van Cutsem, E.7
  • 11
    • 0037805547 scopus 로고    scopus 로고
    • RAS oncogenes: The first 30 years
    • DOI 10.1038/nrc1097
    • M Malumbres M Barbacid 2003 RAS oncogenes: The first 30 years Nat Rev Cancer 3 459 465 10.1038/nrc1097 1:CAS:528:DC%2BD3sXktFOnsbs%3D 12778136 (Pubitemid 37328850)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.6 , pp. 459-465
    • Malumbres, M.1    Barbacid, M.2
  • 12
    • 33947594129 scopus 로고    scopus 로고
    • Hyperactive Ras in developmental disorders and cancer
    • DOI 10.1038/nrc2109, PII NRC2109
    • S Schubbert K Shannon G Bollag 2007 Hyperactive Ras in developmental disorders and cancer Nat Rev Cancer 7 295 308 10.1038/nrc2109 1:CAS:528:DC%2BD2sXjtlyhtLs%3D 17384584 (Pubitemid 46480970)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.4 , pp. 295-308
    • Schubbert, S.1    Shannon, K.2    Bollag, G.3
  • 13
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • 10.1158/0008-5472.CAN-06-0191 1:CAS:528:DC%2BD28XjsFSlsb0%3D 16618717
    • A Lievre JB Bachet D Le Corre, et al. 2006 KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer Cancer Res 66 3992 3995 10.1158/0008-5472.CAN-06-0191 1:CAS:528:DC%2BD28XjsFSlsb0%3D 16618717
    • (2006) Cancer Res , vol.66 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3
  • 14
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • DOI 10.1158/0008-5472.CAN-06-4158
    • S Benvenuti A Sartore-Bianchi F Di Nicolantonio, et al. 2007 Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies Cancer Res 67 2643 2648 10.1158/0008-5472.CAN-06-4158 1:CAS:528: DC%2BD2sXivV2ns7w%3D 17363584 (Pubitemid 46548951)
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Zanon, C.4    Moroni, M.5    Veronese, S.6    Siena, S.7    Bardelli, A.8
  • 16
    • 39349083477 scopus 로고    scopus 로고
    • EGFR, HER2 and Kras as predictive factors for cetuximab sensitivity in colorectal cancer
    • G Finocchiaro F Cappuzzo PA Janne, et al. 2007 EGFR, HER2 and Kras as predictive factors for cetuximab sensitivity in colorectal cancer J Clin Oncol 25 168s
    • (2007) J Clin Oncol , vol.25
    • Finocchiaro, G.1    Cappuzzo, F.2    Janne, P.A.3
  • 20
    • 0027412665 scopus 로고
    • Prognostic significance of K-ras mutations in colorectal carcinoma
    • J Benhattar L Losi P Chaubert, et al. 1993 Prognostic significance of K-ras mutations in colorectal carcinoma Gastroenterology 104 1044 1048 1:STN:280:DyaK3s3hs1SisQ%3D%3D 8462792 (Pubitemid 23090756)
    • (1993) Gastroenterology , vol.104 , Issue.4 , pp. 1044-1048
    • Benhattar, J.1    Losi, L.2    Chaubert, P.3    Givel, J.-C.4    Costa, J.5
  • 21
    • 0030499353 scopus 로고    scopus 로고
    • K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers
    • 1:STN:280:DyaK2s7psVyhuw%3D%3D 9042267
    • JC Lee ST Wang MD Lai, et al. 1996 K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers Anticancer Res 16 3839 3844 1:STN:280:DyaK2s7psVyhuw%3D%3D 9042267
    • (1996) Anticancer Res , vol.16 , pp. 3839-3844
    • Lee, J.C.1    Wang, S.T.2    Lai, M.D.3
  • 22
    • 51049092984 scopus 로고    scopus 로고
    • K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy
    • 10.1158/1078-0432.CCR-07-4906 1:CAS:528:DC%2BD1cXpt1ejtbg%3D 18676755
    • MC Etienne-Grimaldi JL Formento M Francoual, et al. 2008 K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy Clin Cancer Res 14 4830 4835 10.1158/1078-0432.CCR-07- 4906 1:CAS:528:DC%2BD1cXpt1ejtbg%3D 18676755
    • (2008) Clin Cancer Res , vol.14 , pp. 4830-4835
    • Etienne-Grimaldi, M.C.1    Formento, J.L.2    Francoual, M.3
  • 23
