Effects of fasting on evaluation of gastrointestinal transit with charcoal meal

Journal of Pharmacological and Toxicological Methods

Volumn 52, Issue 1, 2005, Pages 154-158

  Mittelstadt, S W ^a   Hemenway, C L ^a   Spruell, R D ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

Clonidine; Gastrointestinal transit; Loperamide; Methods; Morphine; Rats

Indexed keywords

CHARCOAL; CLONIDINE; LOPERAMIDE; MORPHINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCULATION; CONTROLLED STUDY; DRUG EFFECT; GASTROINTESTINAL TRACT; INTESTINE TRANSIT TIME; MALE; NONHUMAN; RAT; SMALL INTESTINE; STATISTICAL SIGNIFICANCE;

ANIMALS; CHARCOAL; CLONIDINE; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FASTING; FOOD DEPRIVATION; GASTROINTESTINAL AGENTS; GASTROINTESTINAL TRANSIT; LOPERAMIDE; MALE; MORPHINE; NARCOTICS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 22444445248     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2005.04.017     Document Type: Article

References (14)

1. P. Baldrick, D.G. Bamford, and M.L. Tattersall An assessment of two gastric transport models currently used in safety pharmacology testing Human and Experimental Toxicology 17 1998 1 7
2. K.H. Erlwanger, V.S. Elbrond, N.K. Anderson, and M.A. Unmack Gastrointestinal-tract models and techniques for use in safety pharmacology Journal of Pharmacological and Toxicological Methods 49 2004 187 199
3. N. Kihara, M. Fujimura, I. Yamamoto, E. Itoh, A. Inui, and M. Fujimiya Effects of central and peripheral urocortin on fed and fasted motor activity in conscious rats American Journal of Physiology 280 2001 G406 G419
4. L. Manara, G. Bianchi, P. Ferretti, and A. Tavani Inhibition of gastrointestinal transit by morphine in rats results primarily from direct drug action on gut opioid sites Journal of Pharmacology and Experimental Therapeutics 237 1986 945 949
5. H.R.N. Marona, and M.B.B. Lucchesi Protocol to refine intestinal motility test in mice Laboratory Animals 38 2004 257 260
6. A.A.H.P. Megens, L.L.J. Canters, F.H.L. Awouters, and C.J.E. Niemegeers Is in vivo dissociation between the antipropulsive and antidiarrheal properties of opioids in rats related to gut selectivity? Archives Internationales De Pharmacodynamie Et De Therapie 298 1989 220 229
7. L.I. Mortin, C.J. Horvath, and M.S. Wyand Safety pharmacology screening: Practical problems in drug development International Journal of Toxicology 16 1997 41 65
8. C.J.E. Niemegeers, J.L. McGuire, J.J.P. Heykants, and P.A.J. Janssen Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs Journal of Pharmacology and Experimental Therapeutics 210 1979 327 333
9. M. Ruckebusch, and J. Fioramonti Electrical spiking activity and propulsion in small intestine in fed and fasted rats Gastroenterology 68 1975 1500 1508
10. A. Tavani, G. Bianchi, P. Ferretti, and L. Manara Morphine is most effective on gastrointestinal propulsion in rats by intraperitoneal route: Evidence for local action Life Sciences 27 1980 2211 2217
11. J.K. Vermeulen, A. De Vries, F. Schlingmann, and R. Remie Food deprivation: Common sense or nonsense? Animal Technology 48 1997 45 54
12. N.W. Weisbrodt Patterns of intestinal motility Annual Review of Physiology 43 1981 21 31
13. N.W. Weisbrodt, S.E. Sussman, J.J. Stewart, and T.F. Burks Effect of morphine sulfate on intestinal transit and myoelectric activity of the small intestine of the rat Journal of Pharmacology and Experimental Therapeutics 214 1980 333 338
14. M.E. Zenilman, J.E. Parodi, and J.M. Becker Preservation and propagation of cyclic myoelectric activity after feeding in rat small intestine American Journal of Physiology 263 1992 G248 G253