메뉴 건너뛰기




Volumn 18, Issue 1, 2012, Pages 41-51

The paradox of triple negative breast cancer: Novel approaches to treatment

Author keywords

ixabepilone; novel agents; platinum agents; poly(ADP ribose) polymerase; triple negative breast cancer

Indexed keywords

AN 162; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; BOSUTINIB; BRCA1 PROTEIN; BRCA2 PROTEIN; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CYTOTOXIC AGENT; DASATINIB; DOCETAXEL; ENTINOSTAT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERIBULIN; GEMCITABINE; HEAT SHOCK PROTEIN 90 INHIBITOR; INIPARIB; IRINOTECAN; IXABEPILONE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OLAPARIB; PACLITAXEL; PLATINUM; SUNITINIB; TAXANE DERIVATIVE; TRABECTEDIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84855712591     PISSN: 1075122X     EISSN: 15244741     Source Type: Journal    
DOI: 10.1111/j.1524-4741.2011.01175.x     Document Type: Article
Times cited : (77)

References (85)
  • 1
    • 34247569300 scopus 로고    scopus 로고
    • Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: A population-based study from the California Cancer Registry
    • DOI 10.1002/cncr.22618
    • Bauer KR, Brown M, Cress RD, Parise CA, Caggiano V,. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry. Cancer 2007; 109: 1721-8. (Pubitemid 46668532)
    • (2007) Cancer , vol.109 , Issue.9 , pp. 1721-1728
    • Bauer, K.R.1    Brown, M.2    Cress, R.D.3    Parise, C.A.4    Caggiano, V.5
  • 2
    • 48649108724 scopus 로고    scopus 로고
    • The prognostic importance of triple negative breast carcinoma
    • Mersin H, Yildirim E, Berberoglu U, Gulben K,. The prognostic importance of triple negative breast carcinoma. Breast 2008; 17: 341-6.
    • (2008) Breast , vol.17 , pp. 341-346
    • Mersin, H.1    Yildirim, E.2    Berberoglu, U.3    Gulben, K.4
  • 3
    • 59149087596 scopus 로고    scopus 로고
    • Is triple negative a prognostic factor in breast cancer?
    • Nishimura R, Arima N,. Is triple negative a prognostic factor in breast cancer? Breast Cancer 2008; 15: 303-8.
    • (2008) Breast Cancer , vol.15 , pp. 303-308
    • Nishimura, R.1    Arima, N.2
  • 4
    • 63549116437 scopus 로고    scopus 로고
    • Survival among women with triple receptor-negative breast cancer and brain metastases
    • Dawood S, Broglio K, Esteva FJ, et al. Survival among women with triple receptor-negative breast cancer and brain metastases. Ann Oncol 2009; 20: 621-7.
    • (2009) Ann Oncol , vol.20 , pp. 621-627
    • Dawood, S.1    Broglio, K.2    Esteva, F.J.3
  • 6
    • 41649102048 scopus 로고    scopus 로고
    • Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    • Liedtke C, Mazouni C, Hess KR, et al. Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol 2008; 26: 1275-81.
    • (2008) J Clin Oncol , vol.26 , pp. 1275-1281
    • Liedtke, C.1    Mazouni, C.2    Hess, K.R.3
  • 7
    • 55849132481 scopus 로고    scopus 로고
    • Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: High incidence of central nervous system metastases
    • Lin NU, Claus E, Sohl J, Razzak AR, Arnaout A, Winer EP,. Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases. Cancer 2008; 113: 2638-45.
    • (2008) Cancer , vol.113 , pp. 2638-2645
    • Lin, N.U.1    Claus, E.2    Sohl, J.3    Razzak, A.R.4    Arnaout, A.5    Winer, E.P.6
  • 8
    • 51349102645 scopus 로고    scopus 로고
    • Impact of triple negative phenotype on breast cancer prognosis
    • Kaplan HG, Malmgren JA,. Impact of triple negative phenotype on breast cancer prognosis. Breast J 2008; 14: 456-63.
    • (2008) Breast J , vol.14 , pp. 456-463
    • Kaplan, H.G.1    Malmgren, J.A.2
  • 9
    • 34547860028 scopus 로고    scopus 로고
    • Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: A single-institution compilation compared with the national cancer institute's surveillance, epidemiology, and end results database
    • DOI 10.1002/cncr.22836
    • Morris GJ, Naidu S, Topham AK, et al. Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: a single-institution compilation compared with the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Cancer 2007; 110: 876-84. (Pubitemid 47257667)
    • (2007) Cancer , vol.110 , Issue.4 , pp. 876-884
    • Morris, G.J.1    Naidu, S.2    Topham, A.K.3    Guiles, F.4    Xu, Y.5    McCue, P.6    Schwartz, G.F.7    Park, P.K.8    Rosenberg, A.L.9    Brill, K.10    Mitchell, E.P.11
  • 11
    • 49049099406 scopus 로고    scopus 로고
    • High prevalence of triple-negative tumors in an urban cancer center
    • Lund MJ, Butler EN, Bumpers HL, et al. High prevalence of triple-negative tumors in an urban cancer center. Cancer 2008; 113: 608-15.