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • 10.1056/NEJMoa0804385 1:CAS:528:DC%2BD1cXht12nu77J 18946061
    • CS Karapetis S Khambata-Ford DJ Jonker, et al. 2008 K-ras mutations and benefit from cetuximab in advanced colorectal cancer N Engl J Med 359 1757 1765 10.1056/NEJMoa0804385 1:CAS:528:DC%2BD1cXht12nu77J 18946061
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 24
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • 10.1200/JCO.2007.14.7116 1:CAS:528:DC%2BD1cXltlWhsrw%3D 18316791
    • RG Amado M Wolf M Peeters, et al. 2008 Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer J Clin Oncol 26 1626 1634 10.1200/JCO.2007.14.7116 1:CAS:528:DC%2BD1cXltlWhsrw%3D 18316791
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 25
    • 58249093955 scopus 로고    scopus 로고
    • Results from panitumumab (pmab) regimen evaluation in colorectal cancer to estimate primary response to treatment (PRECEPT): Second-line treatment with pmab and FOLFIRI by tumor KRAS status
    • 10.1200/JCO.2008.16.6785
    • AL Cohn DA Smith A Neubauer, et al. 2009 Results from panitumumab (pmab) regimen evaluation in colorectal cancer to estimate primary response to treatment (PRECEPT): Second-line treatment with pmab and FOLFIRI by tumor KRAS status J Clin Oncol 27 184s 10.1200/JCO.2008.16.6785
    • (2009) J Clin Oncol , vol.27
    • Cohn, A.L.1    Smith, D.A.2    Neubauer, A.3
  • 26
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • 10.1200/JCO.2008.20.8397 1:CAS:528:DC%2BD1MXjsVCjsrk%3D 19114683
    • C Bokemeyer I Bondarenko A Makhson, et al. 2009 Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer J Clin Oncol 27 663 671 10.1200/JCO.2008.20.8397 1:CAS:528:DC%2BD1MXjsVCjsrk%3D 19114683
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 27
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • 10.1056/NEJMoa0805019 19339720
    • E Van Cutsem C-H Kohene E Hitre, et al. 2009 Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer N Engl J Med 360 1408 1417 10.1056/NEJMoa0805019 19339720
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Kohene, C.-H.2    Hitre, E.3
  • 28
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • DOI 10.1016/0092-8674(90)90186-I
    • ER Fearon B Vogelstein 1990 A genetic model for colorectal tumorigenesis Cell 61 759 767 10.1016/0092-8674(90)90186-I 1:CAS:528:DyaK3cXktlyhtrg%3D 2188735 (Pubitemid 20185636)
    • (1990) Cell , vol.61 , Issue.5 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 29
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • 1:STN:280:DyaL1czgt1aqtQ%3D%3D 2841597
    • B Vogelstein ER Fearon SR Hamilton, et al. 1988 Genetic alterations during colorectal-tumor development N Engl J Med 319 525 532 1:STN:280:DyaL1czgt1aqtQ%3D%3D 2841597
    • (1988) N Engl J Med , vol.319 , pp. 525-532
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3
  • 30
    • 0028822834 scopus 로고
    • Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
    • 1:CAS:528:DyaK2MXoslWms7Y%3D 7553632
    • J Rak Y Mitsuhashi L Bayko, et al. 1995 Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis Cancer Res 55 4575 4580 1:CAS:528:DyaK2MXoslWms7Y%3D 7553632
    • (1995) Cancer Res , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, Y.2    Bayko, L.3
  • 34
    • 77952094011 scopus 로고    scopus 로고
    • A comparability study of 4 commercial KRAS tests (abstract 1811)
    • San Diego, CA
    • Juan T, Suggs S, Wolf M, et al. A comparability study of 4 commercial KRAS tests (abstract 1811). Paper presented at: 99th AACR Annual Meeting; 2008; San Diego, CA.
