메뉴 건너뛰기




Volumn 42, Issue 11, 2004, Pages 1273-1287

Oral fluid as a diagnostic tool

Author keywords

Illicit drugs; Oral fluid; Saliva; Therapeutic drug monitoring

Indexed keywords

ALCOHOL; CARBAMAZEPINE; CLARITHROMYCIN; CLOBAZAM; DIAZEPAM; DIGOXIN; ESTRADIOL; ESTROGEN; ETHOSUXIMIDE; ETIRACETAM; GENTAMICIN; HYDROCORTISONE; ILLICIT DRUG; ISONIAZID; LAMOTRIGINE; METOPROLOL; MOXIFLOXACIN; NITRAZEPAM; OFLOXACIN; OXPRENOLOL; PHENYTOIN; PRIMIDONE; PROCAINAMIDE; PROGESTERONE; SULFANILAMIDE; TESTOSTERONE; THEOPHYLLINE; TOPIRAMATE; UNINDEXED DRUG; VALPROIC ACID;

EID: 10044228158     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2004.248     Document Type: Review
Times cited : (145)

References (138)
  • 2
    • 0021088259 scopus 로고
    • Monitoring of drug concentrations in saliva: A non-invasive pharmacokinetic procedure
    • Ritschel WA, Tompson GA. Monitoring of drug concentrations in saliva: a non-invasive pharmacokinetic procedure. Methods Findings Exp Clin Pharmacol 1983;5:511-25.
    • (1983) Methods Findings Exp. Clin. Pharmacol. , vol.5 , pp. 511-525
    • Ritschel, W.A.1    Tompson, G.A.2
  • 3
    • 0026668614 scopus 로고
    • Therapeutic drug monitoring in saliva. An update
    • Drobitch RK, Svensson CK. Therapeutic drug monitoring in saliva. An update. Clin Pharmacokinet 1992;23:365-79.
    • (1992) Clin. Pharmacokinet. , vol.23 , pp. 365-379
    • Drobitch, R.K.1    Svensson, C.K.2
  • 4
    • 0026461902 scopus 로고
    • Effects of nine difference chewing-gums and lozenges on salivary flow rate and pH
    • Dawes C, Macpherson LM. Effects of nine difference chewing-gums and lozenges on salivary flow rate and pH. Caries Res 1992;26:176-82.
    • (1992) Caries Res. , vol.26 , pp. 176-182
    • Dawes, C.1    MacPherson, L.M.2
  • 5
    • 0033920686 scopus 로고    scopus 로고
    • Biochemical composition and electrolyte balance of 'unstimulated' whole human saliva
    • Rehak NN, Cecco SA, Csako G. Biochemical composition and electrolyte balance of 'unstimulated' whole human saliva. Clin Chem Lab Med 2000;38:335-43.
    • (2000) Clin. Chem. Lab. Med. , vol.38 , pp. 335-343
    • Rehak, N.N.1    Cecco, S.A.2    Csako, G.3
  • 6
    • 0008546926 scopus 로고
    • Past and present methods and results of sugar analysis of saliva
    • Young D. Past and present methods and results of sugar analysis of saliva. J Dental Res 1941;20:597-626.
    • (1941) J. Dental Res. , vol.20 , pp. 597-626
    • Young, D.1
  • 7
    • 0018622672 scopus 로고
    • Creatinine Vill: Saliva levels of endogenous 'true' creatinine in normal subjects
    • Chiou WL, Pu FS. Creatinine Vill: saliva levels of endogenous 'true' creatinine in normal subjects. Clin Pharmacol Therapeut 1979;25:777-82.
    • (1979) Clin. Pharmacol. Therapeut. , vol.25 , pp. 777-782
    • Chiou, W.L.1    Pu, F.S.2
  • 8
    • 0036889579 scopus 로고    scopus 로고
    • Concentrations of major elements and mercury in unstimulated human saliva
    • Monaci F, Bargagli E, Bravi F, Rottoli P. Concentrations of major elements and mercury in unstimulated human saliva. Biol Trace Element Res 2002;89:193-203.
    • (2002) Biol. Trace Element Res. , vol.89 , pp. 193-203
    • Monaci, F.1    Bargagli, E.2    Bravi, F.3    Rottoli, P.4
  • 9
    • 0033019029 scopus 로고    scopus 로고
    • Therapeutic drug concentration monitoring using saliva samples. Focus on anticonvulsants
    • Delgado LH. Therapeutic drug concentration monitoring using saliva samples. Focus on anticonvulsants. Clin Pharmacokinet 1999;36:453-70.
    • (1999) Clin. Pharmacokinet. , vol.36 , pp. 453-470
    • Delgado, L.H.1
  • 10
    • 0019962771 scopus 로고
    • The use of saliva in therapeutic drug monitoring
    • Mucklow JC. The use of saliva in therapeutic drug monitoring. Therapeut Drug Monitor 1982;4:229-47.
    • (1982) Therapeut. Drug Monitor. , vol.4 , pp. 229-247
    • Mucklow, J.C.1
  • 13
    • 0032114210 scopus 로고    scopus 로고
    • Salivary cortisol testing in children
    • Schmidt NA. Salivary cortisol testing in children. Issues Comprehen Ped Nurs 1997;20:183-90.
    • (1997) Issues Comprehen. Ped. Nurs. , vol.20 , pp. 183-190
    • Schmidt, N.A.1
  • 14
    • 0033593086 scopus 로고    scopus 로고
    • Saliva research leads to new diagnostic tools and therapeutic options
    • Kefalides PT. Saliva research leads to new diagnostic tools and therapeutic options. Ann Intern Med 1999;131:991-2.
    • (1999) Ann. Intern. Med. , vol.131 , pp. 991-992
    • Kefalides, P.T.1
  • 15
    • 0036512301 scopus 로고    scopus 로고
    • Salivary markers of systemic disease: Noninvasive diagnosis of disease and monitoring of general health
    • Lawrence HP. Salivary markers of systemic disease: noninvasive diagnosis of disease and monitoring of general health. J Can Dental Assoc 2002;68:170-4.
