Inotropic Stimulation Induces Cardiac Dysfunction in Transgenic Mice Expressing a Troponin T (I79N) Mutation Linked to Familial Hypertrophic Cardiomyopathy

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 10039-10048

  Knollmann, Björn C ^a   Blatt, Stephen A ^a   Horton, Kenneth ^b   De Freitas, Fatima ^d   Miller, Todd ^d   Bell, Michael ^d   Housmans, Philippe R ^c   Weissman, Neil J ^b   Morad, Martin ^a   Potter, James D ^d  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b WASHINGTON HOSPITAL CENTER   (United States)

^c MAYO CLINIC   (United States)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSENSORS; CALCIUM; CARDIOLOGY; DISEASES; ECHOCARDIOGRAPHY;

CARDIOMYOPATHY;

BIOMEDICAL ENGINEERING;

CALCIUM; ISOPRENALINE; TROPONIN T; CARDIOTONIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA OCCLUSION; ARTICLE; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; ECHOCARDIOGRAPHY; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; GENETIC LINKAGE; HEART DISEASE; HEART FUNCTION; HEART PERFORMANCE; HEART VENTRICLE ENDDIASTOLIC PRESSURE; INOTROPISM; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; SUDDEN DEATH; SYSTOLE; TRANSGENIC MOUSE; ANIMAL; BLOOD PRESSURE; CELL CULTURE; COMPUTER SIMULATION; DIASTOLE; DOSE RESPONSE; DRUG EFFECT; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; GENETICS; HEART; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; METABOLISM; MITRAL VALVE; PATHOLOGY; PERFUSION; PHYSIOLOGY; TIME;

ACRONICTA LEPORINA; ANIMALIA; MUS MUSCULUS;

ANIMALS; BLOOD PRESSURE; CALCIUM; CARDIOMYOPATHY, HYPERTROPHIC; CARDIOTONIC AGENTS; CELLS, CULTURED; COMPUTER SIMULATION; DIASTOLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; HEART; HUMANS; ISOPROTERENOL; MICE; MICE, TRANSGENIC; MITRAL VALVE; MUTATION; MYOCARDIAL CONTRACTION; MYOCARDIUM; PERFUSION; PHYSICAL CONDITIONING, ANIMAL; TIME FACTORS; TROPONIN T; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0035971216     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M006745200     Document Type: Article

References (31)