    • (2008) Cancer , vol.113 , pp. 608-615
    • Lund, M.J.1    Butler, E.N.2    Bumpers, H.L.3
  • 12
    • 68149163711 scopus 로고    scopus 로고
    • Triple-negative breast cancers are increased in black women regardless of age or body mass index
    • Stead LA, Lash TL, Sobieraj JE, et al. Triple-negative breast cancers are increased in black women regardless of age or body mass index. Breast Cancer Res 2009; 11: R18.
    • (2009) Breast Cancer Res , vol.11
    • Stead, L.A.1    Lash, T.L.2    Sobieraj, J.E.3
  • 13
    • 77953589667 scopus 로고    scopus 로고
    • Clinicopathologic and prognostic features of triple-negative breast cancer analyzed in registration data of the Japanese Breast Cancer Society, 11705 cases
    • Abstract e22122
    • Iwase H, Yamamoto Y, Kurebayashi J, et al. Clinicopathologic and prognostic features of triple-negative breast cancer analyzed in registration data of the Japanese Breast Cancer Society, 11705 cases. J Clin Oncol 2009; 27. Abstract e22122.
    • (2009) J Clin Oncol , vol.27
    • Iwase, H.1    Yamamoto, Y.2    Kurebayashi, J.3
  • 14
    • 33747819585 scopus 로고    scopus 로고
    • Clinicopathologic significance of the basal-like subtype of breast cancer: A comparison with hormone receptor and Her2/neu-overexpressing phenotypes
    • DOI 10.1016/j.humpath.2006.04.015, PII S0046817706002644
    • Kim MJ, Ro JY, Ahn SH, Kim HH, Kim SB, Gong G,. Clinicopathologic significance of the basal-like subtype of breast cancer: a comparison with hormone receptor and Her2/neu-overexpressing phenotypes. Hum Pathol 2006; 37: 1217-26. (Pubitemid 44286991)
    • (2006) Human Pathology , vol.37 , Issue.9 , pp. 1217-1226
    • Kim, M.-J.1    Ro, J.Y.2    Ahn, S.-H.3    Kim, H.H.4    Kim, S.-B.5    Gong, G.6
  • 15
    • 54949144968 scopus 로고    scopus 로고
    • Triple-negative breast cancer types exhibit a distinct poor clinical characteristic in lymph node-negative Chinese patients
    • Liu ZB, Liu GY, Yang WT, et al. Triple-negative breast cancer types exhibit a distinct poor clinical characteristic in lymph node-negative Chinese patients. Oncol Rep 2008; 20: 987-94.
    • (2008) Oncol Rep , vol.20 , pp. 987-994
    • Liu, Z.B.1    Liu, G.Y.2    Yang, W.T.3
  • 16
    • 58849120532 scopus 로고    scopus 로고
    • Clinicopathologic and prognostic characteristics of triple-negative breast cancer
    • Tian XS, Cong MH, Zhou WH, Zhu J, Chen YZ, Liu Q,. Clinicopathologic and prognostic characteristics of triple-negative breast cancer. Onkologie 2008; 31: 610-4.
    • (2008) Onkologie , vol.31 , pp. 610-614
    • Tian, X.S.1    Cong, M.H.2    Zhou, W.H.3    Zhu, J.4    Chen, Y.Z.5    Liu, Q.6
  • 17
    • 77953600449 scopus 로고    scopus 로고
    • Triple-negative breast cancer in Hong Kong Chinese patients
    • Abstract e22127
    • Tsang J, Lai TL, Lau DH, Au GK, Chua DT,. Triple-negative breast cancer in Hong Kong Chinese patients. J Clin Oncol 2009; 27. Abstract e22127.
    • (2009) J Clin Oncol , vol.27
    • Tsang, J.1    Lai, T.L.2    Lau, D.H.3    Au, G.K.4    Chua, D.T.5
  • 18
    • 77953598832 scopus 로고    scopus 로고
    • Incidence of triple negative breast cancer phenotype in a predominantly Hispanic cohort
    • Abstract e22188
    • Khan A, Tovar YE, Rodriguez C, et al. Incidence of triple negative breast cancer phenotype in a predominantly Hispanic cohort. J Clin Oncol 2009; 27. Abstract e22188.
    • (2009) J Clin Oncol , vol.27
    • Khan, A.1    Tovar, Y.E.2    Rodriguez, C.3
  • 19
    • 58249085911 scopus 로고    scopus 로고
    • Triple receptor-negative breast cancer: The effect of race on response to primary systemic treatment and survival outcomes
    • Dawood S, Broglio K, Kau SW, et al. Triple receptor-negative breast cancer: the effect of race on response to primary systemic treatment and survival outcomes. J Clin Oncol 2009; 27: 220-6.
