Role of myoepithelial cells in breast tumor progression

Frontiers in Bioscience

Volumn 15, Issue 1, 2010, Pages 226-236

  Pandey, Puspa Raj ^a   Saidou, Jamila ^a   Watabe, Kounosuke ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Basement membrane; DCIS; Matrix metalloproteinases; Myoepithelial cells; Natural tumor suppressors; Review; Tumor microenvironment; Tumor progression

Indexed keywords

CYTOKINE; SIGNAL PEPTIDE;

BIOLOGICAL MODEL; BREAST TUMOR; CANCER INVASION; DISEASE COURSE; EPITHELIUM CELL; FEMALE; HUMAN; MAMMARY GLAND; METABOLISM; PATHOLOGY; REVIEW;

BREAST NEOPLASMS; CYTOKINES; DISEASE PROGRESSION; EPITHELIAL CELLS; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAMMARY GLANDS, HUMAN; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS;

EID: 77951229680     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3617     Document Type: Article

References (68)

1. Adriance M. C, J. L. Inman, O. W. Petersen, M. J. Bissell: Myoepithelial cells: good fences make good neighbors. Breast Cancer Res, 7(5):190-7 (2005). (Pubitemid 41387430)
2. Murrell, T. G. C: The potential for oxytocin (OT) to prevent breast cancer: a hypothesis. Breast Cancer Res. Trea., 35, 225-229 (1995).
3. Deugnier M. A, J. Teulière, M. M. Faraldo, J. P. Thiery and M.A. Glukhova: The importance of being a myoepithelial cell. Breast Cancer Res, 4(6):224-30 (2002). (Pubitemid 35386056)
4. Man Y. G, Q. X. Sang: Significance of focal myoepithelial cell layer disruptions in human breast tumor invasion: a paradigm shift from the "protease-centered" hypothesis. Exp Cell Res, 301(2):103-18 (2004).
5. Clarke C, J. Sandle, S. R. Lakhani: Myoepithelial cells: pathology, cell separation and markers of myoepithelial differentiation. J Mammary Gland Biol Neoplasia, (3):273-80 (2005).
6. O'Hare M. J, M. G. Ormerod, P. Monaghan, E.B. Lane, B.A. Gusterson: Characterization in vitro of luminal and myoepithelial cells isolated from the human mammary gland by cell sorting. Differentiation, 6(3):209-21 (1991).
7. Man Y. G: Focal degeneration of aged or injured myoepithelial cells and the resultant auto-immunoreactions are trigger factors for breast tumor invasion. Med Hypotheses, 69(6):1340-57 (2007).
8. Kolar Z., J. Ehrmann, Jr, G. Turashvili, J. Bouchal, J. Mokry: A novel myoepithelial/progenitor cell marker in the breast? Virchows Arch, 450(5):607-9 (2007). (Pubitemid 46676253)
9. Joshi K, J. A. Smith, N. Perusinghe, P. Monoghan: Cell proliferation in the human mammary epithelium. Differential contribution by epithelial and myoepithelial cells. Am J Pathol, 124(2):199-206 (1986). (Pubitemid 16016635)
10. Polyak K, M. Hu: Do myoepithelial cells hold the key for breast tumor progression? J Mammary Gland Biol Neoplasia, 10(3):231-47 (2005).
11. Barsky S. H, N. J. Karlin: Myoepithelial cells: autocrine and paracrine suppressors of breast cancer progression. J Mammary Gland Biol Neoplasia, 10(3):249-60 (2005).
12. Sternlicht M. D, S. H. Barsky: The myoepithelial defense: a host defense against cancer. Med Hypotheses, 48(1):37-46 (1997). (Pubitemid 27072863)
13. Jones J. L, J. A. Shaw, J. H. Pringle, R. A. Walker: Primary breast myoepithelial cells exert an invasionsuppressor effect on breast cancer cells via paracrine downregulation of MMP expression in fibroblasts and tumour cells. J Pathol, 562-572 (2003). (Pubitemid 38256405)
14. Djonov V, K. Högger, R. Sedlacek, J. Laissue, A. Draeger: MMP-19: cellular localization of a novel metalloproteinase within normal breast tissue and mammary gland tumours, J pathol, 195, 147-155 (2001). (Pubitemid 32899022)
