Cannabinoid-like anti-inflammatory compounds from flax fiber

Cellular and Molecular Biology Letters

Volumn 17, Issue 3, 2012, Pages 479-499

  Styrczewska, Monika ^a   Kulma, Anna ^a   Ratajczak, Katarzyna ^b   Amarowicz, Ryszard ^c   Szopa, Jan ^a  

^a UNIVERSITY OF WROC AW   (Poland)

^b WROCLAW MEDICAL UNIVERSITY   (Poland)

^c INSTITUTE OF ANIMAL REPRODUCTION AND FOOD RESEARCH   (Poland)

Author keywords

Cannabinoid; Cannabinoid signaling; Flax; Flax fibers; Inflammation; Linen; Linum usitatissimum; Terpenoids

Indexed keywords

CANNABIDIOL; CANNABINOID 2 RECEPTOR; INTERLEUKIN 6; LINUM USITATISSIMUM EXTRACT; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PLANT EXTRACT; SUPPRESSOR OF CYTOKINE SIGNALING 1; TERPENOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CB2 GENE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IL6 GENE; MASS FRAGMENTOGRAPHY; MCP 1 GENE; MOUSE; NONHUMAN; SOCS 1 GENE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY;

CANNABIS SATIVA; LINUM USITATISSIMUM;

EID: 84863563893     PISSN: 14258153     EISSN: 16891392     Source Type: Journal    
DOI: 10.2478/s11658-012-0023-6     Document Type: Article

References (36)

