Efficacy and safety of two doses of low molecular weight heparin enoxaparin in pregnant women with a history of recurrent abortion secondary to antiphospholipid syndrome

Journal of Obstetrics and Gynaecology

Volumn 30, Issue 8, 2010, Pages 842-846

  Fouda, U M ^a   Sayed, A M ^a   Ramadan, D I ^a   Fouda, I M ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Antiphospholipid syndrome; Enoxaparin; Low dose aspirin; Recurrent pregnancy loss

Indexed keywords

ACETYLSALICYLIC ACID; CALCIUM; CARDIOLIPIN ANTIBODY; ENOXAPARIN; HEPARIN; LUPUS ANTICOAGULANT; VITAMIN D;

ADULT; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BIRTH RATE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; FEMALE; GESTATIONAL AGE; HUMAN; LIVE BIRTH; LOW DRUG DOSE; OSTEOPOROSIS; OUTCOME ASSESSMENT; PATHOLOGIC FRACTURE; POSTPARTUM HEMORRHAGE; PREGNANCY; PREGNANT WOMAN; PRIORITY JOURNAL; PUERPERIUM; RANDOMIZED CONTROLLED TRIAL; RECURRENT ABORTION; SOLUTIO PLACENTAE; THROMBOCYTOPENIA; THROMBOSIS;

ABORTION, HABITUAL; ADULT; ANTICOAGULANTS; ANTIPHOSPHOLIPID SYNDROME; ENOXAPARIN; FEMALE; HUMANS; INFANT, NEWBORN; PREGNANCY; PREGNANCY OUTCOME; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 78649927403     PISSN: 01443615     EISSN: 13646893     Source Type: Journal    
DOI: 10.3109/01443615.2010.518651     Document Type: Article

References (21)

1. Backos M, Rai R, Baxter N, Chilcott IT, Cohen H, Regan L. 1999. Pregnancy complications in women with recurrent miscarriage associated with antiphospholipid antibodies treated with low dose heparin and aspirin. British Journal of Obstetrics Gynaecology 106:102-107.
2. Brenner B, Hoffman R, Blumenfeld Z, Weiner Z, Younis JS. 2000. Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin. Thrombosis and Haemostasis 83:693-697.
3. Brenner B, Hoffman R, Carp H, Dulitsky M, Younis J; LIVE-ENOX Investigators. 2005. Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LIVE-ENOX study. Journal of Thrombosis and Haemostasis 3:227-229.
4. Casele H, Haney EI, James A, Rosene-Montella K, Carson M. 2006. Bone density changes in women who receive thromboprophylaxis in pregnancy. American Journal of Obstetrics and Gynecology 195:1109-1113.
5. Dendrinos S, Sakkas E, Makrakis E. 2009. Low-molecular-weight heparin versus intravenous immunoglobulin for recurrent abortion associated with antiphospholipid antibody syndrome. International Journal of Gynaecology and Obstetrics 104:223-225.
6. Deruelle P, Coulon C. 2007. The use of low-molecular-weight heparins in pregnancy-how safe are they? Current Opinion in Obstetrics and Gynecology 19:573-577.
7. Dimitrakakis C, Papageorgiou P, Papageorgiou I, Antzaklis A, Sakarelou N, Michalas S. 2000. Absence of transplacental passage of the low molecular weight heparin enoxaparin. Haemostasis 30:243-248.
8. Empson M, Lassere M, Craig J, Scott J. 2005. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Systematic Reviews 2: CD002859.
9. Fausett MB, Vogtlander M, Lee RM, Esplin MS, Branch DW, Rodgers GM, et al. 2001. Heparin-induced thrombocytopenias rare in pregnancy. American Journal of Obstetrics and Gynecology 185:148-152.
10. Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, et al. 2003. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. Journal of Clinical Investigation 112:1644-1654.
11. Girardi G, Redecha P, Salmon JE. 2004. A potential mechanism for therapeutics efficacy of heparin in antiphospholipid antibodies-induced pregnancy loss-inhibition of complement. Nature Medicine 10:1222-1226.
12. Girardi G. 2005. Heparin treatment in pregnancy loss: Potential therapeutic benefits beyond anticoagulation. Journal of Reproductive Immunology 66:45-51.
13. Greer IA, Nelson-Piercy C. 2005. Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy. Blood 106:401-407.
14. Mo D, Saravelos S, Metwally M, Makris M, Li TC. 2009. Treatment of recurrent miscarriage and antiphospholipid syndrome with low-dose enoxaparin and aspirin. Reproductive Biomedicine Online 19:216-220.
15. Noble LS, Kutteh WH, Lashey N, Franklin RD, Herrada J. 2005. Antiphospholipid antibodies associated with recurrent pregnancy loss: prospective, multicenter, controlled pilot study comparing treatment with low-molecular weight heparin versus unfractionated heparin. Fertility & Sterility 83:684-690.
16. Rai RS, Clifford K, Cohen H, Regan L. 1995. High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies. Human Reproduction 10:3301-3304.
17. Robin F, Lecuru F, Desfeux P, Boucaya V, Taurelle R. 1999. Anticoagulant therapy in pregnancy. European Journal of Obstetrics, Gynecology and Reproductive Biology 83:171-177.
18. Rodger MA, Kahn SR, Cranney A, Hodsman A, Kovacs MJ, Clement AM, et al. 2007. Long-term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trial. Journal of Thrombosis and Haemostasis 5:1600-1606.
19. Salafia CM, Cowchock FS. 1997. Placental pathology and antiphospholipid antibodies: A descriptive study. American Journal of Perinatology 14:435-441.
20. Triolo G, Ferrante A, Ciccia F, Accardo-Palumbo A, Perino A, Castelli A, et al. 2003. Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulin in the treatment of recurrent fetal loss associated with antiphospholipid antibodies. Arthritis and Rheumatism 48:728-731.
21. Tuthill JI, Khamashta MA. 2009. Management of antiphospholipid syndrome. Journal of Autoimmunity 33:92-98.