1. Watkins, H., McKenna, W. J., Thierfelder, L., Suk, H. J., Anan, R., O'Donoghue, A., Spirito, P., Matsumori, A., Moravec, C. S., Seidman, J. G., and Seidman, C. E. (1995) N. Engl. J. Med. 332, 1058-1064
2. Watkins, H., Seidman, C. E., Seidman, J. G., Feng, H. S., and Sweeney, H. L. (1996) J. Clin. Invest. 98, 2456-2461
3. Moolman, J. C., Corfield, V. A., Posen, B., Ngumbela, K., Seidman, C., Brink, P. A., and Watkins, H. (1997) J. Am. Coll. Cardiol. 29, 549-555
4. Varnava, A., Baboonian, C., Davison, F., de Cruz, L., Elliott, P. M., Davies, M. J., and McKenna, W. J. (1999) Heart 82, 621-624
5. Ho, C. Y., Lever, H. M., DeSanctis, R., Farver, C. F., Seidman, J. G., and Seidman, C. E. (2000) Circulation 102, 1950-1955
6. Maron, B. J., Shen, W. K., Link, M. S., Epstein, A. E., Almquist, A. K., Daubert, J. P., Bardy, G. H., Favale, S., Rea, R. F., Boriani, G., Estes, N. A., III, and Spirito, P. (2000) N. Engl. J. Med. 342, 365-373
7. Miller, T., Szczesna, D., Housmans, P. R., Zhao, J., deFreitas, F., Gomes, A. V., Culbreath, L., McCue, J., Wang, Y., Xu, Y., Kerrick, W. G., and Potter, J. D. (2001) J. Biol. Chem. 276, 3743-3755
8. Lim, C. C., Liao, R., Varma, N., and Apstein, C. S. (1999) Aro. J. Physiol. 277, H2083-H2090
9. Fabiato, A. (1988) Methods Enzymol. 157, 378-417
10. Knollmann, B. C., Knollmann-Ritschel, B. E. C., Weissman, N. J., Jones, L. R., and Morad, M. (2000) J. Physiol. 525, 483-498
11. Mitchell, G. F., Jeron, A., and Koren, G. (1998) Am. J. Physiol. 274, H747-H751
12. Hoit, B. D., Khoury, S. F., Kranias, E. G., Ball, N., and Walsh, R. A. (1995) Circ. Res. 77, 632-637
13. Geisterfer-Lowrance, A. A., Christe, M., Conner, D. A., Ingwall, J. S., Schoen, F. J., Seidman, C. E., and Seidman, J. G. (1996) Science 272, 731-734
14. Robertson, S. P., Johnson, J. D., and Potter, J. D. (1981) Biophys. J. 34, 559-569
15. Mikane, T., Araki, J., Kohno, K., Nakayama, Y., Suzuki, S., Shimizu, J., Matsubara, H., Hirakawa, M., Takaki, M., and Suga, H. (1997) Am. J. Physiol. 273, H2891-H2898
16. Landesberg, A., and Sideman, S. (1999) Am. J. Physiol. 276, H998-H1011
17. Tardiff, J. C., Hewett, T. E., Palmer, B. M., Olsson, C., Factor, S. M., Moore, R. L., Robbins, J., and Leinwand, L. A. (1999) J. Clin. Invest. 104, 469-481
18. Spindler, M., Saupe, K. W., Christe, M. E., Sweeney, H. L., Seidman, C. E., Seidman, J. G., and Ingwall, J. S. (1998) J. Clin. Invest. 101, 1775-1783
19. Georgakopoulos, D., Christe, M. E., Giewat, M., Seidman, C. M., Seidman, J. G., and Kass, D. A. (1999) Nat. Med. 5, 327-330
20. Apstein, C. S., Deckelbaum, L., Hagopian, L., and Hood, W. B., Jr. (1978) Am. J. Physiol. 235, H637-H648
21. Christensen, G., Wang, Y., and Chien, K. R. (1997) Am. J. Physiol. 272, H2513-H2524
22. Lim, D. S., Oberst, L., McCluggage, M., Youker, K., Lacy, J., DeMayo, F., Entman, M. L., Roberts, R., Michael, L. H., and Marian, A. J. (2000) J. Mol. Cell. Cardiol. 32, 365-374
23. Berul, C. I., Christe, M. E., Aronovitz, M. J., Seidman, C. E., Seidman, J. G., and Mendelsohn, M. E. (1997) J. Clin. Invest. 99, 570-576
24. Subramaniam, A., Jones, W. K., Gulick, J., Wert, S., Neumann, J., and Robbins, J. (1991) J. Biol. Chem. 266, 24613-24620
25. Little, W. C., Ohno, M., Kitzman, D. W., Thomas, J. D., and Cheng, C. P. (1995) Circulation 92, 1933-1939
26. McKenney, P. A., Apstein, C. S., Mendes, L. A., Connelly, G. P., Aldea, G. S., Shemin, R. J., and Davidoff, R. (1999) Am. J. Cardiol. 84, 914-918
27. McKenney, P. A., Apstein, C. S., Mendes, L. A., Connelly, G. P., Aldea, G. S., Shemin, R. J., and Davidoff, R. (1994) J. Am. Coll. Cardiol. 24, 1189-1194
28. Wigle, E. D., Rakowski, H., Kimball, B. P., and Williams, W. G. (1995) Circulation 92, 1680-1692
29. Dilsizian, V., Bonow, R. O., Epstein, S. E., and Fananapazir, L. (1993) J. Am. Coll. Cardiol. 22, 796-804
30. Prasad, K., and Frenneaux, M. P. (1998) Heart 79, 538-540
31. Stromer, H., Cittadini, A., Szymanska, G., Apstein, C. S., and Morgan, J. P. (1997) Am. J. Physiol. 272, H501-H510