Cyclosporine treatment reduces oxygen free radical generation and oxidative stress in the brain of hypoxia-reoxygenated newborn piglets

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Gill, Richdeep S ^a   Lee, Tze Fun ^a   Liu, Jiang Qin ^a   Chaudhary, Hetal ^a   Brocks, Dion R ^a   Bigam, David L ^a   Cheung, Po Yin ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; CYTOCHROME C; GLUTATHIONE; HYDROGEN PEROXIDE; LACTIC ACID; OXYGEN RADICAL; PLACEBO;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CARDIOGENIC SHOCK; CAROTID ARTERY FLOW; CONCENTRATION RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; ELECTROCHEMICAL ANALYSIS; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMODYNAMICS; HYPOTENSION; HYPOXIC ISCHEMIC ENCEPHALOPATHY; MEAN ARTERIAL PRESSURE; NEUROPROTECTION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PH; PIGLET; PROTEIN EXPRESSION; PROTEIN FUNCTION; REOXYGENATION; TREATMENT RESPONSE; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; BLOOD PRESSURE; CAROTID ARTERIES; CEREBRAL CORTEX; CYCLOSPORINE; CYTOCHROMES C; GLUTATHIONE; HEART RATE; HYDROGEN PEROXIDE; HYPOXIA-ISCHEMIA, BRAIN; LACTIC ACID; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REGIONAL BLOOD FLOW; SUS SCROFA;

ANIMALIA; SUIDAE;

EID: 84863625154     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040471     Document Type: Article

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