M-opsin protein degradation is inhibited by MG-132 in Rpe65 -/- retinal explant culture

Molecular Vision

Volumn 18, Issue , 2012, Pages 1516-1525

  Sato, Kota ^a   Ozaki, Taku ^a   Ishiguro, Sei Ichi ^a   Nakazawa, Mitsuru ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

9 CIS RETINAL; ALOXISTATIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; M OPSIN; OPSIN; PEPSTATIN; RETINAL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPLANT; GENE; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RETINA; RPE65 GENE;

ANIMALS; CIS-TRANS-ISOMERASES; CONE OPSINS; CYSTEINE PROTEINASE INHIBITORS; EYE; LEUCINE; LEUPEPTINS; LYSOSOMES; MICE; MICE, KNOCKOUT; ORGAN CULTURE TECHNIQUES; PEPSTATINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; REAL-TIME POLYMERASE CHAIN REACTION; RETINALDEHYDE; TRANSCRIPTION, GENETIC;

EID: 84863314504     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Palczewski K. G protein-coupled receptor rhodopsin. Annu Rev Biochem 2006; 75:743-67. [PMID: 16756510]
2. Nathans J. Rhodopsin: structure, function, and genetics. Biochemistry 1992; 31:4923-31. [PMID: 1599916]
3. Travis GH, Golczak M, Moise AR, Palczewski K. Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol 2007; 47:469-512. [PMID: 16968212]
4. Hamel CP, Tsilou E, Pfeffer BA, Hooks JJ, Detrick B, Redmond TM. Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro. J Biol Chem 1993; 268:15751-7. [PMID: 8340400]
5. Jin M, Li S, Moghrabi WN, Sun H, Travis GH. Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Cell 2005; 122:449-59. [PMID: 16096063]
6. Moiseyev G, Chen Y, Takahashi Y, Wu BX, Ma JX. RPE65 is the isomerohydrolase in the retinoid visual cycle. Proc Natl Acad Sci USA 2005; 102:12413-8. [PMID: 16116091]
7. Redmond TM, Yu S, Lee E, Bok D, Hamasaki D, Chen N, Goletz P, Ma JX, Crouch RK, Pfeifer K. Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet 1998; 20:344-51. [PMID: 9843205]
8. Van Hooser JP, Aleman TS, He YG, Cideciyan AV, Kuksa V, Pittler SJ, Stone EM, Jacobson SG, Palczewski K. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci USA 2000; 97:8623-8. [PMID: 10869443]
9. Van Hooser JP, Liang Y, Maeda T, Kuksa V, Jang GF, He YG, Rieke F, Fong HK, Detwiler PB, Palczewski K. Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem 2002; 277:19173-82. [PMID: 11897783]
10. Ablonczy Z, Crouch RK, Goletz PW, Redmond TM, Knapp DR, Ma JX, Rohrer B. 11-cis-retinal reduces constitutive opsin phosphorylation and improves quantum catch in retinoid-deficient mouse rod photoreceptors. J Biol Chem 2002; 277:40491-8. [PMID: 12176991]
11. Znoiko SL, Rohrer B, Lu K, Lohr HR, Crouch RK, Ma JX. Downregulation of cone-specific gene expression and degeneration of cone photoreceptors in the Rpe65-/-mouse at early ages. Invest Ophthalmol Vis Sci 2005; 46:1473-9. [PMID: 15790918]
12. Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W. Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci 2008; 28:4008-14. [PMID: 18400900]
13. Hamann S, Schorderet DF, Cottet S. Bax-induced apoptosis in Leber's congenital amaurosis: a dual role in rod and cone degeneration. PLoS ONE 2009; 4:e6616. [PMID: 19672311]
14. Samardzija M, Tanimoto N, Kostic C, Beck S, Oberhauser V, Joly S, Thiersch M, Fahl E, Aesenijevic Y, von Lintig J, Wenzel A, Seelinger MW, Grimm C. In conditions of limited chromophore supply rods entrap 11-cis-retinal leading to loss of cone function and cell death. Hum Mol Genet 2009; 18:1266-75. [PMID: 19147682]
15. Huang YM, Yin ZQ, Liu K, Huo SJ. Temporal and spatial characteristics of cone degeneration in RCS rats. Jpn J Ophthalmol 2011; 55:155-62. [PMID: 21400062]
