Topical vitamin D 3 analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions

British Journal of Dermatology

Volumn 167, Issue 1, 2012, Pages 77-84

  Sato Deguchi, E ^a   Imafuku, Shinichi ^a   Chou, B ^a   Ishii, K ^a   Hiromatsu, K ^a   Nakayama, J ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

22 OXACALCITRIOL; CALCIPOTRIOL; CATHELICIDIN; CHEMOKINE RECEPTOR CCR4; COLECALCIFEROL DERIVATIVE; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 23P40; STEROID; TACALCITOL; THYMIC STROMAL LYMPHOPOIETIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; PSORIATIC LESION; PUNCH BIOPSY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BIOPSY; STEROID THERAPY;

ADMINISTRATION, CUTANEOUS; ADULT; AGED; ANTIMICROBIAL CATIONIC PEPTIDES; BLOTTING, WESTERN; CALCITRIOL; CHOLECALCIFEROL; CYTOKINES; DERMATOLOGIC AGENTS; DIHYDROXYCHOLECALCIFEROLS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INTERLEUKINS; MALE; MIDDLE AGED; PSORIASIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863332794     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2012.10917.x     Document Type: Article

References (49)

1. Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med 2009; 361:496-509.
2. Tonel G, Conrad C, Laggner U et al. Cutting edge: a critical functional role for IL-23 in psoriasis. J Immunol 2010; 185:5688-91.
3. Papp KA, Langley RG, Lebwohl M et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 2008; 371:1675-84. (Pubitemid 351671884)
4. Chaudhari U, Romano P, Mulcahy LD et al. Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial. Lancet 2001; 357:1842-7. (Pubitemid 32539117)
5. Reich K, Nestle FO, Papp K et al. Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, double-blind trial. Lancet 2005; 366:1367-74. (Pubitemid 41443403)
6. Frohm M, Agerberth B, Ahangari G et al. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 1997; 272:15258-63. (Pubitemid 27255544)
7. Dubertret L, Wallach D, Souteyrand P et al. Efficacy and safety of calcipotriol (MC 903) ointment in psoriasis vulgaris. A randomized, double-blind, right/left comparative, vehicle-controlled study. J Am Acad Dermatol 1992; 27:983-8.
8. 3) on cutaneous inflammation, epidermal proliferation and keratinization in psoriasis: a placebo-controlled, double-blind study. Br J Dermatol 1994; 131:57-63.
9. Barker JN, Ashton RE, Marks R et al. Topical maxacalcitol for the treatment of psoriasis vulgaris: a placebo-controlled, double-blind, dose-finding study with active comparator. Br J Dermatol 1999; 141:274-8. (Pubitemid 29397995)
10. Christakos S, Raval-Pandya M, Wernyj RP et al. Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3. Biochem J 1996; 316:361-71. (Pubitemid 26182127)
11. Malloy PJ, Feldman D. Vitamin D resistance. Am J Med 1999; 106:355-70. (Pubitemid 29153415)
12. Binderup L, Bramm E. Effects of a novel vitamin D analogue MC903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochem Pharmacol 1988; 37:889-95. (Pubitemid 18058461)
13. 3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol Toxicol 1993; 72:240-4.
14. Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J 2005; 19:1067-77. (Pubitemid 40946432)
15. 3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 2004; 173:2909-12.
16. 3 exerts opposing effects to IL-4 on MHC class-II antigen expression, accessory activity, and phagocytosis of human monocytes. Scand J Immunol 1993; 38:535-40.
17. 3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe 2009; 6:231-43.
18. Ong PY, Ohtake T, Brandt C et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 2002; 347:1151-60.
19. Lande R, Gregorio J, Facchinetti V et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 2007; 449:564-9. (Pubitemid 47525141)
20. Ganguly D, Chamilos G, Lande R et al. Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med 2009; 206:1983-94.