    • (2009) J Clin Oncol , vol.27 , pp. 220-226
    • Dawood, S.1    Broglio, K.2    Kau, S.W.3
  • 21
    • 38549125159 scopus 로고    scopus 로고
    • Early onset of breast cancer in a group of British black women
    • DOI 10.1038/sj.bjc.6604174, PII 6604174
    • Bowen RL, Duffy SW, Ryan DA, Hart IR, Jones JL,. Early onset of breast cancer in a group of British black women. Br J Cancer 2008; 98: 277-81. (Pubitemid 351161260)
    • (2008) British Journal of Cancer , vol.98 , Issue.2 , pp. 277-281
    • Bowen, R.L.1    Duffy, S.W.2    Ryan, D.A.3    Hart, I.R.4    Jones, J.L.5
  • 22
    • 66649101370 scopus 로고    scopus 로고
    • Risk factors for triple-negative breast cancer in women under the age of 45 years
    • Dolle JM, Daling JR, White E, et al. Risk factors for triple-negative breast cancer in women under the age of 45 years. Cancer Epidemiol Biomarkers Prev 2009; 18: 1157-66.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 1157-1166
    • Dolle, J.M.1    Daling, J.R.2    White, E.3
  • 24
    • 77953578801 scopus 로고    scopus 로고
    • The association of metabolic syndrome with triple-negative breast cancer
    • 1038
    • Maiti B, Kundranda MN, Jin T, Spiro TP, Daw HA,. The association of metabolic syndrome with triple-negative breast cancer. J Clin Oncol 2009; 27. Abstract 1038.
    • (2009) J Clin Oncol , vol.27
    • Maiti, B.1    Kundranda, M.N.2    Jin, T.3    Spiro, T.P.4    Daw, H.A.5
  • 27
    • 34547852260 scopus 로고    scopus 로고
    • Does triple-negative phenotype accurately identify basal-like tumour? An immunohistochemical analysis based on 143 'triple-negative' breast cancers [5]
    • DOI 10.1093/annonc/mdm360
    • Bidard FC, Conforti R, Boulet T, Michiels S, Delaloge S, Andre F,. Does triple-negative phenotype accurately identify basal-like tumour? An immunohistochemical analysis based on 143 'triple-negative' breast cancers. Ann Oncol 2007; 18: 1285-6. (Pubitemid 47244379)
    • (2007) Annals of Oncology , vol.18 , Issue.7 , pp. 1285-1286
    • Bidard, F.-C.1    Conforti, R.2    Boulet, T.3    Michiels, S.4    Delaloge, S.5    Andre, F.6
  • 28
    • 65249104546 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Distinguishing between basal and nonbasal subtypes
    • Rakha EA, Elsheikh SE, Aleskandarany MA, et al. Triple-negative breast cancer: distinguishing between basal and nonbasal subtypes. Clin Cancer Res 2009; 15: 2302-10.
    • (2009) Clin Cancer Res , vol.15 , pp. 2302-2310
    • Rakha, E.A.1    Elsheikh, S.E.2    Aleskandarany, M.A.3
  • 29
    • 56949103031 scopus 로고    scopus 로고
    • What is triple-negative breast cancer?
    • Irvin WJ Jr, Carey LA,. What is triple-negative breast cancer? Eur J Cancer 2008; 44: 2799-805.
    • (2008) Eur J Cancer , vol.44 , pp. 2799-2805
    • Irvin Jr., W.J.1    Carey, L.A.2
  • 31
    • 70349932822 scopus 로고    scopus 로고
    • Patterns of recurrence in the basal and non-basal subtypes of triple-negative breast cancers
    • Nofech-Mozes S, Trudeau M, Kahn HK, et al. Patterns of recurrence in the basal and non-basal subtypes of triple-negative breast cancers. Breast Cancer Res Treat 2009; 118: 131-7.
    • (2009) Breast Cancer Res Treat , vol.118 , pp. 131-137
    • Nofech-Mozes, S.1    Trudeau, M.2    Kahn, H.K.3
  • 32
    • 84855654179 scopus 로고    scopus 로고
    • Heterogeneity of triple negative breast cancer (TNBC): TNBC might be divided into two or more subgroups by clinicopathologic findings
    • 6032
    • Park YH, Chang MH, Lee S, et al. Heterogeneity of triple negative breast cancer (TNBC): TNBC might be divided into two or more subgroups by clinicopathologic findings. Cancer Res 2009; 69 (Suppl 24). Abstract 6032.
    • (2009) Cancer Res , vol.69 , Issue.SUPPL 24
    • Park, Y.H.1    Chang, M.H.2    Lee, S.3
  • 33
    • 84855672120 scopus 로고    scopus 로고
    • NCCN clinical practice guidelines in oncology
    • National Comprehensive Cancer Network (NCCN).:, BINV-N. Available at: (accessed September 16, 2009)
    • National Comprehensive Cancer Network (NCCN). NCCN clinical practice guidelines in oncology. Metastatic Breast Cancer. 2008; 2: BINV19, BINV-N. Available at: (accessed September 16, 2009).