    • (2002) J. Can. Dental Assoc. , vol.68 , pp. 170-174
    • Lawrence, H.P.1
  • 16
    • 0141794187 scopus 로고    scopus 로고
    • Evaluation of a modified commercial assay in detecting antibody to hepatitis C virus in oral fluids and dried blood spots
    • Judd A, Parry J, Hickman M, McDonald T, Jordan L, Lewis K, et al. Evaluation of a modified commercial assay in detecting antibody to hepatitis C virus in oral fluids and dried blood spots. J Med Virol 2003;71:49-55.
    • (2003) J. Med. Virol. , vol.71 , pp. 49-55
    • Judd, A.1    Parry, J.2    Hickman, M.3    McDonald, T.4    Jordan, L.5    Lewis, K.6
  • 18
    • 0034096263 scopus 로고    scopus 로고
    • The presence of soluble c-erbB-2 in saliva and serum among women with breast carcinoma: A preliminary study
    • Streckfus C, Bigler L, Dellinger T, Dai X, Kingman A, Thigpen JT. The presence of soluble c-erbB-2 in saliva and serum among women with breast carcinoma: a preliminary study. Clin Cancer Res 2000;6:2363-70.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2363-2370
    • Streckfus, C.1    Bigler, L.2    Dellinger, T.3    Dai, X.4    Kingman, A.5    Thigpen, J.T.6
  • 19
    • 0034004679 scopus 로고    scopus 로고
    • A preliminary study of CA15-3, c-erbB-2, epidermal growth factor receptor, cathespsin-D, and p53 in saliva among women with breast carcinoma
    • Streckfus C, Bigler L, Tucci M, Thigpen JT. A preliminary study of CA15-3, c-erbB-2, epidermal growth factor receptor, cathespsin-D, and p53 in saliva among women with breast carcinoma. Cancer Invest 2000;18:101-9.
    • (2000) Cancer Invest. , vol.18 , pp. 101-109
    • Streckfus, C.1    Bigler, L.2    Tucci, M.3    Thigpen, J.T.4
  • 20
    • 0036668771 scopus 로고    scopus 로고
    • The potential use of saliva to detect recurrence of disease in women with breast carcinoma
    • Bigler L, Streckfus CF, Copeland L, Burns R, Dai X, Kuhn M, et al. The potential use of saliva to detect recurrence of disease in women with breast carcinoma. J Oral Pathol Med 2002;31:421-31.
    • (2002) J. Oral Pathol. Med. , vol.31 , pp. 421-431
    • Bigler, L.1    Streckfus, C.F.2    Copeland, L.3    Burns, R.4    Dai, X.5    Kuhn, M.6
  • 21
    • 0025304123 scopus 로고
    • Saliva and serum CA 125 assays for detecting malignant ovarian tumors
    • Chen DX, Schwartz PE. Saliva and serum CA 125 assays for detecting malignant ovarian tumors. Obstet Gynecol 1990;75:701-4.
    • (1990) Obstet. Gynecol. , vol.75 , pp. 701-704
    • Chen, D.X.1    Schwartz, P.E.2
  • 22
    • 0028006641 scopus 로고
    • Gene mutations in saliva as molecular markers for head and neck squamous cell carcinomas
    • Boyle JO, Mao L, Brennan JA, Koch WM, Eisele DW, Saunders JR, et al. Gene mutations in saliva as molecular markers for head and neck squamous cell carcinomas. Am J Surg 1994;168:429-32.
    • (1994) Am. J. Surg. , vol.168 , pp. 429-432
    • Boyle, J.O.1    Mao, L.2    Brennan, J.A.3    Koch, W.M.4    Eisele, D.W.5    Saunders, J.R.6
  • 24
    • 0034915726 scopus 로고    scopus 로고
    • Has oral fluid the potential to replace serum for the evaluation of population immunity levels? A study of measles, rubella and hepatitis B in rural Ethiopia
    • Nokes DJ, Enquselassie F, Nigatu W, Vyse AJ, Cohen B, Brown DWG, et al. Has oral fluid the potential to replace serum for the evaluation of population immunity levels? A study of measles, rubella and hepatitis B in rural Ethiopia. Bull WHO 2001;79:588-95.
    • (2001) Bull. WHO , vol.79 , pp. 588-595
    • Nokes, D.J.1    Enquselassie, F.2    Nigatu, W.3    Vyse, A.J.4    Cohen, B.5    Brown, D.W.G.6
  • 25
    • 0036233973 scopus 로고    scopus 로고
    • Oral fluid collection by post - A pilot study of two approaches
    • Morris MC, Edmunds WJ, Miller E, Brown DWG. Oral fluid collection by post - a pilot study of two approaches. Public Health 2002;116:113-9.
    • (2002) Public Health , vol.116 , pp. 113-119
    • Morris, M.C.1    Edmunds, W.J.2    Miller, E.3    Brown, D.W.G.4
  • 26
    • 12444331929 scopus 로고    scopus 로고
    • Salivary and serum B2-microglobulin and gamma-glutamyl-transferase in patients with primary Sjogren syndrome and Sjogren syndrome secondary to systemic lupus erythematosus
    • Castro J, Jimenez-Alonso J, Sabio JM, Rivera-Civico F, Martin-Armada M, Rodriguez MA, et al. Salivary and serum B2-microglobulin and gamma-glutamyl-transferase in patients with primary Sjogren syndrome and Sjogren syndrome secondary to systemic lupus erythematosus. Clin Chim Acta 2003;334:225-31.
    • (2003) Clin. Chim. Acta , vol.334 , pp. 225-231
    • Castro, J.1    Jimenez-Alonso, J.2    Sabio, J.M.3    Rivera-Civico, F.4    Martin-Armada, M.5    Rodriguez, M.A.6
  • 27
    • 0036334493 scopus 로고    scopus 로고
    • Role of salivary IgA in the pathogenesis of Sjogren syndrome
    • Berra A, Sterin-Borda L, Bacman S, Borda E. Role of salivary IgA in the pathogenesis of Sjogren syndrome. Clin Immunol 2002;104:49-57.
    • (2002) Clin. Immunol. , vol.104 , pp. 49-57
    • Berra, A.1    Sterin-Borda, L.2    Bacman, S.3    Borda, E.4
  • 29
    • 0029837271 scopus 로고    scopus 로고
    • Serum and salivary antigliadin antibodies and serum IgA anti-endomysium antibodies as a screening test for coeliac disease
    • Rujner J, Socha J, Barra E, Gregorek H, Madalinski K, Wozniewicz B, et al. Serum and salivary antigliadin antibodies and serum IgA anti-endomysium antibodies as a screening test for coeliac disease. Acta Paediatr 1996;85:814-7.
