Primary human endothelial cells secrete agents that reduce responsiveness to lysophosphatidic acid (LPA)

Bioscience Reports

Volumn 32, Issue 4, 2012, Pages 393-400

  Park, Eun Young ^a   Kazlauskas, Andrius ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

Conditioned medium; Endothelial cell; Intracellular signalling; Lysophosphatidic acid; Vascular endothelial growth factor A

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; INHIBITOR OF LYSOPHOSPHATIDIC ACID MEDIATED RESPONSIVENESS; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 1; NATURAL PRODUCT; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; BIOASSAY; CELL ACTIVITY; CELL ASSAY; CONTROLLED STUDY; CULTURE MEDIUM; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; NONHUMAN; PROTEIN FUNCTION; RAT; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INDUCING AGENTS; ANGIOGENESIS INHIBITORS; ANIMALS; CELL LINE; CELL MOVEMENT; CULTURE MEDIA, CONDITIONED; FIBROBLAST GROWTH FACTOR 2; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LYSOPHOSPHOLIPIDS; MICROVESSELS; PAXILLIN; PHOSPHORYLATION; PRIMARY CELL CULTURE; RATS; SKIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84863693653     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20120033     Document Type: Article

References (29)

1. Aoki, J. (2004) Mechanisms of lysophosphatidic acid production. Semin. Cell Dev. Biol. 15, 477-489
2. Moolenaar, W. H., van Meeteren, L. A. and Giepmans, B. N. (2004) The ins and outs of lysophosphatidic acid signaling. BioEssays 26, 870-881 (Pubitemid 39128101)
3. Ishii, S., Noguchi, K. and Yanagida, K. (2009) Non-Edg family lysophosphatidic acid (LPA) receptors. Prostaglandins Other Lipid Mediat. 89, 57-65
4. Valentine, W. J., Fujiwara, Y., Tsukahara, R. and Tigyi, G. (2008) Lysophospholipid signaling: beyond the EDGs. Biochim. Biophys. Acta 1780, 597-605 (Pubitemid 351381241)
5. van Meeteren, L. A., Ruurs, P., Stortelers, C., Bouwman, P., van Rooijen, M. A., Pradere, J. P., Pettit, T. R., Wakelam, M. J., Saulnier-Blache, J. S., Mummery, C. L. et al. (2006) Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol. Cell. Biol. 26, 5015-5022 (Pubitemid 43955815)
6. Tanaka, M., Okudaira, S., Kishi, Y., Ohkawa, R., Iseki, S., Ota, M., Noji, S., Yatomi, Y., Aoki, J. and Arai, H. (2006) Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J. Biol. Chem. 281, 25822-25830 (Pubitemid 44401970)
7. Im, E., Motiejunaite, R., Aranda, J., Park, E. Y., Federico, L., Kim, T. I., Clair, T., Stracke, M. L., Smyth, S. and Kazlauskas, A. (2010) Phospholipase Cγ activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression. Mol. Cell. Biol. 30, 2401-2410
8. Osborn, T. M., Dahlgren, C., Hartwig, J. H. and Stossel, T. P. (2007) Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. Am. J. Physiol. Cell Physiol. 292, C1323-C1330 (Pubitemid 46631726)
9. Tigyi, G. and Miledi, R. (1992) Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells. J. Biol. Chem. 267, 21360-21367
10. Goetzl, E. J., Lee, H., Azuma, T., Stossel, T. P., Turck, C. W. and Karliner, J. S. (2000) Gelsolin binding and cellular presentation of lysophosphatidic acid. J. Biol. Chem. 275, 14573-14578 (Pubitemid 30339747)
11. Brindley, D. N. and Pilquil, C. (2009) Lipid phosphate phosphatases and signaling. J. Lipid Res. 50 (Suppl.), S225-S230
12. Avendano-Vazquez, S. E., Garcia-Caballero, A. and Garcia-Sainz, J. A. (2005) Phosphorylation and desensitization of the lysophosphatidic acid receptor LPA1. Biochem. J. 385, 677-684 (Pubitemid 40208827)
13. Aranda, J., Motiejunaite, R., Im, E. and Kazlauskas, A. (2012) Diabetes disrupts the response of retinal endothelial cells to the angiomodulator lysophosphatidic acid. Diabetes 61, 661-666
14. Lee, Z., Cheng, C. T., Zhang, H., Subler, M. A., Wu, J., Mukherjee, A., Windle, J. J., Chen, C. K. and Fang, X. (2008) Role of LPA4/ p2y9/GPR23 in negative regulation of cell motility. Mol. Biol. Cell 19, 5435-5445
15. Im, E., Venkatakrishnan, A. and Kazlauskas, A. (2005) Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells. Mol. Biol. Cell 16, 3488-3500 (Pubitemid 41077063)
16. Valius, M., Bazenet, C. and Kazlauskas, A. (1993) Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor β subunit and are required for binding of phospholipase Cγ and a 64-kilodalton protein, respectively. Mol. Cell. Biol. 13, 133-143 (Pubitemid 23006891)
17. Saulnier-Blache, J. S., Girard, A., Simon, M. F., Lafontan, M. and Valet, P. (2000) A simple and highly sensitive radioenzymatic assay for lysophosphatidic acid quantification. J. Lipid Res. 41, 1947-1951 (Pubitemid 32038989)
18. Kume, K. and Shimizu, T. (1997) cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase. Biochem. Biophys. Res. Commun. 237, 663-666 (Pubitemid 27434744)
19. Jasinska, R., Zhang, Q. X., Pilquil, C., Singh, I., Xu, J., Dewald, J., Dillon, D. A., Berthiaume, L. G., Carman, G. M., Waggoner, D. W. et al. (1999) Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters. Biochem. J. 340, 677-686 (Pubitemid 29312864)
20. Fukushima, N., Kimura, Y. and Chun, J. (1998) A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc. Natl. Acad. Sci. U.S.A. 95, 6151-6156
21. Seufferlein, T. and Rozengurt, E. (1994) Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor. J. Biol. Chem. 269, 9345-9351
22. Teo, S. T., Yung, Y. C., Herr, D. R. and Chun, J. (2009) Lysophosphatidic acid in vascular development and disease. IUBMB Life 61, 791-799
23. Murph, M. M., Scaccia, L. A., Volpicelli, L. A. and Radhakrishna, H. (2003) Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway. J. Cell Sci. 116, 1969-1980 (Pubitemid 36622295)
24. Marchese, A., Paing, M. M., Temple, B. R. and Trejo, J. (2008) G protein-coupled receptor sorting to endosomes and lysosomes. Annu. Rev. Pharmacol Toxicol. 48, 601-629 (Pubitemid 351738165)
25. Lin, M. E., Herr, D. R. and Chun, J. (2010) Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance. Prostaglandins Other Lipid Mediat. 91, 130-138
26. Rivera-Lopez, C. M., Tucker, A. L. and Lynch, K. R. (2008) Lysophosphatidic acid (LPA) and angiogenesis. Angiogenesis 11, 301-310
27. Skoura, A. and Hla, T. (2009) Lysophospholipid receptors in vertebrate development, physiology, and pathology. J. Lipid Res. 50 (Suppl.), S293-S298
28. Arnon, T. I., Xu, Y., Lo, C., Pham, T., An, J., Coughlin, S., Dorn, G. W. and Cyster, J. G. (2011) GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science 333, 1898-1903
29. Aziziyeh, A. I., Li, T. T., Pape, C., Pampillo, M., Chidiac, P., Possmayer, F., Babwah, A. V. and Bhattacharya, M. (2009) Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. Cell. Signalling 21, 1207-1217