-
1
-
-
34748887764
-
Neuroprotective effects of propofol in acute cerebral injury
-
Adembri, C., Venturi, L., and Pellegrini-Giampietro, D. E. (2007). Neuroprotective effects of propofol in acute cerebral injury. CNS Drug Rev. 13, 333-351.
-
(2007)
CNS Drug Rev.
, vol.13
, pp. 333-351
-
-
Adembri, C.1
Venturi, L.2
Pellegrini-Giampietro, D.E.3
-
2
-
-
0035036258
-
Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases
-
Banaclocha, M. M. (2001). Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases. Med. Hypo. 56, 472-477.
-
(2001)
Med. Hypo
, vol.56
, pp. 472-477
-
-
Banaclocha, M.M.1
-
3
-
-
5444245109
-
Peroxynitrite inhibits relaxation and induces pulmonary artery muscle contraction in the newborn rat
-
Belik, J., Jankov, R. P., Pan, J., and Tanswell, A. K. (2004). Peroxynitrite inhibits relaxation and induces pulmonary artery muscle contraction in the newborn rat. Free Radical Biol. Med. 37, 384-392.
-
(2004)
Free Radical Biol. Med.
, vol.37
, pp. 384-392
-
-
Belik, J.1
Jankov, R.P.2
Pan, J.3
Tanswell, A.K.4
-
4
-
-
74449093727
-
Seizures are associated with brain injury severity in a neonatal model of hypoxia-ischemia
-
Björkman, S. T., Miller, S. M., Rose, S. E., Burke, C., and Colditz, P. B. (2010). Seizures are associated with brain injury severity in a neonatal model of hypoxia-ischemia. Neuroscience 166, 157-167.
-
(2010)
Neuroscience
, vol.166
, pp. 157-167
-
-
Björkman, S.T.1
Miller, S.M.2
Rose, S.E.3
Burke, C.4
Colditz, P.B.5
-
5
-
-
0035971091
-
Synergistic activation of caspase-3 by m-calpain after neonatal hypoxiaischemia
-
Blomgren, K., Zhu, C., Wang, X., Karlsson, J. O., Leverin, A. L., Bahr, B. A., Mallard, C., and Hagberg, H. (2001). Synergistic activation of caspase-3 by m-calpain after neonatal hypoxiaischemia. J. Biol. Chem. 276, 10191-10198.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10191-10198
-
-
Blomgren, K.1
Zhu, C.2
Wang, X.3
Karlsson, J.O.4
Leverin, A.L.5
Bahr, B.A.6
Mallard, C.7
Hagberg, H.8
-
6
-
-
33646506832
-
Effect of N-acetylcysteine on blood and tissue lipid peroxidation in lipopolysaccharideinduced obstructive jaundice
-
Caglikulekci, M., Dirlik, M., Pata, C., Plasse, M., Tamer, L., Ogetman, Z., and Ercan, B. (2006). Effect of N-acetylcysteine on blood and tissue lipid peroxidation in lipopolysaccharideinduced obstructive jaundice. J. Invest. Surg. 19, 175-184.
-
(2006)
J. Invest. Surg.
, vol.19
, pp. 175-184
-
-
Caglikulekci, M.1
Dirlik, M.2
Pata, C.3
Plasse, M.4
Tamer, L.5
Ogetman, Z.6
Ercan, B.7
-
7
-
-
68049107447
-
Cardiovascular responses to hydrogen peroxide into the nucleus tractus solitarius
-
Cardoso, L. M., Colombari, D. S., Menani, J. V., Toney, G. M., Chianca, D. A. Jr., and Colombari, E. (2009). Cardiovascular responses to hydrogen peroxide into the nucleus tractus solitarius. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297, R462-R469.
