Cannabinoid stability in authentic oral fluid after controlled cannabis smoking

Clinical Chemistry

Volumn 58, Issue 7, 2012, Pages 1101-1109

  Lee, Dayong ^a   Milman, Garry ^a   Schwope, David M ^a   Barnes, Allan J ^a   Gorelick, David A ^a   Huestis, Marilyn A ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUFFER; CANNABIDIOL; CANNABINOL; DRONABINOL; TETRAHYDROCANNABINOLIC ACID;

ACCURACY; ADULT; ARTICLE; BODY FLUID; CANNABIS SMOKING; CONTROLLED STUDY; DRUG STABILITY; ELUTION; FLUID INTAKE; FREEZING; HUMAN; SAMPLE; SPUTUM; STORAGE; TEMPERATURE;

ADOLESCENT; ADULT; CANNABINOIDS; COLD TEMPERATURE; DRUG STABILITY; HUMANS; MARIJUANA SMOKING; MIDDLE AGED; SALIVA; SPECIMEN HANDLING; SUBSTANCE ABUSE DETECTION; TIME FACTORS; YOUNG ADULT;

CANNABIS;

EID: 84863559835     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2012.184929     Document Type: Article

References (40)

1. Cone EJ, Huestis MA. Interpretation of oral fluid tests for drugs of abuse. Ann NY Acad Sci 2007; 1098:51-103. (Pubitemid 47092558)
2. Bosker WM, Huestis MA. Oral fluid testing for drugs of abuse. Clin Chem 2009;55:1910-31.
3. Huestis MA, Cone EJ. Relationship of delta 9-tetrahydrocannabinol concentrations in oral fluid and plasma after controlled administration of smoked cannabis. J Anal Toxicol 2004;28: 394-9. (Pubitemid 39150355)
4. Verstraete AG. Detection times of drugs of abuse in blood, urine, and oral fluid. Ther Drug Monit 2004;26:200-5. (Pubitemid 38501218)
5. United Nations Office on Drugs and Crime. World drug report 2011. http://info.publicintelligence. net/UNODC-Drugs2011.pdf (Accessed February 2012).
6. Fairbairn JW, Liebmann JA, Rowan MG. The stability of cannabis and its preparations on storage. J Pharm Pharmacol 1976;28:1-7.
7. Garrett ER, Tsau J. Stability of tetrahydrocannabinols I. J Pharm Sci 1974;63:1563-74.
8. ElSohly MA. Chemical constituents of cannabis. In: Grotenhermen F, Russo E, eds. Cannabis and cannabinoids: pharmacology, toxicology, and therapeutic potential. New York: Haworth Integrative Healing Press; 2002. p 27-36.
9. Turner CE, Hadley KW, Fetterman PS, Doorenbos NJ, Quimby MW, Waller C. Constituents of Cannabis sativa L. IV. Stability of cannabinoids in stored plant material. J Pharm Sci 1973;62: 1601-5.
10. Garrett ER, Hunt CA. Physiochemical properties, solubility, and protein binding of delta9-tetrahydrocannabinol. J Pharm Sci 1974;63: 1056-64.
11. Moore C, Vincent M, Rana S, Coulter C, Agrawal A, Soares J. Stability of delta(9)-tetrahydrocannabinol (THC) in oral fluid using the Quantisal collection device. Forensic Sci Int 2006; 164:126-30. (Pubitemid 44667355)
12. Moore C, Rana S, Coulter C. Simultaneous identification of 2-carboxy-tetrahydrocannabinol, tetrahydrocannabinol, cannabinol and cannabidiol in oral fluid. J Chromatogr B Analyt Technol Biomed Life Sci 2007;852:459-64. (Pubitemid 46830152)
13. Crouch DJ. Oral fluid collection: the neglected variable in oral fluid testing. Forensic Sci Int 2005;150:165-73. (Pubitemid 41583219)
14. Substance Abuse and Mental Health Services Administration (SAMHSA). Proposed revisions to the mandatory guidelines for federal workplace drug testing programs. http://www.workplace.samhsa.gov/Drug Testing/pdf/ Notice%20of%20Proposed%20Revisions %20to%20the%20Mandatory%20Guidelines%20%28FR%20DOC04-7984%29.pdf (Accessed February 2012).
15. National Institute for Health and Welfare: Finland. Analytical evaluation of oral fluid screening devices and preceding selection procedures. Blencowe T, Pehrsson A, Lillsunde P, eds. http://www. druid-project.eu/nn-107548/Druid/EN/ deliverales-list/ downloads/Deliverable-3-2-2,templateId=raw, property=publicationFile.pdf/Deliverable-3-2-2.pdf (Accessed February 2012).
16. Lee D, Milman G, Barnes AJ, Goodwin RS, Hirvonen J, Huestis MA. Oral fluid cannabinoids in chronic, daily cannabis smokers during sustained, monitored abstinence. Clin Chem 2011;57:1127-36.
17. Lee D, Schwope DM, Milman G, Barnes AJ, Gorelick DA, Huestis MA. Cannabinoid disposition in oral fluid after controlled smoked cannabis. Clin Chem 2012;58:748-56.