    • (2008) 99th AACR Annual Meeting
    • Juan, T.1    Suggs, S.2    Wolf, M.3
  • 35
    • 65349189958 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    • 10.1200/JCO.2009.21.9170 19188670
    • CJ Allegra JM Jessup MR Sommerfield, et al. 2009 American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy J Clin Oncol 27 2091 2096 10.1200/JCO.2009.21.9170 19188670
    • (2009) J Clin Oncol , vol.27 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Sommerfield, M.R.3
  • 36
    • 54249098184 scopus 로고    scopus 로고
    • KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: Proposal for an European quality assurance program
    • 10.1007/s00428-008-0665-y
    • JH van Krieken A Jung T Kirchner, et al. 2009 KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: Proposal for an European quality assurance program Virchows Arch 453 417 431 10.1007/s00428-008-0665-y
    • (2009) Virchows Arch , vol.453 , pp. 417-431
    • Van Krieken, J.H.1    Jung, A.2    Kirchner, T.3
  • 38
    • 30644473641 scopus 로고    scopus 로고
    • Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies
    • DOI 10.1093/annonc/mdi907
    • A Russo V Bazan V Agnese, et al. 2005 Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies Ann Oncol 16 Suppl 4 iv44 iv49 10.1093/annonc/mdi907 15923428 (Pubitemid 43084945)
    • (2005) Annals of Oncology , vol.16 , Issue.SUPPL. 4
    • Russo, A.1    Bazan, V.2    Agnese, V.3    Rodolico, V.4    Gebbia, N.5
  • 40
    • 61449202998 scopus 로고    scopus 로고
    • The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
    • 10.1634/theoncologist.2008-0213 1:CAS:528:DC%2BD1MXjt1Clt7o%3D 19144677
    • HI Hurwitz J Yi W Ince, et al. 2009 The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer Oncologist 14 22 28 10.1634/ theoncologist.2008-0213 1:CAS:528:DC%2BD1MXjt1Clt7o%3D 19144677
    • (2009) Oncologist , vol.14 , pp. 22-28
    • Hurwitz, H.I.1    Yi, J.2    Ince, W.3
  • 41
    • 72249101664 scopus 로고    scopus 로고
    • Final STEPP results of prophylactic versus reactive skin toxicity (ST) treatment (tx) for panitumumab (pmab)-related ST in patients (pts) with metastatic colorectal cancer (mCRC)
    • 10.1200/JCO.2008.17.0910
    • EP Mitchell M LaCouture H Shearer, et al. 2009 Final STEPP results of prophylactic versus reactive skin toxicity (ST) treatment (tx) for panitumumab (pmab)-related ST in patients (pts) with metastatic colorectal cancer (mCRC) J Clin Oncol 27 805s 10.1200/JCO.2008.17.0910
    • (2009) J Clin Oncol , vol.27
    • Mitchell, E.P.1    Lacouture, M.2    Shearer, H.3
  • 42
    • 70449528360 scopus 로고    scopus 로고
    • Cetuximab plus FOLFOX6 or cetuximab plus FOLFIRI as neoadjuvant treatment of nonresectable colorectal liver metastases: A randomized multicenter study (CELIM-study)
    • January 15-17, 2009; San Francisco, CA
    • Folprecht G, Gruenberger T, Hartmann JT, et al. Cetuximab plus FOLFOX6 or cetuximab plus FOLFIRI as neoadjuvant treatment of nonresectable colorectal liver metastases: A randomized multicenter study (CELIM-study). Paper presented at: 2009 Gastrointestinal Cancers Symposium; January 15-17, 2009; San Francisco, CA.