-
(2009)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.297
-
-
Cardoso, L.M.1
Colombari, D.S.2
Menani, J.V.3
Toney, G.M.4
Chianca Jr., D.A.5
Colombari, E.6
-
8
-
-
0032080673
-
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury
-
Cheng, Y., Deshmukh, M., D'Costa, A., Demaro, J. A., Gidday, J. M., Shah, A., Sun, Y., Jacquin, M. F., Johnson, E. M., and Holtzman, D. M. (1998). Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury. J. Clin. Invest. 101, 1992-1999.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 1992-1999
-
-
Cheng, Y.1
Deshmukh, M.2
D'Costa, A.3
Demaro, J.A.4
Gidday, J.M.5
Shah, A.6
Sun, Y.7
Jacquin, M.F.8
Johnson, E.M.9
Holtzman, D.M.10
-
9
-
-
0035219323
-
The pathophysiology, diagnosis, and management of acute hepatic encephalopathy
-
Colquhoun, S. D., Lipkin, C., and Connelly, C. A. (2001). The pathophysiology, diagnosis, and management of acute hepatic encephalopathy. Adv. Intern. Med. 46, 155-176.
-
(2001)
Adv. Intern. Med.
, vol.46
, pp. 155-176
-
-
Colquhoun, S.D.1
Lipkin, C.2
Connelly, C.A.3
-
10
-
-
0037333201
-
Origin and timing of brain lesions in term infants with neonatal encephalopathy
-
Cowan, F., Rutherford, M., Groenendaal, F., Eken, P., Mercuri, E., Bydder, G. M., Meiners, L. C., Dubowitz, L. M., and de Vries, L. S. (2003). Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet 361, 736-742.
-
(2003)
Lancet
, vol.361
, pp. 736-742
-
-
Cowan, F.1
Rutherford, M.2
Groenendaal, F.3
Eken, P.4
Mercuri, E.5
Bydder, G.M.6
Meiners, L.C.7
Dubowitz, L.M.8
Vries, L.S.9
-
11
-
-
0031750386
-
Oxidative stress and altered endothelial cell function in preeclampsia
-
Davidge, S. T. (1998). Oxidative stress and altered endothelial cell function in preeclampsia. Semin Reprod Endocrinol. 16, 65-73.
-
(1998)
Semin. Reprod. Endocrinol.
, vol.16
, pp. 65-73
-
-
Davidge, S.T.1
-
12
-
-
0037195723
-
Regulation of brain's vascular responses to oxygen
-
Demchenko, I. T., Oury, T. D., Crapo, J. D., and Piantadosi, C. A. (2002). Regulation of brain's vascular responses to oxygen. Circ. Res. 91, 1031-1037.
-
(2002)
Circ. Res.
, vol.91
, pp. 1031-1037
-
-
Demchenko, I.T.1
Oury, T.D.2
Crapo, J.D.3
Piantadosi, C.A.4
-
13
-
-
0028916027
-
N-acetylcysteine (D-and L-stereoisomers) prevents apoptotic death of neuronal cells
-
Ferrari, G., Yan, C. Y., and Greene, L. A. (1995). N-acetylcysteine (D-and L-stereoisomers) prevents apoptotic death of neuronal cells. J. Neurosci. 15, 2857-2866.
-
(1995)
J. Neurosci.
, vol.15
, pp. 2857-2866
-
-
Ferrari, G.1
Yan, C.Y.2
Greene, L.A.3
-
14
-
-
0030067559
-
Carotid arterial blood flow in the bovine fetus as a continuous measure of cerebral blood flow
-
Gratton, R., Carmichael, L., Homan, J., and Richardson, B. (1996). Carotid arterial blood flow in the bovine fetus as a continuous measure of cerebral blood flow. J. Soc. Gynecol. Invest. 3, 60-65.
