-
1
-
-
67449099150
-
Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells
-
Suzuki S, Nakasato M, Shibue T, Koshima I, Tanigushi T. Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells. Cancer Sci 2009; 100: 759-769.
-
(2009)
Cancer Sci.
, vol.100
, pp. 759-769
-
-
Suzuki, S.1
Nakasato, M.2
Shibue, T.3
Koshima, I.4
Tanigushi, T.5
-
2
-
-
79954418914
-
Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways
-
Zhang L, Lopez H, George NM, Liu X, Pang X, Luo X. Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways. Cell Death Differ 2010; 18: 864-873.
-
(2010)
Cell Death Differ
, vol.18
, pp. 864-873
-
-
Zhang, L.1
Lopez, H.2
George, N.M.3
Liu, X.4
Pang, X.5
Luo, X.6
-
3
-
-
33745962416
-
BH3-only proteins in cell death initiation, malignant disease and anticancer therapy
-
Labi V, Erlacher M, Kiessling S, Villunger A. BH3-only proteins in cell death initiation, malignant disease and anticancer therapy. Cell Death Differ 2006; 13: 1325-1338.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1325-1338
-
-
Labi, V.1
Erlacher, M.2
Kiessling, S.3
Villunger, A.4
-
4
-
-
68149153007
-
NOXA: At the tip of the balance between life and death
-
Ploner C, Kofler R, Villunger A. NOXA: At the tip of the balance between life and death. Oncogene 2009; 27: S84-S92.
-
(2009)
Oncogene
, vol.27
-
-
Ploner, C.1
Kofler, R.2
Villunger, A.3
-
5
-
-
33748862585
-
BH3-only proteins: Integrated control point of apoptosis
-
Shibue T, Taniguchi T. BH3-only proteins: Integrated control point of apoptosis. Int J Cancer 2006; 119: 2036-2043.
-
(2006)
Int. J. Cancer
, vol.119
, pp. 2036-2043
-
-
Shibue, T.1
Taniguchi, T.2
-
6
-
-
78649991678
-
An ERK dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs
-
Sheridan C, Brumatti G, Elgendy M, Brunet M, Martin SJ, An ERK. dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs. Oncogene 2010; 29: 6428-6441.
-
(2010)
Oncogene
, vol.29
, pp. 6428-6441
-
-
Sheridan, C.1
Brumatti, G.2
Elgendy, M.3
Brunet, M.4
Martin, S.J.5
-
7
-
-
79951512093
-
ROS-mediated upregulation of NOXA overcomes chemoresistance in chronic lymphocytic leukemia
-
Tonino SH, van Laar J, van Oers MH, Wang JY, Eldering E, Kater AP. ROS-mediated upregulation of NOXA overcomes chemoresistance in chronic lymphocytic leukemia. Oncogene 2010; 30: 701-713.
-
(2010)
Oncogene
, vol.30
, pp. 701-713
-
-
Tonino, S.H.1
Van Laar, J.2
Van Oers, M.H.3
Wang, J.Y.4
Eldering, E.5
Kater, A.P.6
-
8
-
-
30144442233
-
The proteasome inhibitor bortezomibe induces apoptosis in mantle-cell lymphoma through generation of ROS and NOXA activation independent of p53 status
-
Pérez-Galán P, Roué G, Villamor N, Montserrat E, Campo E, Colomer D. The proteasome inhibitor bortezomibe induces apoptosis in mantle-cell lymphoma through generation of ROS and NOXA activation independent of p53 status. Blood 2006; 107: 257-264.
-
(2006)
Blood
, vol.107
, pp. 257-264
-
-
Pérez-Galán, P.1
Roué, G.2
Villamor, N.3
Montserrat, E.4
Campo, E.5
Colomer, D.6
-
9
-
-
68149108384
-
PUMA, a potent killer with or without p53
-
Yu J, Zhang L. PUMA, a potent killer with or without p53. Oncogene 2009; 27: S71-S83.
-
(2009)
Oncogene
, vol.27
-
-
Yu, J.1
Zhang, L.2
-
10
-
-
4344609047
-
Betulinic acid-induced apoptosis in leukaemia cells
-
Ehrhardt H, Fulda S, Führer M, Debatin KM, Jeremias I. Betulinic acid-induced apoptosis in leukaemia cells. Leukemia 2004; 18: 1406-1412.
-
(2004)
Leukemia
, vol.18
, pp. 1406-1412
-
-
Ehrhardt, H.1
Fulda, S.2
Führer, M.3
Debatin, K.M.4
Jeremias, I.5
-
11
-
-
58149357667
-
Betulinic acid: A natural product with anticancer activity
-
Fulda S. Betulinic acid: A natural product with anticancer activity. Mol Nutr Food Res 2009; 53: 140-146.
