Postresuscitation N-acetylcysteine treatment reduces cerebral hydrogen peroxide in the hypoxic piglet brain

Intensive Care Medicine

Volumn 34, Issue 1, 2008, Pages 190-197

  Lee, Tze Fun ^a   Jantzie, Lauren L ^a   Todd, Kathryn G ^a   Cheung, Po Yin ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b ROYAL ALEXANDRA HOSPITAL   (Canada)

Author keywords

Hydrogen peroxide; Hypoxia reoxygenation; N acetylcysteine; Neonates; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; AMINO ACID; GLUTATHIONE; HYDROGEN PEROXIDE; LIPID HYDROPEROXIDE; REACTIVE OXYGEN METABOLITE; TAURINE;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN HYPOXIA; BRAIN METABOLISM; CONTROLLED STUDY; DIALYSATE; HEART RATE; HYPOTENSION; HYPOVENTILATION; MEAN ARTERIAL PRESSURE; NEUROPROTECTION; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PIGLET; REOXYGENATION; RESUSCITATION;

ACETYLCYSTEINE; ANIMALS; ANOXIA; BRAIN; FREE RADICAL SCAVENGERS; HYDROGEN PEROXIDE; OXIDATIVE STRESS; PROSPECTIVE STUDIES; RESUSCITATION; SWINE;

EID: 38149038522     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-007-0880-z     Document Type: Article

References (34)