-
(1996)
J. Soc. Gynecol. Invest.
, vol.3
, pp. 60-65
-
-
Gratton, R.1
Carmichael, L.2
Homan, J.3
Richardson, B.4
-
15
-
-
0242663945
-
Selective, reversible caspase-3 inhibitor is neuroprotective and reveals a distinct pathway of cell death after neonatal hypoxic-ischemic brain injury
-
Han, B. H., Xu, D., Choi, J., Han, Y., Xanthoudakis, S., Roy, S., Tam, J., Villancourt, J., Colucci, J., Siman, R., Giroux, A., Robertson, G. S., Zamboni, R., Nicholson, D. W., and Holtzman, D. M. (2002). Selective, reversible caspase-3 inhibitor is neuroprotective and reveals a distinct pathway of cell death after neonatal hypoxic-ischemic brain injury. J. Biol. Chem. 277, 30128-30136.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30128-30136
-
-
Han, B.H.1
Xu, D.2
Choi, J.3
Han, Y.4
Xanthoudakis, S.5
Roy, S.6
Tam, J.7
Villancourt, J.8
Colucci, J.9
Siman, R.10
Giroux, A.11
Robertson, G.S.12
Zamboni, R.13
Nicholson, D.W.14
Holtzman, D.M.15
-
16
-
-
0032971704
-
Relationship between proton magnetic resonance spectroscopy within 18 hours of birth asphyxia and neurodevelopment at 1 year of age
-
Hanrahan, J. D., Cox, I. J., Azzopardi, D., Cowan, F. M., Sargentoni, J., Bell, J. D., Bryant, D. J., and Edwards, A. D. (1999). Relationship between proton magnetic resonance spectroscopy within 18 hours of birth asphyxia and neurodevelopment at 1 year of age. Dev. Med. Child. Neurol. 41, 76-82.
-
(1999)
Dev. Med. Child. Neurol.
, vol.41
, pp. 76-82
-
-
Hanrahan, J.D.1
Cox, I.J.2
Azzopardi, D.3
Cowan, F.M.4
Sargentoni, J.5
Bell, J.D.6
Bryant, D.J.7
Edwards, A.D.8
-
17
-
-
14644437067
-
Doxycycline reduced cleaved caspase-3 and microglial activation in an animal model of neonatal hypoxia-ischemia
-
Jantzie, L. L., Cheung, P. Y., and Todd, K. G. (2005). Doxycycline reduced cleaved caspase-3 and microglial activation in an animal model of neonatal hypoxia-ischemia. J. Cereb. Blood Flow Metab. 25, 314-324.
-
(2005)
J. Cereb. Blood Flow Metab.
, vol.25
, pp. 314-324
-
-
Jantzie, L.L.1
Cheung, P.Y.2
Todd, K.G.3
-
18
-
-
33646688898
-
Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats
-
Jatana, M., Singh, I., Singh, A. K., and Jenkins, D. (2006). Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr. Res. 59, 684-689.
-
(2006)
Pediatr. Res.
, vol.59
, pp. 684-689
-
-
Jatana, M.1
Singh, I.2
Singh, A.K.3
Jenkins, D.4
-
19
-
-
34548691604
-
N-acetylcysteine improves the hemodynamics and oxidative stress in hypoxic newborn pigs reoxygenated with 100% oxygen
-
Johnson, S. T., Bigam, D. L., Emara, M., Obaid, L., Slack, G., Korbutt, G., Jewell, L. D., Van Aerde, J., and Cheung, P. Y. (2007). N-acetylcysteine improves the hemodynamics and oxidative stress in hypoxic newborn pigs reoxygenated with 100% oxygen. Shock 28, 484-490.
-
(2007)
Shock
, vol.28
, pp. 484-490
-
-
Johnson, S.T.1
Bigam, D.L.2
Emara, M.3
Obaid, L.4
Slack, G.5
Korbutt, G.6
Jewell, L.D.7
Van Aerde, J.8
Cheung, P.Y.9
-
20
-
-
2342562573
-
Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in rat model of experimental stroke
-
Khan, M., Sekhon, B., Jatana, M., Giri, S., Gilg, A. G., Sekhon, C., Singh, I., and Singh, A. K. (2004). Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in rat model of experimental stroke. J. Neurosci. Res. 76, 519-527.
-
(2004)
J. Neurosci. Res.
, vol.76
, pp. 519-527
-
-
Khan, M.1
Sekhon, B.2
Jatana, M.3
Giri, S.4
Gilg, A.G.5
Sekhon, C.6
Singh, I.7
Singh, A.K.8
-
21
-
-
33845499287
-
Caspases and their many biological functions
-
Kumar, S. (2007). Caspases and their many biological functions. Cell Death Differ. 14, 1-2.
