Recurrent miscarriage and thrombophilia: An update

Current Opinion in Obstetrics and Gynecology

Volumn 24, Issue 4, 2012, Pages 229-234

  McNamee, Kelly ^a   Dawood, Feroza ^a   Farquharson, Roy ^a  

^a LIVERPOOL WOMEN'S NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

antiphospholipid syndrome; aspirin; heparin; recurrent pregnancy loss; thrombophilia

Indexed keywords

ACETYLSALICYLIC ACID; ENOXAPARIN; HEPARIN; PLACEBO;

ANTICOAGULANT THERAPY; ANTIPHOSPHOLIPID SYNDROME; DIAGNOSTIC TEST; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG SAFETY; ENVIRONMENTAL FACTOR; HUMAN; LABORATORY TEST; LIVE BIRTH; LOW DRUG DOSE; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SPONTANEOUS ABORTION; THROMBOPHILIA;

ABORTION, HABITUAL; ANTICOAGULANTS; ANTIPHOSPHOLIPID SYNDROME; ASPIRIN; EVIDENCE-BASED MEDICINE; FEMALE; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PREGNANCY, HIGH-RISK; THROMBOPHILIA;

EID: 84863717985     PISSN: 1040872X     EISSN: 1473656X     Source Type: Journal    
DOI: 10.1097/GCO.0b013e32835585dc     Document Type: Review

References (41)