    • (2008) Metastatic Breast Cancer. , vol.2
  • 34
    • 33645729203 scopus 로고    scopus 로고
    • Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer
    • Berry DA, Cirrincione C, Henderson IC, et al. Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer. JAMA 2006; 295: 1658-67.
    • (2006) JAMA , vol.295 , pp. 1658-1667
    • Berry, D.A.1    Cirrincione, C.2    Henderson, I.C.3
  • 37
    • 70350464164 scopus 로고    scopus 로고
    • Frequent pathologic complete responses in aggressive stages II to III breast cancers with every-4-week carboplatin and weekly paclitaxel with or without trastuzumab: A Brown University Oncology Group Study
    • Sikov WM, Dizon DS, Strenger R, et al. Frequent pathologic complete responses in aggressive stages II to III breast cancers with every-4-week carboplatin and weekly paclitaxel with or without trastuzumab: a Brown University Oncology Group Study. J Clin Oncol 2009; 27: 4693-700.
    • (2009) J Clin Oncol , vol.27 , pp. 4693-4700
    • Sikov, W.M.1    Dizon, D.S.2    Strenger, R.3
  • 38
    • 54949097426 scopus 로고    scopus 로고
    • Platinum-based chemotherapy in triple-negative breast cancer
    • Sirohi B, Arnedos M, Popat S, et al. Platinum-based chemotherapy in triple-negative breast cancer. Ann Oncol 2008; 19: 1847-52.
    • (2008) Ann Oncol , vol.19 , pp. 1847-1852
    • Sirohi, B.1    Arnedos, M.2    Popat, S.3
  • 40
    • 34248145042 scopus 로고    scopus 로고
    • Molecular subtypes of breast cancer in relation to paclitaxel response and outcomes in women with metastatic disease: Results from CALGB 9342
    • Harris LN, Broadwater G, Lin NU, et al. Molecular subtypes of breast cancer in relation to paclitaxel response and outcomes in women with metastatic disease: results from CALGB 9342. Breast Cancer Res 2006; 8: R66.
    • (2006) Breast Cancer Res , vol.8
    • Harris, L.N.1    Broadwater, G.2    Lin, N.U.3
  • 41
    • 65649151690 scopus 로고    scopus 로고
    • Survival outcomes for patients with metastatic triple-negative breast cancer: Implications for clinical practice and trial design
    • Kassam F, Enright K, Dent R, et al. Survival outcomes for patients with metastatic triple-negative breast cancer: implications for clinical practice and trial design. Clin Breast Cancer 2009; 9: 29-33.
    • (2009) Clin Breast Cancer , vol.9 , pp. 29-33
    • Kassam, F.1    Enright, K.2    Dent, R.3
  • 42
    • 49249096760 scopus 로고    scopus 로고
    • Dose-dense and/or metronomic schedules of specific chemotherapies consolidate the chemosensitivity of triple-negative breast cancer: A step toward reversing triple-negative paradox
    • Author reply 3288
    • Mehta RS,. Dose-dense and/or metronomic schedules of specific chemotherapies consolidate the chemosensitivity of triple-negative breast cancer: a step toward reversing triple-negative paradox. J Clin Oncol 2008; 26: 3286-8. Author reply 3288.
    • (2008) J Clin Oncol , vol.26 , pp. 3286-3288
    • Mehta, R.S.1
  • 43
    • 77953582837 scopus 로고    scopus 로고
    • Safety and effectiveness of dose dense neoadjuvant chemotherapy in patients with stage II/III breast cancer
    • e11566
    • Koya S, Li Y, McDaniel SA, et al. Safety and effectiveness of dose dense neoadjuvant chemotherapy in patients with stage II/III breast cancer. J Clin Oncol 2009; 27. Abstract e11566.
    • (2009) J Clin Oncol , vol.27
    • Koya, S.1    Li, Y.2    McDaniel, S.A.3
  • 44
    • 77955714265 scopus 로고    scopus 로고
    • Preliminary safety and activity results of trabectedin in a phase II trial dedicated to triple-negative (ER-, PR-, HER2-), HER2 + ++, or BRCA1/2 germ-line-mutated metastatic breast cancer (MBC) patients (pts)
    • 1010
    • Delaloge S, Tedesco KL, Blum J, et al. Preliminary safety and activity results of trabectedin in a phase II trial dedicated to triple-negative (ER-, PR-, HER2-), HER2 + ++, or BRCA1/2 germ-line-mutated metastatic breast cancer (MBC) patients (pts). J Clin Oncol 2009; 27. Abstract 1010.
    • (2009) J Clin Oncol , vol.27
    • Delaloge, S.1    Tedesco, K.L.2    Blum, J.3
  • 45
    • 78751610848 scopus 로고    scopus 로고
    • Iniparib plus chemotherapy in metastatic triple-negative breast cancer
    • O'Shaughnessy J, Osborne C, Pippen JE, et al. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med 2011; 364: 205-14.
