Migfilin regulates esophageal cancer cell motility through promoting GSK-3β-mediated degradation of β-catenin

Molecular Cancer Research

Volumn 10, Issue 3, 2012, Pages 273-281

  He, Huan ^a   Ding, Fang ^a   Li, Yi ^a   Luo, Aiping ^a   Chen, Hongyan ^a   Wu, Chuanyue ^b   Liu, Zhihua ^a  

^a CANCER HOSPITAL   (China)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; MIGFILIN; SERINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ZYXIN;

ARTICLE; CANCER INHIBITION; CELL INVASION; CELL MOTILITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

BETA CATENIN; CARCINOMA, SQUAMOUS CELL; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL MOVEMENT; CYTOSKELETAL PROTEINS; ESOPHAGEAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEOLYSIS; TRANSCRIPTION, GENETIC;

EID: 84863391161     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-11-0419     Document Type: Article

References (42)

1. Gupta GP, Massague J. Cancer metastasis: building a framework. Cell 2006;127:679-95. (Pubitemid 44781029)
2. Huber O, Bierkamp C, Kemler R. Cadherins and catenins in development. Curr Opin Cell Biol 1996;8:685-91. (Pubitemid 26381726)
3. Polakis P. Wnt signaling and cancer. Genes Dev 2000;14:1837-51. (Pubitemid 30639518)
4. Ben-Ze'ev A, Geiger B. Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer. Curr Opin Cell Biol 1998;10:629-39. (Pubitemid 28477022)
5. Kikuchi A. Roles of Axin in the Wnt signalling pathway. Cell Signal 1999;11:777-88. (Pubitemid 29507486)
6. Orford K, Crockett C, Jensen JP, Weissman AM, Byers SW. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J Biol Chem 1997;272:24735-8. (Pubitemid 27415637)
7. Desbois-Mouthon C, Cadoret A, Blivet-Van Eggelpoel MJ, Bertrand F, Cherqui G, Perret C, et al. Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation. Oncogene 2001;20:252-9. (Pubitemid 32150270)
8. Wang H, Zhou H, Zou Y, Liu Q, Guo C, Gao G, et al. Resveratrol modulates angiogenesis through the GSK3beta/beta-catenin/TCF-dependent pathway in human endothelial cells. Biochem Pharmacol 2010;80:1386-95.
9. Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, et al. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem 2007;282:11221-9. (Pubitemid 47100795)
10. Tu Y, Wu S, Shi X, Chen K, Wu C. Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell 2003;113:37-47. (Pubitemid 36411958)
11. Akazawa H, Kudoh S, Mochizuki N, Takekoshi N, Takano H, Nagai T, et al. A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5. J Cell Biol 2004;164:395-405. (Pubitemid 38174767)
12. Gkretsi V, Zhang Y, Tu Y, Chen K, Stolz DB, Yang Y, et al. Physical and functional association of migfilin with cell-cell adhesions. J Cell Sci 2005;118:697-710. (Pubitemid 40372579)
13. Wu C. Migfilin and its binding partners: from cell biology to human diseases. J Cell Sci 2005;118:659-64. (Pubitemid 40372575)
14. Ithychanda SS, Das M, Ma YQ, Ding K, Wang X, Gupta S, et al. Migfilin, a molecular switch in regulation of integrin activation. J Biol Chem 2009;284:4713-22.
15. Lad Y, Jiang P, Ruskamo S, Harburger DS, Ylanne J, Campbell ID, et al. Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. J Biol Chem 2008;283:35154-63.
16. Takafuta T, Saeki M, Fujimoto TT, Fujimura K, Shapiro SS. A new member of the LIM protein family binds to filamin B and localizes at stress fibers. J Biol Chem 2003;278:12175-81. (Pubitemid 36800197)
17. Zhang Y, Tu Y, Gkretsi V, Wu C. Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration. J Biol Chem 2006;281:12397-407. (Pubitemid 43855324)
18. Zhao J, Zhang Y, Ithychanda SS, Tu Y, Chen K, Qin J, et al. Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling. J Biol Chem 2009;284:34308-20.
19. Papachristou DJ, Gkretsi V, Tu Y, Shi X, Chen K, Larjava H, et al. Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma. Histopathology 2007;51:499-508. (Pubitemid 47437823)
