12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity

Experimental and Molecular Medicine

Volumn 44, Issue 6, 2012, Pages 378-386

  Lee, Jin Wook ^a   Ryu, Ho Cheol ^a   Ng, Yee Ching ^a   Kim, Cheolmin ^a   Wei, Jun Dong ^a   Sabaratnam, Vikineswary ^b   Kim, Jae Hong ^a  

^a Korea University   (South Korea)

^b UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

12 hydroxy 5,8,10 heptadecatrienoic acid; Dermatitis; Dual specificity phosphatase 1; Interleukin 6; Ultraviolet rays

Indexed keywords

ANTIINFLAMMATORY AGENT; HYDROXYHEPTADECA TRIENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME REGULATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; KERATINOCYTE; SIGNAL TRANSDUCTION; ULTRAVIOLET B RADIATION;

EID: 84863446062     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2012.44.6.043     Document Type: Article

References (45)

1. Abraham SM, Clark AR. Dual-specificity phosphatase 1: a critical regulator of innate immune responses. Biochem Soc Trans 2006;34:1018-23
2. Bode AM, Dong Z. Mitogen-activated protein kinase activation in UV-induced signal transduction. Sci STKE 2003;2003:RE2
3. Caprino L, Dolci N, Togna G, Villa P, Bucci R, Carunchio V. Effects of cadmium on platelet thromboxane and vascular prostacyclin production. Toxicol Appl Pharmacol 1982;65: 185-8
4. Casals-Casas C, Alvarez E, Serra M, de la Torre C, Farrera C, Sánchez-Tilló E, Caelles C, Lloberas J, Celada A. CREB and AP-1 activation regulates MKP-1 induction by LPS or M-CSF and their kinetics correlate with macrophage activation versus proliferation. Eur J Immunol 2009;39: 1902-13
5. Chen W, Bowden GT. Activation of p38 MAP kinase and ERK are required for ultraviolet-B induced c-fos gene expression in human keratinocytes. Oncogene 1999;18:7469-76
6. Cho KJ, Seo JM, Kim JH. Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen species. Mol Cells 2011;32:1-5
7. Chung JH, Youn SH, Koh WS, Eun HC, Cho KH, Park KC, Youn JI. Ultraviolet B irradiation-enhanced interleukin (IL)-6 production and mRNA expression are mediated by IL-1 alpha in cultured human keratinocytes. J Invest Dermatol 1996;106:715-20
8. Clydesdale GJ, Dandie GW, Muller HK. Ultraviolet light induced injury: immunological and inflammatory effects. Immunol Cell Biol 2001;79:547-68
9. Gebhardt C, Averbeck M, Viertel A, Kauer F, Saalbach A, Anderegg U, Simon JC. Ultraviolet-B irradiation enhances melanoma cell motility via induction of autocrine interleukin 8 secretion. Exp Dermatol 2007;16:636-43
10. Grone A. Keratinocytes and cytokines. Vet Immunol Immunopathol 2002;88:1-12
11. Grossman RM, Krueger J, Yourish D, Granelli-Piperno A, Murphy DP, May LT, Kupper TS, Sehgal PB, Gottlieb AB. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci USA 1989;86:6367-71
12. Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 2001;13:85-94
13. Hamberg M, Svensson J, Samuelsson B. Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Proc Natl Acad Sci USA 1974;71:3824-8
14. Hennig R, Osman T, Esposito I, Giese N, Rao SM, Ding XZ, Tong WG, Buchler MW, Yokomizo T, Friess H, Adrian TE. BLT2 is expressed in PanINs, IPMNs, pancreatic cancer and stimulates tumour cell proliferation. Br J Cancer 2008;99: 1064-73
15. Iizuka Y, Okuno T, Saeki K, Uozaki H, Okada S, Misaka T, Sato T, Toh H, Fukayama M, Takeda N, Kita Y, Shimizu T, Nakamura M, Yokomizo T. Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis. FASEB J 2010;24:4678-90
16. John H, Cammann K, Schlegel W. Development and review of radioimmunoassay of 12-S-hydroxyheptadecatrienoic acid. Prostaglandins Other Lipid Mediat 1998;56:53-76
17. Katiyar SK, Meeran SM. Obesity increases the risk of UV radiation-induced oxidative stress and activation of MAPK and NF-kappaB signaling. Free Radic Biol Med 2007;42: 299-310
18. Keyse SM. An emerging family of dual specificity MAP kinase phosphatases. Biochim Biophys Acta 1995;1265:152-60
19. Kim AL, Labasi JM, Zhu Y, Tang X, McClure K, Gabel CA, Athar M, Bickers DR. Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J Invest Dermatol 2005a;124:1318-25
20. Kim C, Ryu HC, Kim JH. Low-dose UVB irradiation stimulates matrix metalloproteinase-1 expression via a BLT2-linked pathway in HaCaT cells. Exp Mol Med 2010;42:833-41
21. Kim HJ, Rho YH, Choi SJ, Lee YH, Cheon H, Um JW, Sohn J, Song GG, Ji JD. 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. Exp Mol Med 2005b;37:179-85
