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Volumn 13, Issue 6, 2012, Pages 760-766

Growing up with midazolam in the neonatal and pediatric intensive care

Author keywords

Midazolam; Neonatal intensive care unit; Pediatric intensive care unit; Pharmacodynamics; Pharmacokinetics

Indexed keywords

MIDAZOLAM;

EID: 84863678855     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/138920012800840347     Document Type: Article
Times cited : (10)

References (64)
  • 1
    • 0034653987 scopus 로고    scopus 로고
    • Sedation in the intensive care unit: A systematic review
    • Ostermann, M. E.; Keenan, S. P.; Seiferling, R. A.; Sibbald, W. J. Sedation in the intensive care unit: a systematic review. JAMA, 2000, 283, 1451-9
    • (2000) JAMA , vol.283 , pp. 1451-1459
    • Ostermann, M.E.1    Keenan, S.P.2    Seiferling, R.A.3    Sibbald, W.J.4
  • 2
    • 0033989101 scopus 로고    scopus 로고
    • Frequency severity, and treatment of agitation in young versus elderly patients in the ICU
    • Fraser, G. L.; Prato, B. S.; Riker, R. R.; Berthiaume, D.; Wilkins, M. L. Frequency, severity, and treatment of agitation in young versus elderly patients in the ICU. Pharmacotherapy, 2000, 20, 75-82
    • (2000) Pharmacotherapy , vol.20 , pp. 75-82
    • Fraser, G.L.1    Prato, B.S.2    Riker, R.R.3    Berthiaume, D.4    Wilkins, M.L.5
  • 3
    • 0031596438 scopus 로고    scopus 로고
    • The use of continuous i.v. sedation is associated with prolongation of mechanical ventilation
    • Kollef, M. H.; Levy, N. T.; Ahrens, T. S.; Schaiff, R.; Prentice, D.; Sherman, G. The use of continuous i.v. sedation is associated with prolongation of mechanical ventilation. Chest, 1998, 114, 541-8.
    • (1998) Chest , vol.114 , pp. 541-548
    • Kollef, M.H.1    Levy, N.T.2    Ahrens, T.S.3    Schaiff, R.4    Prentice, D.5    Sherman, G.6
  • 4
    • 33747152472 scopus 로고    scopus 로고
    • United Kingdom paediatric intensive care society sedation and analgesia and neuromuscular blockade working group. Consensus guidelines on sedation and analgesia in critically ill children
    • Playfor, S.; Jenkins, I.; Boyles, C.; Choonara, I.; Davies, G.; Haywood, T.; Hinson, G.; Mayor, A.; Morton, N.; Ralph, T.; Wolf, A. United Kingdom Paediatric Intensive Care Society Sedation and Analgesia and Neuromuscular Blockade Working Group. Consensus guidelines on sedation and analgesia in critically ill children. Intensive Care Med., 2006, 32, 1125-36
    • (2006) Intensive Care Med. , vol.32 , pp. 1125-1136
    • Playfor, S.1    Jenkins, I.2    Boyles, C.3    Choonara, I.4    Davies, G.5    Haywood, T.6    Hinson, G.7    Mayor, A.8    Morton, N.9    Ralph, T.10    Wolf, A.11
  • 5
    • 68849115621 scopus 로고    scopus 로고
    • Efficacy of sedation regimens to facilitate mechanical ventilation in the pediat-ric intensive care unit: A systemic review
    • Hartman, M. E.; McCrory, D. C.; Schulman, S. R. Efficacy of sedation regimens to facilitate mechanical ventilation in the pediat-ric intensive care unit: a systemic review. Pediatr. Crit. Care Med., 2009, 10, 246-55.
    • (2009) Pediatr. Crit. Care Med. , vol.10 , pp. 246-255
    • Hartman, M.E.1    McCrory, D.C.2    Schulman, S.R.3
  • 8
    • 84863707452 scopus 로고    scopus 로고
    • Principles of pharmacokinetics and phar-macodynamics
    • Gluckman PD, Heymann MA (eds) 2nd ed. Arnold, London
    • Scolnik, D.; Koren, G. Principles of pharmacokinetics and phar-macodynamics. In: Gluckman PD, Heymann MA (eds) Pediatrics and perinatology, the scientific basis, 2nd ed. Arnold, London, 1996;pp. 963-7
    • (1996) Pediatrics and Perinatology, the Scientific Basis , pp. 963-967
    • Scolnik, D.1    Koren, G.2
  • 12
    • 0030783008 scopus 로고    scopus 로고
    • Haemodynamic responses and population pharmacokinetics of mi-dazolam following administration to ventilated, preterm neonates
    • Harte, G. J.; Gray, P. H.; Lee, T. C.; Steer, P. A.; Charles, B. G. Haemodynamic responses and population pharmacokinetics of mi-dazolam following administration to ventilated, preterm neonates. Paediatr. Child Health, 1997, 33, 335-8.