    • (1996) Acta Paediatr. , vol.85 , pp. 814-817
    • Rujner, J.1    Socha, J.2    Barra, E.3    Gregorek, H.4    Madalinski, K.5    Wozniewicz, B.6
  • 30
    • 0022893554 scopus 로고
    • Salivary insulin concentrations in type 2 (non-insulin-dependent) diabetic patients and obese non-diabetic subjects: Relationship to changes in plasma insulin levels after an oral glucose load
    • Marchetti P, Benzi L, Masoni A, Cecchetti P, Giannarelli R, Di Cianni G, et al. Salivary insulin concentrations in type 2 (non-insulin-dependent) diabetic patients and obese non-diabetic subjects: relationship to changes in plasma insulin levels after an oral glucose load. Diabetologia 1986;29:695-8.
    • (1986) Diabetologia , vol.29 , pp. 695-698
    • Marchetti, P.1    Benzi, L.2    Masoni, A.3    Cecchetti, P.4    Giannarelli, R.5    Di Cianni, G.6
  • 31
    • 0021254598 scopus 로고
    • Salivary cortisol assessment in the evaluation of hypothalamic-pituitary-adrenal function
    • Kahn SE, Maxwell JU, Barron JL. Salivary cortisol assessment in the evaluation of hypothalamic-pituitary-adrenal function. S Afr Med J 1984;65:843-6.
    • (1984) S. Afr. Med. J. , vol.65 , pp. 843-846
    • Kahn, S.E.1    Maxwell, J.U.2    Barron, J.L.3
  • 32
    • 0030969571 scopus 로고    scopus 로고
    • Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: Clinical and immunologic correlates
    • Koelle DM, Huang ML, Chandran B, Vieira J, Piepkorn M, Corey L. Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: clinical and immunologic correlates. J Infect Dis 1997; 176:94-102.
    • (1997) J. Infect. Dis. , vol.176 , pp. 94-102
    • Koelle, D.M.1    Huang, M.L.2    Chandran, B.3    Vieira, J.4    Piepkorn, M.5    Corey, L.6
  • 33
    • 0030913031 scopus 로고    scopus 로고
    • Comparison of serum, salivary, and rapid whole blood diagnostic tests for Helicobacter pylori and their validation against endoscopy based tests
    • Reilly TG, Poxon V, Sanders DSA, Elliott TSJ, Wait RP. Comparison of serum, salivary, and rapid whole blood diagnostic tests for Helicobacter pylori and their validation against endoscopy based tests. Gut 1997;40:454-8.
    • (1997) Gut , vol.40 , pp. 454-458
    • Reilly, T.G.1    Poxon, V.2    Sanders, D.S.A.3    Elliott, T.S.J.4    Wait, R.P.5
  • 35
    • 0035053622 scopus 로고    scopus 로고
    • Development and evaluation of an antibody capture ELISA for detection of IgG to Epstein-Barr virus in oral fluid samples
    • Sheppard C, Cohen B, Andrews N, Surridge H. Development and evaluation of an antibody capture ELISA for detection of IgG to Epstein-Barr virus in oral fluid samples. J Virol Methods 2001;93:157-66.
    • (2001) J. Virol. Methods , vol.93 , pp. 157-166
    • Sheppard, C.1    Cohen, B.2    Andrews, N.3    Surridge, H.4
  • 36
    • 0035967425 scopus 로고    scopus 로고
    • Biology and disease associations of Epstein-Barr virus
    • Crawford DH. Biology and disease associations of Epstein-Barr virus. Phil Trans R Soc Lond B 2001; 356:461-73.
    • (2001) Phil. Trans. R. Soc. Lond. B , vol.356 , pp. 461-473
    • Crawford, D.H.1
  • 38
    • 0031424559 scopus 로고    scopus 로고
    • HIV topic update: Salivary testing for antibodies
    • Scully C. HIV topic update: salivary testing for antibodies. Oral Dis 1997;3:212-5.
    • (1997) Oral Dis. , vol.3 , pp. 212-215
    • Scully, C.1
  • 39
    • 0030963237 scopus 로고    scopus 로고
    • Accuracy of oral specimen testing for human immunodeficiency virus
    • Emmons W. Accuracy of oral specimen testing for human immunodeficiency virus. Am J Med 1997; 102:15-20.
    • (1997) Am. J. Med. , vol.102 , pp. 15-20
    • Emmons, W.1
  • 40
    • 0030910538 scopus 로고    scopus 로고
    • Oral diagnostic testing for detecting human immunodeficiency virus-1 antibodies: A technology whose time has come
    • Malamud D. Oral diagnostic testing for detecting human immunodeficiency virus-1 antibodies: a technology whose time has come. Am J Med 1997;102:9-14.
    • (1997) Am. J. Med. , vol.102 , pp. 9-14
    • Malamud, D.1
  • 41
    • 0842306287 scopus 로고    scopus 로고
    • The feasibility and acceptability of collecting oral fluid from healthy children for anti-HCV testing
    • Chatzipantazi P, Roy KM, Cameron SO, Goldberg D, Welbury R, Bagg J. The feasibility and acceptability of collecting oral fluid from healthy children for anti-HCV testing. Arch Dis Child 2004;89:185-7.
    • (2004) Arch. Dis. Child. , vol.89 , pp. 185-187
    • Chatzipantazi, P.1    Roy, K.M.2    Cameron, S.O.3    Goldberg, D.4    Welbury, R.5    Bagg, J.6
  • 45
    • 0037357235 scopus 로고    scopus 로고
    • Salivary free concentrations of anti-epileptic drugs: An evaluation in a routine clinical setting
    • Al Za'Abi M, Deleu D, Batchelor C. Salivary free concentrations of anti-epileptic drugs: an evaluation in a routine clinical setting. Acta Neurol Belg 2003;103:19-23.
    • (2003) Acta Neurol. Belg. , vol.103 , pp. 19-23
    • Al Za'Abi, M.1    Deleu, D.2    Batchelor, C.3
  • 46
    • 0036150387 scopus 로고    scopus 로고
    • Review: Therapeutic drug monitoring in pediatrics
    • Soldin OP, Soldin SJ. Review: therapeutic drug monitoring in pediatrics. Therapeut Drug Monitor 2002;24:1-8.
