Ultraviolet B Irradiation-Enhanced Interleukin (IL)-6Production and mRNA Expression Are Mediated by IL-1α in Cultured Human Keratinocytes

Journal of Investigative Dermatology

Volumn 106, Issue 4, 1996, Pages 715-720

  Chung, Jin Ho ^a,b   Youn, Sang Ho ^a   Koh, Woo Seok ^a   Eun, Hee Chul ^a   Cho, Kwang Hyun ^a   Park, Kyung Chan ^a   Youn, Jai Il ^a  

^a Seoul National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

Cytokines

Indexed keywords

CYTOKINE; INTERLEUKIN 6; MESSENGER RNA; RECOMBINANT INTERLEUKIN 1ALPHA;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; KERATINOCYTE; MALE; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL; ULTRAVIOLET B RADIATION;

ANIMALS; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; KERATINOCYTES; MICE; RABBITS; RNA, MESSENGER; ULTRAVIOLET RAYS;

EID: 0029988545     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12345608     Document Type: Article

References (27)

1. Ansel JC, Luger TA, Lowry D, Perry P, Roop DR, Mountz JD: The expression and modulation of IL-1α in murine keratinocytes. J Immunol 140:2274-2278, 1988
2. Ansel JC, Perry P, Brown J, Damm H, Phan T, Hart C, Luger T, Hefeneider S: Cytokine modulation of keratinocyte cytokines. J Invest Dermatol 94:101S-107S, 1990
3. Boyce ST, Ham RG: Calcium-regualted differentiations of normal human epidermal keratinocytes in chemically defined clonal culture. J Invest Dermatol 81:33S-40S, 1983
4. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987
5. Chung JH, Youn JI: Effect of ultraviolet A on the IL-1 production by ultraviolet B in cultured human keratinocytes. J Dermatol Sci 9:87-93, 1995
6. de Vos S, Brach M, Budnik A, Grewe M, Herrmann F, Krutmann J: Post-transcriptional regulation of interleukin-6 gene expression in human keratinocytes by ultraviolet B radiation. J Invest Dermatol 103:92-96, 1994
7. Didierjean L, Salomon D, Merot Y, Siegenthaler G, Shaw A, Dayer JM: Localization and characterization of the interleukin 1 immunoreactive pool (IL-1 alpha and beta forms) in normal human epidermis. J Invest Dermatol 92:809-816, 1989
8. Elder JT, Sartor CI, Boman DK, Benrazavi S, Fisher GJ, Pittelkow MR: Interleukin-6 in psoriasis: expression and mitogenicity studies. Arch Dermatol Res 284:324-332, 1992
9. Gallo RL, Staszewski R, Sauder DN, Knisely TL, Granstein RD: Regulation of GM-CSF and IL-3 production from the murine keratinocyte cell line PAM 212 following exposure to ultraviolet radiation. J Invest Dermatol 97:203-209, 1991
10. Hentze MW: Determinants and regulation of cytoplasmic mRNA stability in eukaryotic cells. Biochim Biophys Acta 1090:281-292, 1991
11. Kirnhauer R, Kock A, Neurier P, Foster E, Krutmann J, Urbanski A, Schauer E, Ansel JC, Schwarz T, Luger FA: Regulation of epidermal cell interleukin-6 production by UV light and corticosteroids. J Invest Dermatol 96:484-489, 1991
12. Kupper TS: Interleukin 1 and other immunologically active cytokines: molecular and functional characterization. Adv Dermatol 3:293-305, 1988
13. Kupper TS: Mechanisms of cutaneous inflammation. Arch Dermatol 125:1406-1412, 1989
14. Kupper TS: The activated keratinocyte: a model for inducible cytokine production by non-bone marrow-derived cells in cutaneous inflammatory and immune responses. J Invest Dermatol 94:146S-150S, 1990
15. Kupper TS, Chua AO, Flood P, McGuire H, Gubler U: Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation. J Clin Invest 80:430-436, 1987
16. Le PT, Lazorick S, Whichatd LP, Haynes BF, Singer KH: Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor α regulate mRNA levels of interleukin 1α (IL-1α), IL-1β, and IL-6 in human thymic epithelial cells at a post-transcriptional level. J Exp Med 174:1147-1157, 1991
17. Lee SW, Morhenn VB, Ilnicka M, Eugui EM, Allison AC: Autocrine stimulation of interleukin-1 n and transforming growth factor α production in human keratinoytes and its antagonism by glucocorticoids. J Invest Dermatol 97:106-110, 1991
18. Mizutani H, Black R., Kupper TS: Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes. J Clin Invest 87:1066-1071, 1991
19. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay. J Immunol Methods 65:55-63, 1983
20. Nozaki S, Abrams JS, Pearce MK, Sander DN: Augmentation of granulocyte/ macrophage colony-stimulating factor expression by ultraviolet irradiation is mediated by interleukin 1 in pam 212 keratinocytes. J Invest Dermatol 97:10-14, 1991
21. Nozaki S, Sander DN: Ultraviolet irradiation downregulates the IL-1 receptor in Pam 212 keratinocytes. J Dermatol 21:244-247, 1994
22. Oppenheim JJ, Kovacs EJ, Matsushima K, Durum SK: There is more than one interleukin 1. Immunol Today 7:45-56, 1986
23. Oxholm A, Oxholm P, Staberg B, Bendtzen K. Immunohistological detection of interleukin 1-like molecules and tumor necrosis factor in human epidermis before and after UVB-irradiation in vivo. Br J Dermatol 118:369-378, 1988
24. Partridge M, Chantry D, Turner M, Feldmann M: Production of interleukin-1 and interleukin-6 by human keratinocytes and squamous cell carcinoma cell lines. J Invest Dermatol 96:771-776, 1991
25. Shimada S, Katz S: The skin as an immunologie organ. Arch Pathol Lab Med 112:231-234, 1988
26. Thomas PS: Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci USA 77:5201-5205, 1980
27. Urbanski A, Schwarz T, Neuner P, Krutmann J, Kirnbauer R, Kock A, Luger TA: Ultraviolet light induces increased circulating interleukin 6 in humans. J Invest Dermatol 94:808-811, 1990