15. Zou Z, A. Anisowicz, M. J. C. Hendrix, A. Thor, M. Neveu, S, Sheng, K, Rafidi, E, Seftor, R Sager: Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science, 263:5 26-9 (1994).
16. Hopkins P. C. R, J. Whisstock: Function of maspin. Science, 265: 1893-4 (1994). (Pubitemid 24324250)
17. Pemberton P. A, D. T. Wong, H. L. Gibson, M. C. Kiefer, P. A. Fitzpatrick, R. Sager, P. J. Barr: The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases: evidence that maspin is not a protease inhibitory serpin. J Biol Chem, 270: 15832-7 (1995).
18. Andreasen P. A, B. Georg, L.R Lund, A. Riccio, S. N. Stacey: Plasminogen activator inhibitors: hormonally regulated serpins. Mol Cell Endocrinol; 68:1-19 (1990). (Pubitemid 20015463)
19. Kataoka H, K. Seguchi, T. Iwamura, T. Moriyama, K. Nabeshima, M. Koono: Reverse-zymographic analysis of protease nexin-II/amyloid b protein precursor of human carcinoma cell lines, with special reference to the grade of differentiation and metastatic phenotype. Int J Cancer, 60:123-8 (1995).
20. Bissell M.J, D. Radisky: Putting tumours in context. Nat Rev Cancer, 1:46-54 (2001). (Pubitemid 33741880)
21. Brew K, D. Dinakarpandian, H. Nagase: Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim Biophys Acta, 1477 (1-2): 267-83 (2000). (Pubitemid 30119906)
22. Williams T. M, F. Medina, I. Badano, R.B. Hazan, J. Hutchinson, W.J. Muller, N.G. Chopra, P. E. Scherer, R.G. Pestell, M. P. Lisanti: Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J Biol Chem, 279(49):51630-46 (2004). (Pubitemid 40017914)
23. Lee S. W, C.L. Reimer, P. Oh, D.B. Campbell, J. E. Schnitzer: Tumor cell growth inhibition by caveolin reexpression in human breast cancer cells. Oncogene, 16(11):1391-7 (1998). (Pubitemid 28151846)
24. Hurlstone A. F, G. Reid, J. R. Reeves, J. Fraser, G. Strathdee, M. Rahilly, E. K. Parkinson, D. M. Black.: Analysis of the Caveolin-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. Oncogene. 11; 18(10):1881-90 (1999). (Pubitemid 29145855)
25. Sloan E. K., K. L. Stanley, R. L. Anderson: Caveolin-1 inhibits breast cancer growth and metastasis Oncogene, 23(47):7893-7 (2004). (Pubitemid 39457039)
26. Stefansson I. M, H. B. Salvesen, L. A. Akslen: Loss of p63 and cytokeratin 5/6 expression is associated with more aggressive tumors in endometrial carcinoma patients. Int J Cancer, 118(5): 1227-33 (2006). (Pubitemid 43185610)
27. Stefansson I.M, H. B. Salvesen, L. A. Akslen: Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer. J Clin Oncol, 22: 1242-52 (2004). (Pubitemid 41079838)
28. Ronnov-Jessen L, O. W. Petersen: A function for filamentous alpha-smooth muscle actin: retardation of motility in fibroblasts. J Cell Biol, 134:67-80 (1996). (Pubitemid 26231521)
29. Okamoto-Inoue M, S. Kamada, G. Kimura, S, Taniguchi: The induction of smooth muscle alpha actin in a transformed rat cell line suppresses malignant properties in vitro and in vivo. Cancer Lett, 142:173-178(1999). (Pubitemid 29304573)
30. Bani D, E. Masini, M. G. Bello, M. Bigazzi, T. B. Sacchi: Relaxin activates the L-arginine-nitric oxide pathway in human breast cancer cells. Cancer Res, 55(22):5272-5 (1995).
31. Zhou Y, H. Sun, D. C. Danila: Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling. Mol Endocrinol, 14:2066-75 (2000).
32. Su G. H, R. Bansal, K.M. Murphy: ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma. Proc Natl Acad Sci, 98:3254-7(2001). (Pubitemid 32220832)
