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Volumn 12, Issue 4, 2007, Pages 418-425

Cancer of unknown primary site: Missing primary or missing biology?

Author keywords

Cancer; Molecular biology; Unknown primary

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ONCOPROTEIN; STEM CELL FACTOR RECEPTOR;

EID: 34247869752     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.12-4-418     Document Type: Review
Times cited : (119)

References (40)
  • 2
    • 0036024595 scopus 로고    scopus 로고
    • Epidemiology of unknown primary tumours
    • Levi F, Te VC, Erler G et al. Epidemiology of unknown primary tumours. Eur J Cancer 2002;38:1810-1812.
    • (2002) Eur J Cancer , vol.38 , pp. 1810-1812
    • Levi, F.1    Te, V.C.2    Erler, G.3
  • 3
    • 0037294510 scopus 로고    scopus 로고
    • The unknown biology of the unknown primary tumour: A literature review
    • Van de Wouw AJ, Jansen RL, Speel EJ et al. The unknown biology of the unknown primary tumour: A literature review. Ann Oncol 2003;14:191-196.
    • (2003) Ann Oncol , vol.14 , pp. 191-196
    • Van de Wouw, A.J.1    Jansen, R.L.2    Speel, E.J.3
  • 4
    • 0037905503 scopus 로고    scopus 로고
    • Diagnostic and therapeutic management of cancer of an unknown primary
    • Pavlidis N, Briasoulis E, Hainsworth J et al. Diagnostic and therapeutic management of cancer of an unknown primary. Eur J Cancer 2003;39:1990-2005.
    • (2003) Eur J Cancer , vol.39 , pp. 1990-2005
    • Pavlidis, N.1    Briasoulis, E.2    Hainsworth, J.3
  • 5
    • 0025744859 scopus 로고
    • Hepatic metastasis of unknown primary site.]
    • French
    • Mousseau M, Schaerer R, Lutz JM et al. [Hepatic metastasis of unknown primary site.] Bull Cancer 1991;78:725-736. French.
    • (1991) Bull Cancer , vol.78 , pp. 725-736
    • Mousseau, M.1    Schaerer, R.2    Lutz, J.M.3
  • 6
    • 27944503024 scopus 로고    scopus 로고
    • FDG PET in patients with cancer of an unknown primary
    • Kolesnikov-Gauthier H, Levy E, Merlet P et al. FDG PET in patients with cancer of an unknown primary. Nucl Med Commun 2005;26:1059-1066.
    • (2005) Nucl Med Commun , vol.26 , pp. 1059-1066
    • Kolesnikov-Gauthier, H.1    Levy, E.2    Merlet, P.3
  • 7
    • 0017336436 scopus 로고
    • Metastatic and histologic presentations in unknown primary cancer
    • Nystrom JS, Weiner JM, Heffelfinger-Juttner J et al. Metastatic and histologic presentations in unknown primary cancer. Semin Oncol 1977;4:53-58.
    • (1977) Semin Oncol , vol.4 , pp. 53-58
    • Nystrom, J.S.1    Weiner, J.M.2    Heffelfinger-Juttner, J.3
  • 8
    • 0023753946 scopus 로고
    • Early metastatic cancer of unknown primary origin at presentation. A clinical study of 302 consecutive autopsied patients
    • Le Chevalier T, Cvitkovic E, Caille P et al. Early metastatic cancer of unknown primary origin at presentation. A clinical study of 302 consecutive autopsied patients. Arch Intern Med 1988;148:2035-2039.
    • (1988) Arch Intern Med , vol.148 , pp. 2035-2039
    • Le Chevalier, T.1    Cvitkovic, E.2    Caille, P.3
  • 9
    • 17144371296 scopus 로고    scopus 로고
    • Chemotherapy for patients with two favourable subsets of unknown primary carcinoma: Active, but how effective?
    • Pentheroudakis G, Briasoulis E, Karavasilis V et al. Chemotherapy for patients with two favourable subsets of unknown primary carcinoma: Active, but how effective? Acta Oncol 2005;44:155-160.
    • (2005) Acta Oncol , vol.44 , pp. 155-160
    • Pentheroudakis, G.1    Briasoulis, E.2    Karavasilis, V.3
  • 10
    • 0035524309 scopus 로고    scopus 로고
    • Chromosome segregation and cancer: Cutting through the mystery
    • Jallepalli PV, Lengauer C. Chromosome segregation and cancer: Cutting through the mystery. Nat Rev Cancer 2001;1:109-117.