    • (1997) Paediatr. Child Health , vol.33 , pp. 335-338
    • Harte, G.J.1    Gray, P.H.2    Lee, T.C.3    Steer, P.A.4    Charles, B.G.5
  • 13
    • 0032935544 scopus 로고    scopus 로고
    • Population pharmacokinetic modeling in very premature infants receiving midazolam during mechanical ventilation: Midazolam neonatal pharmacokinetics
    • Lee, T. C.; Charles, B. G.; Harte, G. J.; Gray, P. H.; Steer, P. A.; Flenady, V. J. Population pharmacokinetic modeling in very premature infants receiving midazolam during mechanical ventilation: midazolam neonatal pharmacokinetics. Anesthesiology, 1999, 90, 451-7
    • (1999) Anesthesiology , vol.90 , pp. 451-457
    • Lee, T.C.1    Charles, B.G.2    Harte, G.J.3    Gray, P.H.4    Steer, P.A.5    Flenady, V.J.6
  • 17
    • 0035200148 scopus 로고    scopus 로고
    • Pediatric Pharmacology Research Unit Network. The single-dose pharmacokinetics of midazolam and its primary metabolite in pediatric patients after oral and intravenous administration
    • Reed, M. D.; Rodarte, A.; Blumer, J. L.; Khoo, K. C.; Akbari, B.; Pou, S.; Kearns, G. L. Pediatric Pharmacology Research Unit Network. The single-dose pharmacokinetics of midazolam and its primary metabolite in pediatric patients after oral and intravenous administration. J. Clin. Pharmacol., 2001, 41, 1359-69
    • (2001) J. Clin. Pharmacol. , vol.41 , pp. 1359-1369
    • Reed, M.D.1    Rodarte, A.2    Blumer, J.L.3    Khoo, K.C.4    Akbari, B.5    Pou, S.6    Kearns, G.L.7
  • 18
    • 0042367215 scopus 로고    scopus 로고
    • Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients
    • De Wildt, S. N.; de Hoog, M.; Vinks, A. A.; van der Giesen, E.; van den Anker, J. N. Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients. Crit. Care Med., 2003, 31, 1952-8
    • (2003) Crit. Care Med. , vol.31 , pp. 1952-1958
    • De Wildt, S.N.1    De Hoog, M.2    Vinks, A.A.3    Van Der Giesen, E.4    Van Den Anker, J.N.5
  • 21
    • 77952475236 scopus 로고    scopus 로고
    • Population pharmacokinetics of midazolam and its metabolites during venoarterial extracorporeal membrane oxygenation in neonates
    • Ahsman, M. J.; Hanekamp, M.; Wildschut, E. D.; Tibboel, D.; Mathot, R. Population pharmacokinetics of midazolam and its metabolites during venoarterial extracorporeal membrane oxygenation in neonates. Clin. Pharmacokinet., 2010, 49, 407-19
    • (2010) Clin. Pharmacokinet. , vol.49 , pp. 407-419
    • Ahsman, M.J.1    Hanekamp, M.2    Wildschut, E.D.3    Tibboel, D.4    Mathot, R.5
  • 22
    • 0042344946 scopus 로고    scopus 로고
    • Pharmacokinetics of midazolam in neonates undergoing extra-corporeal membrane oxygenation
    • Mulla, H.; McCormack, P.; Lawson, G.; Firmin, R. K.; Upton, D. R. Pharmacokinetics of midazolam in neonates undergoing extra-corporeal membrane oxygenation. Anesthesiology, 2003, 99, 275-82
    • (2003) Anesthesiology , vol.99 , pp. 275-282
    • Mulla, H.1    McCormack, P.2    Lawson, G.3    Firmin, R.K.4    Upton, D.R.5
  • 23
    • 51649114041 scopus 로고    scopus 로고
    • Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions
    • Muchohi, S. N.; Kokwaro, G. O.; Ogutu, B. R.; Edwards, G.; Ward, S. A.; Newton, C. R. Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions. Br. J. Clin. Pharmacol., 2008, 66, 529-38
    • (2008) Br. J. Clin. Pharmacol. , vol.66 , pp. 529-538
    • Muchohi, S.N.1    Kokwaro, G.O.2    Ogutu, B.R.3    Edwards, G.4    Ward, S.A.5    Newton, C.R.6
  • 24
