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Volumn 3, Issue 6, 2012, Pages

NOXA as critical mediator for drug combinations in polychemotherapy

Author keywords

betulinic acid; doxorubicin; NOXA; p53; PUMA

Indexed keywords

ACETYLCYSTEINE; APOPTOSIS INDUCING FACTOR; BETULIC ACID; BIM PROTEIN; CASPASE; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; CYCLOHEXIMIDE; CYTOCHROME C; DACTINOMYCIN; DOXORUBICIN; ENDONUCLEASE G; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HISTONE H1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN MCL 1; PROTEIN NOXA; PROTEIN P53; PUMA PROTEIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNINDEXED DRUG; VINCRISTINE; X LINKED INHIBITOR OF APOPTOSIS;

EID: 84863450256     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.53     Document Type: Article
Times cited : (19)

References (40)
  • 1
    • 67449099150 scopus 로고    scopus 로고
    • Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells
    • Suzuki S, Nakasato M, Shibue T, Koshima I, Tanigushi T. Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells. Cancer Sci 2009; 100: 759-769.
    • (2009) Cancer Sci. , vol.100 , pp. 759-769
    • Suzuki, S.1    Nakasato, M.2    Shibue, T.3    Koshima, I.4    Tanigushi, T.5
  • 2
    • 79954418914 scopus 로고    scopus 로고
    • Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways
    • Zhang L, Lopez H, George NM, Liu X, Pang X, Luo X. Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways. Cell Death Differ 2010; 18: 864-873.
    • (2010) Cell Death Differ , vol.18 , pp. 864-873
    • Zhang, L.1    Lopez, H.2    George, N.M.3    Liu, X.4    Pang, X.5    Luo, X.6
  • 3
    • 33745962416 scopus 로고    scopus 로고
    • BH3-only proteins in cell death initiation, malignant disease and anticancer therapy
    • Labi V, Erlacher M, Kiessling S, Villunger A. BH3-only proteins in cell death initiation, malignant disease and anticancer therapy. Cell Death Differ 2006; 13: 1325-1338.
    • (2006) Cell Death Differ , vol.13 , pp. 1325-1338
    • Labi, V.1    Erlacher, M.2    Kiessling, S.3    Villunger, A.4
  • 4
    • 68149153007 scopus 로고    scopus 로고
    • NOXA: At the tip of the balance between life and death
    • Ploner C, Kofler R, Villunger A. NOXA: At the tip of the balance between life and death. Oncogene 2009; 27: S84-S92.
    • (2009) Oncogene , vol.27
    • Ploner, C.1    Kofler, R.2    Villunger, A.3
  • 5
    • 33748862585 scopus 로고    scopus 로고
    • BH3-only proteins: Integrated control point of apoptosis
    • Shibue T, Taniguchi T. BH3-only proteins: Integrated control point of apoptosis. Int J Cancer 2006; 119: 2036-2043.
    • (2006) Int. J. Cancer , vol.119 , pp. 2036-2043
    • Shibue, T.1    Taniguchi, T.2
  • 6
    • 78649991678 scopus 로고    scopus 로고
    • An ERK dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs
    • Sheridan C, Brumatti G, Elgendy M, Brunet M, Martin SJ, An ERK. dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs. Oncogene 2010; 29: 6428-6441.
    • (2010) Oncogene , vol.29 , pp. 6428-6441
    • Sheridan, C.1    Brumatti, G.2    Elgendy, M.3    Brunet, M.4    Martin, S.J.5
  • 7
    • 79951512093 scopus 로고    scopus 로고
    • ROS-mediated upregulation of NOXA overcomes chemoresistance in chronic lymphocytic leukemia
    • Tonino SH, van Laar J, van Oers MH, Wang JY, Eldering E, Kater AP. ROS-mediated upregulation of NOXA overcomes chemoresistance in chronic lymphocytic leukemia. Oncogene 2010; 30: 701-713.
    • (2010) Oncogene , vol.30 , pp. 701-713
    • Tonino, S.H.1    Van Laar, J.2    Van Oers, M.H.3    Wang, J.Y.4    Eldering, E.5    Kater, A.P.6
  • 8
    • 30144442233 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomibe induces apoptosis in mantle-cell lymphoma through generation of ROS and NOXA activation independent of p53 status
