Low p53 binding protein 1 (53BP1) expression is associated with increased local recurrence in breast cancer patients treated with breast-conserving surgery and radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 83, Issue 5, 2012, Pages

  Neboori, Hanmanth J R ^a   Haffty, Bruce G ^a   Wu, Hao ^a   Yang, Qifeng ^b   Aly, Amal ^a   Goyal, Sharad ^a   Schiff, Devora ^a   Moran, Meena S ^c   Golhar, Ryan ^a   Chen, Chunxia ^a   Moore, Dirk ^a   Ganesan, Shridar ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b SHANDONG UNIVERSITY   (China)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; Breast conserving surgery; Molecular markers; p53 binding protein 1 (53BP1); Radiotherapy

Indexed keywords

BINDING PROTEINS; BREAST CANCER; BREAST CONSERVING SURGERY; CAUSE-SPECIFIC SURVIVAL; EARLY-STAGE BREAST CANCER; ESTROGEN RECEPTOR; IMMUNOHISTOCHEMISTRY; INDEPENDENT PREDICTORS; LOCAL RECURRENCE; MOLECULAR MARKER; MULTI VARIATE ANALYSIS; MULTIVARIATE MODELS; OVERALL SURVIVAL; PROGESTERONE RECEPTOR; PROGNOSTIC INDICATORS; PROGNOSTIC SIGNIFICANCE; RECURRENCE-FREE SURVIVAL; TISSUE MICROARRAYS; UNIVARIATE;

PATHOLOGY; PATIENT MONITORING; PROTEINS; RADIOTHERAPY; SURGERY; TUMORS;

DISEASES;

BINDING PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; P53 BINDING PROTEIN 1; PROGESTERONE RECEPTOR; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER HORMONE THERAPY; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RELAPSE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ASSESSMENT; DISTANT METASTASIS FREE SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MULTIMODALITY CANCER THERAPY; OVERALL SURVIVAL; PARTIAL MASTECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RECURRENCE FREE SURVIVAL; RISK ASSESSMENT; TISSUE MICROARRAY; TRIPLE NEGATIVE BREAST CANCER; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MASTECTOMY, SEGMENTAL; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM PROTEINS; NEOPLASM RECURRENCE, LOCAL; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RETROSPECTIVE STUDIES; TISSUE ARRAY ANALYSIS; TREATMENT OUTCOME;

EID: 84863626243     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2012.01.089     Document Type: Article

References (23)

1. T. Walsh, and M.C. King Ten genes for inherited breast cancer Cancer Cell 11 2007 103 105
2. T. Byrski, T. Huzarski, and R. Dent Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients Breast Cancer Res Treat 115 2009 359 363
3. H. Farmer, N. McCabe, and C.J. Lord Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature 434 2005 917 921
4. S. Rottenberg, J.E. Jaspers, and A. Kersbergen High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs Proc Natl Acad Sci U S A 105 2008 17079 17084
5. P. Tassone, M.T. Di Martino, and M. Ventura Loss of BRCA1 function increases the antitumor activity of cisplatin against human breast cancer xenografts in vivo Cancer Biol Ther 8 2009 648 653
6. T. Sorlie, R. Tibshirani, and J. Parker Repeated observation of breast tumor subtypes in independent gene expression data sets Proc Natl Acad Sci U S A 100 2003 8418 8423
7. N.C. Turner, and J.S. Reis-Filho Basal-like breast cancer and the BRCA1 phenotype Oncogene 25 2006 5846 5853
8. N. Turner, A. Tutt, and A. Ashworth Hallmarks of 'BRCAness' in sporadic cancers Nat Rev Cancer 4 2004 814 819
9. N.C. Turner, J.S. Reis-Filho, and A.M. Russell BRCA1 dysfunction in sporadic basal-like breast cancer Oncogene 26 2007 2126 2132
10. J.E. FitzGerald, M. Grenon, and N.F. Lowndes 53BP1: function and mechanisms of focal recruitment Biochem Soc Trans 37 2009 897 904
11. J.C. Morales, Z. Xia, and T. Lu Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability J Biol Chem 278 2003 14971 14977
12. B. Wang, S. Matsuoka, and P.B. Carpenter 53BP1, a mediator of the DNA damage checkpoint Science 298 2002 1435 1438
13. I.M. Ward, K. Minn, and J. van Deursen p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice Mol Cell Biol 23 2003 2556 2563
14. P. Bouwman, A. Aly, and J.M. Escandell 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers Nat Struct Mol Biol 17 2010 688 695
15. S.F. Bunting, E. Callen, and N. Wong 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks Cell 141 2010 243 254
16. L. Cao, X. Xu, and S.F. Bunting A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency Mol Cell 35 2009 534 541
17. A. Aly, and S. Ganesan BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability J Mol Cell Biol 3 2011 66 74
18. B.G. Haffty, Q. Yang, and M. Reiss Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer J Clin Oncol 24 2006 5652 5657
19. B.G. Haffty, D. Fischer, and J.J. Fischer Regional nodal irradiation in the conservative treatment of breast cancer Int J Radiat Oncol Biol Phys 19 1990 859 865
20. J. Bartkova, Z. Horejsi, and M. Sehested DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours Oncogene 26 2007 7414 7422
21. E.M. Kass, and M. Jasin Collaboration and competition between DNA double-strand break repair pathways FEBS Lett 584 2010 3703 3708
22. B.G. Haffty, S. Goyal, and D. Kulkarni Evaluation of single nucleotide polymorphisms (SNPs) in the p53 binding protein 1 (TP53BP1) gene in breast cancer patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT) Int J Radiat Oncol Biol Phys 80 2011 385 391
23. L.M. McShane, D.G. Altman, and W. Sauerbrei REporting recommendations for tumor MARKer prognostic studies (REMARK) Breast Cancer Res Treat 100 2006 229 235