    • (2011) N Engl J Med , vol.364 , pp. 205-214
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.E.3
  • 46
    • 68149161777 scopus 로고    scopus 로고
    • Phase II trial of the oral PARP inhibitor olaparib in BRCA-deficient advanced breast cancer
    • CRA501
    • Tutt A, Robson M, Garber JE, et al. Phase II trial of the oral PARP inhibitor olaparib in BRCA-deficient advanced breast cancer. J Clin Oncol 2009; 27. Abstract CRA501.
    • (2009) J Clin Oncol , vol.27
    • Tutt, A.1    Robson, M.2    Garber, J.E.3
  • 47
    • 84855654178 scopus 로고    scopus 로고
    • Clinical activity of ixabepilone, a novel epothilone B analog, across the breast cancer disease continuum
    • 2119
    • Fumoleau P, Llombart-Cussac A, Roche H, et al. Clinical activity of ixabepilone, a novel epothilone B analog, across the breast cancer disease continuum. Eur J Cancer 2007; 5 (Suppl). Abstract 2119.
    • (2007) Eur J Cancer , vol.5 , Issue.SUPPL
    • Fumoleau, P.1    Llombart-Cussac, A.2    Roche, H.3
  • 48
    • 67049142413 scopus 로고    scopus 로고
    • Ixabepilone plus capecitabine vs capecitabine in patients with triple negative tumors: A pooled analysis of patients from two large phase III clinical studies
    • 3057
    • Rugo HS, Roche H, Thomas ES, et al. Ixabepilone plus capecitabine vs capecitabine in patients with triple negative tumors: a pooled analysis of patients from two large phase III clinical studies. Cancer Res 2009; 69 (Suppl 2). Abstract 3057.
    • (2009) Cancer Res , vol.69 , Issue.SUPPL 2
    • Rugo, H.S.1    Roche, H.2    Thomas, E.S.3
  • 49
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007; 357: 2666-76.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 50
    • 42949148257 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    • Burstein HJ, Elias AD, Rugo HS, et al. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2008; 26: 1810-6.
    • (2008) J Clin Oncol , vol.26 , pp. 1810-1816
    • Burstein, H.J.1    Elias, A.D.2    Rugo, H.S.3
  • 51
    • 61349152550 scopus 로고    scopus 로고
    • TBCRC 001: EGFR inhibition with cetuximab added to carboplatin in metastatic triple-negative (basal-like) breast cancer
    • 1009
    • Carey LA, Mayer E, Marcom PK, et al. TBCRC 001: EGFR inhibition with cetuximab added to carboplatin in metastatic triple-negative (basal-like) breast cancer. J Clin Oncol 2008; 26. Abstract 1009.
    • (2008) J Clin Oncol , vol.26
    • Carey, L.A.1    Mayer, E.2    Marcom, P.K.3
  • 52
    • 80053598498 scopus 로고    scopus 로고
    • Preliminary results of a phase I/II of a combination of cetuximab and taxane for triple negative breast cancer patients
    • e12018
    • Nechushtan H, Steinberg H, Peretz T,. Preliminary results of a phase I/II of a combination of cetuximab and taxane for triple negative breast cancer patients. J Clin Oncol 2009; 27. Abstract e12018.
    • (2009) J Clin Oncol , vol.27
    • Nechushtan, H.1    Steinberg, H.2    Peretz, T.3
  • 53
    • 43549106185 scopus 로고    scopus 로고
    • Randomized phase II study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer
    • 308
    • O'Shaughnessy J, Weckstein DJ, Vukelja S, et al. Randomized phase II study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer. Breast Cancer Res Treat 2007; 106 (Suppl 1). Abstract 308.
    • (2007) Breast Cancer Res Treat , vol.106 , Issue.SUPPL 1
    • O'Shaughnessy, J.1    Weckstein, D.J.2    Vukelja, S.3
  • 54
    • 73549086662 scopus 로고    scopus 로고
    • Phase II trial of dasatinib in triple-negative breast cancer: Results of study CA180059
    • 3118
    • Finn RS, Bengala C, Ibrahim N, et al. Phase II trial of dasatinib in triple-negative breast cancer: results of study CA180059. Cancer Res 2009; 69 (Suppl 2). Abstract 3118.
