6β-N-Heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4731-4734

  Yuan, Yunyun ^a   Stevens, David L ^a   Braithwaite, Amanda ^b   Scoggins, Krista L ^a   Bilsky, Edward J ^b   Akbarali, Hamid I ^a   Dewey, William L ^a   Zhang, Yan ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF NEW ENGLAND   (United States)

Author keywords

Intestinal motility; MOR; NAP; Pripheral opioid antagonist

Indexed keywords

CHARCOAL; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; NALTREXAMINE DERIVATIVE; NALTREXONE; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG DETERMINATION; INTESTINE MOTILITY; LOCOMOTION; MOUSE; NOCICEPTION; NONHUMAN; SUBSTITUTION REACTION;

ANIMALS; CHO CELLS; CRICETINAE; MICE; MOLECULAR STRUCTURE; NALTREXONE; RATS; RECEPTORS, OPIOID, MU;

ANIMALIA; CANIS FAMILIARIS; MUS;

EID: 84863480944     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.075     Document Type: Article

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