    • Pérez-Galán P, Roué G, Villamor N, Montserrat E, Campo E, Colomer D. The proteasome inhibitor bortezomibe induces apoptosis in mantle-cell lymphoma through generation of ROS and NOXA activation independent of p53 status. Blood 2006; 107: 257-264.
    • (2006) Blood , vol.107 , pp. 257-264
    • Pérez-Galán, P.1    Roué, G.2    Villamor, N.3    Montserrat, E.4    Campo, E.5    Colomer, D.6
  • 9
    • 68149108384 scopus 로고    scopus 로고
    • PUMA, a potent killer with or without p53
    • Yu J, Zhang L. PUMA, a potent killer with or without p53. Oncogene 2009; 27: S71-S83.
    • (2009) Oncogene , vol.27
    • Yu, J.1    Zhang, L.2
  • 11
    • 58149357667 scopus 로고    scopus 로고
    • Betulinic acid: A natural product with anticancer activity
    • Fulda S. Betulinic acid: A natural product with anticancer activity. Mol Nutr Food Res 2009; 53: 140-146.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 140-146
    • Fulda, S.1
  • 12
    • 0030815250 scopus 로고    scopus 로고
    • Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
    • Fulda S, Friesen C, Los M, Scaffidi C, Mier W, Benedict M et al. Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res 1997; 57: 4956-4964.
    • (1997) Cancer Res. , vol.57 , pp. 4956-4964
    • Fulda, S.1    Friesen, C.2    Los, M.3    Scaffidi, C.4    Mier, W.5    Benedict, M.6
  • 13
    • 0032545386 scopus 로고    scopus 로고
    • Activation of mitochondria and release of mitochondrial apoptogenetic factors by betulinic acid
    • Fulda S, Scaffidi C, Susin SA, Krammer PH, Kroemer G, Peter ME et al. Activation of mitochondria and release of mitochondrial apoptogenetic factors by betulinic acid. J Biol Chem 1998; 273: 33942-33948.
    • (1998) J. Biol. Chem. , vol.273 , pp. 33942-33948
    • Fulda, S.1    Scaffidi, C.2    Susin, S.A.3    Krammer, P.H.4    Kroemer, G.5    Peter, M.E.6
  • 14
    • 0033023669 scopus 로고    scopus 로고
    • Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein syn thesis, formation of reactive oxygen species, and caspase processing
    • Wick W, Grimmel C, Wagenknecht B, Dichgans J, Weller M. Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing. J Pharmacol Exp Ther 1999; 289: 1306-1312.
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 1306-1312
    • Wick, W.1    Grimmel, C.2    Wagenknecht, B.3    Dichgans, J.4    Weller, M.5
  • 15
    • 0033753764 scopus 로고    scopus 로고
    • The clinical and cellular pharmacology of vincristine, corticosteroids, L-Asparaginase, anthracyclines and cyclophosphamide in relation to childhood acute lymphoblastic leukaemia
    • Estlin EJ, Ronghe M, Burke GA, Yule SM. The clinical and cellular pharmacology of vincristine, corticosteroids, L-Asparaginase, anthracyclines and cyclophosphamide in relation to childhood acute lymphoblastic leukaemia. Br J Haematol 2000; 110: 780-790.
    • (2000) Br. J. Haematol. , vol.110 , pp. 780-790
    • Estlin, E.J.1    Ronghe, M.2    Burke, G.A.3    Yule, S.M.4
  • 16
    • 0032858861 scopus 로고    scopus 로고
    • Determination of betulinic acid in mouse blood, tumor and tissue homogenates by liquid chromatographyelectrospray mass spectrometry
    • Shin YG, Cho KH, Chung SM, Graham J, Das Gupta TK, Pezzuto JM. Determination of betulinic acid in mouse blood, tumor and tissue homogenates by liquid chromatographyelectrospray mass spectrometry. J Chromatogr B Biomed Sci Appl 1999; 732: 331-336.
    • (1999) J. Chromatogr. B. Biomed. Sci. Appl. , vol.732 , pp. 331-336
    • Shin, Y.G.1    Cho, K.H.2    Chung, S.M.3    Graham, J.4    Das Gupta, T.K.5    Pezzuto, J.M.6
  • 17
    • 0034631974 scopus 로고    scopus 로고
    • Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells
    • Gamen S, Anel A, Pérez-Galán P, Lasierra P, Johnson D, Piñeiro A et al. Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp Cell Res 2000; 258: 223-235.
    • (2000) Exp. Cell Res. , vol.258 , pp. 223-235
    • Gamen, S.1    Anel, A.2    Pérez-Galán, P.3    Lasierra, P.4    Johnson, D.5    Piñeiro, A.6
  • 18
    • 12144289654 scopus 로고    scopus 로고
