The key role of PGC-1α in mitochondrial biogenesis and the proliferation of pulmonary artery vascular smooth muscle cells at an early stage of hypoxic exposure

Molecular and Cellular Biochemistry

Volumn 367, Issue 1-2, 2012, Pages 9-18

  Rao, Jingjing ^a   Li, Jing ^a   Liu, Yun ^a   Lu, Ping ^a   Sun, Xiaojiao ^a   Sugumaran, P K ^a   Zhu, Daling ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Bio pharmaceutical Key Laboratory of Heilongjiang Province   (China)

Author keywords

Hypoxia; Hypoxic pulmonary hypertension; Mitochondrial biogenesis; PGC 1 ; Pulmonary vascular remodeling

Indexed keywords

CYCLIN A; CYCLIN E; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOGENESIS; CELL HYPOXIA; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; MALE; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION; PULMONARY ARTERY; RAT; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELL HYPOXIA; CELL PROLIFERATION; CELLS, CULTURED; CYCLINS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; MALE; MITOCHONDRIA, MUSCLE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY ARTERY; RATS; RATS, WISTAR; RNA INTERFERENCE; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

CYCLINA;

EID: 84863448111     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1313-z     Document Type: Article

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