G-protein and signalling in pituitary tumours

Hormone Research

Volumn 71, Issue SUPPL. 2, 2009, Pages 95-100

  Lania, Andrea ^a   Spada, Anna ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

1 regulatory subunit of protein kinase A; Cyclic adenosine monophosphate; Gsp oncogene; Phosphodiesterases; PKA regulatory subunit

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GROWTH HORMONE; GUANINE NUCLEOTIDE BINDING PROTEIN;

CARCINOGENESIS; CARNEY COMPLEX; CONFERENCE PAPER; G PROTEIN GENE; GENE MUTATION; GENOME IMPRINTING; GROWTH HORMONE SECRETING CELL; HORMONE RELEASE; HUMAN; HYPOPHYSIS TUMOR; IN VITRO STUDY; NONHUMAN; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; CELL PROLIFERATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIALPHA SUBUNIT; GROWTH HORMONE-SECRETING PITUITARY ADENOMA; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; MUTATION; PROTO-ONCOGENE PROTEINS; SYNDROME;

EID: 66749123499     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000192446     Document Type: Conference Paper

References (38)

1. Lania A, Mantovani G, Spada A: G protein mutations in endocrine diseases. Eur J Endocrinol 2001; 145:543-559.
2. Asa SL, Ezzat S: The pathogenesis of pituitary tumours. Nat Rev Cancer 2002;2:836-849.
3. Herman V, Fagin J, Gonsky R, Kovacs K, Melmed S: Clonal origin of pituitary adenomas. J Clin Endocrinol Metab 1990;71:1427-1433.
4. Vallar L, Spada A, Giannattasio G: Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature 1987;330:566-567.
5. Landis C, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L: GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 1989;340:692-696.
6. Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E, Spiegel AM: Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Engl J Med 1991;325:1688-1695.
7. Ham J, Ivan M, Wynford-Thomas D, Scan-Ion MF: GH3 expressing constitutively active Gs alpha (Q227L) show enhanced hormone secretion and proliferation. Mol Cell Endocrinol 1997;127:41-47.
8. Zachary I, Masters SB, Bourne HR: Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gsa. Biochem Biophys Res Commun 1990; 168:1184-1193.
9. Spada A, Arosio M, Bochicchio D, Bazzoni N, Vallar L, Bassetti M, Faglia G: Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase. J Clin Endocrinol Metab 1990;71:1421-1426.
10. Barlier A, Gunz G, Zamora AJ, Morange-Ramos I, Figarella-Branger D, Dufour H, Enjalbert A, Jaquet P: Prognostic and therapeutic consequences of Gs alpha mutations in somatotroph adenomas. J Clin Endocrinol Metab 1998;83:1604-1610.
11. Patel YC, Greenwood M, Kent G, Panetta R, Skribant CB: Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation. Biochem Biophys Res Commun 1993;192:288-294.
12. Barlier A, Pellegrini-Bouiller I, Gunz G, Zamora AJ, Jaquet F, Enjalbert A: Impact of gsp oncogene on the expression of genes coding for Gsα, Pit-1, Gi2α, and somatostatin receptor 2 in human somatotroph adenomas: involvement in octreotide sensitivity. J Clin Endocrinol Metab 1999;84:2759-2765.
13. Corbetta S, Ballare E, Mantovani G, Lania A, Losa M, Di Blasio AM, Spada A: Somatostatin receptor subtype 2 and 5 in human GH-secreting pituitary adenomas: analysis of gene sequence and mRNA expression. Eur J Clin Invest 2001;31:208-214.
14. Lania A, Persani L, Ballaré E, Mantovani S, Losa M, Spada A: Constitutively active Gs alpha is associated with an increased phosphodiesterase activity in human growth hormone secreting adenomas. J Clin Endocrinol Metab 1998;83:1624-1628.
15. Persani L, Borgato S, Lania A, Filopanti M, Mantovani G, Conti M, Spada A: Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations. J Clin Endocrinol Metab 2001;86: 3795-3800.
16. Ballare E, Mantovani S, Lania A, Di Blasio AM, Vallar L, Spada A: Activating mutations of the Gs alpha gene are associated with low levels of Gs alpha protein in growth hormone-secreting tumors. J Clin Endocrinol Metab 1998;83:4386-4390.
17. Yu S, Yu D, Lee E, Eckhaus M, Lee R, Corria Z, Accili D, Westphal H, Weinstein LS: Variable and tissue-specific hormone resistance in heterotrimeric Gs protein α-subunit (Gsα) knockout mice is due to tissue-specific imprinting of the Gsα gene. Proc Natl Acad Sci USA 1998;95:8715-8720.
18. Hayward BE, Kamiya M, Strain L, Moran V, Campbell R, Hayashizaki Y, Bonthron DT: The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins. Proc Natl Acad Sci USA 1998;95:10038-10043.