    • Tumor necrosis factorrelated apoptosis-inducing ligand cooperates with anticancer drugs to overcome chemoresistance in antiapoptotic Bcl-2 family members expressing jurkat cells
    • Ballestrero A, Nencioni A, Boy D, Rocco I, Garuti A, Mela GS et al. Tumor necrosis factorrelated apoptosis-inducing ligand cooperates with anticancer drugs to overcome chemoresistance in antiapoptotic Bcl-2 family members expressing jurkat cells. Clin Cancer Res 2004; 10: 1463-1470.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 1463-1470
    • Ballestrero, A.1    Nencioni, A.2    Boy, D.3    Rocco, I.4    Garuti, A.5    Mela, G.S.6
  • 19
    • 77951294919 scopus 로고    scopus 로고
    • Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells
    • López-Royuela N, Pérez-Galán P, Galán-Malo P, Yuste VJ, Anel A, Susín SA et al. Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells. Biochem Pharmacol 2010; 79: 1746-1758.
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 1746-1758
    • López-Royuela, N.1    Pérez-Galán, P.2    Galán-Malo, P.3    Yuste, V.J.4    Anel, A.5    Susín, S.A.6
  • 20
    • 38549145044 scopus 로고    scopus 로고
    • Diagnosing and exploiting cancer's addiction to blocks in apoptosis
    • Letai AG. Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nat Rev Cancer 2008; 8: 121-132.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 121-132
    • Letai, A.G.1
  • 21
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • Youle RJ, Strasser A. The BCL-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9: 47-59.
    • (2008) Nat. Rev. Mol Cell Biol , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 22
    • 33749459941 scopus 로고    scopus 로고
    • Gene-specific mechanisms of p53 transcriptional control and prospects for cancer therapy
    • Resnick-Silverman L, Manfredi JJ. Gene-specific mechanisms of p53 transcriptional control and prospects for cancer therapy. J Cell Biochem 2006; 99: 679-689.
    • (2006) J. Cell Biochem. , vol.99 , pp. 679-689
    • Resnick-Silverman, L.1    Manfredi, J.J.2
  • 23
    • 34248379012 scopus 로고    scopus 로고
    • Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database
    • Petitjean A, Mathe E, Kato S, Ishioka C, Tavtigian SV, Hainaut P et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database. Hum Mutat 2007; 28: 622-629.
    • (2007) Hum. Mutat. , vol.28 , pp. 622-629
    • Petitjean, A.1    Mathe, E.2    Kato, S.3    Ishioka, C.4    Tavtigian, S.V.5    Hainaut, P.6
  • 25
    • 82955207718 scopus 로고    scopus 로고
    • Optimized antitumor effects of anthracyclines plus vinca alkaloids using a novel, mechanism-based application schedule
    • Ehrhardt H, Schrembs D, Moritz C, Wachter F, Haldar S, Graubner U et al. Optimized antitumor effects of anthracyclines plus vinca alkaloids using a novel, mechanism-based application schedule. Blood 2011; 118: 6123-6113.
    • (2011) Blood , vol.118 , pp. 6123-6113
    • Ehrhardt, H.1    Schrembs, D.2    Moritz, C.3    Wachter, F.4    Haldar, S.5    Graubner, U.6
  • 27
    • 34248582829 scopus 로고    scopus 로고
    • Cancer cell lines as genetic models of their parent histology: Analyses based on array comparative genomic hybridization
    • Greshock J, Nathanson K, Martin AM, Zhang L, Coukos G, Weber BL et al. Cancer cell lines as genetic models of their parent histology: Analyses based on array comparative genomic hybridization. Cancer Res 2007; 67: 3594-3600.
    • (2007) Cancer Res. , vol.67 , pp. 3594-3600
    • Greshock, J.1    Nathanson, K.2    Martin, A.M.3    Zhang, L.4    Coukos, G.5    Weber, B.L.6
  • 28
    • 13844312493 scopus 로고    scopus 로고
    • Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI
    • Sandberg R, Ernberg I. Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI).Proc Natl Acad Sci USA 2005; 102: 2052-2057.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2052-2057
    • Sandberg, R.1    Ernberg, I.2
  • 29