    • 2009 Gastrointestinal Cancers Symposium
    • Folprecht, G.1    Gruenberger, T.2    Hartmann, J.T.3
  • 43
    • 57149101253 scopus 로고    scopus 로고
    • Phase III study (PRIME/20050203) of panitumumab (pmab) with FOLFOX compared with FOLFOX alone in patients (pts) with previously untreated metastatic colorectal cancer (mCRC): Pooled safety data
    • S Siena J Tabernero RL Burkes, et al. 2008 Phase III study (PRIME/20050203) of panitumumab (pmab) with FOLFOX compared with FOLFOX alone in patients (pts) with previously untreated metastatic colorectal cancer (mCRC): Pooled safety data J Clin Oncol 26 186s
    • (2008) J Clin Oncol , vol.26
    • Siena, S.1    Tabernero, J.2    Burkes, R.L.3
  • 44
    • 55249110754 scopus 로고    scopus 로고
    • Phase III study (20050181) of panitumumab (pmab) with FOLFIRI versus FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC): Pooled safety results
    • M Peeters G Wilson M Ducreux, et al. 2008 Phase III study (20050181) of panitumumab (pmab) with FOLFIRI versus FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC): Pooled safety results J Clin Oncol 26 194s
    • (2008) J Clin Oncol , vol.26
    • Peeters, M.1    Wilson, G.2    Ducreux, M.3
  • 45
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • 10.1200/JCO.2008.19.8135 1:CAS:528:DC%2BD1MXjsVCjs74%3D 19114685
    • JR Hecht E Mitchell T Chidiac, et al. 2009 A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer J Clin Oncol 27 672 680 10.1200/JCO.2008.19.8135 1:CAS:528:DC%2BD1MXjsVCjs74%3D 19114685
    • (2009) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 46
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • 10.1056/NEJMoa0808268 1:CAS:528:DC%2BD1MXhsFyitrw%3D 19196673
    • J Tol M Koopman A Cats, et al. 2009 Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer N Engl J Med 360 563 572 10.1056/NEJMoa0808268 1:CAS:528:DC%2BD1MXhsFyitrw%3D 19196673
    • (2009) N Engl J Med , vol.360 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3
  • 49
    • 68749119351 scopus 로고    scopus 로고
    • KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer
    • 10.1038/sj.bjc.6605177 1:CAS:528:DC%2BD1MXpvFyisb0%3D 19603018
    • F Loupakis A Ruzzo C Cremolini, et al. 2009 KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer Br J Cancer 101 715 721 10.1038/sj.bjc.6605177 1:CAS:528:DC%2BD1MXpvFyisb0%3D 19603018
    • (2009) Br J Cancer , vol.101 , pp. 715-721
    • Loupakis, F.1    Ruzzo, A.2    Cremolini, C.3
  • 50
    • 62449302407 scopus 로고    scopus 로고
    • PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
    • 10.1158/0008-5472.CAN-08-2466
    • A Sartore-Bianchi M Martini F Molinari, et al. 2009 PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies Cancer Res 69 7 1857 10.1158/0008-5472.CAN-08-2466
    • (2009) Cancer Res , vol.69 , pp. 7-1857
    • Sartore-Bianchi, A.1    Martini, M.2    Molinari, F.3
  • 51
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • 10.1200/JCO.2008.18.0786 1:CAS:528:DC%2BD1MXotFemsA%3D%3D 19001320
    • F Di Nicolantonio M Martini F Molinari, et al. 2008 Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer J Clin Oncol 26 5705 5712 10.1200/JCO.2008.18.0786 1:CAS:528: DC%2BD1MXotFemsA%3D%3D 19001320
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 52
    • 65649086786 scopus 로고    scopus 로고
    • PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer
    • 10.1158/1078-0432.CCR-08-2961 1:CAS:528:DC%2BD1MXltFOrur0%3D 19366826
    • H Prenen J De Schutter B Jacobs, et al. 2009 PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer Clin Cancer Res 15 3184 3188 10.1158/1078-0432.CCR-08-2961 1:CAS:528:DC%2BD1MXltFOrur0%3D 19366826
    • (2009) Clin Cancer Res , vol.15 , pp. 3184-3188
    • Prenen, H.1    De Schutter, J.2    Jacobs, B.3
  • 53
    • 72449204284 scopus 로고    scopus 로고
    • Et al. High epiregulin (EREG) plus K-ras (WT) status as predictors of cetuximab benefit in the treatments of advanced colorectal cancer (ACRC): Results from NCIC CTG CO.17-a phase III trial of cetuximab versus best supportive care (BSC)
    • DJ Jonker C Karapetis C Harbison 2009 et al. High epiregulin (EREG) plus K-ras (WT) status as predictors of cetuximab benefit in the treatments of advanced colorectal cancer (ACRC): Results from NCIC CTG CO.17-a phase III trial of cetuximab versus best supportive care (BSC) J Clin Oncol 27 172s
    • (2009) J Clin Oncol , vol.27
    • Jonker, D.J.1    Karapetis, C.2    Harbison, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.