    • (2002) Therapeut. Drug Monitor. , vol.24 , pp. 1-8
    • Soldin, O.P.1    Soldin, S.J.2
  • 48
    • 0023235640 scopus 로고
    • Saliva concentrations of disopyramide cannot substitute the drug's plasma concentrations
    • Cordonnier J, Van den Heede M, Heyndrickx A. Saliva concentrations of disopyramide cannot substitute the drug's plasma concentrations. J Anal Toxicol 1987; 11:179-81.
    • (1987) J. Anal. Toxicol. , vol.11 , pp. 179-181
    • Cordonnier, J.1    Van den Heede, M.2    Heyndrickx, A.3
  • 49
    • 0036432653 scopus 로고    scopus 로고
    • Clinical utility of free drug monitoring
    • Dasgupta A. Clinical utility of free drug monitoring. Clin Chem Lab Med 2002;40:986-93.
    • (2002) Clin. Chem. Lab. Med. , vol.40 , pp. 986-993
    • Dasgupta, A.1
  • 50
    • 0025983941 scopus 로고
    • Developmental toxicity of valproic acid
    • Cotariu D, Zaidman JL. Developmental toxicity of valproic acid. Life Sci 1991;48:1341-50.
    • (1991) Life Sci. , vol.48 , pp. 1341-1350
    • Cotariu, D.1    Zaidman, J.L.2
  • 51
    • 0019469770 scopus 로고
    • Intravenous valproate: Effects on plasma and saliva phenytoin levels
    • Pisani FD, Di Perri RG. Intravenous valproate: effects on plasma and saliva phenytoin levels. Neurology 1981;31:467-70.
    • (1981) Neurology , vol.31 , pp. 467-470
    • Pisani, F.D.1    Di Perri, R.G.2
  • 54
    • 0027370242 scopus 로고
    • The role of saliva in drug monitoring
    • Siegel IA. The role of saliva in drug monitoring. Ann NY Acad Sci 1993;694:86-90.
    • (1993) Ann. NY Acad. Sci. , vol.694 , pp. 86-90
    • Siegel, I.A.1
  • 57
  • 61
    • 0018833858 scopus 로고
    • Diazepam and N-desmethyldiazepam concentrations in saliva, plasma and CSF
    • Hallstrom C, Lader MH, Curry SH. Diazepam and N-desmethyldiazepam concentrations in saliva, plasma and CSF. Br J Clin Pharmacol 1980;9:333-9.
    • (1980) Br. J. Clin. Pharmacol. , vol.9 , pp. 333-339
    • Hallstrom, C.1    Lader, M.H.2    Curry, S.H.3
  • 64
    • 0025259233 scopus 로고
    • Salivary levels of isoniozid and rifampicin in tuberculous patients
    • Gurumurthy P, Rahman F, Narayana AS, Sarma GR. Salivary levels of isoniozid and rifampicin in tuberculous patients. Tubercle 1990;71:29-33.
    • (1990) Tubercle , vol.71 , pp. 29-33
    • Gurumurthy, P.1    Rahman, F.2    Narayana, A.S.3    Sarma, G.R.4
  • 65
    • 0036362825 scopus 로고    scopus 로고
    • Salivary and urinary excretion and plasma-saliva concentration ratios of isoniazid in the presence of co-administered ciprofloxacin
    • Ofoefule SI, Obodo CE, Orisakwe CE, Afonne JO, Ilondu NA, Agbasi PU, et al. Salivary and urinary excretion and plasma-saliva concentration ratios of isoniazid in the presence of co-administered ciprofloxacin. Am J Therapeut 2002;9:15-8.
    • (2002) Am. J. Therapeut. , vol.9 , pp. 15-18
    • Ofoefule, S.I.1    Obodo, C.E.2    Orisakwe, C.E.3    Afonne, J.O.4    Ilondu, N.A.5    Agbasi, P.U.6
  • 67
    • 0025194052 scopus 로고
    • Multiple-dose pharmacokinetics of ofloxacin in serum, saliva, and skin blister fluid of healthy volunteers
    • Warlich R, Korting HC, Schafer-Korting M, Mutschler E. Multiple-dose pharmacokinetics of ofloxacin in serum, saliva, and skin blister fluid of healthy volunteers. Antimicrob Agents Chemother 1990;34:78-81.
    • (1990) Antimicrob. Agents Chemother. , vol.34 , pp. 78-81
    • Warlich, R.1    Korting, H.C.2    Schafer-Korting, M.3    Mutschler, E.4
  • 69
    • 0344009720 scopus 로고    scopus 로고
    • Is oral fluid analysis as accurate as urinalysis in detecting drug use in a treatment setting?
    • Bennett GA, Davies E, Thomas P. Is oral fluid analysis as accurate as urinalysis in detecting drug use in a treatment setting? Drug Alcohol Depend 2003;72:265-9.
    • (2003) Drug Alcohol Depend. , vol.72 , pp. 265-269
    • Bennett, G.A.1    Davies, E.2    Thomas, P.3
  • 71
    • 0034011991 scopus 로고    scopus 로고
    • High-dose rectal and oral acetaminophen in postoperative patients - Serum and saliva concentrations
    • Hahn TW, Mogensen T, Lund C, Schouenborg L, Rasmussen M. High-dose rectal and oral acetaminophen in postoperative patients - serum and saliva concentrations. Acta Anaesthesiol Scand 2000;44:302-6.
    • (2000) Acta Anaesthesiol. Scand. , vol.44 , pp. 302-306
    • Hahn, T.W.1    Mogensen, T.2    Lund, C.3    Schouenborg, L.4    Rasmussen, M.5
  • 72
    • 0142152266 scopus 로고    scopus 로고
    • The influence of morphine on the absorption of paracetamol from various formulations in subjects in the supine position, as assessed by TDx measurement of salivary paracetamol concentrations
    • Kennedy JM, Tyers NM, Davey AK. The influence of morphine on the absorption of paracetamol from various formulations in subjects in the supine position, as assessed by TDx measurement of salivary paracetamol concentrations. J Pharm Pharmacol 2003;55:1345-50.