-
(2009)
Mol. Nutr. Food Res.
, vol.53
, pp. 140-146
-
-
Fulda, S.1
-
12
-
-
0030815250
-
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
-
Fulda S, Friesen C, Los M, Scaffidi C, Mier W, Benedict M et al. Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res 1997; 57: 4956-4964.
-
(1997)
Cancer Res.
, vol.57
, pp. 4956-4964
-
-
Fulda, S.1
Friesen, C.2
Los, M.3
Scaffidi, C.4
Mier, W.5
Benedict, M.6
-
13
-
-
0032545386
-
Activation of mitochondria and release of mitochondrial apoptogenetic factors by betulinic acid
-
Fulda S, Scaffidi C, Susin SA, Krammer PH, Kroemer G, Peter ME et al. Activation of mitochondria and release of mitochondrial apoptogenetic factors by betulinic acid. J Biol Chem 1998; 273: 33942-33948.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 33942-33948
-
-
Fulda, S.1
Scaffidi, C.2
Susin, S.A.3
Krammer, P.H.4
Kroemer, G.5
Peter, M.E.6
-
14
-
-
0033023669
-
Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein syn thesis, formation of reactive oxygen species, and caspase processing
-
Wick W, Grimmel C, Wagenknecht B, Dichgans J, Weller M. Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing. J Pharmacol Exp Ther 1999; 289: 1306-1312.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.289
, pp. 1306-1312
-
-
Wick, W.1
Grimmel, C.2
Wagenknecht, B.3
Dichgans, J.4
Weller, M.5
-
15
-
-
0033753764
-
The clinical and cellular pharmacology of vincristine, corticosteroids, L-Asparaginase, anthracyclines and cyclophosphamide in relation to childhood acute lymphoblastic leukaemia
-
Estlin EJ, Ronghe M, Burke GA, Yule SM. The clinical and cellular pharmacology of vincristine, corticosteroids, L-Asparaginase, anthracyclines and cyclophosphamide in relation to childhood acute lymphoblastic leukaemia. Br J Haematol 2000; 110: 780-790.
-
(2000)
Br. J. Haematol.
, vol.110
, pp. 780-790
-
-
Estlin, E.J.1
Ronghe, M.2
Burke, G.A.3
Yule, S.M.4
-
16
-
-
0032858861
-
Determination of betulinic acid in mouse blood, tumor and tissue homogenates by liquid chromatographyelectrospray mass spectrometry
-
Shin YG, Cho KH, Chung SM, Graham J, Das Gupta TK, Pezzuto JM. Determination of betulinic acid in mouse blood, tumor and tissue homogenates by liquid chromatographyelectrospray mass spectrometry. J Chromatogr B Biomed Sci Appl 1999; 732: 331-336.
-
(1999)
J. Chromatogr. B. Biomed. Sci. Appl.
, vol.732
, pp. 331-336
-
-
Shin, Y.G.1
Cho, K.H.2
Chung, S.M.3
Graham, J.4
Das Gupta, T.K.5
Pezzuto, J.M.6
-
17
-
-
0034631974
-
Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells
-
Gamen S, Anel A, Pérez-Galán P, Lasierra P, Johnson D, Piñeiro A et al. Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp Cell Res 2000; 258: 223-235.
-
(2000)
Exp. Cell Res.
, vol.258
, pp. 223-235
-
-
Gamen, S.1
Anel, A.2
Pérez-Galán, P.3
Lasierra, P.4
Johnson, D.5
Piñeiro, A.6
-
18
-
-
12144289654
-
Tumor necrosis factorrelated apoptosis-inducing ligand cooperates with anticancer drugs to overcome chemoresistance in antiapoptotic Bcl-2 family members expressing jurkat cells
-
Ballestrero A, Nencioni A, Boy D, Rocco I, Garuti A, Mela GS et al. Tumor necrosis factorrelated apoptosis-inducing ligand cooperates with anticancer drugs to overcome chemoresistance in antiapoptotic Bcl-2 family members expressing jurkat cells. Clin Cancer Res 2004; 10: 1463-1470.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 1463-1470
-
-
Ballestrero, A.1
Nencioni, A.2
Boy, D.3
Rocco, I.4
Garuti, A.5
Mela, G.S.6
-
19
-
-
77951294919
-
Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells
-
López-Royuela N, Pérez-Galán P, Galán-Malo P, Yuste VJ, Anel A, Susín SA et al. Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells. Biochem Pharmacol 2010; 79: 1746-1758.