-
(2007)
Cell. Death Differ
, vol.14
, pp. 1-2
-
-
Kumar, S.1
-
22
-
-
33845483887
-
Caspases in cell survival, proliferation and differentiation
-
Lamkanfi, M., Festjens, N., Declercq, W., Vanden Berghe, T., and Vandenabeele, P. (2007). Caspases in cell survival, proliferation and differentiation. Cell Death Differ. 14, 44-55.
-
(2007)
Cell. Death Differ
, vol.14
, pp. 44-55
-
-
Lamkanfi, M.1
Festjens, N.2
Declercq, W.3
Vanden Berghe, T.4
Vandenabeele, P.5
-
23
-
-
0034112915
-
Cerebral perfusion, cardiac output, and arterial pressure in patients with fulminant hepatic failure
-
Larsen, F. S., Strauss, G., Knudsen, G. M., Herzog, T. M., Hansen, B. A., and Secher, N. H. (2000). Cerebral perfusion, cardiac output, and arterial pressure in patients with fulminant hepatic failure. Crit. Care Med. 28, 996-1000.
-
(2000)
Crit. Care Med.
, vol.28
, pp. 996-1000
-
-
Larsen, F.S.1
Strauss, G.2
Knudsen, G.M.3
Herzog, T.M.4
Hansen, B.A.5
Secher, N.H.6
-
24
-
-
38149038522
-
Postresuscitation N-acetylcysteine treatment reduces cerebral hydrogen peroxide in the hypoxic piglet brain
-
Lee, T. F., Jantzie, L. L., Todd, K. G., and Cheung, P. Y. (2008a). Postresuscitation N-acetylcysteine treatment reduces cerebral hydrogen peroxide in the hypoxic piglet brain. Intensive Care Med. 34, 190-197.
-
(2008)
Intensive Care Med.
, vol.34
, pp. 190-197
-
-
Lee, T.F.1
Jantzie, L.L.2
Todd, K.G.3
Cheung, P.Y.4
-
25
-
-
55749101366
-
Effects of postresuscitation N-acetylcysteine on cerebral free radical production and perfusion during reoxygenation of hypoxic newborn piglets
-
Lee, T. F., Tymafichuk, C. N., Bigam, D. L., and Cheung, P. Y. (2008b). Effects of postresuscitation N-acetylcysteine on cerebral free radical production and perfusion during reoxygenation of hypoxic newborn piglets. Pediatr. Res. 64, 256-261.
-
(2008)
Pediatr. Res.
, vol.64
, pp. 256-261
-
-
Lee, T.F.1
Tymafichuk, C.N.2
Bigam, D.L.3
Cheung, P.Y.4
-
26
-
-
54349116734
-
Cerebral function monitoring in neonates with perinatal asphyxia-preliminary results
-
Lukaskova, J., Tomsikova, Z., and Kokstein, Z. (2008). Cerebral function monitoring in neonates with perinatal asphyxia-preliminary results. Neuroendocrinol. Lett. 29, 522-528.
-
(2008)
Neuroendocrinol. Lett.
, vol.29
, pp. 522-528
-
-
Lukaskova, J.1
Tomsikova, Z.2
Kokstein, Z.3
-
27
-
-
0032922184
-
Correlation of flow probe determinations of common carotid artery blood flow and internal carotid artery blood flow with microsphere determinations of cerebral blood flow in piglets
-
Meadow, W., Rudinsky, B., Raju, T., John, E., Fornell, L., and Shankararao, R. (1999). Correlation of flow probe determinations of common carotid artery blood flow and internal carotid artery blood flow with microsphere determinations of cerebral blood flow in piglets. Pediatr. Res. 45, 324-330.
-
(1999)
Pediatr. Res.