    • 33747835599 scopus 로고    scopus 로고
    • Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations
    • Strolin Benedetti, M.; Whomsley, R.; Baltes, E. L. Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations. Expert Opin. Drug Metab. Toxicol., 2005, 1, 447-71
    • (2005) Expert Opin. Drug Metab. Toxicol. , vol.1 , pp. 447-471
    • Strolin Benedetti, M.1    Whomsley, R.2    Baltes, E.L.3
  • 25
    • 20644465189 scopus 로고    scopus 로고
    • Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: Theophylline and midazolam as model drugs
    • Björkman, S. Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs. Br. J. Clin. Pharmacol., 2004, 59, 691-704
    • (2004) Br. J. Clin. Pharmacol. , vol.59 , pp. 691-704
    • Björkman, S.1
  • 26
    • 0030813117 scopus 로고    scopus 로고
    • Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients
    • Anderson, B. J.; McKee, A. D.; Holford, N. H. Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients. Clin. Pharmacokinet., 1997, 33, 313-27
    • (1997) Clin. Pharmacokinet. , vol.33 , pp. 313-327
    • Anderson, B.J.1    McKee, A.D.2    Holford, N.H.3
  • 27
    • 0036041107 scopus 로고    scopus 로고
    • Contribution of midazolam and its 1-hydroxy metabolite to preoperative sedation in children: A pharmacokinetic-pharmacodynamic analysis
    • Johnson, T. N.; Rostami-Hodjegan, A.; Goddard, J. M.; Tanner, M. S.; Tucker, G. T. Contribution of midazolam and its 1-hydroxy metabolite to preoperative sedation in children: a pharmacokinetic-pharmacodynamic analysis. Br. J. Anaesth., 2002, 87, 428-37
    • (2002) Br. J. Anaesth. , vol.87 , pp. 428-437
    • Johnson, T.N.1    Rostami-Hodjegan, A.2    Goddard, J.M.3    Tanner, M.S.4    Tucker, G.T.5
  • 29
    • 36048959792 scopus 로고    scopus 로고
    • Ontogeny of human hepatic cytochromes P450
    • Hines, R. N. Ontogeny of human hepatic cytochromes P450. J. Biochem. Mol. Toxicol., 2007, 21, 169-75
    • (2007) J. Biochem. Mol. Toxicol. , vol.21 , pp. 169-175
    • Hines, R.N.1
  • 30
    • 33646079393 scopus 로고    scopus 로고
    • New perspectives on the impact of cytochrome P450 3A expression for pediatric pharmacology
    • Stevens, J. C. New perspectives on the impact of cytochrome P450 3A expression for pediatric pharmacology. Drug Discov. Today, 2006, 11, 440-5
    • (2006) Drug Discov. Today , vol.11 , pp. 440-445
    • Stevens, J.C.1
  • 31
    • 0036396419 scopus 로고    scopus 로고
    • Ontogeny of hepatic and renal systemic clearance pathways in infants. Part II
    • Alcorn, J.; McNamara, P. J. Ontogeny of hepatic and renal systemic clearance pathways in infants. Part II. Clin. Pharmacokinet., 2002, 41, 1077-94
    • (2002) Clin. Pharmacokinet. , vol.41 , pp. 1077-1094
    • Alcorn, J.1    McNamara, P.J.2
  • 32
    • 38749135827 scopus 로고    scopus 로고
    • Characterization of 1'-hydroxymidazolam glucuronidation in human liver microsomes
    • Zhu, B.; Bush, D.; Doss, G. A.; Vincent, S.; Franklin, R. B.; Xu, S. Characterization of 1'-hydroxymidazolam glucuronidation in human liver microsomes. Drug Metab. Disp., 2008, 36, 331-8
    • (2008) Drug Metab. Disp. , vol.36 , pp. 331-338
    • Zhu, B.1    Bush, D.2    Doss, G.A.3    Vincent, S.4    Franklin, R.B.5    Xu, S.6
  • 36
    • 0036150897 scopus 로고    scopus 로고
    • Developmental aspects of human hepatic drug glucuronidation in young children and adults
    • Strassburg, C. P.; Strassburg, A.; Kneip, S.; Barut, A.; Tukey, R. H.; Rodeck, B.; Manns, M. P. Developmental aspects of human hepatic drug glucuronidation in young children and adults. Gut, 2002, 50, 259-65
