The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress

Acta Pharmacologica Sinica

Volumn 33, Issue 7, 2012, Pages 953-963

  Wang, Ying ^a   Yang, Jie ^a   Yang, Kai ^a   Cang, Hui ^a   Huang, Xin Zhi ^a   Li, Hui ^a   Yi, Jing ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

HeLa cells; HIF 1; p300; redox; ROS; SENP3; SUMOylation

Indexed keywords

ACTIN; CYSTEINE DERIVATIVE; CYSTEINE PROTEINASE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LUCIFERASE; MESSENGER RNA; PROTEIN P300; PROTEIN SENP3; REACTIVE OXYGEN METABOLITE; SUMO 2 PROTEIN; SUMO 3 PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SUMOYLATION; TRANSACTIVATION;

CYSTEINE; CYSTEINE ENDOPEPTIDASES; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; HYPOXIA-INDUCIBLE FACTOR 1; OXIDATION-REDUCTION; OXIDATIVE STRESS; P300-CBP TRANSCRIPTION FACTORS; REACTIVE OXYGEN SPECIES; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; TRANSCRIPTIONAL ACTIVATION; UBIQUITINS;

EID: 84863658456     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.40     Document Type: Article

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