Synthesis of Novel Nalidixic Acid-Based 1,3,4-Thiadiazole and 1,3,4-Oxadiazole Derivatives as Potent Antibacterial Agents

Chemical Biology and Drug Design

Volumn 79, Issue 4, 2012, Pages 384-397

  Aggarwal, Nisha ^a,b   Kumar, Rajesh ^a   Dureja, Prem ^a   Khurana, Jitender Mohan ^b  

^a INDIAN AGRICULTURAL RESEARCH INSTITUTE   (India)

^b UNIVERSITY OF DELHI   (India)

Author keywords

1; 3; 4 oxadiazole; 4 thiadiazole; Antibacterial activity; Mannich bases; Nalidixic acid

Indexed keywords

1 ETHYL 3 (5 ETHYLSULFANYL 1,3,4 THIADIAZOL 2 YL) 7 METHYL 1H 1,8 NAPHTHYRIDIN 4 ONE; 1 ETHYL 3 (5 MERCAPTO 1,3,4 THIADIAZOL 2 YL) 7 METHYL 1H 1,8 NAPHTHYRIDIN 4 ONE; 1 ETHYL 3 (5 METHANESULFONYL 1,3,4 THIADIAZOL 2 YL) 7 METHYL 1H 1,8 NAPHTHYRIDIN 4 ONE; 1 ETHYL 7 METHYL 3 (5 METHYLSULFANYL 1,3,4 THIADIAZOL 2 YL) 1H 1,8 NAPHTHYRIDIN 4 ONE; 1 ETHYL 7 METHYL 3 (5 PENTYLSULFANYL 1,3,4 THIADIAZOL 2 YL) 1H 1,8 NAPHTHYRIDIN 4 ONE; 1 ETHYL 7 METHYL 3 (5 PROPYLSULFANYL 1,3,4 THIADIAZOL 2 YL) 1H 1,8 NAPHTHYRIDIN 4 ONE; 1 ETHYL 7 METHYL 3 [5 (PROPANE 1 SULFONYL) 1,3,4 THIADIAZOL 2 YL] 1H 1,8 NAPHTHYRIDIN 4 ONE; 1,2,4 THIADIAZOLE DERIVATIVE; 1,3,4 OXADIAZOLE DERIVATIVE; 3 (5 ALLYLSULFANYL 1,3,4 THIADIAZOL 2 YL) 1 ETHYL 7 METHYL 1H 1,8 NAPHTHYRIDIN 4 ONE; 3 (5 BUTYLSULFANYL 1,3,4 THIADIAZOL 2 YL) 1 ETHYL 7 METHYL 1H 1,8 NAPHTHYRIDIN 4 ONE; 3 (5 ETHANESULFONYL 1,3,4 THIADIAZOL 2 YL) 1 ETHYL 7 METHYL 1H 1,8 NAPHTHYRIDIN 4 ONE; 3 [5 (BUTANE 1 SULFONYL) 1,3,4 THIADIAZOL 2 YL] 1 ETHYL 7 METHYL 1H 1,8 NAPHTHYRIDIN 4 ONE; ANTIBIOTIC AGENT; NALIDIXIC ACID; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ELEMENTAL ANALYSIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INFRARED SPECTROSCOPY; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; KLEBSIELLA PNEUMONIAE; NALIDIXIC ACID; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXAZOLES; PSEUDOMONAS AERUGINOSA; THIADIAZOLES;

BACILLUS SUBTILIS; KLEBSIELLA PNEUMONIAE; NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA; THIA;

EID: 84863413020     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2011.01316.x     Document Type: Article

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