N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: A novel class of potent orally active human NK1 antagonists

Journal of Medicinal Chemistry

Volumn 39, Issue 15, 1996, Pages 2907-2914

  Ladduwahetty, T ^a   Baker, R ^a   Cascieri, M A ^b   Chambers, M S ^a   Haworth, K ^a   Keown, L E ^a   MacIntyre, D E ^b   Metzger, J M ^b   Owen, S ^a   Rycroft, W ^a   Sadowski, S ^b   Seward, E M ^a   Shepheard, S L ^a   Swain, C J ^a   Tattersall, F D ^a   Watt, A P ^a   Williamson, D W ^a   Hargreaves, R J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [[3 [3,5 BIS(TRIFLUOROMETHYL)BENZYLOXY] 2 PHENYL 1 PIPERIDINYL]METHYL] 1,2 DIHYDRO 3H 1,2,4 TRIAZOL 3 ONE; CALCIUM CHANNEL; ETHER DERIVATIVE; NEUROKININ 1 RECEPTOR ANTAGONIST; PIPERIDINE DERIVATIVE; SUBSTANCE P ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG BIOAVAILABILITY; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LIVER MICROSOME; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RECEPTOR AFFINITY;

ANIMALS; BIOLOGICAL AVAILABILITY; DRUG STABILITY; FERRETS; GUINEA PIGS; HUMANS; INFLAMMATION; MACACA MULATTA; MALE; MICROSOMES, LIVER; MIGRAINE DISORDERS; PIPERIDINES; RATS; RECEPTORS, NEUROKININ-1; TRIAZOLES; VOMITING;

EID: 8944260413     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9506534     Document Type: Article

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