1. Richter-Landsberg C, Vollgraf U (1998) Mode of cell injury and death after hydrogen peroxide exposure in cultured oligodendroglia cells. Exp Cell Res 244:218-229
2. Whittemore ER, Loo DT, Watt JA, Cotman CW (1995) A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture. Neuroscience 67:921-932
3. Lafemina MJ, Sheldon RA, Ferriero ADM (2006) Acute hypoxia-ischemia results in hydrogen peroxide accumulation in neonatal but not adult mouse brain. Pediatr Res 59:680-683
4. Fullerton HJ, Ditelberg JS, Chen SF, Sarco DP, Chan PH, Epstein CJ, Ferriero DM (1998) Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia. Ann Neurol 44:357-364
5. 2 production during ischemia and reperfusion: a microdialysis study in the gerbil hippocampus. Neurosci Lett 222:91-94
6. Patt A, Harken AH, Burton LK, Rodell TC, Piermattei D, Schorr WJ, Parker NB, Berger EM, Horesh IR, Terada LS (1988) Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains. J Clin Invest 81:1556-1562
7. Banaclocha MM (2001) Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases. Med Hypo 56:472-477
8. Zafarullah M, Li WQ, Sylvester J, Ahmad M (2003) Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 60:6-20
9. Khan M, Sekhon B, Jatana M, Giri S, Gilg AG, Sekhon C, Singh I, Singh AK (2004) Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in rat model of experimental stroke. J Neurosci Res 76:519-527
10. Wang X, Svedin P, Nie C, Lapatto R, Zhu C, Gustavsson M, Sandberg M, Karlsson JO, Romero R, Hagberg H, Mallard C (2007) N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury. Ann Neurol 61:263-271
11. Lee TF, Jantzie LL, Todd KG, Cheung P-Y (2007) Postresuscitation administration of N-acetylcysteine attenuates cerebral free radical generation during reoxygenation of hypoxic newborn piglets. E-PAS:618443.8 (abstract)
12. Ortalani O, Conti A, De Gaudio AR, Moraldi E, Cantini Q, Novelli G (2000) The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock. Am J Respir Crit Care Med 161:1907-1911
13. Haase E, Bigam DL, Nakonechny QB, Jewell LD, Korbutt G, Cheung PY (2004) Resuscitation with 100% oxygen causes intestinal glutathione oxidation and reoxygenation injury in asphyxiated newborn piglets. Ann Surg 240:364-373
14. Martin LJ, Brambrink A, Koehler RC, Traystman RJ (1997) Primary sensory and forebrain motor systems in the newborn brain are preferentially damaged by hypoxia-ischemia. J Comp Neurol 377:262-285
15. Richards JG, Todd KG, Emara M, Haase E, Cooper SL, Bigam DL, Cheung PY (2006) A dose-response study of graded reoxygenation on the carotid haemodynamics, matrix metalloproteinase-2 activities and amino acid concentrations in the brain of asphyxiated newborn piglets. Resuscitation 69:319-327
16. Johnson ST, Bigam DL, Emara M, Obaid L, Slack G, Korbutt G, Korbutt G, Jewell LD, Van Aerde J, Cheung PY (2007) N-acetylcysteine improves the hemodynamics and oxidative stress in hypoxic newborn pigs reoxygenated with 100% oxygen. Shock 2007 Jun 17 [Epub ahead of print]
17. Jantzie LL, Rauw GA, Todd KG (2006) The effects of doxycycline administration on amino acid neurotransmitters in an animal model of neonatal hypoxia-ischemia. Neurochem Inter 49:771-728
18. Parent M, Bush D, Rauw G, Master S, Vaccarino F, Baker G (2001) Analysis of amino acids and catecholamines, 5-hydroxytryptamine and their metabolites in brain areas in the rat using in vivo microdialysis. Methods 23:11-20
19. 2 in vitro. Brain Res 671:181-186
20. 2 in the brain by microdialysis. Brain Res Protoc 3:33-36
21. Kutzsche S, Ilves P, Kirkeby OJ, Saugstad OD (2001) Hydrogen peroxide production in leukocytes during cerebral hypoxia and reoxygenation with 100% or 21% oxygen in newborn piglets. Pediatr Res 49:834-842
22. Sprong RC, Winkelhuyzen-Janssen AM, Aarsman CJ, van Oirschot JF, van der Bruggen T, van Asbeck BS (1998) Low dose N-acetylcysteine protects rats against endotoxin-mediated oxidative stress, but high-dose increase mortality. Am J Respir Crit Care Med 157:1283-1293
23. Szkudlarek U, Zdziechowski A, Witkowski K, Kasielski M, Luczynska M, Luczynski R, Sarniak A, Nowak D (2004) Effect of inhaled N-acetylcysteine on hydrogen peroxide exhalation in healthy subjects. Pulm Pharmacol Ther 17:155-162
24. Palmer C, Menzies SL, Roberts RL, Pavlick G, Connor JR (1999) Changes in iron histochemistry after hypoxic-ischemic brain injury in neonatal rat. J Neurosci Res 56:60-71
25. Caglikulekci M, Dirlik M, Pata C, Plasse M, Tamer L, Ogetman Z, Ercan B (2006) Effect of N-acetylcysteine on blood and tissue lipid peroxidation in lipopolysaccharide-induced obstructive jaundice. J Invest Surg 19:175-184
26. Kingston R, Kelly CJ, Murray P (2004) The therapeutic role of taurine in ischemia-reperfusion injury. Curr Pharm Design 10:2401-2410
27. Estevez AY, O'Regan MH, Song D, Phillis JW (1999) Effects of anion channel blockers on hyposmotically induced amino acid release from the in vivo rat cerebral cortex. Neurochem Res 24:447-452
28. Andine P, Sandberg M, Bagenholm R, Lehmann A, Hagberg H (1991) Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxic-ischemia. Brain Res Dev Brain Res 64:115-120
29. Huppi PS, Posse S, Lazeyras F, Burri R, Bossi E, Herschkowitz N (1991) Magnetic resonance in preterm and term newborns: 1H-spectroscopy in developing human brain. Pediatr Res 30:574-578
30. Wharton BA, Morley R, Isaacs EB, Cole TJ, Lucas A (2004) Low plasma taurine and later neurodevelopment. Arch Dis Child Fetal Neonatal Ed 89:F497-498
31. Cortijo J, Cerda-Nicolas M, Serrano A, Bioque G, Estrela JM, Santangelo F, Esteras A, Llombart-Bosch A, Morcillo EJ (2001) Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats. Eur Respir J 17:1228-1235
32. Muhling J, Nickolaus KA, Halabi M, Fuchs M, Krull M, Engel J, Wolff M, Matejec R, Langefeld TW, Welters ID, Menges T, Dehne MG, Sablotzki A, Hempelmann G (2005) Alterations in neutrophil (PMN) free intracellular alpha-keto a profiles and immune functions induced by L-alanyl-L-glutamine, arginine or taurine. Amino Acids 29:289-300
33. Sekhon B, Sehkon C, Khan M, Patel SJ, Singh I, Singh AK (2003) N-acetyl cysteine protects against injury in a rat model of focal cerebral ischemia. Brain Res 971:1-8
34. Zhang QG, Tian H, Li HC, Zhang GY (2006) Antioxidant N-acetylcysteine inhibits the activation of JNK3 mediated by the GluR6-PSD95-MLK3 signaling module during cerebral ischemia in rat hippocampus. Neurosci Lett 408:159-164