1. Prasad, K. Flaxseed and cardiovascular health. J. Cardiovasc. Pharmacol. 54 (2009) 369-377.
2. Prasad, K. Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flax-seed. Mol. Cell. Biochem. 168 (1997) 117-123.
3. Wang, L., Chen, J. and Thompson, L. U. The inhibitory effect of flaxseed on the growth and metastasis of estrogen receptor negative human breast cancer xenograftsis attributed to both its lignan and oil components, Int. J. Cancer116 (2005) 793-798.
4. Muir, A. D. and Westcott, N. D. Flax, the genus Linum, Saskatchewan: T. F. Group, 2003.
5. Huwiler, A. and Pfeilschifter, J. Lipids as targets for novel antiinflammatory therapies. Pharmacol. Ther. 124 (2009) 96-112.
6. Russo, G. L. Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention. Biochem. Pharmacol. 77 (2009) 937-946.
7. Skorkowska-Telichowska, K., Zuk, M., Kulma, A., Bugajska-Prusak, A., Ratajczak, K., Gasiorowski, K. and Szopa, J. New dressing materials derived from transgenic flax products to treat long-standing venous ulcersa pilot study. Wound. Repair. Regen. 18 (2010) 168-719.
8. Lorenc-Kukula, K., Amarowicz, R., Oszmianski, J., Doermann, P., Starzycki, M., Skala, J., Zuk, M., Kulma, A. and Szopa, J. Pleiotropic effect of phenolic compounds content increases in transgenic flax plant. J. Agric. Food Chem. 53 (2005) 3685-3692.
9. Raharjo, T. J., Chang, W.-T., Choi, Y. H., Peltenburg-Looman, A. M. G. and Verpoorte, R. Olivetol as product of a polyketide synthase in Cannabis sativa L. Plant Sci. 166 (2004) 381-385.
10. Sirikantaramas, S., Taura, F., Morimoto, S. and Shoyama, Y. Recent advances in Cannabis sativa research: biosynthetic studies and its potential in biotechnology. Curr. Pharm. Biotechnol. 8 (2007) 237-243.
11. Mechoulam, R., Peters, M., Murillo-Rodriguez, E. and Hanus, L. O. Cannabidiol-recent advances. Chem. Biodivers. 4 (2007) 1678-1692.
12. Alexander, A., Smith, P. F. and Rosengren, R. J. Cannabinoids in the treatment of cancer. Cancer Lett. 285 (2009) 6-12.
13. Ligresti, A., Petrosino, S. and Di Marzo, V. From endocannabinoid profiling to 'endocannabinoid therapeutics'. Curr. Opin. Chem. Biol. 13 (2009) 321-331.
14. Pacher, P., Batkai, S. and Kunos, G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol. Rev. 58 (2006) 389-462.
15. Zoratti, C., Kipmen-Korgun, D., Osibow, K., Malli, R. and Graier, W. F. Anandamide initiates Ca(2+) signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells. Br. J. Pharmacol. 140 (2003) 1351-1362.
16. Rajesh, M., Mukhopadhyay, P., Batkai, S., Hasko, G., Liaudet, L., Huffman, J. W., Csiszar, A., Ungvari, Z., Mackie, K., Chatterjee, S. and Pacher, P. CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyteendothelial adhesion. Am. J. Physiol. Heart Circ. Physiol. 293 (2007) H2210-H2218.
17. Schatz, A. R., Lee, M., Condie, R. B., Pulaski, J. T. and Kaminski, N. E. Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system, Toxicol. Appl. Pharmacol. 142 (1997) 278-287.
18. Klein, T. W. Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat. Rev. Immunol. 5 (2005) 400-411.
19. Klein, T. W., Lane, B., Newton, C. A. and Friedman, H. The cannabinoid system and cytokine network. Proc. Soc. Exp. Biol. Med. 225 (2000) 1-8.
20. Derocq, J. M., Jbilo, O., Bouaboula, M., Segui, M., Clere, C. and Casellas, P. Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation. J. Biol. Chem. 275 (2000) 15621-15628.
21. Wrobel-Kwiatkowska, M., Zebrowski, J., Starzycki, M., Oszmianski, J. and Szopa, J. Engineering of PHB synthesis causes improved elastic properties of flax fibers. Biotechnol. Prog. 23 (2007) 269-277.
22. Lorenc-Kukula, K., Wrobel-Kwiatkowska, M., Starzycki, M. and Szopa, J. Engineering flax with increased flavonoid content and thus Fusarium resistance. Physiol. Mol. Plant P. 70 (2007) 38-48.
23. Boba, A., Kulma, A., Kostyn, K., Starzycki, M., Starzycka, E. and Szopa, J. The influence of carotenoid biosynthesis modification on the Fusarium culmorum and Fusarium oxysporum resistance in flax. Physiol. Mol. Plant P. 76 (2011) 39-47.
24. Hazekamp, A., Peltenburg, A., Verpoorte, R. and Giroud, C. Chromatographic and Spectroscopic Data of Cannabinoids from Cannabis sativa L. J. Liq. Chromatog. R. T. 28 (2005) 2361-2382.
25. Gredes, T., Kunert-Keil, C., Dominiak, M., Gedrange, T., Wrobel-Kwiatkowska, M. and Szopa, J. The influence of biocomposites containing genetically modified flax fibers on gene expression in rat skeletal muscle. Biomed. Tech. (Berl). 55 323-329.
26. Klein, T. W., Newton, C., Larsen, K., Lu, L., Perkins, I., Nong, L. and Friedman, H. The cannabinoid system and immune modulation. J. Leukoc. Biol. 74 (2003) 486-496.
27. Klegeris, A., Bissonnette, C. J. and McGeer, P. L. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. Br. J. Pharmacol. 139 (2003) 775-786.
28. Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C. and Bonner, T. I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature346 (1990) 561-564.
29. Munro, S., Thomas, K. L. and Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature365 (1993) 61-65.
30. McAllister, S. D. and Glass, M. CB1 and CB2 receptor-mediated signalling: a focus on endocannabinoids. Prostag. Leukotr. Ess. 66 (2002) 161-171.
31. Howlett, A. C. Cannabinoid receptor signaling. Handb. Exp. Pharmacol. (2005) 53-79.
32. Doyle, S. L. and O'Neill, L. A. J. Toll-like receptors: From the discovery of NF[kappa]B to new insights into transcriptional regulations in innate immunity. Biochem. Pharmacol. 72 (2006) 1102-1113.
33. Kawai, T. and Akira, S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol. Med. 13 (2007) 460-469.
34. Libermann, T. A. and Baltimore, D. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol. Cell. Biol. 10 (1990) 2327-2334.
35. Watts, T. H. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23 (2005) 23-68.
36. Ryo, A., Suizu, F., Yoshida, Y., Perrem, K., Liou, Y. C., Wulf, G., Rottapel, R., Yamaoka, S. and Lu, K. P. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol. Cell12 (2003) 1413-1426.