Efficacy of short-term FK506 administration on accelerating nerve regeneration

Neurorehabilitation and Neural Repair

Volumn 26, Issue 6, 2012, Pages 570-580

  Yan, Ying ^a   Sun, Hank H ^a   Hunter, Daniel A ^a   MacKinnon, Susan E ^a   Johnson, Philip J ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

accelerated nerve regeneration; FK506; nerve injury; tacrolimus; walking track

Indexed keywords

TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD NERVE BARRIER; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFICACY; MALE; MORPHOMETRICS; NERVE CRUSH; NERVE GRAFT; NERVE REGENERATION; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; TREATMENT DURATION; TREATMENT OUTCOME;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD-NERVE BARRIER; DISEASE MODELS, ANIMAL; HINDLIMB; IMMUNOSUPPRESSIVE AGENTS; LOCOMOTION; MALE; NERVE CRUSH; NERVE REGENERATION; RATS; RATS, INBRED LEW; RECOVERY OF FUNCTION; TACROLIMUS; TIBIAL NEUROPATHY; TIME FACTORS; TISSUE TRANSPLANTATION; TRANSFECTION;

EID: 84863710333     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968311431965     Document Type: Article

References (51)

1. Battiston B, Geuna S, Ferrero M, Tos P. Nerve repair by means of tubulization: literature review and personal clinical experience comparing biological and synthetic conduits for sensory nerve repair. Microsurgery. 2005 ; 25: 258-267
2. Casha S, Yong VW, Midha R. Minocycline for axonal regeneration after nerve injury: a double-edged sword. Exp Neurol. 2008 ; 213: 245-248
3. Hoke A. Mechanisms of disease: what factors limit the success of peripheral nerve regeneration in humans?. Nat Clin Pract Neurol. 2006 ; 2: 448-454
4. Kobayashi J, Mackinnon SE, Watanabe O, et al. The effect of duration of muscle denervation on functional recovery in the rat model. Muscle Nerve. 1997 ; 20: 858-866
5. Sunderland S. A classification of peripheral nerve injuries producing loss of function. Brain. 1951 ; 74: 491-516
6. Chabas JF, Alluin O, Rao G, et al. FK506 induces changes in muscle properties and promotes metabosensitive nerve fiber regeneration. J Neurotrauma. 2009 ; 26: 97-108
7. Doolabh VB, Mackinnon SE. FK506 accelerates functional recovery following nerve grafting in a rat model. Plast Reconstr Surg. 1999 ; 103: 1928-1936
8. Gold BG, Katoh K, Storm-Dickerson T. The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve. J Neurosci. 1995 ; 15: 7509-7516
9. Gold BG, Storm-Dickerson T, Austin DR. The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury. Restor Neurol Neurosci. 1994 ; 6: 287-296
10. Jensen JN, Brenner MJ, Tung TH, Hunter DA, Mackinnon SE. Effect of FK506 on peripheral nerve regeneration through long grafts in inbred swine. Ann Plast Surg. 2005 ; 54: 420-427
11. Jost SC, Doolabh VB, Mackinnon SE, Lee M, Hunter D. Acceleration of peripheral nerve regeneration following FK506 administration. Restor Neurol Neurosci. 2000 ; 17: 39-44
12. Lee M, Doolabh VB, Mackinnon SE, Jost S. FK506 promotes functional recovery in crushed rat sciatic nerve. Muscle Nerve. 2000 ; 23: 633-640
13. Sobol JB, Lowe IJ, Yang RK, Sen SK, Hunter DA, Mackinnon SE. Effects of delaying FK506 administration on neuroregeneration in a rodent model. J Reconstr Microsurg. 2003 ; 19: 113-118
14. Sulaiman OA, Voda J, Gold BG, Gordon T. FK506 increases peripheral nerve regeneration after chronic axotomy but not after chronic Schwann cell denervation. Exp Neurol. 2002 ; 175: 127-137
15. Udina E, Ceballos D, Gold BG, Navarro X. FK506 enhances reinnervation by regeneration and by collateral sprouting of peripheral nerve fibers. Exp Neurol. 2003 ; 183: 220-231
16. Udina E, Gold BG, Navarro X. Comparison of continuous and discontinuous FK506 administration on autograft or allograft repair of sciatic nerve resection. Muscle Nerve. 2004 ; 29: 812-822
17. Yang RK, Lowe JB, Sobol JB, Sen SK, Hunter DA, Mackinnon SE. Dose-dependent effects of FK506 on neuroregeneration in a rat model. Plast Reconstr Surg. 2003 ; 112: 1832-1840
18. Clipstone NA, Crabtree GR. Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. Ann N Y Acad Sci. 1993 ; 696: 20-30
19. Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 ; 66: 807-815
20. Wang MS, Zeleny-Pooley M, Gold BG. Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve. J Pharmacol Exp Ther. 1997 ; 282: 1084-1093
21. Doolabh VB, Mackinnon SE. FK506 accelerates functional recovery following nerve grafting in a rat model. Plast Reconstr Surg. 1999 ; 103: 1928-1936
22. Feng FY, Ogden MA, Myckatyn TM, et al. FK506 rescues peripheral nerve allografts in acute rejection. J Neurotrauma. 2001 ; 18: 217-229
