Bronchial and Bronchiolar Fibrosis in Rats Exposed to 2,3-Pentanedione Vapors: Implications for Bronchiolitis Obliterans in Humans

Toxicologic Pathology

Volumn 40, Issue 3, 2012, Pages 448-465

  Morgan, Daniel L ^a   Jokinen, Micheal P ^b   Price, Herman C ^c   Gwinn, William M ^a   Palmer, Scott M ^d   Flake, Gordon P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b CHARLES RIVER LABORATORIES   (United States)

^c ALION SCIENCE AND TECHNOLOGY   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

2,3 pentanedione; acetyl propionyl; airways; bronchiolitis obliterans; butter flavoring; diacetyl; mice; nasal cavity; rats

Indexed keywords

2,3 PENTANEDIONE; C REACTIVE PROTEIN; DIKETONE; FIBRINOGEN; FIBROBLAST GROWTH FACTOR 9; FLAVORING AGENT; GRANULOCYTE CHEMOTACTIC PROTEIN 2; LACTATE DEHYDROGENASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; ONCOSTATIN M; UNCLASSIFIED DRUG; 2,3-PENTANEDIONE; ALKANONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; B6C3F1 MOUSE; BRONCHIAL FIBROSIS; BRONCHIOLAR FIBROSIS; BRONCHIOLITIS OBLITERANS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHUS DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; EXUDATE; FEMALE; HISTOPATHOLOGY; LUNG FIBROSIS; LUNG WEIGHT; MALE; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL AIRWAY DISEASE; SQUAMOUS CELL METAPLASIA; TISSUE DEGENERATION; VAPOR; WEIGHT REDUCTION; ANALYSIS OF VARIANCE; ANIMAL; BODY WEIGHT; BRONCHIOLITIS; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; FIBROSIS; IMMUNOHISTOCHEMISTRY; INHALATIONAL DRUG ADMINISTRATION; LARYNX; LUNG LAVAGE; NECROSIS; NOSE CAVITY; NOSE MUCOSA; ORGAN SIZE; PATHOLOGY; TOXICITY TESTING; WISTAR RAT;

ADMINISTRATION, INHALATION; ANALYSIS OF VARIANCE; ANIMALS; BODY WEIGHT; BRONCHIOLITIS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; IMMUNOHISTOCHEMISTRY; LARYNX; MALE; MICE; NASAL CAVITY; NASAL MUCOSA; NECROSIS; ORGAN SIZE; PENTANONES; RATS; RATS, WISTAR; TOXICITY TESTS;

EID: 84863587642     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623311431946     Document Type: Article

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