, vol.45
, pp. 324-330
-
-
Meadow, W.1
Rudinsky, B.2
Raju, T.3
John, E.4
Fornell, L.5
Shankararao, R.6
-
28
-
-
0034329279
-
Apoptosis has a prolonged role in neurodegeneration after hypoxic ischemia in newborn rat
-
Nakajima, W., Ishida, A., Lange, M. S., Gabrielson, K. L., Wilson, M. A., Martin, L. J., Blue, M. E., and Johnston, M. V. (2000). Apoptosis has a prolonged role in neurodegeneration after hypoxic ischemia in newborn rat. J. Neurosci. 20, 7994-8004.
-
(2000)
J. Neurosci.
, vol.20
, pp. 7994-8004
-
-
Nakajima, W.1
Ishida, A.2
Lange, M.S.3
Gabrielson, K.L.4
Wilson, M.A.5
Martin, L.J.6
Blue, M.E.7
Johnston, M.V.8
-
29
-
-
0033119001
-
Changes in iron histochemistry after hypoxicischemic brain injury in neonatal rat
-
Palmer, C., Menzies, S. L., Roberts, R. L., Pavlick, G., and Connor, J. R. (1999). Changes in iron histochemistry after hypoxicischemic brain injury in neonatal rat. J. Neurosci. Res. 56, 60-71.
-
(1999)
J. Neurosci. Res.
, vol.56
, pp. 60-71
-
-
Palmer, C.1
Menzies, S.L.2
Roberts, R.L.3
Pavlick, G.4
Connor, J.R.5
-
30
-
-
18044375993
-
Apoptosis and necrosis in developing cerebellum and brainstem induced after focal cerebral hypoxic-ischemic injury
-
Peng, J. H., Feng, Y., Le Blanc, M. H., Rhodes, P. G., and Parker, J. C. Jr. (2005). Apoptosis and necrosis in developing cerebellum and brainstem induced after focal cerebral hypoxic-ischemic injury. Brain Res. Dev. Brain Res. 156, 87-92.
-
(2005)
Brain Res. Dev. Brain Res.
, vol.156
, pp. 87-92
-
-
Peng, J.H.1
Feng, Y.2
Le Blanc, M.H.3
Rhodes, P.G.4
Parker Jr., J.C.5
-
31
-
-
33751002345
-
Intervention strategies for neonatal hypoxic-ischemic cerebral injury
-
Perlman, J. M. (2006). Intervention strategies for neonatal hypoxic-ischemic cerebral injury. Clin. Ther. 28, 1353-1365.
-
(2006)
Clin. Ther.
, vol.28
, pp. 1353-1365
-
-
Perlman, J.M.1
-
32
-
-
19644364808
-
The role of free radicals in cerebral hypoxia and ischemia
-
Rodrigo, J., Fernandez, A. P., Serrano, J., Peinado, M. A., and Martinez, A. (2005). The role of free radicals in cerebral hypoxia and ischemia. Free Radic. Biol. Med. 39, 26-50.
-
(2005)
Free Radic. Biol. Med.
, vol.39
, pp. 26-50
-
-
Rodrigo, J.1
Fernandez, A.P.2
Serrano, J.3
Peinado, M.A.4
Martinez, A.5
-
33
-
-
0036222155
-
Cerebral resuscitation potentials for cardiac arrest
-
Safar, P., Behringer, W., Böttiger, B. W., and Sterz, F. (2002). Cerebral resuscitation potentials for cardiac arrest. Crit. Care Med. 30 (Suppl.), S140-S144.
-
(2002)
Crit. Care Med.
, vol.30
, Issue.SUPPL.
-
-
Safar, P.1
Behringer, W.2
Böttiger, B.W.3
Sterz, F.4
-
34
-
-
0037414415
-
N-acetylcysteine protects against injury in a rat model of focal cerebral ischemia
-
Sekhon, B., Sekhon, C., Khan, M., Patel, S. J., Singh, I., and Singh, A. K. (2003). N-acetylcysteine protects against injury in a rat model of focal cerebral ischemia. Brain Res. 971, 1-8.
-
(2003)
Brain Res.
