Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in Beagle dog left ventricular midmyocardial myocytes

Journal of Pharmacological and Toxicological Methods

Volumn 60, Issue 1, 2009, Pages 94-106

  Hardy, Matthew E L ^a   Pollard, Chris E ^a   Small, Ben G ^a   Bridgland Taylor, Matthew ^a   Woods, Ann J ^a   Valentin, Jean Pierre ^a   Abi Gerges, Najah ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Action potential duration; Cardiac ion channels; Dog species; IonWorks ; Left ventricular midmyocardial myocytes; Methods; Voltage sensitive dye

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; ALFUZOSIN; CISAPRIDE; DILTIAZEM; DOFETILIDE; DYE; ION CHANNEL; PINACIDIL; POTASSIUM CHANNEL HERG; SOTALOL; TERFENADINE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CHO CELL; CONTROLLED STUDY; DOG; DRUG EFFECT; DRUG EXPOSURE; ELECTRIC FIELD; ELECTRODE; FEMALE; GENETIC TRANSFECTION; HEART ELECTROPHYSIOLOGY; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART REPOLARIZATION; IC 50; NONHUMAN; RISK ASSESSMENT; VALIDATION PROCESS;

ACTION POTENTIALS; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FEMALE; FLUORESCENT DYES; HEART VENTRICLES; ION CHANNELS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHARMACEUTICAL PREPARATIONS; PYRIDINIUM COMPOUNDS;

CANIS FAMILIARIS;

EID: 68549092547     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2009.03.005     Document Type: Article

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