33. Cocolakis E, S. Lemay, S. Ali, J. J. Lebrun: The p38 MAPK pathway is required for cell growth inhibition of human breast cancer cells in response to activin. J Biol Chem, 276:18430-6 (2001).
34. McLachlan E, Q. Shao, H. L.Wang, S. Langlois, W. L. Dale: Connexins act as Tumor Suppressors in Threedimensional Mammary Cell Organoids by Regulating Differentiation and Angiogenesis. Cancer Research, 66 (20), 9886-94 (2006). (Pubitemid 44672040)
35. Xu H. T., Q. C. Li, Y. X. Zhang, Y. Zhao, Y. Liu, Z. Q. Yang, E. H. Wang: Connexin 43 recruits E-cadherin expression and inhibits the malignant behaviour of lung cancer cells. Folia Histochem Cytobiol. 46(3):315-21 (2008).
36. Grossfeld G.D, D. A. Ginsberg, J. P. Stein, B. H. Bochner, D. Esrig, S. Groshen, M. Dunn, P.W. Nichols, C. R. Taylor, D. G. Skinner, R. J. Cote: Thrombospondin-1 expression in bladder cancer: association with p53 alterations, tumor angiogenesis, and tumor progression. J Natl Cancer Inst, 89(3):219-27 (1997). (Pubitemid 27073759)
37. Xiao G, Y. E. Liu, R. Gentz, Q.A. Sang, J. Ni, I. D. Goldberg, Y. E. Shi: Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells. Proc Natl Acad Sci, 96: 3700-5 (1999). (Pubitemid 29168973)
38. Keeling S. L, J. M. Gad, H. M. Cooper. Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis. Oncogene, 15(6):691-700 (1997). (Pubitemid 27389932)
39. Lee J. E, H. J. Kim, J. Y. Bae, S. W. Kim, J. S. Park, H. J. Shin, W. Han, S. W. Kim, K. S. Kang and D. Y. Noh. Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer. BMC Cancer. 3; 5: 154 (2005).
40. Alpaugh M. L, M. C. Lee, M. Nguyen, M. Deato, L. Dishakjian, H. Barsky: Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells. Exp Cell Res. Nov 25; 261(1):150-8 (2000).
41. Liotta L. A, P. S. Steeg, W. G. Stetler-Stevenson: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell, 64(2):327-36 (1991). (Pubitemid 121001258)
42. Gudjonsson T, L. Ronnov-Jessen, R. Villadsen, F. Rank, M.J. Bissell, O. P. William: Normal and tumorderived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. Journal of Cell Science, 115:39-50 (2002). (Pubitemid 34105527)
43. Allinen M, R. Beroukhim, L. Cai, C. Brennan, J. Lahti-Domenici, H. Huang, D. Porter, M. Hu, L. Chin, A. Richardson, S. Schnitt, W. R. Sellers, K. Polyak:. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell, 6(1):17-32 (2004). (Pubitemid 38903159)
44. Nguyen M, M. C. Lee, J. L. Wang, J. S. Tomlinson, Z. M. Shao, M. L. Alpaugh, S. H. Barsky: The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype. Oncogene, 19(31):3449-59 (2000). (Pubitemid 30487442)
45. Rudland P.S: Stem cells and the development of mammary cancers in experimental rats and in humans. Cancer Metastasis Rev, 6(1):55-83(1987).
46. Cornil I, D. Theodorescu, S. Man, M. Herlyn, J. Jambrosic, R. S. Kerbel: Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression. Proc Natl Acad Sci, 88(14):6028-32 (1991). (Pubitemid 21914879)
47. Cutler L. S: The role of extracellular matrix in the morphogenesis and differentiation of salivary glands. Adv Dent Res, 4:27-33 (1990).
48. Schnitt S.J: The transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin. Breast Cancer Res, 27; 11(1):101 (2009).
49. Beckmann M. W, D. Niederacher, H. G. Schnürch, B. A. Gusterson, H. G. Bender: Multistep carcinogenesis of breast cancer and tumour heterogeneity. J Mol Med, 75(6):429-39 (1997). (Pubitemid 27297013)
50. Li F, R. Strange, R. R. Friis, V. Djonov, H. J. Altermatt, S. Saurer, H. Niemann, A. C. Andres: Expression of stromelysin-1 and TIMP-1 in the involuting mammary gland and in early invasive tumors of the mouse. Int J Cancer, 59(4):560-8 (1994). (Pubitemid 24357284)