    • (2003) J. Pharm. Pharmacol. , vol.55 , pp. 1345-1350
    • Kennedy, J.M.1    Tyers, N.M.2    Davey, A.K.3
  • 73
    • 0036652764 scopus 로고    scopus 로고
    • The role of salivary function in modulating chemotherapy-induced oropharyngeal mucositis: A review of the literature
    • Epstein JB, Tsang AH, Warkentin D, Ship JA. The role of salivary function in modulating chemotherapy-induced oropharyngeal mucositis: a review of the literature. Oral Surg Oral Med Oral Pathol 2002;94:39-44.
    • (2002) Oral Surg. Oral Med. Oral Pathol. , vol.94 , pp. 39-44
    • Epstein, J.B.1    Tsang, A.H.2    Warkentin, D.3    Ship, J.A.4
  • 74
    • 0027451479 scopus 로고
    • Salivary excretion of anticancer drugs
    • Slavik M, Wu J, Riley C. Salivary excretion of anticancer drugs. Ann NY Acad Sci 1993;694:319-21.
    • (1993) Ann. NY Acad. Sci. , vol.694 , pp. 319-321
    • Slavik, M.1    Wu, J.2    Riley, C.3
  • 76
    • 0036875897 scopus 로고    scopus 로고
    • Relationship between pharmacokinetics of 5-FU in plasma and in saliva, and toxicity of 5-fluorouracil/folinic acid
    • Jansman FG, Coenen JL, De Graaf JC, Tobi H, Sleijfer DT, Brouwers JR. Relationship between pharmacokinetics of 5-FU in plasma and in saliva, and toxicity of 5-fluorouracil/folinic acid. Anticancer Res 2002;22: 3449-56.
    • (2002) Anticancer Res. , vol.22 , pp. 3449-3456
    • Jansman, F.G.1    Coenen, J.L.2    De Graaf, J.C.3    Tobi, H.4    Sleijfer, D.T.5    Brouwers, J.R.6
  • 77
    • 0033083155 scopus 로고    scopus 로고
    • Plasma and salivary pharmacokinetics of 5-fluorouracil (5-FU) in patients with mestastic colorectal cancer receiving 5-FU bolus plus continuous infusion with high-dose folinic acid
    • Joulia JM, Pinguet F, Ychou M, Duffour J, Astre C, Bressolle F. Plasma and salivary pharmacokinetics of 5-fluorouracil (5-FU) in patients with mestastic colorectal cancer receiving 5-FU bolus plus continuous infusion with high-dose folinic acid. Eur J Cancer 1999; 35:296-301.
    • (1999) Eur. J. Cancer , vol.35 , pp. 296-301
    • Joulia, J.M.1    Pinguet, F.2    Ychou, M.3    Duffour, J.4    Astre, C.5    Bressolle, F.6
  • 80
    • 0141889555 scopus 로고    scopus 로고
    • Modeling plasma and saliva topotecan concentration time course using a population approach
    • Boucaud M, Pinguet F, Culine S, Poujol S, Astre C, Gomeni R, et al. Modeling plasma and saliva topotecan concentration time course using a population approach. Oncol Res 2003;13:211-9.
    • (2003) Oncol. Res. , vol.13 , pp. 211-219
    • Boucaud, M.1    Pinguet, F.2    Culine, S.3    Poujol, S.4    Astre, C.5    Gomeni, R.6
  • 83
    • 0022494297 scopus 로고
    • The salivary flow rate and composition of whole and parotid resting and stimulated saliva in young and old healthy subjects
    • Ben-Aryeh H, Shalev A, Szargel R, Laor A, Laufer D, Gutman D. The salivary flow rate and composition of whole and parotid resting and stimulated saliva in young and old healthy subjects. Biochem Med Metabol Biol 1986;36:260-5.
    • (1986) Biochem. Med. Metabol. Biol. , vol.36 , pp. 260-265
    • Ben-Aryeh, H.1    Shalev, A.2    Szargel, R.3    Laor, A.4    Laufer, D.5    Gutman, D.6
  • 84
    • 0024837463 scopus 로고
    • Saliva lithium: A poor predictor of plasma and erythrocyte levels
    • McKeage MJ, Maling TJB. Saliva lithium: a poor predictor of plasma and erythrocyte levels. N Zealand Med J 1989;102:559-60.
    • (1989) N. Zealand Med. J. , vol.102 , pp. 559-560
    • McKeage, M.J.1    Maling, T.J.B.2
  • 86
    • 0032987306 scopus 로고    scopus 로고
    • Biologic variation of serum and salivary lithium
    • Moody JP. Biologic variation of serum and salivary lithium. Therapeut Drug Monitor 1999;21:97-101.
    • (1999) Therapeut. Drug Monitor , vol.21 , pp. 97-101
    • Moody, J.P.1
  • 87
    • 0019943412 scopus 로고
    • On the relationship between free plasma and saliva amitriptyline and nortriptyline
    • Baumann P, Tinguely D, Koeb L, Schopf J, Le PK. On the relationship between free plasma and saliva amitriptyline and nortriptyline. Int Pharmacopsychiat 1982; 17:136-46.
    • (1982) Int. Pharmacopsychiat. , vol.17 , pp. 136-146
    • Baumann, P.1    Tinguely, D.2    Koeb, L.3    Schopf, J.4    Le, P.K.5
  • 88
    • 0027008057 scopus 로고
    • Discussion: Caveats in testing for drugs of abuse
    • Kidwell DA. Discussion: caveats in testing for drugs of abuse. NIDA Res Monogr 1992;117:98-120.
    • (1992) NIDA Res. Monogr. , vol.117 , pp. 98-120
    • Kidwell, D.A.1
  • 89
    • 0036862464 scopus 로고    scopus 로고
    • Oral fluid testing for drugs of abuse: Positive prevalence rates by Intercept Immunoassay Screening and GC-MS-MS confirmation and suggested cutoff concentrations
    • Cone EJ, Presley L, Lehrer M, Seiter W, Smith M, Kardos KW, et al. Oral fluid testing for drugs of abuse: positive prevalence rates by Intercept Immunoassay Screening and GC-MS-MS confirmation and suggested cutoff concentrations. J Anal Toxicol 2002;26:541-6.
    • (2002) J. Anal. Toxicol. , vol.26 , pp. 541-546
    • Cone, E.J.1    Presley, L.2    Lehrer, M.3    Seiter, W.4    Smith, M.5    Kardos, K.W.6
  • 90
    • 0025021230 scopus 로고
    • Alcohol screening with the alcoscan test strip in forensic praxis
    • Penttila A, Karhunen PJ, Pikkarainen J. Alcohol screening with the alcoscan test strip in forensic praxis. Forensic Sci Int 1990;44:43-8.