    • (2001) Nat Rev Cancer , vol.1 , pp. 109-117
    • Jallepalli, P.V.1    Lengauer, C.2
  • 11
    • 0021927525 scopus 로고
    • Metastatic adenocarcinoma of unknown primary site: Abnormalities of cellular DNA content and survival
    • Hedley DW, Leary JA, Kirsten F. Metastatic adenocarcinoma of unknown primary site: Abnormalities of cellular DNA content and survival. Eur J Cancer Clin Oncol 1985;21:185-189.
    • (1985) Eur J Cancer Clin Oncol , vol.21 , pp. 185-189
    • Hedley, D.W.1    Leary, J.A.2    Kirsten, F.3
  • 12
  • 13
    • 0026417760 scopus 로고
    • Genetic analysis as an aid in diagnosis for patients with midline carcinomas of uncertain histologies
    • Motzer RJ, Rodriguez E, Reuter VE et al. Genetic analysis as an aid in diagnosis for patients with midline carcinomas of uncertain histologies. J Natl Cancer Inst 1991;83:341-346.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 341-346
    • Motzer, R.J.1    Rodriguez, E.2    Reuter, V.E.3
  • 14
    • 0036143687 scopus 로고    scopus 로고
    • Automated screening for genomic imbalances using matrix-based comparative genomic hybridization
    • Wessendorf S, Fritz B, Wrobel G et al. Automated screening for genomic imbalances using matrix-based comparative genomic hybridization. Lab Invest 2002;82:47-60.
    • (2002) Lab Invest , vol.82 , pp. 47-60
    • Wessendorf, S.1    Fritz, B.2    Wrobel, G.3
  • 15
    • 0029549980 scopus 로고
    • Overexpression of C-myc, Ras and C-erbB-2 oncoproteins in carcinoma of unknown primary origin
    • Pavlidis N, Briasoulis E, Bai M et al. Overexpression of C-myc, Ras and C-erbB-2 oncoproteins in carcinoma of unknown primary origin. Anticancer Res 1995;15:2563-2567.
    • (1995) Anticancer Res , vol.15 , pp. 2563-2567
    • Pavlidis, N.1    Briasoulis, E.2    Bai, M.3
  • 16
    • 0033966154 scopus 로고    scopus 로고
    • Overexpression of Her-2 in patients with poorly differentiated carcinoma or poorly differentiated adenocarcinoma of unknown primary site
    • Hainsworth JD, Lennington WJ, Greco FA. Overexpression of Her-2 in patients with poorly differentiated carcinoma or poorly differentiated adenocarcinoma of unknown primary site. J Clin Oncol 2000;18:632-635.
    • (2000) J Clin Oncol , vol.18 , pp. 632-635
    • Hainsworth, J.D.1    Lennington, W.J.2    Greco, F.A.3
  • 17
    • 31644447830 scopus 로고    scopus 로고
    • Carcinoma of unknown primary (CUP): Are the tyrosine kinase receptors HER-2, EGF-R, and c-Kit suitable targets for therapy?
    • Fizazi K, Voigt JJ, Lesimple T et al. Carcinoma of unknown primary (CUP): Are the tyrosine kinase receptors HER-2, EGF-R, and c-Kit suitable targets for therapy? Proc Am Soc Clin Oncol 2003;22:3549.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 3549
    • Fizazi, K.1    Voigt, J.J.2    Lesimple, T.3
  • 18
    • 33750467066 scopus 로고    scopus 로고
    • Overexpression and prevalence of molecular markers in patients with cancer of unknown primary (CUP)
    • Rashid A, Hess KR, Lenzi R et al. Overexpression and prevalence of molecular markers in patients with cancer of unknown primary (CUP). Proc Am Soc Clin Oncol 2005;24:9683.
    • (2005) Proc Am Soc Clin Oncol , vol.24 , pp. 9683
    • Rashid, A.1    Hess, K.R.2    Lenzi, R.3
  • 19
    • 17844372539 scopus 로고    scopus 로고
    • Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
    • Baselga J, Arteaga CL. Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol 2005;23:2445-2459.
