Action potential characterization in intact mouse heart: Steady-state cycle length dependence and electrical restitution

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 292, Issue 1, 2007, Pages

  Knollmann, Björn C ^a   Schober, Tilmann ^b   Petersen, Andreas O ^b   Sirenko, Syevda G ^b   Franz, Michael R ^b,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Atrium; Calcium transients; Monophasic action potential; Ventricle

Indexed keywords

CALCIUM; ION CHANNEL;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ELECTROSTIMULATION; HEART MUSCLE CELL; HEART RATE; HEART VENTRICLE FUNCTION; ION TRANSPORT; ISOLATED HEART; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

ACTION POTENTIALS; ANIMALS; ATRIAL FUNCTION, LEFT; BIOLOGICAL CLOCKS; CELLS, CULTURED; ELECTRIC STIMULATION; ELECTROCARDIOGRAPHY; HEART CONDUCTION SYSTEM; HEART RATE; HEART VENTRICLES; MEMBRANE POTENTIALS; MICE; MYOCYTES, CARDIAC; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL;

EID: 33846235156     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01085.2005     Document Type: Article

References (34)

1. Anumonwo JM, Tallini YN, Vetter FJ, Jalife J. Action potential characteristics and arrhythmogenic properties of the cardiac conduction system of the murine heart. Circ Res 89: 329-335, 2001.
2. Baker LC, London B, Choi BR, Koren G, Salama G. Enhanced dispersion of repolarization and refractoriness in transgenic mouse hearts promotes reentrant ventricular tachycardia. Circ Res 86: 396-407, 2000.
3. Banville I, Gray RA. Effect of action potential duration and conduction velocity restitution and their spatial dispersion on alternans and the stability of arrhythmias. J Cardiovasc Electrophysiol 13: 1141-1149, 2002.
4. Banville I, Chattipakorn N, Gray RA. Restitution dynamics during pacing and arrhythmias in isolated pig hearts. J Cardiovasc Electrophysiol 15: 455-463, 2004.
5. Bass BG. Restitution of the action potential in cat papillary muscle. Am J Physiol 228: 1717-1724, 1975.
6. Boyett MR, Jewell BR. Analysis of the effects of changes in rate and rhythm upon electrical activity in the heart. Prog Biophys Mol Biol 36: 1-52, 1980.
7. + currents in adult mouse ventricles. J Physiol 559: 103-120, 2004.
8. 2+ concentration and rate adaptation of the cardiac action potential. Cell Calcium 35: 557-573, 2004.
9. Cherry EM, Fenton FH. Suppression of alternans and conduction blocks despite steep APD restitution: electrotonic, memory, and conduction velocity restitution effects. Am J Physiol Heart Circ Physiol 286: H2332-H2341, 2004.
10. DuBell WH, Boyett MR, Spurgeon HA, Talo A, Stern MD, Lakatta EG. The cytosolic calcium transient modulates the action potential of rat ventricular myocytes. J Physiol 436: 347-369, 1991.
11. Franz MR, Schaefer J, Schottler M, Seed WA, Noble MI. Electrical and mechanical restitution of the human heart at different rates of stimulation. Circ Res 53: 815-822, 1983.
12. Franz MR, Swerdlow CD, Liem LB, Schaefer J. Cycle length dependence of human action potential duration in vivo. Effects of single extrastimuli, sudden sustained rate acceleration and deceleration, and different steady-state frequencies. J Clin Invest 82: 972-979, 1988.
13. Franz MR. The electrical restitution curve revisited: steep or flat slope - which is better? J Cardiovasc Electrophysiol 14: S140-S147, 2003.
14. Goldhaber JI, Xie LH, Duong T, Motter C, Khuu K, Weiss JN. Action potential duration restitution and alternans in rabbit ventricular myocytes: the key role of intracellular calcium cycling. Circ Res 96: 459-466, 2005.
15. to,f and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction. Circ Res 97: 1342-1350, 2005.
16. 2+ exchange current in electrical restitution in ferret ventricular cells. J Physiol 504: 301-314, 1997.
17. Knollmann BC, Knollmann-Ritschel BE, Weissman NJ, Jones LR, Morad M. Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin. J Physiol 525: 483-498, 2000.
18. Knollmann BC, Katchman AN, Franz MR. Monophasic action potential recordings from intact mouse heart: validation, regional heterogeneity, and relation to refractoriness. J Cardiovasc Electrophysiol 12: 1286-1294, 2001.
19. Knollmann BC, Tranquillo J, Sirenko SG, Henriquez C, Franz MR. Microelectrode study of the genesis of the monophasic action potential by contact electrode technique. J Cardiovasc Electrophysiol 13: 1246-1252, 2002.
20. 2+-dependent action potential remodeling. Circ Res 92: 428-436, 2003.
21. Koller ML, Riccio ML, Gilmour RF Jr. Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation. Am J Physiol Heart Circ Physiol 275: H1635-H1642, 1998.
22. Le Grand B, Le Heuzey JY, Perier P, Peronneau P, Lavergne T, Hatem S, Guize L. Cellular electrophysiological effects of flecainide on human atrial fibres. Cardiovasc Res 24: 232-238, 1990.
23. 2+ currents in myocytes from left and right atria of adult mice. Am J Physiol Heart Circ Physiol 285: H1837-H1848, 2003.
24. London B. Cardiac arrhythmias: from (transgenic) mice to men. J Cardiovasc Electrophysiol 12: 1089-1091, 2001.
25. Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS. Requirement of a macromolecular signaling complex for β adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 295: 496-499, 2002.
26. + channel diversity in the mammalian myocardium. J Physiol 525: 285-298, 2000.
27. Noble D, Noble SJ, Bett GC, Earm YE, Ho WK, So IK. The role of sodium-calcium exchange during the cardiac action potential. Ann NY Acad Sci 639: 334-353, 1991.
28. Nygren A, Lomax AE, Giles WR. Heterogeneity of action potential durations in isolated mouse left and right atria recorded using voltage-sensitive dye mapping. Am J Physiol Heart Circ Physiol 287: H2634-H2643, 2004.
29. Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS. Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation 99: 1385-1394, 1999.
30. Schouten VJ, ter Keurs HE. The slow repolarization phase of the action potential in rat heart. J Physiol 360: 13-25, 1985.
31. Watanabe MA, Koller ML. Mathematical analysis of dynamics of cardiac memory and accommodation: theory and experiment. Am J Physiol Heart Circ Physiol 282: H1534-H1547, 2002.
32. Weiss JN, Chen PS, Qu Z, Karagueuzian HS, Garfinkel A. Ventricular fibrillation: how do we stop the waves from breaking? Circ Res 87: 1103-1107, 2000.
33. + currents in adult mouse ventricular myocytes. J Gen Physiol 113: 661-678, 1999.
34. Xu H, Li H, Nerbonne JM. Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 α subunit. J Physiol 519: 11-21, 1999.