    • (2002) Gut , vol.50 , pp. 259-265
    • Strassburg, C.P.1    Strassburg, A.2    Kneip, S.3    Barut, A.4    Tukey, R.H.5    Rodeck, B.6    Manns, M.P.7
  • 37
    • 34548099546 scopus 로고    scopus 로고
    • Pediatric development of glucuronida-tion: The ontogeny of hepatic UGT1A4
    • Miyagi, S. J.; Collier, A. C. Pediatric development of glucuronida-tion: the ontogeny of hepatic UGT1A4. Drug Metab. Dispos., 2007, 35, 1587-92
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 1587-1592
    • Miyagi, S.J.1    Collier, A.C.2
  • 39
    • 84863643279 scopus 로고    scopus 로고
    • Glomerular filtration
    • Gluckman PD, Heymann MA (eds) 2nd ed. Arnold, London
    • Robillard JE. Glomerular Filtration. In: Gluckman PD, Heymann MA (eds) Pediatrics and perinatology, the scientific basis, 2nd ed. Arnold, London, 1996 pp. 939-941
    • (1996) Pediatrics and Perinatology, the Scientific Basis , pp. 939-941
    • Robillard, J.E.1
  • 41
    • 0026332310 scopus 로고
    • The effects of acute changes in renal function on the pharmacokinetics of midazolam during long-term infusion in ICU patients
    • Driessen, J. J.; Vree, T. B.; Guelen, P. J. M. The effects of acute changes in renal function on the pharmacokinetics of midazolam during long-term infusion in ICU patients. Acta. Anaesth. Belg., 1991, 42, 149-155
    • (1991) Acta. Anaesth. Belg. , vol.42 , pp. 149-155
    • Driessen, J.J.1    Vree, T.B.2    Guelen, P.J.M.3
  • 42
    • 0027332557 scopus 로고
    • Ontogeny of GABAA receptor subunit mRNAs in rat spinal cord and dorsal root ganglia
    • Ma, W.; Saunders, P. A.; Somogyi, R.; Poulter, M. O.; Barker, J. L. Ontogeny of GABAA receptor subunit mRNAs in rat spinal cord and dorsal root ganglia. J. Comp. Neurol., 1993, 338, 337-59
    • (1993) J. Comp. Neurol. , vol.338 , pp. 337-359
    • Ma, W.1    Saunders, P.A.2    Somogyi, R.3    Poulter, M.O.4    Barker, J.L.5
  • 43
    • 0036719162 scopus 로고    scopus 로고
    • Excitatory actions of GABA during development: The nature of the nurture
    • Ben-Ari, Y. Excitatory actions of GABA during development: the nature of the nurture. Nat. Rev. Neurosci., 2002, 3, 728-39
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 728-739
    • Ben-Ari, Y.1
  • 44
    • 37549022653 scopus 로고    scopus 로고
    • Midazolam potentiates nociceptive behavior, sensitizes cutaneous reflexes, and is devoid of sedative action in neonatal rats
    • Koch, S. C.; Fitzgerald, M.; Hathway, G. J. Midazolam potentiates nociceptive behavior, sensitizes cutaneous reflexes, and is devoid of sedative action in neonatal rats. Anesthesiology, 2008, 108, 122-9
    • (2008) Anesthesiology , vol.108 , pp. 122-129
    • Koch, S.C.1    Fitzgerald, M.2    Hathway, G.J.3
  • 45
    • 0026080080 scopus 로고
    • Ontogeny of the benzodiazepine receptor in human brain: Fluorographic, immunochemical, and reversible binding studies
    • Reichelt, R.; Hofmann, D.; Fodisch, H. J.; Mohler, H.; Knapp, M.; Hebebrand, J. Ontogeny of the benzodiazepine receptor in human brain: fluorographic, immunochemical, and reversible binding studies. J. Neurochem., 1991, 57, 1128-35
    • (1991) J. Neurochem. , vol.57 , pp. 1128-1135
    • Reichelt, R.1    Hofmann, D.2    Fodisch, H.J.3    Mohler, H.4    Knapp, M.5    Hebebrand, J.6
  • 46
    • 0035026384 scopus 로고    scopus 로고
    • Postnatal maturation of human GABAA receptors measured with positron emission tomography