22. Kock A, Schwarz T, Kirnbauer R, Urbanski A, Perry P, Ansel JC, Luger TA. Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 1990;172:1609-14
23. Kwak SP, Hakes DJ, Martell KJ, Dixon JE. Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene. J Biol Chem 1994;269:3596-604
24. Lang R, Hammer M, Mages J. DUSP meet immunology: dual specificity MAPK phosphatases in control of the inflammatory response. J Immunol 2006;177:7497-504
25. Lederle W, Depner S, Schnur S, Obermueller E, Catone N, Just A, Fusenig NE, Mueller MM. IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines. Int J Cancer 2011;128:2803-14
26. Lee JH, Woo JH, Woo SU, Kim KS, Park SM, Joe EH, Jou I. The 15-deoxy-delta12,14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1. J Immunol 2008;181:8642-9
27. Li S, Zhu F, Zykova T, Kim MO, Cho YY, Bode AM, Peng C, Ma W, Carper A, Langfald A, Dong Z. T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway. J Biol Chem 2011;286:29601-9
28. Matsumura Y, Ananthaswamy HN. Toxic effects of ultraviolet radiation on the skin. Toxicol Appl Pharmacol 2004;195: 298-308
29. Nishimoto N, Kishimoto T. Inhibition of IL-6 for the treatment of inflammatory diseases. Curr Opin Pharmacol 2004;4: 386-91
30. Nishimura N, Tohyama C, Satoh M, Nishimura H, Reeve VE. Defective immune response and severe skin damage following UVB irradiation in interleukin-6-deficient mice. Immunology 1999;97:77-83
31. Okuno T, Iizuka Y, Okazaki H, Yokomizo T, Taguchi R, Shimizu T. 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. J Exp Med 2008;205:759-66
32. Peus D, Vasa RA, Beyerle A, Meves A, Krautmacher C, Pittelkow MR. UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. J Invest Dermatol 1999;112:751-6
33. Pfundt R, van Vlijmen-Willems I, Bergers M, Wingens M, Cloin W, Schalkwijk J. In situ demonstration of phosphorylated c-jun and p38 MAP kinase in epidermal keratinocytes following ultraviolet B irradiation of human skin. J Pathol 2001;193:248-55
34. Punnonen K, Uotila P, Mantyla E. The effects of aspirin and OKY-1581 on the metabolism of exogenous arachidonic acid in rat alveolar macrophages. Res Commun Chem Pathol Pharmacol 1984;44:367-74
35. Quante T, Ng YC, Ramsay EE, Henness S, Allen JC, Parmentier J, Ge Q, Ammit AJ. Corticosteroids reduce IL-6 in ASM cells via up-regulation of MKP-1. Am J Respir Cell Mol Biol 2008;39:208-17
36. Ryu HC, Kim C, Kim JY, Chung JH, Kim JH. UVB radiation induces apoptosis in keratinocytes by activating a pathway linked to BLT2-reactive oxygen species. J Invest Dermatol 2010;130:1095-106
37. Shin JS, Noh YS, Lee YS, Cho YW, Baek NI, Choi MS, Jeong TS, Kang E, Chung HG, Lee KT. Arvelexin from Brassica rapa suppresses NF-κB-regulated pro-inflammatory geneexpression by inhibiting activation of IκB kinase. Br J Pharmacol 2011;164:145-58
38. Shinoda S, Kameyoshi Y, Hide M, Morita E, Yamamoto S. Histamine enhances UVB-induced IL-6 production by human keratinocytes. Arch Dermatol Res 1998;290:429-34
39. Simon MM, Aragane Y, Schwarz A, Luger TA, Schwarz T. UVB light induces nuclear factor kappa B (NF kappa B) activity independently from chromosomal DNA damage in cell-free cytosolic extracts. J Invest Dermatol 1994;102: 422-7
40. Tager AM, Luster AD. BLT1 and BLT2: the leukotriene B(4) receptors. Prostaglandins Leukot Essent Fatty Acids 2003;69:123-34
41. Wan YS, Wang ZQ, Voorhees J, Fisher G. EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes. Cell Signal 2001;13:139-44
42. Wang D, Richmond A. Nuclear factor-kappa B activation by the CXC chemokine melanoma growth-stimulatory activity/growth-regulated protein involves the MEKK1/p38 mitogen-activated protein kinase pathway. J Biol Chem 2001;276:3650-9
43. Wang X, Liu Y. Regulation of innate immune response by MAP kinase phosphatase-1. Cell Signal 2007;19:1372-82
44. Wlaschek M, Heinen G, Poswig A, Schwarz A, Krieg T, Scharffetter-Kochanek K. UVA-induced autocrine stimulation of fibroblast-derived collagenase/MMP-1 by interrelated loops of interleukin-1 and interleukin-6. Photochem Photobiol 1994;59:550-6
45. Woo CH, Lim JH, Kim JH. VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNFalpha-induced leukocyte adhesion and emigration in the lung airway epithelium. Am J Physiol Lung Cell Mol Physiol 2005;288:L307-16.