    • (1990) Forensic Sci. Int. , vol.44 , pp. 43-48
    • Penttila, A.1    Karhunen, P.J.2    Pikkarainen, J.3
  • 91
    • 0018950481 scopus 로고
    • Correlation of ethanol concentrations in blood and saliva
    • Royston JP. Correlation of ethanol concentrations in blood and saliva. Clin Sci 1980;58:179-81.
    • (1980) Clin. Sci. , vol.58 , pp. 179-181
    • Royston, J.P.1
  • 92
    • 0036549953 scopus 로고    scopus 로고
    • Biochemical changes of saliva in tobacco chewers, tobacco smokers, alcohol consumers, leukoplakia and oral cancer patients
    • Girja KP, Sundharam BS, Krishnan PA, Devi CS. Biochemical changes of saliva in tobacco chewers, tobacco smokers, alcohol consumers, leukoplakia and oral cancer patients. Indian J Dental Res 2002;13:102-7.
    • (2002) Indian J. Dental Res. , vol.13 , pp. 102-107
    • Girja, K.P.1    Sundharam, B.S.2    Krishnan, P.A.3    Devi, C.S.4
  • 93
    • 0035408314 scopus 로고    scopus 로고
    • Saliva alcohol concentrations in accident and emergency attendances
    • Simpson T, Murphy N, Peck DF. Saliva alcohol concentrations in accident and emergency attendances. Emerg Med 2001;18:250-4.
    • (2001) Emerg. Med. , vol.18 , pp. 250-254
    • Simpson, T.1    Murphy, N.2    Peck, D.F.3
  • 95
    • 0030626520 scopus 로고    scopus 로고
    • New developments in biological measures of drug prevalence
    • Cone EJ. New developments in biological measures of drug prevalence. NIDA Res Monogr 1997;167:108-29.
    • (1997) NIDA Res. Monogr. , vol.167 , pp. 108-129
    • Cone, E.J.1
  • 96
    • 0017904948 scopus 로고
    • Kinetics, salivary excretion of amphetamine isomers, and effect of urinary pH
    • Wan SH, Matin SB, Azarnoff DL. Kinetics, salivary excretion of amphetamine isomers, and effect of urinary pH. Clin Pharmacol Therapeut 1978;23:585-90.
    • (1978) Clin. Pharmacol. Therapeut. , vol.23 , pp. 585-590
    • Wan, S.H.1    Matin, S.B.2    Azarnoff, D.L.3
  • 97
    • 0034827534 scopus 로고    scopus 로고
    • Usefulness of saliva for measurement of 3,4-methylenedioxymehamphetamine and its metabolites: Correlation with plasma drug concentrations and effect of salivary pH
    • Navarro M, Pichini S, Farre M, Ortuno J, Roset PN, Segura J, et al. Usefulness of saliva for measurement of 3,4-methylenedioxymehamphetamine and its metabolites: correlation with plasma drug concentrations and effect of salivary pH. Clin Chem 2001;47:1788-95.
    • (2001) Clin. Chem. , vol.47 , pp. 1788-1795
    • Navarro, M.1    Pichini, S.2    Farre, M.3    Ortuno, J.4    Roset, P.N.5    Segura, J.6
  • 98
    • 0032968382 scopus 로고    scopus 로고
    • Cardiovascular and neuroendocrine effects and pharmacokinetics of 3,4-methylenedioxymethamphetamine in humans
    • Mas M, Farre M, de La Torre R, Roset PN, Ortuno J, Seguar J, et al. Cardiovascular and neuroendocrine effects and pharmacokinetics of 3,4-methylenedioxymethamphetamine in humans. J Pharmacol Exp Therapeut 1999;290:136-45.
    • (1999) J. Pharmacol. Exp. Therapeut. , vol.290 , pp. 136-145
    • Mas, M.1    Farre, M.2    de La Torre, R.3    Roset, P.N.4    Ortuno, J.5    Seguar, J.6
  • 100
    • 0037232980 scopus 로고    scopus 로고
    • Methamphetamine and amphetamine pharmacokinetics in oral fluid and plasma after controlled oral methamphetamine administration to human volunteers
    • Schepers RJ, Oyler JM, Joseph RE Jr, Cone EJ, Moolchan ET, Huestis MA. Methamphetamine and amphetamine pharmacokinetics in oral fluid and plasma after controlled oral methamphetamine administration to human volunteers. Clin Chem 2003;49:121-32.
    • (2003) Clin. Chem. , vol.49 , pp. 121-132
    • Schepers, R.J.1    Oyler, J.M.2    Joseph Jr., R.E.3    Cone, E.J.4    Moolchan, E.T.5    Huestis, M.A.6
  • 102
    • 0034947475 scopus 로고    scopus 로고
    • Detection of marijuana use by oral fluid and urine analysis following single-dose administration of smoked and oral marijuana
    • Niedbala RS, Kardos KW, Fritch DF, Kardos S, Fries T, Waga J. Detection of marijuana use by oral fluid and urine analysis following single-dose administration of smoked and oral marijuana. J Anal Toxicol 2001;25:289-303.
    • (2001) J. Anal. Toxicol. , vol.25 , pp. 289-303
    • Niedbala, R.S.1    Kardos, K.W.2    Fritch, D.F.3    Kardos, S.4    Fries, T.5    Waga, J.6
  • 103
    • 0035177781 scopus 로고    scopus 로고
    • Blind trials of an onsite saliva drug test for marijuana and opiates
    • Jehanli A, Brannan S, Moore L, Spiehler VR. Blind trials of an onsite saliva drug test for marijuana and opiates. J Forensic Sci 2001;46:1214-20.
    • (2001) J. Forensic Sci. , vol.46 , pp. 1214-1220
    • Jehanli, A.1    Brannan, S.2    Moore, L.3    Spiehler, V.R.4
  • 104
    • 0016584748 scopus 로고
    • The marijuana dilemma: Implications of recent research into the pharmacokinetics, psychomotor effects and cardiovascular actions of THC
    • Winek CL, Shanor SP, editors. New York: Marcel Dekker
    • Manno BR, Manno JE. The marijuana dilemma: implications of recent research into the pharmacokinetics, psychomotor effects and cardiovascular actions of THC. In: Winek CL, Shanor SP, editors. Toxicology annual 1974. New York: Marcel Dekker, 1976:129-50.