20. Labalette C, Renard CA, Neuveut C, Buendia MA, Wei Y. Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin. Mol Cell Biol 2004;24:10689-702. (Pubitemid 39603127)
21. Haraguchi K, Ohsugi M, Abe Y, Semba K, Akiyama T, Yamamoto T. Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. Oncogene 2008;27:274-84.
22. Shimada Y, Imamura M, Wagata T, Yamaguchi N, Tobe T. Characterization of 21 newly established esophageal cancer cell lines. Cancer 1992;69:277-84.
23. Tian Y, Luo A, Cai Y, Su Q, Ding F, Chen H, et al. MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines. J Biol Chem 2010;285:7986-94.
24. Zhang L, Ding F, Cao W, Liu Z, Liu W, Yu Z, et al. Stomatin-like protein 2 is overexpressed in cancer and involved in regulating cell growth and cell adhesion in human esophageal squamous cell carcinoma. Clin Cancer Res 2006;12:1639-46.
25. Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, et al. Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma. Cancer Res 2009;69:3451-7.
26. Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, et al. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 2002;108:837-47. (Pubitemid 34327534)
27. Agarwal A, Das K, Lerner N, Sathe S, Cicek M, Casey G, et al. The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene 2005;24:1021-31. (Pubitemid 40313879)
28. Benelli R, Monteghirfo S, Vene R, Tosetti F, Ferrari N. The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3beta pathway and beta-catenin stability. Mol Cancer 2010;9:142.
29. Robertson BW, Chellaiah MA. Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells. Exp Cell Res 2010;316:1-11.
30. Wang Y, Zhou X, Zhu H, Liu S, Zhou C, Zhang G, et al. Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway. Oncogene 2005;24:6637-45.
31. Crawford HC, Fingleton BM, Rudolph-Owen LA, Goss KJ, Rubinfeld B, Polakis P, et al. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene 1999;18:2883-91. (Pubitemid 29250878)
32. Liu P, Yang J, Pei J, Pei D, Wilson MJ. Regulation of MT1-MMP activity by beta-catenin in MDCK non-cancer and HT1080 cancer cells. J Cell Physiol 2010;225:810-21.
33. Roy LD, Sahraei M, Subramani DB, Besmer D, Nath S, Tinder TL, et al. MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition. Oncogene 2011;30:1449-59.
34. Hart MJ, de los Santos R, Albert IN, Rubinfeld B, Polakis P. Down-regulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Biol 1998;8:573-81. (Pubitemid 28222891)
35. Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, et al. Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 2001;7:927-36. (Pubitemid 32525740)
36. Xiao JH, Ghosn C, Hinchman C, Forbes C, Wang J, Snider N, et al. Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway. J Biol Chem 2003;278:29954-62. (Pubitemid 36962384)
37. Chitalia VC, Foy RL, Bachschmid MM, Zeng L, Panchenko MV, Zhou MI, et al. Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. Nat Cell Biol 2008;10:1208-16.
38. Nastasi T, Bongiovanni A, Campos Y, Mann L, Toy JN, Bostrom J, et al. Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis. Dev Cell 2004;6:269-82. (Pubitemid 38195218)
39. Salic A, Lee E, Mayer L, Kirschner MW. Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol Cell 2000;5:523-32.
40. Song S, Mazurek N, Liu C, Sun Y, Ding QQ, Liu K, et al. Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity. Cancer Res 2009;69:1343-9.
41. Moik DV, Janbandhu VC, Fassler R. Loss of migfilin expression has no overt consequences on murine development and homeostasis. J Cell Sci 2011;124:414-21.
42. Hoffman LM, Nix DA, Benson B, Boot-Hanford R, Gustafsson E, Jamora C, et al. Targeted disruption of the murine zyxin gene. Mol Cell Biol 2003;23:70-9. (Pubitemid 36008502)