    • Chugani, D. C.; Muzik, O.; Juhasz, C.; Janisse, J. J.; Ager, J.; Chugani, H. T. Postnatal maturation of human GABAA receptors measured with positron emission tomography. Ann. Neurol., 2001, 49, 618-26
    • (2001) Ann. Neurol. , vol.49 , pp. 618-626
    • Chugani, D.C.1    Muzik, O.2    Juhasz, C.3    Janisse, J.J.4    Ager, J.5    Chugani, H.T.6
  • 47
    • 0030456714 scopus 로고    scopus 로고
    • Benzodiazepine site pharmacokinetic/pharmacodynamic quantification in man: Direct measurement of drug occupancy and effects on the human brain in vivo
    • Malizia, A. L.; Gunn, R. N.; Wilson, S. J.; Waters, S. H.; Bloomfield, P. M.; Cunningham, V. J.; Nutt, D. J. Benzodiazepine site pharmacokinetic/ pharmacodynamic quantification in man: direct measurement of drug occupancy and effects on the human brain in vivo. Neuropharmacology, 1996, 35, 1483-91
    • (1996) Neuropharmacology , vol.35 , pp. 1483-1491
    • Malizia, A.L.1    Gunn, R.N.2    Wilson, S.J.3    Waters, S.H.4    Bloomfield, P.M.5    Cunningham, V.J.6    Nutt, D.J.7
  • 48
    • 0022522087 scopus 로고
    • Sedation of childrem requiring artificial ventilation using an infusion of mida-zolam
    • Booker, P. D.; Beechey, A.; Lloyd-Thomas, A. R. Sedation of childrem requiring artificial ventilation using an infusion of mida-zolam. Br. J. Anaesth., 1986, 58, 1104-8
    • (1986) Br. J. Anaesth. , vol.58 , pp. 1104-1108
    • Booker, P.D.1    Beechey, A.2    Lloyd-Thomas, A.R.3
  • 49
    • 0022501031 scopus 로고
    • Infusion of midazolam in paediatric patienst after cardiac surgery
    • Lloyd-Thomas, A. R.; Booker, P. D. Infusion of midazolam in paediatric patienst after cardiac surgery. Br. J. Anaesth., 1986, 58, 110-15
    • (1986) Br. J. Anaesth. , vol.58 , pp. 110-115
    • Lloyd-Thomas, A.R.1    Booker, P.D.2
  • 50
    • 0023874171 scopus 로고
    • Continuous intravenous midazolam infusion for sedation in the pediatric intensive care unit
    • Silvasi, D. L.; Rosen, D. A.; Rosen, K. R. Continuous intravenous midazolam infusion for sedation in the pediatric intensive care unit. Anesth. Analg., 1988, 67, 286-8
    • (1988) Anesth. Analg. , vol.67 , pp. 286-288
    • Silvasi, D.L.1    Rosen, D.A.2    Rosen, K.R.3
  • 51
    • 0025738935 scopus 로고
    • Clinical experience with con-tinous intravenous sedation using midazolam and fentanyl in the paediatric intensive care unit
    • Hartwig, S.; Roth, B.; Theisohn, M. Clinical experience with con-tinous intravenous sedation using midazolam and fentanyl in the paediatric intensive care unit. Eur. J. Pediatr., 1991, 150, 784-8
    • (1991) Eur. J. Pediatr. , vol.150 , pp. 784-788
    • Hartwig, S.1    Roth, B.2    Theisohn, M.3
  • 52
    • 0025836951 scopus 로고
    • Midazolam for sedation in the paediat-ric intensive care unit
    • Rosen, D. A.; Rosen, K. R. Midazolam for sedation in the paediat-ric intensive care unit. Intensive Care Med., 1991, 17, S15-9
    • (1991) Intensive Care Med. , vol.17
    • Rosen, D.A.1    Rosen, K.R.2
  • 53
    • 0028149251 scopus 로고
    • Midazolam infusion in pediatric patients with burns who are undergoing mechanical ventilation
    • Sheridan, R. l.; McEttricj, M.; Bacha, G.; Stoddard, F.; Tompins, R. G. Midazolam infusion in pediatric patients with burns who are undergoing mechanical ventilation. J. Burn. Care Rehabil., 1994, 15, 515-8
    • (1994) J. Burn. Care Rehabil. , vol.15 , pp. 515-518