    • (2009) Cancer Res , vol.69 , Issue.SUPPL 2
    • Finn, R.S.1    Bengala, C.2    Ibrahim, N.3
  • 55
    • 0034604716 scopus 로고    scopus 로고
    • The Breast Cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin
    • DOI 10.1074/jbc.C000276200
    • Bhattacharyya A, Ear US, Koller BH, et al. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin. J Biol Chem 2000; 275: 23899-903. (Pubitemid 30624678)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.31 , pp. 23899-23903
    • Bhattacharyya, A.1    Ear, U.S.2    Koller, B.H.3    Weichselbaum, R.R.4    Bishop, D.K.5
  • 56
    • 0035874894 scopus 로고    scopus 로고
    • Homology-directed DNA repair, mitomycin-C resistance, and chromosome stability is restored with correction of a Brca1 mutation
    • Moynahan ME, Cui TY, Jasin M,. Homology-directed DNA repair, mitomycin-C resistance, and chromosome stability is restored with correction of a Brca1 mutation. Cancer Res 2001; 61: 4842-50. (Pubitemid 32691900)
    • (2001) Cancer Research , vol.61 , Issue.12 , pp. 4842-4850
    • Moynahan, M.E.1    Cui, T.Y.2    Jasin, M.3
  • 57
    • 77249099446 scopus 로고    scopus 로고
    • Neoadjuvant platinum-based chemotherapy (CT) for triple-negative locally advanced breast cancer (LABC): Retrospective analysis of 125 patients
    • 625
    • Leone JP, Guardiola V, Venkatraman A, et al. Neoadjuvant platinum-based chemotherapy (CT) for triple-negative locally advanced breast cancer (LABC): retrospective analysis of 125 patients. J Clin Oncol 2009; 27. Abstract 625.
    • (2009) J Clin Oncol , vol.27
    • Leone, J.P.1    Guardiola, V.2    Venkatraman, A.3
  • 58
    • 67650382241 scopus 로고    scopus 로고
    • Preoperative weekly cisplatin-epirubicin-paclitaxel with G-CSF support in triple-negative large operable breast cancer
    • Frasci G, Comella P, Rinaldo M, et al. Preoperative weekly cisplatin-epirubicin-paclitaxel with G-CSF support in triple-negative large operable breast cancer. Ann Oncol 2009; 20: 1185-92.
    • (2009) Ann Oncol , vol.20 , pp. 1185-1192
    • Frasci, G.1    Comella, P.2    Rinaldo, M.3
  • 59
    • 84855700664 scopus 로고    scopus 로고
    • Primary systemic chemotherapy with carboplatin AUC 6 and docetaxel 75 mg/m2 (q3w) in triple-negative early breast cancer
    • e11063
    • Kern P, Kolberg HC, Stoblen F, et al. Primary systemic chemotherapy with carboplatin AUC 6 and docetaxel 75 mg/m2 (q3w) in triple-negative early breast cancer. J Clin Oncol 2010; 28 (Suppl). Abstract e11063.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL
    • Kern, P.1    Kolberg, H.C.2    Stoblen, F.3
  • 60
    • 60549106251 scopus 로고    scopus 로고
    • Treatment outcomes and clinicopathologic characteristics of triple-negative breast cancer patients who received platinum-containing chemotherapy
    • Uhm JE, Park YH, Yi SY, et al. Treatment outcomes and clinicopathologic characteristics of triple-negative breast cancer patients who received platinum-containing chemotherapy. Int J Cancer 2009; 124: 1457-62.
    • (2009) Int J Cancer , vol.124 , pp. 1457-1462
    • Uhm, J.E.1    Park, Y.H.2    Yi, S.Y.3
  • 61
    • 80054098596 scopus 로고    scopus 로고
    • The comparison of the benefits obtained from platinum-containing chemotherapy between triple-negative and non-triple-negative metastatic breast cancer
    • 1071
    • Kim T, Lee H, Han S, et al. The comparison of the benefits obtained from platinum-containing chemotherapy between triple-negative and non-triple-negative metastatic breast cancer. J Clin Oncol 2010; 28. Abstract 1071.
    • (2010) J Clin Oncol , vol.28
    • Kim, T.1    Lee, H.2    Han, S.3
  • 63
    • 66049084743 scopus 로고    scopus 로고
    • Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: Potential for therapy of myeloid leukemia and myelodysplastic syndromes
    • Gaymes TJ, Shall S, MacPherson LJ, et al. Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica 2009; 94: 638-46.
    • (2009) Haematologica , vol.94 , pp. 638-646
    • Gaymes, T.J.1    Shall, S.2    MacPherson, L.J.3
  • 65
    • 55949092708 scopus 로고    scopus 로고
    • High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
    • Rottenberg S, Jaspers JE, Kersbergen A, et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A 2008; 105: 17079-84.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 17079-17084
    • Rottenberg, S.1    Jaspers, J.E.2    Kersbergen, A.3
  • 66
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. NEJM 2009; 361: 123-34.
    • (2009) NEJM , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 67
    • 58749113261 scopus 로고    scopus 로고
    • Clinical development of ixabepilone and other epothilones in patients with advanced solid tumors
    • Rivera E, Lee J, Davies A,. Clinical development of ixabepilone and other epothilones in patients with advanced solid tumors. Oncologist 2008; 13: 1207-23.
    • (2008) Oncologist , vol.13 , pp. 1207-1223
    • Rivera, E.1    Lee, J.2    Davies, A.3
  • 68
    • 59149087388 scopus 로고    scopus 로고
    • Phase II genomics study of ixabepilone as neoadjuvant treatment for breast cancer
    • Baselga J, Zambetti M, Llombart-Cussac A, et al. Phase II genomics study of ixabepilone as neoadjuvant treatment for breast cancer. J Clin Oncol 2009; 27: 526-34.
