Conjunction of tumor cells with lymphocytes: Implications for tumor invasion and metastasis

Cancer Epidemiology

Volumn 36, Issue 4, 2012, Pages 354-363

  Song, Guohong ^a   Ren, Jun ^a   Stojadinovic, Alexander ^b,c,d   Chen, Wen ^e   Sahab, Ziad ^f   Fu, Sidney W ^g   Man, Yan gao ^h  

^a PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

^b WALTER REED ARMY MEDICAL CENTER   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^d United States Military Cancer Institute   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f GEORGETOWN UNIVERSITY   (United States)

^g GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^h Henry Jackson Foundation   (United States)

Author keywords

Breast cancer; Cell degeneration; Metastasis; Myoepithelial cell layer; Tumor cell capsule

Indexed keywords

CELL ADHESION MOLECULE; CELL PROTEIN; EOSIN; HEMATOXYLIN;

ANGIOGENESIS; ARTICLE; BLOOD VESSEL; CANCER INVASION; CANCER STEM CELL; CELL ADHESION; CELL COUNT; CELL DEGENERATION; CELL ISOLATION; CELL JUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CHIMERA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH VESSEL; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; METASTASIS; MITOSIS; MYOEPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA; TUMOR CELL; TUMOR VASCULARIZATION;

CELL COMMUNICATION; HUMANS; LYMPHOCYTES; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS; NEOPLASTIC CELLS, CIRCULATING;

EID: 84863436887     PISSN: 18777821     EISSN: 1877783X     Source Type: Journal    
DOI: 10.1016/j.canep.2011.12.006     Document Type: Article

References (37)