    • 0037220020 scopus 로고    scopus 로고
    • TP53 in hematological cancer: Low incidence of mutations with significant clinical relevance
    • Peller S, Rotter V. TP53 in hematological cancer: Low incidence of mutations with significant clinical relevance. Hum Mutat 2003; 21: 277-284.
    • (2003) Hum. Mutat. , Issue.21 , pp. 277-284
    • Peller, S.1    Rotter, V.2
  • 30
    • 33646782954 scopus 로고    scopus 로고
    • P53 and disease: When the guardian angel fails
    • Royds JA, Iacopetta B. p53 and disease: When the guardian angel fails. Cell Death Differ 2006; 13: 1017-1026.
    • (2006) Cell Death Differ , vol.13 , pp. 1017-1026
    • Royds, J.A.1    Iacopetta, B.2
  • 31
    • 0037051095 scopus 로고    scopus 로고
    • P53: An ubiquitous target of anticancer drugs
    • Blagosklonny MV. p53: An ubiquitous target of anticancer drugs. Int J Cancer 2002; 98: 161-166.
    • (2002) Int. J. Cancer , vol.98 , pp. 161-166
    • Blagosklonny, M.V.1
  • 32
    • 34047224955 scopus 로고    scopus 로고
    • Structure-function-rescue: The diverse nature of common p53 cancer mutants
    • Joerger AC, Fersht AR. Structure-function-rescue: The diverse nature of common p53 cancer mutants. Oncogene 2007; 26: 2226-2242.
    • (2007) Oncogene , vol.26 , pp. 2226-2242
    • Joerger, A.C.1    Fersht, A.R.2
  • 33
    • 2442531882 scopus 로고    scopus 로고
    • Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice
    • Sawada N, Kataoka K, Kondo K, Arimochi H, Fujino H, Takahashi Y et al. Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice. Br J Cancer 2004; 90: 1672-1678.
    • (2004) Br. J. Cancer , vol.90 , pp. 1672-1678
    • Sawada, N.1    Kataoka, K.2    Kondo, K.3    Arimochi, H.4    Fujino, H.5    Takahashi, Y.6
  • 35
    • 24744462114 scopus 로고    scopus 로고
    • TRAIL-mediated proliferation of tumor cells with receptor-close apoptosis defects
    • Baader E, Toloczko A, Fuchs U, Schmid I, Beltinger C, Ehrhardt H et al. TRAIL-mediated proliferation of tumor cells with receptor-close apoptosis defects. Cancer Res 2005; 65: 7888-7895.
    • (2005) Cancer Res. , vol.65 , pp. 7888-7895
    • Baader, E.1    Toloczko, A.2    Fuchs, U.3    Schmid, I.4    Beltinger, C.5    Ehrhardt, H.6
  • 36
    • 0038339094 scopus 로고    scopus 로고
    • Trail-induced survival and proliferation in cancer cells resistant towards trail-induced apoptosis mediated by NFkB
    • Ehrhardt H, Fulda S, Schmid I, Hiscott J, Debatin KM, Jeremias I. TRAIL-induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NFkB. Oncogene 2003; 22: 3842-3852.
    • (2003) Oncogene , vol.22 , pp. 3842-3852
    • Ehrhardt, H.1    Fulda, S.2    Schmid, I.3    Hiscott, J.4    Debatin, K.M.5    Jeremias, I.6
  • 37
    • 33644663668 scopus 로고    scopus 로고
    • Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis
    • Gao Z, Shao Y, Jiang X. Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis. J Biol Chem 2005; 280: 38271-38275.
    • (2005) J. Biol. Chem. , vol.280 , pp. 38271-38275
    • Gao, Z.1    Shao, Y.2    Jiang, X.3
  • 38
    • 33847077943 scopus 로고    scopus 로고
    • Fkhrl1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells
    • Obexer P, Geiger K, Ambros PF, Meister B, Ausserlechner MJ. FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death Differ 2007; 14: 534-547.
    • (2007) Cell Death Differ , vol.14 , pp. 534-547
    • Obexer, P.1    Geiger, K.2    Ambros, P.F.3    Meister, B.4    Ausserlechner, M.J.5
  • 40
    • 84860813765 scopus 로고    scopus 로고
    • Efficient RNA interference in patientśacute lymphoblastic leukemia cells amplified as xenografts in mice
    • Höfig I, Ehrhardt H, Jeremias I. Efficient RNA interference in patientśacute lymphoblastic leukemia cells amplified as xenografts in mice. Cell Commun Signal 2012; 10: 8.
    • (2012) Cell Commun. Signal , Issue.10 , pp. 8
    • Höfig, I.1    Ehrhardt, H.2    Jeremias, I.3


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