    • (2009) J Clin Oncol , vol.27 , pp. 526-534
    • Baselga, J.1    Zambetti, M.2    Llombart-Cussac, A.3
  • 69
    • 77955893812 scopus 로고    scopus 로고
    • A phase III study (EMBRACE) of eribulin mesylate versus treatment of physician's choice in patients with locally recurrent or metastatic breast cancer previously treated with an anthracycline and a taxane
    • CRA1004
    • Twelves C, Loesch D, Blum JL, et al. A phase III study (EMBRACE) of eribulin mesylate versus treatment of physician's choice in patients with locally recurrent or metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2010; 28 (Suppl). Abstract CRA1004.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL
    • Twelves, C.1    Loesch, D.2    Blum, J.L.3
  • 70
    • 84855653860 scopus 로고    scopus 로고
    • Eribulin mesylate (E7389) vs treatment of physician's choice (TPC) in patients (pts) with metastatic breast cancer (MBC): Subgroup analyses from the EMBRACE study
    • Abstract 275O
    • Twelves C, Akerele C, Wanders J, et al. Eribulin mesylate (E7389) vs treatment of physician's choice (TPC) in patients (pts) with metastatic breast cancer (MBC): subgroup analyses from the EMBRACE study. Ann Oncol 2010; 21 (Suppl 8): viii96. Abstract 275O.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL 8
    • Twelves, C.1    Akerele, C.2    Wanders, J.3
  • 71
    • 77950475001 scopus 로고    scopus 로고
    • Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer
    • Twelves C, Cortes J, Vahdat LT, Wanders J, Akerele C, Kaufman PA,. Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer. Clin Breast Cancer 2010; 10: 160-3.
    • (2010) Clin Breast Cancer , vol.10 , pp. 160-163
    • Twelves, C.1    Cortes, J.2    Vahdat, L.T.3    Wanders, J.4    Akerele, C.5    Kaufman, P.A.6
  • 72
    • 77955883504 scopus 로고    scopus 로고
    • A meta-analysis of overall survival data from three randomized trials of bevacizumab (BV) and first-line chemotherapy as treatment for patients with metastatic breast cancer (MBC)
    • 1005
    • O'Shaughnessy J, Miles D, Gray RJ, et al. A meta-analysis of overall survival data from three randomized trials of bevacizumab (BV) and first-line chemotherapy as treatment for patients with metastatic breast cancer (MBC). J Clin Oncol 2010; 28. Abstract 1005.
    • (2010) J Clin Oncol , vol.28
    • O'Shaughnessy, J.1    Miles, D.2    Gray, R.J.3
  • 73
    • 74849140751 scopus 로고    scopus 로고
    • Randomized phase II study of weekly vs every-3-week ixabepilone plus bevacizumab (ixa/bev) versus paclitaxel plus bevacizumab (pac/bev) as first-line therapy for metastatic breast cancer
    • 1029
    • Rugo HS, Campone M, Amadori D, et al. Randomized phase II study of weekly vs every-3-week ixabepilone plus bevacizumab (ixa/bev) versus paclitaxel plus bevacizumab (pac/bev) as first-line therapy for metastatic breast cancer. J Clin Oncol 2009; 27. Abstract 1029.
    • (2009) J Clin Oncol , vol.27
    • Rugo, H.S.1    Campone, M.2    Amadori, D.3
  • 74
    • 77955911251 scopus 로고    scopus 로고
    • Sunitinib in combination with docetaxel (D) versus D alone for the first-line treatment of advanced breast cancer (ABC)
    • LBA1010
    • Bergh J, Greil N, Voytko N, et al. Sunitinib in combination with docetaxel (D) versus D alone for the first-line treatment of advanced breast cancer (ABC). J Clin Oncol 2010; 28. Abstract LBA1010.
    • (2010) J Clin Oncol , vol.28
    • Bergh, J.1    Greil, N.2    Voytko, N.3
  • 75
    • 77955894152 scopus 로고    scopus 로고
    • Phase III trial of sunitinib (SU) in combination with capecitabine (C) versus C in previously treated advanced breast cancer (ABC)
    • LBA1011
    • Crown J, Dieras V, Staroslawska E, et al. Phase III trial of sunitinib (SU) in combination with capecitabine (C) versus C in previously treated advanced breast cancer (ABC). J Clin Oncol 2010; 28. Abstract LBA1011.
    • (2010) J Clin Oncol , vol.28
    • Crown, J.1    Dieras, V.2    Staroslawska, E.3
  • 76
    • 65549098841 scopus 로고    scopus 로고
    • Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer
    • Corkery B, Crown J, Clynes M, O'Donovan N,. Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer. Ann Oncol 2009; 20: 862-7.