1. Collin S.M., Martin R.M., Metcalfe C., Gunnell D., Albertsen P.C., Neal D., et al. Prostate-cancer mortality in the USA and UK in 1975-2004: an ecological study. Lancet Oncol 2008, 9(5):445-452.
2. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Thun M.J. Cancer statistics, 2009. CA Cancer J Clin 2009, 59(4):225-249.
3. Pollard J.W Tumour-educated macrophages promote tumour progression metastasis. Nat Rev Cancer 2004, 4(1):71-78.
4. Wyckoff J., Wang W., Lin E.Y., Wang Y., Pixley F., Stanley E.R., et al. A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res 2004, 64(19):7022-7029.
5. Pawelek J.M., Chakraborty A.K. The cancer cell - leukocyte fusion theory of metastasis. Adv Cancer Res 2008, 101:397-444.
6. DeNarddo D.G., Johansson M., Coussens L.M. Immune cells as mediators of solid tumor metastasis. Cancer Metastasis Rev 2008, 27(1):11-18.
7. Hendrix M.J., Seftor E.A., Hess A.R., Setfor R.E. Vasculogic mimicry and tumor-cell plasticity: lessons from melanoma. Nat Rev Cancer 2003, 3(6):411-421.
8. Nauseef J.T., Henry M.D. Epithelial-to-mesenchymal transition in prostate cancer: paradigm or puzzle?. Nat Rev Urol 2011, 8(8):428-439.
9. Hunter K.W., Crawford N.P., Alsarraj J. Mechanisms of metastasis. Breast Cancer Res 2008, 10(Suppl. 1):S2.
10. Man Y.G., Tai L., Barner R., Vang R., Saenger J.S., Shekitka K.M., et al. Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasion. Breast Cancer Res 2003, 5:R231-R241.
11. Man Y.G., Zhang Y., Shen T., Vinh T.N., Zeng X., Tauler J., et al. cDNA expression profiling identifies elevated expressions of tumor progression and invasion related genes in cell clusters of in situ breast tumors. Breast Cancer Res Treat 2005, 89:199-208.
12. Man Y.G., Fu S.W., Pinzone J.J., Schwartz A.M., Simmens S.J., Berg P.E. Expression of BP1, a homobox gene, correlates with progression and invasion of mammary ductal carcinoma. Breast Cancer Res Treat 2005, 90:241-247.
13. Man Y.G., Zhao C.Q., Wang J. Breast tumor cell clusters and their budding derivatives show different immunohistochemical profiles during stromal invasion: implications for hormonal and drug therapies. Cancer Therapy 2006, 4:193-204.
14. Man Y.G. Focal degeneration of aged or injured myoepithelial cells and the resultant auto-immunoreactions are trigger factors for breast tumor invasion. Med Hypoth 2007, 69(6):1340-1357.
15. Man Y.G., Gardner W.A. Focal degeneration of basal cells and the resultant auto-immunoreactions: a novel mechanism for prostate tumor progression and invasion. Med Hypoth 2008, 70:387-408.
16. Sahab Z.J., Man Y.G., Semaan S.M., Newcomer R.G., Byers S.W., Sang Q.X. Alteration in protein expression in estrogen receptor alpha-negative human breast cancer tissues indicates a malignant and metastatic phenotype. Clin Exp Metastasis 2010, 27(7):493-503.
17. Puspa Raj Pandey P.R., Saidou J., Watabe K. Role of myoepithelial cells in breast tumor progression. Front Biosci 2011, 15:226-236.
18. Man Y.G., Harley R., Mason J., Gardner W.A. Contributions of leukocytes to tumor invasion and metastasis: the "piggy-back" hypothesis. Cancer Epidemiol 2010, 34(1):3-6.
19. Man Y.G., Mason J., Harley R., Kim Y.H., Zhu K.M., Gardner W.A. Leukocyte-facilitated tumor dissemination: a novel model for tumor cell dissociation and metastasis. J Cell Biochem 2011, 112(4):1154-1167.
20. Boon T., Coulie P.G., Van den Eynde B. Tumor antigens recognized by T cells. Immunol Today 1997, 18:267-268.
21. Baxevanis C.N., Dedoussis G.V., Papadopoulos N.G., Missitzis I., Stathopoulos G.P., Papamichail M. Tumor specific cytolysis by tumor infiltrating lymphocytes in breast cancer. Cancer 1994, 74:1275-1282.
22. van der Bruggen P., Traversari C., Chomez P., Lurquin C., De Plaen E., Van den Eynde B.J., et al. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 1991, 254:1643-1647.
23. Pentheroudakis G., Briasoulis E., Pavlidis N. Cancer of unknown primary site: missing primary or missing biology?. Oncologist 2007, 12(4):418-425.
24. Vignery A. Macrophage fusion: are somatic and cancer cells possible partners?. Trends Cell Biol 2006, 15(4):188-193.
25. De Baetselier P., Roos E., Brys L., Remets L., Feldman M. Generation of invasive and metastatic variants of a non-metastatic T-cell lymphoma by in vivo fusion with normal host cells. Int J Cancer 1984, 34(5):731-738.
26. Miska E.A. How microRNAs control cell division, differentiation and death. Curr Opin Genet Dev 2005, 15:563-568.
27. Bushati N., Cohen S.M. microRNA functions. Annu Rev Cell Dev Biol 2007, 23:175-205.
28. Valadi H., Ekstrom K., Bossios A., Sjostrand M., Lee J.J., Lotvall J.O. Exosome mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007, 9:654-659.
29. Caby M.P., Lankar D., Vincendeau-Scherrer C., Raposo G., Bonnerot C. Exosomal-like vesicles are present in human blood plasma. Int Immunol 2005, 17:879-887.
30. Yang M., Chen J., Su F., Yu B., Su F., Lin L., et al. Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol Cancer 2011, 10:117-129.
31. Armstrong A.J., Marengo M.S., Oltean S., Kemeny G., Bitting R.L., Turnbull J.D., et al. Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers. Mol Cancer Res 2011, 9(8):997-1007.
32. Feng L.L., Wang X. Targeting Foxp3+ regulatory T cells-related immunosuppression for cancer immuno-therapy. Chin Med J (Engl) 2010, 123(22):3334-3342.
33. Yokokawa J., Cereda V., Remondo C., Gulley J.L., Arlen P.M., Schlom J., et al. Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer. Clin Cancer Res 2008, 14(4):1032-1040.
34. Liu F., Lang R., Zhao J., Zhang X., Pringle G.A., Fan Y., et al. CD8(+) cytotoxic T cell and FOXP3(+) regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes. Breast Cancer Res Treat 2011, 130(2):645-655.
35. Liu M.C., Shields P.G., Warren R.D., Cohen P., Wilkinson M., Ottaviano Y.L., et al. Circulating tumor cells: a useful predictor of treatment efficacy in metastatic breast cancer. J Clin Oncol 2009, 27(31):5153-5159.
36. Matrone M.A., Whipple R.A., Balzer E.M., Martin S.S. Microtentacles tip the balance of cytoskeletal forces in circulating tumor cells. Cancer Res 2010, 70(20):7737-7741.
37. Jeschke U., Mylonas I., Kuhn C., Shabani N., Kunert-Keil C., Schindlbeck C., et al. Expression of E-cadherin in human ductal breast cancer carcinoma in situ, invasive carcinomas, their lymph node metastases, their distant metastases, carcinomas with recurrence and in recurrence. Anticancer Res 2007, 27:1969-1974.