Measurement of drug lipophilicity and pK a using acoustics

Analytical Chemistry

Volumn 84, Issue 6, 2012, Pages 2609-2613

  Li, Xin ^a   Cooper, Matthew A ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC DRUGS; ACOUSTIC SENSING; ALKYL ALCOHOLS; BASIC DRUGS; DISTRIBUTION COEFFICIENT; DRUG CANDIDATES; INTERFACIAL LAYER; LIPOPHILICITY; LIPOPHILICITY DETERMINATION; NAPROXENS; PARTITION COEFFICIENT; PH TITRATION; PIEZOELECTRIC ACOUSTIC SENSORS; PLANAR GOLD ELECTRODES;

ALCOHOLS; SELF ASSEMBLED MONOLAYERS;

NATURAL FREQUENCIES;

DRUG; ETHYLENE GLYCOL DERIVATIVE; GOLD; HEXAETHYLENE GLYCOL; LIPID; STEARIC ACID DERIVATIVE;

ACOUSTICS; ARTICLE; CHEMISTRY; ELECTROCHEMICAL ANALYSIS; ELECTRODE; EQUIPMENT DESIGN; INSTRUMENTATION; PH; SURFACE PROPERTY;

ACOUSTICS; ELECTROCHEMICAL TECHNIQUES; ELECTRODES; EQUIPMENT DESIGN; ETHYLENE GLYCOLS; GOLD; HYDROGEN-ION CONCENTRATION; LIPIDS; PHARMACEUTICAL PREPARATIONS; STEARIC ACIDS; SURFACE PROPERTIES;

EID: 84863353676     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac300087z     Document Type: Article

References (26)

1. Leo, A.; Hansch, C.; Elkins, D. Chem. Rev. (Washington, DC, U. S.) 1971, 71, 525616
2. Miyamoto, S.; Kollman, P. A. Proc. Natl. Acad. Sci. U. S. A. 1993, 90, 8402-8406
3. Scherrer, R. A.; Howard, S. M. J. Med. Chem. 1977, 20, 53-58
4. Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feeney, P. J. Adv. Drug Delivery Rev. 1997, 23, 3-25
5. Mirrlees, M. S.; Moulton, S. J.; Murphy, C. T.; Taylor, P. J. J. Med. Chem. 1976, 19, 615-619
6. Minick, D. J.; Frenz, J. H.; Patrick, M. A.; Brent, D. A. J. Med. Chem. 1988, 31, 1923-1933
7. Tomlinson, E. J. Pharm. Sci. 1982, 71, 602-604
8. Faller, B.; Grimm, H. P.; Loeuillet-Ritzler, F.; Arnold, S.; Briand, X. J. Med. Chem. 2005, 48, 2571-2576
9. Menges, R. A.; Armstrong, D. W. Anal. Chim. Acta 1991, 255, 157-162
10. Balogh, G. T.; Szántó, Z.; Forrai, E.; Gyórffy, W.; Lopata, A. J. Pharm. Biomed. Anal. 2005, 39, 1057-1062
11. Casoni, D.; Kot-Wasik, A.; Namiesnik, J. J. Chromatogr., A 2009, 1216, 2456-2465
12. Guillot, A.; Henchoz, Y.; Moccand, C.; Guillarme, D.; Veuthey, J.-L.; Carrupt, P.-A.; Martel, S. Chem. Biodiversity 2009, 6, 1828-1836
13. Pallicer, J. M.; Sales, J.; Rosés, M.; Ràfols, C.; Bosch, E. J. Chromatogr., A 2011, 1218, 6356-6368
14. Benhaim, D.; Grushka, E. J. Chromatogr., A 2008, 1209, 111-119
15. Liu, X.; Tanaka, H.; Yamauchi, A. J. Chromatogr., A 2005, 1091, 51-59
16. Danelian, E.; Karlen, A.; Karlsson, R.; Winiwarter, S.; Hansson, A.; Lofas, S.; Lennernas, H.; Hamalainen, M. D. J. Med. Chem. 2000, 43, 2083-2086
17. Okahata, Y.; Ye, X.; Shimizu, A.; Ebato, H. Thin Solid Films 1989, 180, 51-59
18. Okahata, Y.; Ebato, H. TrAC, Trends Anal. Chem. 1992, 11, 344-354
19. Okahata, Y.; Ebato, H. Anal. Chem. 1991, 63, 203-207
20. Wink, T.; vanZuilen, S. J.; Bult, A.; vanBennekom, W. P. Analyst 1997, 122, R43-R50
21. Cooper, M. A. Drug Discovery Today 2006, 11, 1068-1074
22. Godber, B.; Thompson, K. S. J.; Rehak, M.; Uludag, Y.; Kelling, S.; Sleptsov, A.; Frogley, M.; Wiehler, K.; Whalen, C.; Cooper, M. A. Clin. Chem. (Washington, DC, U. S.) 2005, 51, 1962-1972
23. Li, X.; Abell, C.; Cooper, M. A. Colloids Surf., B 2008, 61, 113-117
24. Li, X.; Thompson, K. S. J.; Godber, B.; Cooper, M. A. Assay Drug Dev. Technol. 2006, 4, 565-573
25. Huang, L.; Cooper, M. A. Clin. Chem. (Washington, DC, U. S.) 2006, 52, 2148-2151
26. Sauerbrey, G. Z. Phys. 1959, 155, 206-212