, vol.971
, pp. 1-8
-
-
Sekhon, B.1
Sekhon, C.2
Khan, M.3
Patel, S.J.4
Singh, I.5
Singh, A.K.6
-
35
-
-
0030052801
-
Mild resuscitative hypothermia and outcome after cardiopulmonary resuscitation
-
Sterz, F., Zeiner, A., Kürkciyan, I., Janata, K., Müllner, M., Domanovits, H., and Safar, P. (1996). Mild resuscitative hypothermia and outcome after cardiopulmonary resuscitation. J. Neurosurg. Anesthesiol. 8, 88-96.
-
(1996)
J. Neurosurg. Anesthesiol
, vol.8
, pp. 88-96
-
-
Sterz, F.1
Zeiner, A.2
Kürkciyan, I.3
Janata, K.4
Müllner, M.5
Domanovits, H.6
Safar, P.7
-
36
-
-
0028912996
-
Tumor necrosis factor alphainduced apoptosis in human neuronal cells: Protection by antioxidant N-acetylcysteine and the gene bcl-2 and crmA
-
Talley, A. K., Dewhurst, S., Perry, S. W., Dollard, S. C., Gummuluru, S., Fine, S. M., New, D., Epstein, L. G., Gendelman, H. E., and Gelbard, H. A. (1995). Tumor necrosis factor alphainduced apoptosis in human neuronal cells: protection by antioxidant N-acetylcysteine and the gene bcl-2 and crmA. Mol. Cell Biol. 15, 2359-2366.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 2359-2366
-
-
Talley, A.K.1
Dewhurst, S.2
Perry, S.W.3
Dollard, S.C.4
Gummuluru, S.5
Fine, S.M.6
New, D.7
Epstein, L.G.8
Gendelman, H.E.9
Gelbard, H.A.10
-
37
-
-
34147182756
-
N-Acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury
-
Wang, X., Svedin, P., Nie, C., Lapatto, R., Zhu, C., Gustavsson, M., Sandberg, M., Karlsson, J. O., Romero, R., Hagberg, H., and Mallard, C. (2007). N-Acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury. Ann. Neurol. 61, 263-271.
-
(2007)
Ann. Neurol.
, vol.61
, pp. 263-271
-
-
Wang, X.1
Svedin, P.2
Nie, C.3
Lapatto, R.4
Zhu, C.5
Gustavsson, M.6
Sandberg, M.7
Karlsson, J.O.8
Romero, R.9
Hagberg, H.10
Mallard, C.11
-
38
-
-
0028291629
-
Cerebral blood flow and metabolism in fulminant liver failure
-
Wendon, J. A., Harrison, P. M., Keays, R., and Williams, R. (1994). Cerebral blood flow and metabolism in fulminant liver failure. Hepatology 19, 1407-1413.
-
(1994)
Hepatology
, vol.19
, pp. 1407-1413
-
-
Wendon, J.A.1
Harrison, P.M.2
Keays, R.3
Williams, R.4
-
39
-
-
0034775517
-
N-acetylcysteine increases cerebral perfusion pressure in pigs with fulminant hepatic failure
-
Ytrebø, L. M., Korvald, C., Nedredal, G. I., Elvenes, O. P., Nielsen Grymyr, O. J., and Revhaug, A. (2001). N-acetylcysteine increases cerebral perfusion pressure in pigs with fulminant hepatic failure. Crit. Care Med. 29, 1989-1995.
-
(2001)
Crit. Care Med.
, vol.29
, pp. 1989-1995
-
-
Ytrebø, L.M.1
Korvald, C.2
Nedredal, G.I.3
Elvenes, O.P.4
Grymyr, N.O.J.5
Revhaug, A.6
-
40
-
-
0037278466
-
Molecular mechanisms of N-acetylcysteine actions
-
Zafarullah, M., Li, W. Q., Sylvester, J., and Ahmad, M. (2003). Molecular mechanisms of N-acetylcysteine actions. Cell Molec. Life Sci. 60, 6-20.
-
(2003)
Cell. Molec. Life Sci.
, vol.60
, pp. 6-20
-
-
Zafarullah, M.1
Li, W.Q.2
Sylvester, J.3
Ahmad, M.4
|