1. Cohn DM, Goddijn M, Middeldorp S, et al. Recurrent miscarriage and antiphospholipid antibodies: prognosis of subsequent pregnancy. J Thromb Haemost 2010; 8:2208-2213.
2. Jauniaux E, Farquharson RG, Christianson OB, Exalto N. Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Hum Reprod 2006; 21:2216-2222.
3. American Society for Reproductive Medicine. Patient's fact sheet: recurrent pregnancy loss. Birmingham, Alabama: American Society for Reproductive Medicine; 2008.
4. Jaslow CR, Carney JL, Kutteh WH. Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses. Fertil Steril 2010; 93:1234-1243.
5. McNamee K, Dawood F, Farquharson RG. Thrombophilia and early pregnancy loss. Best Pract Res Clin Obstet Gynaecol 2012; 26:91-102. doi:10.1016/j. bpobgyn.2011.10.002.
6. Kaandorp SP, Goddijn M, Van Der Post JA, et al. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med 2010; 362:1586-1596.
7. Clark P, Walker ID, Langhorne P, et al. SPIN: the Scottish Pregnancy Intervention Study - a multicentre randomized control trial of low molecular weight heparin and low dose aspirin in women with recurrent miscarriage. Blood 2010; 115:4162-4167.
8. Branch W, Gibson M, Silver M. Recurrent miscarriage. N Engl J Med 2010; 363:1740-1747.
9. Serrano F, Lima ML, Lopes C, et al. Factor V Leiden and prothrombin G20210A in Portuguese women with recurrent miscarriage: is it worthwhile to investigate? Arch Gynecol Obstet 2011; 284:1127-1132.
10. Kujovic JL. Thrombophilia and pregnancy complications. Am J Obstet Gynecol 2004; 191:412-424.
11. Lissalde-Lavigne G, Fabbro-Peray P, Cochery-Nouvellon E, et al. Factor V Leiden and prothrombin G20210A polymorphisms as risk factors for miscarriage during a first intended pregnancy: the matched case control 'NOHA first' study. J Thromb Haemost 2005; 3:2178-2184.
12. Bates SM. Consultative haematology: the pregnant patient 2010. Hematology 2010; 166-172.
13. Rodger MA, Betancourt MT, Clark P, et al. The association of Factor V Leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies. PLoS Med 2010; 7:e1000292.
14. Lund M, Nielsen HS, Hviid TV. Hereditary thrombophilia and recurrent pregnancy loss: a retrospective cohort study of pregnancy outcome and complications. Hum Reprod 2010; 25:2978-2984.
15. Silver RM, Zhao Y, Spong CY, et al. Prothrombin gene G20210A mutation and obstetric complications. Obstet Gynaecol 2010; 115:14-20.
16. Sabadell J, Castellas M, Alijotas-Reig J, et al. Inherited antithrombin deficiency and pregnancy: maternal and fetal outcomes. Eur J Obstet Gynecol Reprod Biol 2010; 149:47-51.
17. Saiter MS, Finan RR, Mustafa FE, et al. Antiannexin V IgM and IgG autoantobodies and the risk of idiopathic recurrent spontaneous miscarriage. J Reprod Immunol 2011; 89:78-83.
18. Saiter MS, Finan RR, Al-Hammad S. A high frequency of antiprotein Z IgM and IgG autoantibodies in women with idiopathic recurrent spontaneous miscarriage. Am J Repord Immunol 2011; 65:526-531.
19. Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA. Antiphospholipid syndrome. Lancet 2010; 376:1498-1509.
20. Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria and for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4:295-306.
21. Rai R, Regan L. Recurrent miscarriage. Lancet 2006; 368:601-611.
22. Branch W. Report of the Obstetric APS Task Force: 13th International Congress on Antiphospholipid Antibodies. Lupus 2011; 20:158-164.
23. Dawood F. Inherited and acquired thrombophilia in pregnancy. In: Tranquilli AL, editor. Thrombophilia.InTech Europe. University Campus STeP Ri, Slavka Krautzeka 83/A 51000 Rijeka: Croatia; 2011. pp. 99-120.
24. SarigG, Younis JS, Hoffman R, et al. Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage. Fertil Steril 2002; 77:342-347.
25. Dawood F, Mountford R, Farquharson R, Quenby S. Genetic polymorphisms on the factor V gene in women with recurrent miscarriage and acquired APCR. Hum Reprod 2007; 22:2546-2553.
26. Sedano-Selbas S, Lyons M, Cleary B, et al. APCR, factor V and novel SNPs and adverse pregnancy outcomes in an Irish cohort of pregnant women. BMC Pregnancy Childbirth 2010 Mar 10;10:11.
27. Hoppe B, Burmester G, Dorner T. Heparin or aspirin or both in the treatment of recurrent abortions in women with antiphospholipid antibody (syndrome). Curr Opin Rhematol 2011; 23:299-304.
28. Brenner B, Hoffman R, Carp H, et al., for the LIVE-ENOX Investigators. Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy losses: the LIVE-ENOX study. J Thromb Haemost 2005; 3:227-229.
29. Visser J, Ulander VM, Helmerhorst FM, et al. Thromboprophylaxis for recurrent miscarriage in women with or without thrombophilia. HABENOX: a randomised multicentre trial. Thromb Haemost 2010; 105:295-301.
30. Empson MB, Lassere M, Craig JC, Scott JR. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Syst Rev 2005:CD002859.
31. Mak A, Cheung MW, Cheak AA, Ho RC. Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive antiphospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression. Rheumatology (Oxford) 2010; 49:281-288.
32. Ziakas P, Pavlou M, Voulgarelis M. Heparin treatment in antiphospholipid syndrome with recurrent pregnancy loss. Obstet Gynecol 2010; 11:1256-1262.
33. Fouda UM, Sayed AM, Abdou AA. Enoxaparin versus unfractionated heparin in the management of recurrent abortion secondary to antiphospholipid syndrome. BJOG 2011; 112:211-215.
34. Fouda UM, Sayed AM, Ramadan DI, Fouda IM. Efficacy and safety of two doses of low molecular weight heparin (enoxaparin) in pregnant women with a history of recurrent abortion secondary to antiphospholipid syndrome. J Obstet Gynaecol 2010; 30:842-846.
35. Friedrich E, Hameed AB. Fluctuations in antifactor Xa levels with therapeutic enoxaparin and anticoagulation in pregnancy. J Perinatol 2010; 30:253-257.
36. Misra L, Aledort L. Recurrent miscarriages: caution regarding development of clinical trials using low molecular weight heparin and pregnancy. Am J Hematol 2011; 86:235. doi: 10.1002/ajh.21909.
37. Greer IA. Antithrombotic treatment for pregnancy loss? J Thromb Haemost 2011; 9:302-305.
38. Lukanov TH, Veleva GL, Konova EI, et al. Levels of platelet-leukocyte aggregates in women with both thrombophilia and recurrent pregnancy loss. Clin Appl Thromb Hemost 2011; 17:181-187.
39. Jeddi-Tehrani M, Torabi R, Mohammadzadeh A, et al. Investigating association of three polymorphisms of coagulation factor XIII and recurrent pregnancy loss. Am J Reprod Immun 2010; 64:212-217.
40. Bates SM, Greer IA, Pabinger I, et al., American College of Chest Physicians. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition). Chest 2008; 133:844S-886S.
41. Brigham SA, Conlon C, Farquharson RG. A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage. Hum Reprod 1999; 14:2868-2871.