    • (2005) J Clin Oncol , vol.23 , pp. 2445-2459
    • Baselga, J.1    Arteaga, C.L.2
  • 20
    • 33750483145 scopus 로고    scopus 로고
    • EGFR and C-KIT/CD117 gene mutational screening and oncoprotein expression in patients with cancer of unknown primary: Implications for molecular pathophysiology and therapy
    • Dova L, Georgiou I, Vartholomatos G et al. EGFR and C-KIT/CD117 gene mutational screening and oncoprotein expression in patients with cancer of unknown primary: Implications for molecular pathophysiology and therapy. Eur J Cancer 2005;3:424.
    • (2005) Eur J Cancer , vol.3 , pp. 424
    • Dova, L.1    Georgiou, I.2    Vartholomatos, G.3
  • 21
    • 12144291080 scopus 로고    scopus 로고
    • Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group
    • Debiec-Rychter M, Dumez H, Judson I et al. Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer 2004;40:689-695.
    • (2004) Eur J Cancer , vol.40 , pp. 689-695
    • Debiec-Rychter, M.1    Dumez, H.2    Judson, I.3
  • 22
    • 0031927260 scopus 로고    scopus 로고
    • Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: Biological and clinical implications. A Hellenic Cooperative Oncology Group study
    • Briasoulis E, Tsokos M, Fountzilas G et al. Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: Biological and clinical implications. A Hellenic Cooperative Oncology Group study. Anticancer Res 1998;18:1907-1914.
    • (1998) Anticancer Res , vol.18 , pp. 1907-1914
    • Briasoulis, E.1    Tsokos, M.2    Fountzilas, G.3
  • 24
    • 1442350528 scopus 로고    scopus 로고
    • Clinical and immuno-histochemical analysis of patients with unknown primary tumour. A search for prognostic factors in UPT
    • Van de Wouw AJ, Jansen RL, Griffioen AW et al. Clinical and immuno-histochemical analysis of patients with unknown primary tumour. A search for prognostic factors in UPT. Anticancer Res 2004;24:297-301.
    • (2004) Anticancer Res , vol.24 , pp. 297-301
    • Van de Wouw, A.J.1    Jansen, R.L.2    Griffioen, A.W.3
  • 25
    • 0027331870 scopus 로고
    • p53 gene mutation spectrum in human unknown primary tumors
    • Bar-Eli M, Abbruzzese JL, Lee-Jackson D et al. p53 gene mutation spectrum in human unknown primary tumors. Anticancer Res 1993;13:1619-1623.
    • (1993) Anticancer Res , vol.13 , pp. 1619-1623
    • Bar-Eli, M.1    Abbruzzese, J.L.2    Lee-Jackson, D.3
  • 27
    • 0034329595 scopus 로고    scopus 로고
    • Metastasis-suppressor genes: A review and perspective on an emerging field
    • Yoshida BA, Sokoloff MM, Welch DR et al. Metastasis-suppressor genes: A review and perspective on an emerging field. J Natl Cancer Inst 2000;92:1717-1730.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1717-1730
    • Yoshida, B.A.1    Sokoloff, M.M.2    Welch, D.R.3
  • 28
    • 28544441746 scopus 로고    scopus 로고
    • Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: Apotential mechanism for the metastasis suppressor activity of kisspeptins
    • Navenot JM, Wang Z, Chopin M et al. Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: Apotential mechanism for the metastasis suppressor activity of kisspeptins. Cancer Res 2005;65:10450-10456.
    • (2005) Cancer Res , vol.65 , pp. 10450-10456
    • Navenot, J.M.1    Wang, Z.2    Chopin, M.3
  • 29
    • 34247878427 scopus 로고    scopus 로고
    • The metastatic potential of cancer of unknown primary is independent of the KiSS-1 metastasis-suppressor gene: A study of 50 patients. Forum of Clinical
    • Abstract EA23
    • Dova L, Golfinopoulos V, Pentheroudakis G et al. The metastatic potential of cancer of unknown primary is independent of the KiSS-1 metastasis-suppressor gene: A study of 50 patients. Forum of Clinical Oncology 2006;1:Abstract EA23.
    • (2006) Oncology , pp. 1
    • Dova, L.1    Golfinopoulos, V.2    Pentheroudakis, G.3
  • 30
    • 0036734425 scopus 로고    scopus 로고
    • Do metastatic tumours from an unknown primary reflect angiogenic incompetence of the tumour at the primary site? - a hypothesis
    • Naresh KN. Do metastatic tumours from an unknown primary reflect angiogenic incompetence of the tumour at the primary site? - a hypothesis. Med Hypotheses 2002;59:357-360.
