N-acetylcysteine attenuates ventilator-induced lung injury in an isolated and perfused rat lung model

Injury

Volumn 43, Issue 8, 2012, Pages 1257-1263

  Chiang, Chi Huei ^a,b   Chuang, Chiao Hui ^a   Liu, Shiou Ling ^a   Chian, Chih Feng ^c   Zhang, Haibo ^d,e,f   Ryu, Jay H ^g  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d ST MICHAEL'S HOSPITAL   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

^g MAYO CLINIC   (United States)

Author keywords

ARDS; Inflammation; MAPK; N acetylcysteine; NF B; ROS

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CYTOKINE; GLUTATHIONE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 11; MYELOPEROXIDASE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; ENZYME ACTIVATION; INFLAMMATION; LUNG HEMODYNAMICS; LUNG LAVAGE; LUNG PERFUSION; LUNG WEIGHT; MALE; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TIDAL VOLUME; VENTILATOR INDUCED LUNG INJURY;

ACETYLCYSTEINE; ANIMALS; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CXCL2; DISEASE MODELS, ANIMAL; FREE RADICAL SCAVENGERS; INTERLEUKIN-1BETA; MALE; ORGAN SIZE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIDAL VOLUME; TUMOR NECROSIS FACTOR-ALPHA; VENTILATOR-INDUCED LUNG INJURY;

EID: 84863536437     PISSN: 00201383     EISSN: 18790267     Source Type: Journal    
DOI: 10.1016/j.injury.2011.12.026     Document Type: Article

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