    • (2009) Ann Oncol , vol.20 , pp. 862-867
    • Corkery, B.1    Crown, J.2    Clynes, M.3    O'Donovan, N.4
  • 77
    • 62849093453 scopus 로고    scopus 로고
    • EGFR as paradoxical predictor of chemosensitivity and outcome among triple-negative breast cancer
    • Nogi H, Kobayashi T, Suzuki M, et al. EGFR as paradoxical predictor of chemosensitivity and outcome among triple-negative breast cancer. Oncol Rep 2009; 21: 413-7.
    • (2009) Oncol Rep , vol.21 , pp. 413-417
    • Nogi, H.1    Kobayashi, T.2    Suzuki, M.3
  • 78
    • 34548701082 scopus 로고    scopus 로고
    • Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple- negative" breast cancer cell lines growing in vitro
    • DOI 10.1007/s10549-006-9463-x
    • Finn RS, Dering J, Ginther C, et al. Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro. Breast Cancer Res Treat 2007; 105: 319-26. (Pubitemid 47596452)
    • (2007) Breast Cancer Research and Treatment , vol.105 , Issue.3 , pp. 319-326
    • Finn, R.S.1    Dering, J.2    Ginther, C.3    Wilson, C.A.4    Glaspy, P.5    Tchekmedyian, N.6    Slamon, D.J.7
  • 79
    • 68149155522 scopus 로고    scopus 로고
    • Activity of dasatinib with chemotherapy in triple-negative breast cancer cells
    • e14605
    • Tryfonopoulos D, O'Donovan N, Corkery B, Clynes M, Crown J,. Activity of dasatinib with chemotherapy in triple-negative breast cancer cells. J Clin Oncol 2009; 27. Abstract e14605.
    • (2009) J Clin Oncol , vol.27
    • Tryfonopoulos, D.1    O'Donovan, N.2    Corkery, B.3    Clynes, M.4    Crown, J.5
  • 80
    • 68149183733 scopus 로고    scopus 로고
    • Dasatinib plus capecitabine (Cap) for progressive advanced breast cancer (ABC): Phase i study CA180004
    • 1012
    • Somlo G,. Dasatinib plus capecitabine (Cap) for progressive advanced breast cancer (ABC): phase I study CA180004. J Clin Oncol 2009; 27. Abstract 1012.
    • (2009) J Clin Oncol , vol.27
    • Somlo, G.1
  • 81
    • 84855660335 scopus 로고    scopus 로고
    • A phase I-II study of dasatinib (D) in combination with weekly (W) paclitaxel (P) for patients (pts) with metastatic breast carcinoma (MBC)
    • Mar 15 [epub ahead of print]
    • Fornier MN, Morris PG, Abbruzzi A, et al. A phase I-II study of dasatinib (D) in combination with weekly (W) paclitaxel (P) for patients (pts) with metastatic breast carcinoma (MBC). Ann Oncol 2011; Mar 15 [epub ahead of print].
    • (2011) Ann Oncol
    • Fornier, M.N.1    Morris, P.G.2    Abbruzzi, A.3
  • 82
    • 54849414696 scopus 로고    scopus 로고
    • Androgen receptor expression in breast cancer: Relationship with clinicopathological factors and biomarkers
    • Ogawa Y, Hai E, Matsumoto K, et al. Androgen receptor expression in breast cancer: relationship with clinicopathological factors and biomarkers. Int J Clin Oncol 2008; 13: 431-5.
    • (2008) Int J Clin Oncol , vol.13 , pp. 431-435
    • Ogawa, Y.1    Hai, E.2    Matsumoto, K.3
  • 83
    • 66249138886 scopus 로고    scopus 로고
    • Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
    • Caldas-Lopes E, Cerchietti L, Ahn JH, et al. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A 2009; 106: 8368-73.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 8368-8373
    • Caldas-Lopes, E.1    Cerchietti, L.2    Ahn, J.H.3
  • 84
    • 84855669926 scopus 로고    scopus 로고
    • Ex-vivo analysis of the isoform selective histone deacetylase inhibitor entinostat in triple-negative breast cancer tumors
    • e14597
    • Ordentlich P, Tee L, Huynh Y, Mee S, Mamuszka H, Lee G,. Ex-vivo analysis of the isoform selective histone deacetylase inhibitor entinostat in triple-negative breast cancer tumors. J Clin Oncol 2009; 27. Abstract e14597.
    • (2009) J Clin Oncol , vol.27
    • Ordentlich, P.1    Tee, L.2    Huynh, Y.3    Mee, S.4    Mamuszka, H.5    Lee, G.6
  • 85
    • 84855669925 scopus 로고    scopus 로고
    • Effective treatment of triple-negative breast cancer with targeted cytotoxic somatostatin analogue AN-162 (AEZS-124)
    • 619
    • Seitz S, Schally AV, Gluck S, et al. Effective treatment of triple-negative breast cancer with targeted cytotoxic somatostatin analogue AN-162 (AEZS-124). J Clin Oncol 2009; 27. Abstract 619.
    • (2009) J Clin Oncol , vol.27
    • Seitz, S.1    Schally, A.V.2    Gluck, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.