    • (1976) Toxicology Annual 1974 , pp. 129-150
    • Manno, B.R.1    Manno, J.E.2
  • 105
    • 0035885230 scopus 로고    scopus 로고
    • A comparison between onsite immunoassay drug-testing devices and laboratory results
    • Gronholm M, Lillsunde P. A comparison between onsite immunoassay drug-testing devices and laboratory results. Forensic Sci Int 2001;121:37-46.
    • (2001) Forensic Sci. Int. , vol.121 , pp. 37-46
    • Gronholm, M.1    Lillsunde, P.2
  • 106
    • 0034122007 scopus 로고    scopus 로고
    • On-site testing of saliva and sweat with Drugwipe and determination of concentrations of drugs of abuse in saliva, plasma and urine of suspected users
    • Samyn N, van Haeren C. On-site testing of saliva and sweat with Drugwipe and determination of concentrations of drugs of abuse in saliva, plasma and urine of suspected users. Int J Legal Med 2000;113:150-4.
    • (2000) Int. J. Legal Med. , vol.113 , pp. 150-154
    • Samyn, N.1    van Haeren, C.2
  • 109
    • 0033809703 scopus 로고    scopus 로고
    • Cocaine and metabolite elimination patterns in chronic cocaine users during cessation: Plasma and saliva analysis
    • Moolchan ET, Cone EJ, Wstadik A, Huestis MA, Preston KL. Cocaine and metabolite elimination patterns in chronic cocaine users during cessation: plasma and saliva analysis. J Anal Toxicol 2000;24:458-66.
    • (2000) J. Anal. Toxicol. , vol.24 , pp. 458-466
    • Moolchan, E.T.1    Cone, E.J.2    Wstadik, A.3    Huestis, M.A.4    Preston, K.L.5
  • 110
    • 0033815631 scopus 로고    scopus 로고
    • Elimination of cocaine and metabolites in plasma, saliva, and urine following repeated oral administration to human volunteers
    • Jufer RA, Wstadik A, Walsh SL, Levine BS, Cone EJ. Elimination of cocaine and metabolites in plasma, saliva, and urine following repeated oral administration to human volunteers. J Anal Toxicol 2000;24:467-77.
    • (2000) J. Anal. Toxicol. , vol.24 , pp. 467-477
    • Jufer, R.A.1    Wstadik, A.2    Walsh, S.L.3    Levine, B.S.4    Cone, E.J.5
  • 112
    • 0342596389 scopus 로고
    • The influence of the neonatal abstinence syndrome on mother-infant interaction
    • Anthony EJ, Chiland C, editors. New York: John Wiley & Sons
    • Kaltenbach K, Finnegan LP. The influence of the neonatal abstinence syndrome on mother-infant interaction. In: Anthony EJ, Chiland C, editors. The child in his family. New York: John Wiley & Sons, 1988:223-50.
    • (1988) The Child in His Family , pp. 223-250
    • Kaltenbach, K.1    Finnegan, L.P.2
  • 113
    • 0029142782 scopus 로고
    • Comparison of heroin and cocaine concentrations in saliva with concentrations in blood and plasma
    • Jenkins AJ, Oyler JM, Cone EJ. Comparison of heroin and cocaine concentrations in saliva with concentrations in blood and plasma. J Anal Toxicol 1995;19:359-74.
    • (1995) J. Anal. Toxicol. , vol.19 , pp. 359-374
    • Jenkins, A.J.1    Oyler, J.M.2    Cone, E.J.3
  • 115
    • 0032825034 scopus 로고    scopus 로고
    • Correlation of saliva codeine concentrations with plasma concentrations after oral codeine administration
    • O'Neal CL, Crouch DJ, Rollins DE, Fatah A, Cheever ML. Correlation of saliva codeine concentrations with plasma concentrations after oral codeine administration. J Anal Toxicol 1999;23:452-9.
    • (1999) J. Anal. Toxicol. , vol.23 , pp. 452-459
    • O'Neal, C.L.1    Crouch, D.J.2    Rollins, D.E.3    Fatah, A.4    Cheever, M.L.5
  • 116
    • 0033815633 scopus 로고    scopus 로고
    • The effects of collection methods on oral fluid codeine concentrations
    • O'Neal CL, Crouch DL, Rollins DE, Fatah AA. The effects of collection methods on oral fluid codeine concentrations. J Anal Toxicol 2000;24:536-42.
    • (2000) J. Anal. Toxicol. , vol.24 , pp. 536-542
    • O'Neal, C.L.1    Crouch, D.L.2    Rollins, D.E.3    Fatah, A.A.4
  • 117
    • 0035709884 scopus 로고    scopus 로고
    • Validation of self-reported smoking status by simultaneous measurement of carbon monoxide and salivary thiocyanate
    • Morabia A, Bernstein MS, Curtin F, Berode M. Validation of self-reported smoking status by simultaneous measurement of carbon monoxide and salivary thiocyanate. Prev Med 2001;32:82-8.
    • (2001) Prev. Med. , vol.32 , pp. 82-88
    • Morabia, A.1    Bernstein, M.S.2    Curtin, F.3    Berode, M.4
  • 118
    • 0034086337 scopus 로고    scopus 로고
    • Detection of drugs in saliva versus blood
    • Kauert G. Detection of drugs in saliva versus blood. Blutalkohol 2000;37:76-83.
    • (2000) Blutalkohol , vol.37 , pp. 76-83
    • Kauert, G.1
  • 120
    • 0027126760 scopus 로고
    • Saliva: Its secretion, composition and functions
    • Edgar WM. Saliva: its secretion, composition and functions. Br Dental J 1992;172:305-6.
    • (1992) Br. Dental J. , vol.172 , pp. 305-306
    • Edgar, W.M.1
  • 123
    • 0017595333 scopus 로고
    • Oral absorption and secretion of drugs
    • Spiers CF. Oral absorption and secretion of drugs. Br J Clin Pharmacol 1977;4:97-100.