21. Dombrowski Y, Peric M, Koglin S et al. Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions. Sci Transl Med 2011; 3:82ra38.
22. Reche PA, Soumelis V, Gorman DM et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol 2001; 167:336-43. (Pubitemid 32567797)
23. Pandey A, Ozaki K, Baumann H et al. Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Nat Immunol 2000; 1:59-64.
24. Soumelis V, Reche PA, Kanzler H et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 2002; 3:673-80. (Pubitemid 34752477)
25. Tamaki K, Kakinuma T, Saeki H et al. Serum levels of CCL17/TARC in various skin diseases. J Dermatol 2006; 33:300-2.
26. Kakinuma T, Nakamura K, Wakugawa M et al. Thymus and activation-regulated chemokine in atopic dermatitis: serum thymus and activation-regulated chemokine level is closely related with disease activity. J Allergy Clin Immunol 2001; 107:535-41. (Pubitemid 32210037)
27. Taylor BC, Zaph C, Troy AE et al. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J Exp Med 2009; 206:655-67.
28. Rimoldi M, Chieppa M, Larghi P et al. Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different. Blood 2005; 106:2818-26. (Pubitemid 41510759)
29. Rimoldi M, Chieppa M, Salucci V et al. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol 2005; 6:507-14. (Pubitemid 41716764)
30. 3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci USA 2006; 103:11736-41.
31. Baeke F, Takiishi T, Korf H et al. Vitamin D: modulator of the immune system. Curr Opin Pharmacol 2010; 10:482-96.
32. Nestle FO, Di Meglio P, Qin JZ et al. Skin immune sentinels in health and disease. Nat Rev Immunol 2009; 9:679-91.
33. Wolk K, Kunz S, Witte E et al. IL-22 increases the innate immunity of tissues. Immunity 2004; 21:241-54. (Pubitemid 39094053)
34. Liang SC, Tan XY, Luxenberg DP et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006; 203:2271-9. (Pubitemid 44498362)
35. Wilson NJ, Boniface K, Chan JR et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007; 8:950-7. (Pubitemid 47300009)
36. 3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes. J Immunol 2008; 181:8504-12.
37. Conrad C, Meller S, Gilliet M. Plasmacytoid dendritic cells in the skin: to sense or not to sense nucleic acids. Semin Immunol 2009; 21:101-9.
38. Hornung V, Ablasser A, Charrel-Dennis M et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009; 458:514-18.
39. Pinheiro da Silva F, Gallo RL, Nizet V. Differing effects of exogenous or endogenous cathelicidin on macrophage toll-like receptor signaling. Immunol Cell Biol 2009; 87:496-500.
40. Guillot X, Semerano L, Saidenberg-Kermanac'h N et al. Vitamin D and inflammation. Joint Bone Spine 2010; 77:552-7.
41. 3has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol 2001; 167:4974-80.
42. 3: preferential inhibition of Th1 functions. J Nutr 1995; 125:S1704-8.
43. Li M, Messaddeq N, Teletin M et al. Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proc Natl Acad Sci USA 2005; 102:14795-800. (Pubitemid 41457135)
44. Vestergaard C, Bang K, Gesser B et al. A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+ lymphocytes into lesional atopic dermatitis skin. J Invest Dermatol 2000; 115:640-6.
45. Horikawa T, Nakayama T, Hikita I et al. IFN-gamma-inducible expression of thymus and activation-regulated chemokine/CCL17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and their roles in atopic dermatitis. Int Immunol 2002; 14:767-73. (Pubitemid 34814637)
46. Morita E, Takahashi H, Niihara H et al. Stratum corneum TARC level is a new indicator of lesional skin inflammation in atopic dermatitis. Allergy 2010; 65:1166-72.
47. 3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 2000; 164:2405-11.
48. 3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J Clin Invest 1998; 101:252-62.
49. Singh TP, Schön MP, Wallbrecht K et al. 8-Methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder. J Immunol 2010; 184:7257-67.