23. Mackinnon SE, Doolabh VB, Novak CB, Trulock EP. Clinical outcome following nerve allograft transplantation. Plast Reconstr Surg. 2001 ; 107: 1419-1429
24. Hare GM, Evans PJ, Mackinnon SE, et al. Walking track analysis: a long-term assessment of peripheral nerve recovery. Plast Reconstr Surg. 1992 ; 89: 251-258
25. Brenner MJ, Moradzadeh A, Myckatyn TM, et al. Role of timing in assessment of nerve regeneration. Microsurgery. 2008 ; 28: 265-272
26. Snyder AK, Fox IK, Nichols CM, et al. Neuroregenerative effects of preinjury FK-506 administration. Plast Reconstr Surg. 2006 ; 118: 360-367
27. Ray WZ, Pet MA, Yee A, Mackinnon SE. Double fascicular nerve transfer to the biceps and brachialis muscles after brachial plexus injury: clinical outcomes in a series of 29 cases. J Neurosurg. 2011 ; 114: 1520-1528
28. Pet MA, Ray WZ, Yee A, Mackinnon SE. Nerve transfer to the triceps after brachial plexus injury: report of four cases. J Hand Surg Am. 2011 ; 36: 398-405
29. Gutmann E, Guttmann L, Medawar PB, Young JZ. The rate of regeneration of nerve. J Exp Biol. 1942 ; 19 (1). 14-44
30. Pan YA, Misgeld T, Lichtman JW, Sanes JR. Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo. J Neurosci. 2003 ; 23: 11479-11488
31. Black MM, Lasek RJ. Slowing of the rate of axonal regeneration during growth and maturation. Exp Neurol. 1979 ; 63: 108-119
32. Pestronk A, Drachman DB, Griffin JW. Effects of aging on nerve sprouting and regeneration. Exp Neurol. 1980 ; 70: 65-82
33. Mackinnon SE, Dellon AL Surgery of the Peripheral Nerve. New York, NY: Thieme Medical ; 1988 :
34. Gordon T. The role of neurotrophic factors in nerve regeneration. Neurosurg Focus. 2009 ; 26: E3
35. Rosenberg SS, Ng BK, Chan JR. The quest for remyelination: a new role for neurotrophins and their receptors. Brain Pathol. 2006 ; 16: 288-294
36. Gordon T, Chan KM, Sulaiman OA, Udina E, Amirjani N, Brushart TM. Accelerating axon growth to overcome limitations in functional recovery after peripheral nerve injury. Neurosurgery. 2009 ; 65 (4). A132 - A144
37. Brenner MJ, Mackinnon SE, Rickman SR, et al. FK506 and anti-CD40 ligand in peripheral nerve allotransplantation. Restor Neurol Neurosci. 2005 ; 23: 237-249
38. Hayashi N, Minor TX, Carrion R, Price R, Nunes L, Lue TF. The effect of FK1706 on erectile function following bilateral cavernous nerve crush injury in a rat model. J Urol. 2006 ; 176: 824-829
39. Yamaji T, Yamazaki S, Li J, Price RD, Matsuoka N, Mutoh S. FK1706, a novel non-immunosuppressant neurophilin ligand, ameliorates motor dysfunction following spinal cord injury through its neuroregenerative action. Eur J Pharmacol. 2008 ; 591: 147-152
40. Gold BG, Villafranca JE. Neuroimmunophilin ligands: the development of novel neuroregenerative/neuroprotective compounds. Curr Top Med Chem. 2003 ; 3: 1368-1375
41. Gold BG, Zeleny-Pooley M, Chaturvedi P, Wang MS. Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds nerve regeneration. Neuroreport. 1998 ; 9: 553-558
42. Gold BG, Zeleny-Pooley M, Wang MS, Chaturvedi P, Armistead DM. A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration. Exp Neurol. 1997 ; 147: 269-278
43. Gold BG, Gordon HS, Wang MS. Efficacy of delayed or discontinuous FK506 administrations on nerve regeneration in the rat sciatic nerve crush model: lack of evidence for a conditioning lesion-like effect. Neurosci Lett. 1999 ; 267: 33-36
44. Nguyen QT, Sanes JR, Lichtman JW. Pre-existing pathways promote precise projection patterns. Nat Neurosci. 2002 ; 5: 861-867
45. Becker DB, Jensen JN, Myckatyn TM, Doolabh VB, Hunter DA, Mackinnon SE. Effects of FKBP-12 ligands following tibial nerve injury in rats. J Reconstr Microsurg. 2000 ; 16: 613-620
46. Al-Majed AA, Neumann CM, Brushart TM, Gordon T. Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. J Neurosci. 2000 ; 20: 2602-2608
47. Brushart TM, Hoffman PN, Royall RM, Murinson BB, Witzel C, Gordon T. Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron. J Neurosci. 2002 ; 22: 6631-6638
48. Pina-Oviedo S, Ortiz-Hidalgo C. The normal and neoplastic perineurium: a review. Adv Anat Pathol. 2008 ; 15: 147-164
49. Pummi KP, Heape AM, Grenman RA, Peltonen JT, Peltonen SA. Tight junction proteins ZO-1, occludin, and claudins in developing and adult human perineurium. J Histochem Cytochem. 2004 ; 52: 1037-1046
50. Zalewski AA, Kadota Y, Azzam NA, Azzam RN. Observations on the blood and perineurial permeability barriers of surviving nerve allografts in immunodeficient and immunosuppressed rats. J Neurosurg. 1993 ; 78: 794-806
51. Bouldin TW, Earnhardt TS, Goines ND. Restoration of blood-nerve barrier in neuropathy is associated with axonal regeneration and remyelination. J Neuropathol Exp Neurol. 1991 ; 50: 719-728