19. Weinstein LS, Liu J, Sakamoto A, Xie T, Chen M: Minireview: GNAS: normal and abnormal functions. Endocrinology 2004; 145: 5459-5464.
20. Hayward BE, Barlier A, Korbonits M, Grossman AB, Jacquet P, Enjalbert A, Bonthron DT: Imprintingofthe G(s)alpha gene GNASl in the pathogenesis of acromegaly. J Clin Invest 2001; 107:R31-R36.
21. Mantovani G, Ballare E, Giammona E, Beck-Peccoz P, Spada A: The Gsα gene: predominant maternal origin of transcription in human thyroid gland and gonads. J Clin Endocrinol Metab 2002;87:4736-4740.
22. Mantovani G, Bondioni S, Lania AG, Corbetta S, de Sanctis L, Cappa M, Di Battista E, Chanson P, Beck-Peccoz P, Spada A: Parental origin of Gsalpha mutations in the McCune-Albright syndrome and in isolated endocrine tumors. J Clin Endocrinol Metab 2004; 89:3007-3009.
23. Oyesiku NM, Evans CO, Brown MR, Blevins LS, Tindall GT, Parks JS: Pituitary adenomas: screening for Gaq mutations. J Clin Endocrinol Metab 1997;82:4184-4188.
24. Shen Y, Mamers P, Jobling T, Burger GH, Fuller PJ: Absence of the previously reported G protein oncogene (gip2) in ovarian granulosa cell tumors. J Clin Endocrinol Metab 1996;81:4159-4161.
25. Reincke M, Karl M, Travis W, Chrousos GP: No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms. J Clin Endocrinol Metab 1993;77:1419-1422.
26. Williamson EA, Daniels M, Foster S, Kelly WF, Kendall-Taylor P, Harris PE: Gs alpha and Gi alpha mutations in clinically nonfunctioning pituitary tumours. Clin Endocrinol 1994;41:815-820.
27. Dong Q, Brucker-Davis F, Weintraub BD, Smallridge RC, Carr FE, Battey J, Spiegel AM, Shenker A: Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-re-leasing hormone receptor genes. J Clin Endocrinol Metab 1996;81:1134-1140.
28. Petersenn S, Heyens M, Ludecke DK, Beil FU, Schulte HM: Absence of somatostatin receptor type 2 A mutations and gip oncogene in pituitary somatotroph adenomas. Clin Endocrinol (Oxf) 2000;52:35-42.
29. Alvaro V, Levy L, Dubray C, Roche A, Peillon F, Querat B, Joubert D: Invasive human pituitary tumors express a point-mutated alpha-protein kinase C. J Clin Endocrinol Metab 1993;77:1125-1129.
30. Schiemann U, Assert R, Moskopp D, Gellner R, Hengst K, Gullotta F, Domschke W, Pfeiffer A: Analysis of a protein kinase C-a mutation in human pituitary tumours. J Endocrinol 1997;53:131-137.
31. Alvaro V, Prevostel C, Joubert D, Slosberg E, Weinstein BI: Ectopic expression of a mutant form of PKCalpha originally found in human tumors: aberrant subcellular translocation and effects on growth control. Oncogene 1997;14:677-685.
32. Prevostel C, Alvaro V, de Boisvilliers F, Martin A, Jaffiol C, Joubert D: The natural protein kinase C alpha mutant is present in human thyroid neoplasms. Oncogene 1995;11: 669-674.
33. Esapa CT, Harris PE: Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours. Eur J Endocrinol 1999;141:409-412.
34. Casey M, Vaughan CJ, He J, Hatcher CJ, Winter JM, Weremowicz S, Montgomery K, Kucherlapati R, Morton CC, Basson CT: Mutations in the protein kinase A Rlalpha regulatory subunit cause familial cardiac myxomas and Carney complex. J Clin Invest 2000; 106:R31-R38.
35. Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS, Cho-Chung YS, Stratakis CA: Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Nat Genet 2000;26:89-92.
36. Sandrini F, Kirschner LS, Bei T, Farmakidis C, Yasufuku-Takano J, Takano K, Prezant TR, Marx SJ, Farrell WE, Clayton RN, Groussin L, Bertherat J, Stratakis CA: PRKA-R1A, one of the Carney complex genes, and its locus (17q22-24) are rarely altered in pituitary tumours outside the Carney complex. J Med Genet 2002;39:e78.
37. Kaltsas GA, Kola B, Borboli N, Morris DG, Gueorguiev M, Swords FM, Czirjak S, Kirschner LS, Stratakis CA, Korbonits M, Grossman AB: Sequence analysis of the PRKAR1A gene in sporadic somatotroph and other pituitary tumours. Clin Endocrinol (Oxf) 2002;57:443-448.
38. Lania AG, Mantovani G, Ferrero S, Pellegrini C, Bondioni S, Peverelli E, Braidotti P, Locatelli M, Zavanone ML, Ferrante E, Bosari S, Beck-Peccoz P, Spada A: Proliferation of transformed somatotroph cells related to low or absent expression of protein kinase a regulatory subunit 1A protein. Cancer Res 2004; 64:9193-9198.