18. Moore C, Coulter C, Rana S, Vincent M, Soares J. Analytical procedure for the determination of the marijuana metabolite 11-nor-delta9- tetrahydrocannabinol-9-carboxylic acid in oral fluid specimens. J Anal Toxicol 2006;30:409-12. (Pubitemid 44371480)
19. Day D, Kuntz DJ, Feldman M, Presley L. Detection of THCA in oral fluid by GC-MS-MS. J Anal Toxicol 2006;30:645-50. (Pubitemid 44913015)
20. Davis KH, McDaniel IA, Cadwell LW, Moody PL. Some smoking characteristics of marijuana cigarettes. In: Agurell S, Dewey WL, Willette RE, eds. The cannabinoids: chemical, pharmacologic, and therapeutic aspects. Orlando (FL): Academic Press; 1984. p 97-109.
21. Moore C, Coulter C, Uges D, Tuyay J, van der Linde S, van Leeuwen A, et al. Cannabinoids in oral fluid following passive exposure to marijuana smoke. Forensic Sci Int 2011;212:227-30.
22. Milman G, Barnes AJ, Schwope DM, Schwilke EW, Darwin WD, Kelly DL, et al. Disposition of cannabinoids in oral fluid after controlled around-the-clock oral THC administration. Clin Chem 2010;56:1261-9.
23. Milman G, Barnes AJ, Lowe RH, Huestis MA. Simultaneous quantification of cannabinoids and metabolites in oral fluid by two-dimensional gas chromatography mass spectrometry. J Chromatogr A 2010;1217:1513-21.
24. Milman G, Barnes A, Schwope D, Schwilke E, Goodwin R, Kelly D, et al. Cannabinoids and metabolites in expectorated oral fluid after 8 days of controlled around-the-clock oral THC administration. Anal Bioanal Chem 2011;401:599-607.
25. Darling MR, Arendorf TM. Effects of cannabis smoking on oral soft tissue. Community Dent Oral Epidemiol 1993;21:78-81.
26. Peters FT, Drummer OH, Musshoff F. Validation of new methods. Forensic Sci Int 2007;165:216-24. (Pubitemid 46073540)
27. Wong AS, Orbanosky MW, Reeve VC, Beede JD. Stability of delta-9-tetrahydrocannabinol in stored blood and serum. Analysis of cannabinoids Research Monograph. NIDA Res Monogr 1982: 119-24. (Pubitemid 13127564)
28. Choo RE, Huestis MA. Oral fluid as a diagnostic tool. Clin Chem Lab Med 2004;42:1273-87. (Pubitemid 39600330)
29. Hold KM, De Boer D, Zuidema J, Maes RAA. Saliva as an analytical tool in toxicology. Int J Drug Test 1996;1:1-31.
30. Pedersen AM, Bardow A, Jensen SB, Nauntofte B. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Dis 2002;8:117-29. (Pubitemid 34535060)
31. Vining RF, McGinley RA. Hormones in saliva. Crit Rev Clin Lab Sci 1986;23:95-146.
32. Vondracek M, Xi Z, Larsson P, Baker V, Mace K, Pfeifer A, et al. Cytochrome P450 expression and related metabolism in human buccal mucosa. Carcinogenesis 2001;22:481-8. (Pubitemid 32203829)
33. Yang SP, Raner GM. Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract. Toxicol Appl Pharmacol 2005;202:140-50. (Pubitemid 40044828)
34. Sacks PG, Zhao Z-L, Kosinska W, Fleisher KE, Gordon T, Guttenplan JB. Concentration dependent effects of tobacco particulates from different types of cigarettes on expression of drug metabolizing proteins, and benzo(a)pyrene metabolism in primary normal human oral epithelial cells. Food Chem Toxicol 2011;49:2348-55.
35. Aps JK, Martens LC. Review: The physiology of saliva and transfer of drugs into saliva. Forensic Sci Int 2005;150:119-31. (Pubitemid 41594445)
36. Razdan RK. Structure-activity relationships in cannabinoids. Pharmacol Rev 1986;38:75-149. (Pubitemid 16001328)
37. Ross SA, ElSohly MA. CBN and Δ9-THC concentration ratio as an indicator of the age of stored marijuana samples. UNDOC Bull Narc 1997;1: 1-8.
38. Turner CE, ElSohly MA. Constituents of Cannabis sativa L. XVI. A possible decomposition pathway of Δ9-tetrahydrocannabinol to cannabinol. J Heterocycl Chem 1979;16:1667-8. (Pubitemid 10178552)
39. Mechoulam R. Cannabinoid Chemistry. In: Mechoulam R, ed. Marijuana. New York: Academic Press; 1973. p 1-87.
40. Moore C, Rana S, Coulter C, Day D, Vincent M, Soares J. Detection of conjugated 11-nor-delta9-tetrahydrocannabinol-9-carboxylic acid in oral fluid. J Anal Toxicol 2007;31:187-94. (Pubitemid 46708658)