The Effect of FK1706 on Erectile Function Following Bilateral Cavernous Nerve Crush Injury in a Rat Model

Journal of Urology

Volumn 176, Issue 2, 2006, Pages 824-829

  Hayashi, Narihiko ^a   Minor, Thomas X ^a   Carrion, Rafael ^a   Price, Raymond ^b   Nunes, Lora ^a   Lue, Tom F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

FK1706; impotence; nonpenetrating; penis; rats; Sprague Dawley; wounds

Indexed keywords

FK 1706; NEUROMODULIN; NEUROPROTECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; AXONAL INJURY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFECT; DRUG MEGADOSE; ELECTROSTIMULATION; ERECTILE DYSFUNCTION; EXPERIMENTAL MODEL; IMMUNOHISTOCHEMISTRY; MALE; NERVE CRUSH; NERVE REGENERATION; NERVE STIMULATION; NEUROFILAMENT; NONHUMAN; PARASYMPATHETIC INNERVATION; PENIS ERECTION; PRIORITY JOURNAL; RANDOMIZATION; RAT; TREATMENT OUTCOME;

ANIMALS; DISEASE MODELS, ANIMAL; MALE; PENILE ERECTION; PENIS; RATS; RATS, SPRAGUE-DAWLEY; TACROLIMUS;

EID: 33745244235     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2006.03.071     Document Type: Article

References (19)

1. Nehra A., and Moreland R.B. Neurologic erectile dysfunction. Urol Clin North Am 28 (2001) 289
2. Lin C.S., and Lue T.F. Growth factor therapy and neuronal nitric oxide synthase. Int J Impot Res 16 suppl (2004) S38
3. Walsh P.C., and Mostwin J.L. Radical prostatectomy and cystoprostatectomy with preservation of potency. Results using a new nerve-sparing technique. Br J Urol 56 (1984) 694
4. Paick J.S., Donatucci C.F., and Lue T.F. Anatomy of cavernous nerves distal to prostate. microdissection study in adult male cadavers. Urology 42 (1993) 145
5. Stanford J.L., Feng Z., Hamilton A.S., Gilliland F.D., Stephenson R.A., Eley J.W., et al. Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer. the Prostate Cancer Outcomes Study. JAMA 283 (2000) 354
6. Bochinski D., Hsieh P.S., Nunes L., Lin G.T., Lin C.S., Spencer E.M., et al. Effect of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 complex in cavernous nerve cryoablation. Int J Impot Res 16 (2004) 418
7. El-Sakka A.I., Hassan M.U., Selph C., Perinchery G., Dahiya R., and Lue T.F. Effect of cavernous nerve freezing on protein and gene expression of nitric oxide synthase in the rat penis and pelvic ganglia. J Urol 160 (1998) 2245
8. Hsieh P.S., Bochinski D.J., Lin G.T., Nunes L., Lin C.S., and Lue T.F. The effect of vascular endothelial growth factor and brain-derived neurotrophic factor on cavernosal nerve regeneration in a nerve-crush rat model. BJU Int 92 (2003) 470
9. Lin C.S., Lau A., Tu R., and Lue T.F. Expression of three isoforms of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum. Biochem Biophys Res Commun 268 (2000) 628
10. Lin C.S., Lau A., Tu R., and Lue T.F. Identification of three alternative first exons and an intronic promoter of human PDE5A gene. Biochem Biophys Res Commun 268 (2000) 596
11. Lin C.S., Ho H.C., Gholami S., Chen K.C., Jad A., and Lue T.F. Gene expression profiling of an arteriogenic impotence model. Biochem Biophys Res Commun 285 (2001) 565
12. Wang M.S., and Gold B.G. FK506 increases the regeneration of spinal cord axons in a predegenerated peripheral nerve autograft. J Spinal Cord Med 22 (1999) 287
13. Gold B.G. Neuroimmunophilin ligands. evaluation of their therapeutic potential for the treatment of neurological disorders. Expert Opin Investig Drugs 9 (2000) 2331
14. Burnett A.L., and Becker R.E. Immunophilin ligands promote penile neurogenesis and erection recovery after cavernous nerve injury. J Urol 171 (2004) 495
15. Price R.D., Yamaji T., Yamamoto H., Higashi Y., Hanaoka K., Yamazaki S., et al. FK1706, a novel non-immunosuppressive immunophilin. neurotrophic activity and mechanism of action. Eur J Pharmacol 509 (2005) 11
16. Carrier S., Zvara P., Nunes L., Kour N.W., Rehman J., and Lue T.F. Regeneration of nitric oxide synthase-containing nerves after cavernous nerve neurotomy in the rat. J Urol 153 (1995) 1722
17. Liu J., Albers M.W., Wandless T.J., Luan S., Alberg D.G., Belshaw P.J., et al. Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. Biochemistry 31 (1992) 3896
18. Poulter M.O., Payne K.B., and Steiner J.P. Neuroimmunophilins. a novel drug therapy for the reversal of neurodegenerative disease?. Neuroscience 128 (2004) 1
19. Eberling J.L., Pivirotto P., Bringas J., Steiner J.P., Kordower J.H., Chu Y., et al. The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys. Exp Neurol 178 (2002) 236