Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2′-dipyridyl

Free Radical Biology and Medicine

Volumn 53, Issue 3, 2012, Pages 564-576

  Kellett, Andrew ^a   Howe, Orla ^b   O'Connor, Mark ^c   McCann, Malachy ^c   Creaven, Bernadette S ^b   McClean, Siobhán ^b   Foltyn Arfa Kia, Agnieszka ^b   Casey, Alan ^b   Devereux, Michael ^b  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

H2AX; Anticancer; CAT; Copper; DNA binding; Double strand DNA breaks; Free radicals; Nuclease; ROS generation; SOD

Indexed keywords

1,10 PHENANTHROLINE COPPER; 2,2' BIPYRIDINE; ASCORBIC ACID; CATALASE; CISPLATIN; COPPER COMPLEX; CUPRIC ION; DACTINOMYCIN; DICHLORODIHYDROFLUORESCEIN DIACETATE; DOUBLE STRANDED DNA; FREE RADICAL; HISTONE H2AX; LIGAND; PENTAMIDINE; PHTHALIC ACID; PLASMID DNA; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ARTICLE; BREAST CANCER; CANCER CELL; CELL STRAIN MCF 7; CLINICAL ASSESSMENT; COLON CANCER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA CLEAVAGE; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE; GENE TARGETING; HUMAN; HUMAN CELL; IC 50; IMMUNODETECTION; MONITORING; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; QUANTITATIVE ANALYSIS; SYNTHESIS; VISCOSITY;

ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CATALASE; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; COORDINATION COMPLEXES; DACTINOMYCIN; DNA; DNA BREAKS, DOUBLE-STRANDED; DRUG SCREENING ASSAYS, ANTITUMOR; ETHIDIUM; FLOW CYTOMETRY; FREE RADICALS; HISTONES; HUMANS; HYDROGEN PEROXIDE; INHIBITORY CONCENTRATION 50; INTERCALATING AGENTS; MICROSCOPY, CONFOCAL; MOLECULAR MIMICRY; PENTAMIDINE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; VISCOSITY;

EID: 84863448357     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.05.034     Document Type: Article

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