51. Tobacman J. K: Filament disassembly and loss of mammary myoepithelial cells after exposure to lambdacarrageenan. Cancer Re, 15; 57(14):2823-6 (1997). (Pubitemid 27315019)
52. Sapino A, L. Macrì, L. Tonda, G. Bussolati: Oxytocin enhances myoepithelial cell differentiation and proliferation in the mouse mammary gland. Endocrinology, 133(2):838-42 (1993). (Pubitemid 23238900)
53. Goel A, S. S. Chauhan: Role of proteases in tumor invasion and metastasis. Indian J Exp Biol, 35(6):553-64 (1997). (Pubitemid 127485099)
54. Goldfarb R. H, L. A. Liotta: Proteolytic enzymes in cancer invasion and metastasis. Semin Thromb Hemost, (4):294-307 (1986). (Pubitemid 17184641)
55. Duffy M. J, T. M. Maguire, A. Hill, E. McDermott, N. O'Higgins: Metalloproteinases: role in breast carcinogenesis, invasion and metastasis. Breast Cancer Res.; 2(4):252-7 (2000). (Pubitemid 32223594)
56. Orimo A, R. A. Weinberg: Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle, 1597-1601 (2006). (Pubitemid 44285243)
57. Singer C. F, N. Kronsteiner, E. Marton, M. Kubista, K J. Cullen, K. Hirtenlehner, M. Seifert, E. A. Kubista: MMP-2 and MMP-9 expression in breast cancer-derived human fibroblasts is differentially regulated by stromalepithelial interactions. Breast Cancer Res Treat, 72(1):69- 77 (2002). (Pubitemid 34274316)
58. Yu G. H, S. Sethi, R. S. Cajulis, S. T. Gokaslan, D. Frias-Hidvegi: Benign pairs: A useful discriminating feature in fine needle aspiration of the breast. Acta Cytol, 41: 721-726 (1997). (Pubitemid 27231225)
59. Hijazi Y. M, J. L. Lessard, M. A. Weiss: Use of antiactin and S100 protein antibodies in differentiating benign and malignant sclerosing breast lesions. Surg Pathol, 2: 125-35 (1989).
60. Foschini M.P, F. Scarpellini, A. M. Gown: Differential expression of myoepithelial markers in salivary, sweat and mammary glands. Int J Surg Pathol, 8: 29-37(2000). (Pubitemid 30129566)
61. Wang N. P, B. C. Wan, M. Skelly, M. G. Frid, M. A. Glukhova, V. E. Koteliansky, A.M. Gown: Antibodies to novel myoepithelium-associated proteins distinguish benign lesions and in situ carcinoma from invasive carcinoma of the breast. Appl Immunohistochem, 5: 141- 151 (1997).
62. Kalof A. N, D. Tam, B. Beatty, K. Cooper: Immunostaining patterns of myoepithelial cells in breast lesions: a comparison of CD10 and smooth muscle myosin heavy chain. J Clin Pathol, 57 (6): 625-629 (2004). (Pubitemid 38725765)
63. Masood S, L. Lu, M. Assaf-Munasifi, K. McCaulley: Application of immunostaining for muscle specific actin in detection of myoepithelial cells in breast fine needle aspirates. Diagn Cytopathol, 13: 71-74 (1995).
64. Bofin A. M, S. Lydersen, B.M. Hagmar: Cytological criteria for the diagnosis of intraductal hyperplasia, ductal carcinoma in situ, and invasive carcinoma of the breast. Diagn Cytopathol, 31 (4): 207-15 (2004). (Pubitemid 39314815)
65. Pattari S.K, P. Dey, S. K. Gupta, K. Joshi: Myoepithelial Cells: Any role in aspiration cytology smears of breast tumors? Cytojournal. 5:9 (2008).
66. Rofstad E. K: Microenvironment induced cancer metasrasis. Int J Radiat Biol, 76:589-605 (2000).
67. Cardone R. A, V. Casavola, S. J. Reshkin: The role of disturbed pH dynamics and the Na+/H+ exchanges in metastasis. Nat Rev Cancer, 5:786-77795 (2005).
68. Rofstad E. K, B. Methiesen, K. Kindem, G. Galappathi: Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Can Res, 66:6699-6707 (2006). (Pubitemid 44085627)