-
(2010)
Biochem. Pharmacol.
, vol.79
, pp. 1746-1758
-
-
López-Royuela, N.1
Pérez-Galán, P.2
Galán-Malo, P.3
Yuste, V.J.4
Anel, A.5
Susín, S.A.6
-
20
-
-
38549145044
-
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
-
Letai AG. Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nat Rev Cancer 2008; 8: 121-132.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 121-132
-
-
Letai, A.G.1
-
21
-
-
37549048249
-
The BCL-2 protein family: Opposing activities that mediate cell death
-
Youle RJ, Strasser A. The BCL-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9: 47-59.
-
(2008)
Nat. Rev. Mol Cell Biol
, vol.9
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
-
22
-
-
33749459941
-
Gene-specific mechanisms of p53 transcriptional control and prospects for cancer therapy
-
Resnick-Silverman L, Manfredi JJ. Gene-specific mechanisms of p53 transcriptional control and prospects for cancer therapy. J Cell Biochem 2006; 99: 679-689.
-
(2006)
J. Cell Biochem.
, vol.99
, pp. 679-689
-
-
Resnick-Silverman, L.1
Manfredi, J.J.2
-
23
-
-
34248379012
-
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database
-
Petitjean A, Mathe E, Kato S, Ishioka C, Tavtigian SV, Hainaut P et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database. Hum Mutat 2007; 28: 622-629.
-
(2007)
Hum. Mutat.
, vol.28
, pp. 622-629
-
-
Petitjean, A.1
Mathe, E.2
Kato, S.3
Ishioka, C.4
Tavtigian, S.V.5
Hainaut, P.6
-
24
-
-
84055212083
-
Important role of Caspase-8 for chemo-sensitivity of ALL cells
-
Ehrhardt H, Wachter F, Maurer M, Stahnke K, Jeremias I. Important role of Caspase-8 for chemo-sensitivity of ALL cells. Clin Cancer Res 2011; 17: 7605-7613.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 7605-7613
-
-
Ehrhardt, H.1
Wachter, F.2
Maurer, M.3
Stahnke, K.4
Jeremias, I.5
-
25
-
-
82955207718
-
Optimized antitumor effects of anthracyclines plus vinca alkaloids using a novel, mechanism-based application schedule
-
Ehrhardt H, Schrembs D, Moritz C, Wachter F, Haldar S, Graubner U et al. Optimized antitumor effects of anthracyclines plus vinca alkaloids using a novel, mechanism-based application schedule. Blood 2011; 118: 6123-6113.
-
(2011)
Blood
, vol.118
, pp. 6123-6113
-
-
Ehrhardt, H.1
Schrembs, D.2
Moritz, C.3
Wachter, F.4
Haldar, S.5
Graubner, U.6
-
26
-
-
38749133366
-
Cytotoxic drug-induced, p53-mediated upregulation of Caspase-8 in tumor cells
-
Ehrhardt H, Haecker S, Wittmann S, Maurer M, Borkhardt A, Toloczko A et al. Cytotoxic drug-induced, p53-mediated upregulation of Caspase-8 in tumor cells. Oncogene 2008; 27: 783-793.
-
(2008)
Oncogene
, vol.27
, pp. 783-793
-
-
Ehrhardt, H.1
Haecker, S.2
Wittmann, S.3
Maurer, M.4
Borkhardt, A.5
Toloczko, A.6
-
27
-
-
34248582829
-
Cancer cell lines as genetic models of their parent histology: Analyses based on array comparative genomic hybridization
-
Greshock J, Nathanson K, Martin AM, Zhang L, Coukos G, Weber BL et al. Cancer cell lines as genetic models of their parent histology: Analyses based on array comparative genomic hybridization. Cancer Res 2007; 67: 3594-3600.
-
(2007)
Cancer Res.
, vol.67
, pp. 3594-3600
-
-
Greshock, J.1
Nathanson, K.2
Martin, A.M.3
Zhang, L.4
Coukos, G.5
Weber, B.L.6
-
28
-
-
13844312493
-
Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI
-
Sandberg R, Ernberg I. Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI).Proc Natl Acad Sci USA 2005; 102: 2052-2057.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 2052-2057
-
-
Sandberg, R.1
Ernberg, I.2
-
29
-
-
0037220020
-
TP53 in hematological cancer: Low incidence of mutations with significant clinical relevance
-
Peller S, Rotter V. TP53 in hematological cancer: Low incidence of mutations with significant clinical relevance. Hum Mutat 2003; 21: 277-284.
-
(2003)
Hum. Mutat.