    • (2002) Med Hypotheses , vol.59 , pp. 357-360
    • Naresh, K.N.1
  • 32
    • 24044517760 scopus 로고    scopus 로고
    • Angiogenesis in cancer of unknown primary: Clinicopathological study of CD34, VEGF and TSP-1
    • Karavasilis V, Malamou-Mitsi V, Briasoulis E et al. Angiogenesis in cancer of unknown primary: Clinicopathological study of CD34, VEGF and TSP-1. BMC Cancer 2005;5:25-32.
    • (2005) BMC Cancer , vol.5 , pp. 25-32
    • Karavasilis, V.1    Malamou-Mitsi, V.2    Briasoulis, E.3
  • 33
    • 27644562255 scopus 로고    scopus 로고
    • Matrix metalloproteinases in carcinoma of unknown primary
    • Karavasilis V, Malamou-Mitsi V, Briasoulis E et al. Matrix metalloproteinases in carcinoma of unknown primary. Cancer 2005;104:2282-2287.
    • (2005) Cancer , vol.104 , pp. 2282-2287
    • Karavasilis, V.1    Malamou-Mitsi, V.2    Briasoulis, E.3
  • 34
    • 0036827845 scopus 로고    scopus 로고
    • Identification from public data of molecular markers of adenocarcinoma characteristic of the site of origin
    • Dennis JL, Vass JK, Wit EC et al. Identification from public data of molecular markers of adenocarcinoma characteristic of the site of origin. Cancer Res 2002;62:5999-6005.
    • (2002) Cancer Res , vol.62 , pp. 5999-6005
    • Dennis, J.L.1    Vass, J.K.2    Wit, E.C.3
  • 35
    • 0035887459 scopus 로고    scopus 로고
    • Molecular classification of human carcinomas by use of gene expression signatures
    • Su AI, Welsh JB, Sapinoso LM et al. Molecular classification of human carcinomas by use of gene expression signatures. Cancer Res 2001;61:7388-7393.
    • (2001) Cancer Res , vol.61 , pp. 7388-7393
    • Su, A.I.1    Welsh, J.B.2    Sapinoso, L.M.3
  • 36
    • 1542574379 scopus 로고    scopus 로고
    • Multi-platform, multi-site, microarray-based human tumor classification
    • Bloom G, Yang IV, Boulware D et al. Multi-platform, multi-site, microarray-based human tumor classification. Am J Pathol 2004;164:9-16.
    • (2004) Am J Pathol , vol.164 , pp. 9-16
    • Bloom, G.1    Yang, I.V.2    Boulware, D.3
  • 37
    • 20144377712 scopus 로고    scopus 로고
    • An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin
    • Tothill RW, Kowalczyk A, Rischin D et al. An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin. Cancer Res 2005;65:4031-4040.
    • (2005) Cancer Res , vol.65 , pp. 4031-4040
    • Tothill, R.W.1    Kowalczyk, A.2    Rischin, D.3
  • 38
    • 21044444707 scopus 로고    scopus 로고
    • Markers of adenocarcinoma characteristic of the site of origin: Development of a diagnostic algorithm
    • Dennis JL, Hvidsten TR, Wit EC et al. Markers of adenocarcinoma characteristic of the site of origin: Development of a diagnostic algorithm. Clin Cancer Res 2005;11:3766 -3772.
    • (2005) Clin Cancer Res , vol.11 , pp. 3766-3772
    • Dennis, J.L.1    Hvidsten, T.R.2    Wit, E.C.3
  • 39
    • 0347201147 scopus 로고    scopus 로고
    • Multiclass cancer diagnosis using tumor gene expression signatures
    • Ramaswamy S, Tamayo P, Rifkin R et al. Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A 2001;98:15149-15154.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 15149-15154
    • Ramaswamy, S.1    Tamayo, P.2    Rifkin, R.3
  • 40
    • 33645779944 scopus 로고    scopus 로고
    • Molecular classification of human cancers using a 92-gene real-time quantitative polymerase chain reaction assay
    • Ma XJ, Patel R, Wang X et al. Molecular classification of human cancers using a 92-gene real-time quantitative polymerase chain reaction assay. Arch Pathol Lab Med 2006;130:465-473.
    • (2006) Arch Pathol Lab Med , vol.130 , pp. 465-473
    • Ma, X.J.1    Patel, R.2    Wang, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.