    • (1977) Br. J. Clin. Pharmacol. , vol.4 , pp. 97-100
    • Spiers, C.F.1
  • 124
    • 0022976505 scopus 로고
    • Salivary drug measurement: A cautionary tale
    • Paton RD, Logan RW. Salivary drug measurement: a cautionary tale. Lancet 1986;2(8519):1340.
    • (1986) Lancet , vol.2 , Issue.8519 , pp. 1340
    • Paton, R.D.1    Logan, R.W.2
  • 125
    • 0017236875 scopus 로고
    • Interactions between drugs and saliva-stimulating parafilm and their implications in measurements of saliva drug levels
    • Chang K, Chiou WL. Interactions between drugs and saliva-stimulating parafilm and their implications in measurements of saliva drug levels. Res Commun Chem Pathol Pharmacol 1976;13:357-60.
    • (1976) Res. Commun. Chem. Pathol. Pharmacol. , vol.13 , pp. 357-360
    • Chang, K.1    Chiou, W.L.2
  • 126
    • 0027440289 scopus 로고
    • Considerations in the development of diagnostic tests on saliva
    • Dawes C. Considerations in the development of diagnostic tests on saliva. Ann NY Acad Sci 1993;694:265-9.
    • (1993) Ann. NY Acad. Sci. , vol.694 , pp. 265-269
    • Dawes, C.1
  • 128
    • 0141571182 scopus 로고    scopus 로고
    • Sensitivity, specificity, and efficiency in detecting opiates in oral fluid with the Cozart opiate microplate EIA and GC-MS following controlled codeine administration
    • Barnes AJ, Kim I, Schepers R, Moolchan ET, Wilson L, Cooper G, et al. Sensitivity, specificity, and efficiency in detecting opiates in oral fluid with the Cozart opiate microplate EIA and GC-MS following controlled codeine administration. J Anal Toxicol 2003;27:402-6.
    • (2003) J. Anal. Toxicol. , vol.27 , pp. 402-406
    • Barnes, A.J.1    Kim, I.2    Schepers, R.3    Moolchan, E.T.4    Wilson, L.5    Cooper, G.6
  • 130
    • 0032415434 scopus 로고    scopus 로고
    • An evaluation of oral-fluid collection devices for the determination of rubella antibody status in a rural Ethiopian community
    • Nokes DJ, Enquselassie F, Vyse A, Nigatu W, Cutts FT, Brown DWG. An evaluation of oral-fluid collection devices for the determination of rubella antibody status in a rural Ethiopian community. Trans R Soc Trop Med Hyg 1998;92:679-85.
    • (1998) Trans. R. Soc. Trop. Med. Hyg. , vol.92 , pp. 679-685
    • Nokes, D.J.1    Enquselassie, F.2    Vyse, A.3    Nigatu, W.4    Cutts, F.T.5    Brown, D.W.G.6
  • 131
    • 0035500327 scopus 로고    scopus 로고
    • Comparison of point-of-collection screening of drugs of abuse in oral fluid with a laboratory-based urine screen
    • Barrett C, Good C, Moore C. Comparison of point-of-collection screening of drugs of abuse in oral fluid with a laboratory-based urine screen. Forensic Sci Int 2001;122:163-6.
    • (2001) Forensic Sci. Int. , vol.122 , pp. 163-166
    • Barrett, C.1    Good, C.2    Moore, C.3
  • 132
    • 10044283534 scopus 로고    scopus 로고
    • Application of drugwipe in alternative specimens
    • www.vv.se/trafp6sak/t2000/806.pdf
    • Mura P, Kintz P, Samyn N, Vincent F, Mauco G. Application of drugwipe in alternative specimens. www.vv.se/trafp6sak/t2000/806.pdf 2000:1-7.
    • (2000) , pp. 1-7
    • Mura, P.1    Kintz, P.2    Samyn, N.3    Vincent, F.4    Mauco, G.5
  • 133
    • 0029263039 scopus 로고
    • Feasible and valid saliva collection for cortisol in transitional newborn infants
    • Chang HP, Anderson GC, Wood CE. Feasible and valid saliva collection for cortisol in transitional newborn infants. Nursing Res 1995;44:117-9.
    • (1995) Nursing Res. , vol.44 , pp. 117-119
    • Chang, H.P.1    Anderson, G.C.2    Wood, C.E.3
  • 134
    • 0020791718 scopus 로고
    • Salivary steroid assays for assessing variation in endocrine activity
    • Riad-Fahmy D, Read GF, Walker RF. Salivary steroid assays for assessing variation in endocrine activity. J Steroid Biochem 1983;19:265-72.
    • (1983) J. Steroid. Biochem. , vol.19 , pp. 265-272
    • Riad-Fahmy, D.1    Read, G.F.2    Walker, R.F.3
  • 135
    • 0028932285 scopus 로고
    • Salivary cortisol levels throughout childhood and adolescence: Relation with age, pubertal stage, and weight
    • Kiess W, Meidert A, Dressendorfer RA, Schriever K, Kessler U, Konig A, et al. Salivary cortisol levels throughout childhood and adolescence: relation with age, pubertal stage, and weight. Pediatr Res 1995;37:502-6.
    • (1995) Pediatr. Res. , vol.37 , pp. 502-506
    • Kiess, W.1    Meidert, A.2    Dressendorfer, R.A.3    Schriever, K.4    Kessler, U.5    Konig, A.6
  • 136
    • 0027061267 scopus 로고
    • Salivary excretion of drugs in children: Theoretical and practical issues in therapeutic drug monitoring
    • Gorodischer R, Koren G. Salivary excretion of drugs in children: theoretical and practical issues in therapeutic drug monitoring. Dev Pharmacol Therapeut 1992; 19:161-77.
    • (1992) Dev. Pharmacol. Therapeut. , vol.19 , pp. 161-177
    • Gorodischer, R.1    Koren, G.2
  • 138
    • 0036340261 scopus 로고    scopus 로고
    • Influence of menstrual cycle on the pharmacokinetics of paracetamol through salivary compartment in healthy subjects
    • Gugilla SR, Boinpally RR, Bolla SM, Devaraj R. Influence of menstrual cycle on the pharmacokinetics of paracetamol through salivary compartment in healthy subjects. Therapeut Drug Monitor 2002;24:497-501.
    • (2002) Therapeut. Drug Monitor , vol.24 , pp. 497-501
    • Gugilla, S.R.1    Boinpally, R.R.2    Bolla, S.M.3    Devaraj, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.