, Issue.21
, pp. 277-284
-
-
Peller, S.1
Rotter, V.2
-
30
-
-
33646782954
-
P53 and disease: When the guardian angel fails
-
Royds JA, Iacopetta B. p53 and disease: When the guardian angel fails. Cell Death Differ 2006; 13: 1017-1026.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1017-1026
-
-
Royds, J.A.1
Iacopetta, B.2
-
31
-
-
0037051095
-
P53: An ubiquitous target of anticancer drugs
-
Blagosklonny MV. p53: An ubiquitous target of anticancer drugs. Int J Cancer 2002; 98: 161-166.
-
(2002)
Int. J. Cancer
, vol.98
, pp. 161-166
-
-
Blagosklonny, M.V.1
-
32
-
-
34047224955
-
Structure-function-rescue: The diverse nature of common p53 cancer mutants
-
Joerger AC, Fersht AR. Structure-function-rescue: The diverse nature of common p53 cancer mutants. Oncogene 2007; 26: 2226-2242.
-
(2007)
Oncogene
, vol.26
, pp. 2226-2242
-
-
Joerger, A.C.1
Fersht, A.R.2
-
33
-
-
2442531882
-
Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice
-
Sawada N, Kataoka K, Kondo K, Arimochi H, Fujino H, Takahashi Y et al. Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice. Br J Cancer 2004; 90: 1672-1678.
-
(2004)
Br. J. Cancer
, vol.90
, pp. 1672-1678
-
-
Sawada, N.1
Kataoka, K.2
Kondo, K.3
Arimochi, H.4
Fujino, H.5
Takahashi, Y.6
-
34
-
-
0034026724
-
Effects of betulinic acid alone and in combination with irradiation in human melanoma cells
-
Selzer E, Pimentel E, Wacheck V, Schlegel W, Pehamberger H, Jansen B et al. Effects of betulinic acid alone and in combination with irradiation in human melanoma cells. J Invest Dermatol 2000; 114: 935-940.
-
(2000)
J. Invest. Dermatol.
, vol.114
, pp. 935-940
-
-
Selzer, E.1
Pimentel, E.2
Wacheck, V.3
Schlegel, W.4
Pehamberger, H.5
Jansen, B.6
-
35
-
-
24744462114
-
TRAIL-mediated proliferation of tumor cells with receptor-close apoptosis defects
-
Baader E, Toloczko A, Fuchs U, Schmid I, Beltinger C, Ehrhardt H et al. TRAIL-mediated proliferation of tumor cells with receptor-close apoptosis defects. Cancer Res 2005; 65: 7888-7895.
-
(2005)
Cancer Res.
, vol.65
, pp. 7888-7895
-
-
Baader, E.1
Toloczko, A.2
Fuchs, U.3
Schmid, I.4
Beltinger, C.5
Ehrhardt, H.6
-
36
-
-
0038339094
-
Trail-induced survival and proliferation in cancer cells resistant towards trail-induced apoptosis mediated by NFkB
-
Ehrhardt H, Fulda S, Schmid I, Hiscott J, Debatin KM, Jeremias I. TRAIL-induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NFkB. Oncogene 2003; 22: 3842-3852.
-
(2003)
Oncogene
, vol.22
, pp. 3842-3852
-
-
Ehrhardt, H.1
Fulda, S.2
Schmid, I.3
Hiscott, J.4
Debatin, K.M.5
Jeremias, I.6
-
37
-
-
33644663668
-
Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis
-
Gao Z, Shao Y, Jiang X. Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis. J Biol Chem 2005; 280: 38271-38275.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 38271-38275
-
-
Gao, Z.1
Shao, Y.2
Jiang, X.3
-
38
-
-
33847077943
-
Fkhrl1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells
-
Obexer P, Geiger K, Ambros PF, Meister B, Ausserlechner MJ. FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death Differ 2007; 14: 534-547.
-
(2007)
Cell Death Differ
, vol.14
, pp. 534-547
-
-
Obexer, P.1
Geiger, K.2
Ambros, P.F.3
Meister, B.4
Ausserlechner, M.J.5
-
40
-
-
84860813765
-
Efficient RNA interference in patientśacute lymphoblastic leukemia cells amplified as xenografts in mice
-
Höfig I, Ehrhardt H, Jeremias I. Efficient RNA interference in patientśacute lymphoblastic leukemia cells amplified as xenografts in mice. Cell Commun Signal 2012; 10: 8.
-
(2012)
Cell Commun. Signal
, Issue.10
, pp. 8
-
-
Höfig, I.1
Ehrhardt, H.2
Jeremias, I.3
|