    • Sheridan, R.L.1    McEttricj, M.2    Bacha, G.3    Stoddard, F.4    Tompins, R.G.5
  • 56
    • 2442584848 scopus 로고    scopus 로고
    • Sedation during mechanical ventilation in infants and children: Dexmedetomidine versus mida-zolam
    • Tobias, J. D.; Berkenbosch, J. W. Sedation during mechanical ventilation in infants and children: dexmedetomidine versus mida-zolam. South Med. J., 2004, 97, 451-5
    • (2004) South Med. J. , vol.97 , pp. 451-455
    • Tobias, J.D.1    Berkenbosch, J.W.2
  • 58
    • 68849115621 scopus 로고    scopus 로고
    • Efficacy of sedation regimens to facilitate mechanical ventilation in the pediat-ric intensive care unit: A systematic review
    • Hartman, M. E.; McCrory, D. C.; Schulman, S. R. Efficacy of sedation regimens to facilitate mechanical ventilation in the pediat-ric intensive care unit: a systematic review. Pediatr. Crit. Care Med., 2009, 10, 246-55
    • (2009) Pediatr. Crit. Care Med. , vol.10 , pp. 246-255
    • Hartman, M.E.1    McCrory, D.C.2    Schulman, S.R.3
  • 60
    • 67649441085 scopus 로고    scopus 로고
    • Correlation between the Sedation-Agitation Scale and the Bispectral Index in ventilated patients in the intensive care unit
    • Arbour, R.; Waterhouse, J.; Seckel, M. A.; Bucher, L. Correlation between the Sedation-Agitation Scale and the Bispectral Index in ventilated patients in the intensive care unit. Heart Lung, 2009, 38, 336-45
    • (2009) Heart Lung , vol.38 , pp. 336-345
    • Arbour, R.1    Waterhouse, J.2    Seckel, M.A.3    Bucher, L.4
  • 61
    • 31344444671 scopus 로고    scopus 로고
    • Prediction of cytochrome P450-mediated hepatic drug clearance in neonates
    • Björkman, S. Prediction of cytochrome P450-mediated hepatic drug clearance in neonates, infants and children. Clin. Pharma-cokinet., 2006, 42, 1-11
    • (2006) Infants and Children. Clin. Pharma-cokinet. , vol.42 , pp. 1-11
    • Björkman, S.1
  • 62
    • 33746803672 scopus 로고    scopus 로고
    • Prediction of the clearance of eleven drugs and associated variability in neo-nates, infants and children
    • Johnson, T. N.; Rostami-Hodjegan, A.; Tucker, G. T. Prediction of the clearance of eleven drugs and associated variability in neo-nates, infants and children. Clin. Pharmacokinet., 2006, 45, 931-5663
    • (2006) Clin. Pharmacokinet. , vol.45 , pp. 931-5663
    • Johnson, T.N.1    Rostami-Hodjegan, A.2    Tucker, G.T.3
  • 63
    • 34548407048 scopus 로고    scopus 로고
    • Effect of age and sedative agent on the accuracy of bispectral index in detecting depth of sedation in children
    • Malviya, S.; Voepel-Lewis, T.; Tait, A. R.; Watcha, M. F.; Sadha-sivam, S.; Friesen, R. H. Effect of age and sedative agent on the accuracy of bispectral index in detecting depth of sedation in children. Pediatrics, 2007, 120, 461-70
    • (2007) Pediatrics , vol.120 , pp. 461-470
    • Malviya, S.1    Voepel-Lewis, T.2    Tait, A.R.3    Watcha, M.F.4    Sadha-Sivam, S.5    Friesen, R.H.6
  • 64
    • 84855663875 scopus 로고    scopus 로고
    • The effect of critical illness and inflammation on midazolam therapy in children
    • 2010 Nov 4. [Epub ahead of print]
    • Vet, N. J.; de Hoog, M.; Tibboel, D.; de Wildt, S. N. The effect of critical illness and inflammation on midazolam therapy in children. Pediatr. Crit. Care Med., 2010, 2010 Nov 4. [Epub ahead of print]
    • (2010) Pediatr. Crit. Care Med.
    • Vet, N.J.1    De Hoog, M.2    Tibboel, D.3    De Wildt, S.N.4


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