16. Gu SM, Thompson DA, Srikumari CR, Lorenz B, Finckh U, Nicoletti A, Murthy KR, Rathmann M, Kumaramanickavel G, Denton MJ, Gal A. Mutations in RPE65 cause autosomal recessive childhood-onset severe retinal dystrophy. Nat Genet 1997; 17:194-7. [PMID: 9326941]
17. Marlhens F, Bareil C, Griffoin JM, Zrenner E, Amalric P, Eliaou C, Liu SY, Harris E, Redmond TM, Arnaud B, Claustres M, Hamel CP. Mutations in RPE65 cause Leber's congenital amaurosis. Nat Genet 1997; 17:139-41. [PMID: 9326927]
18. Morimura H, Fishman GA, Grover SA, Fulton AB, Berson EL, Dryja TP. Mutations in the RPE65 gene in patients with autosomal recessive retinitis pigmentosa or leber congenital amaurosis. Proc Natl Acad Sci USA 1998; 95:3088-93. [PMID: 9501220]
19. Thompson DA, Gyurus P, Fleischer LL, Bingham EL, McHenry CL, Apfelstedt-Sylla E, Zrenner E, Lorenz B, Richards JE, Jacobson SG, Sieving PA, Gal A. Genetics and phenotypes of RPE65 mutations in inherited retinal degeneration. Invest Ophthalmol Vis Sci 2000; 41:4293-9. [PMID: 11095629]
20. De Grip WJ. Thermal stability of rhodopsin and opsin in some novel detergents. Methods Enzymol 1982; 81:256-65. [PMID: 6212742]
21. Khan SM, Bolen W, Hargrave PA, Santoro MM, McDowell JH. Differential scanning calorimetry of bovine rhodopsin in rodouter-segment disk membranes. Eur J Biochem 1991; 200:53-9. [PMID: 1831759]
22. Landin JS, Katragadda M, Albert AD. Thermal destabilization of rhodopsin and opsin by proteolytic cleavage in bovine rod outer segment disk membranes. Biochemistry 2001; 40:11176-83. [PMID: 11551216]
23. Sato K, Nakazawa M, Takeuchi K, Mizukoshi S, Ishiguro S. Sopsin protein is incompletely modified during N-glycan processing in Rpe65(-/-) mice. Exp Eye Res 2010; 91:54-62. [PMID: 20398652]
24. Zhang T, Zhang N, Baehr W, Fu Y. Cone opsin determines the time course of cone photoreceptor degeneration in Leber congenital amaurosis. Proc Natl Acad Sci USA 2011; 108:8879-84. [PMID: 21555576]
25. Pepperberg DR, Brown PK, Lurie M, Dowling JE. Visual pigment and photoreceptor sensitivity in the isolated skate retina. J Gen Physiol 1978; 71:369-96. [PMID: 660156]
26. Osakada F, Ooto S, Akagi T, Mandai M, Akaike A, Takahashi M. Wnt signaling promotes regeneration in the retina of adult mammals. J Neurosci 2007; 27:4210-9. [PMID: 17428999]
27. Huber A, Wolfrum U, Paulsen R. Opsin maturation and targeting to rhabdomeral photoreceptor membranes requires the retinal chromophore. Eur J Cell Biol 1994; 63:219-29. [PMID: 8082646]
28. Noorwez SM, Malhotra R, McDowell JH, Smith KA, Krebs MP, Kaushal S. Retinoids assist the cellular folding of the autosomal dominant retinitis pigmentosa opsin mutant P23H. J Biol Chem 2004; 279:16278-84. [PMID: 14769795]
29. Noorwez SM, Sama RR, Kaushal S. Calnexin improves the folding efficiency of mutant rhodopsin in the presence of pharmacological chaperone 11-cis-retinal. J Biol Chem 2009; 284:33333-42. [PMID: 19801547]
30. Mendes HF, Cheetham ME. Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa. Hum Mol Genet 2008; 17:3043-54. [PMID: 18635576]
31. Rohrer B, Lohr HR, Humphries P, Redmond TM, Seeliger MW, Crouch RK. Cone opsin mislocalization in Rpe65-/-mice: a defect that can be corrected by 11-cis retinal. Invest Ophthalmol Vis Sci 2005; 46:3876-82. [PMID: 16186377]
32. Maeda T, Cideciyan AV, Maeda A, Golczak M, Aleman TS, Jacobson SG, Palczewski K. Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate. Hum Mol Genet 2009; 18:2277-87. [PMID: 19339306]
33. Maeda T, Maeda A, Casadesus G, Palczewski K, Margaron P. Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/-mice. Invest Ophthalmol Vis Sci 2009; 50:4368-78. [PMID: 19407008]
34. Tang PH, Fan J, Goletz PW, Wheless L, Crouch RK. Effective and sustained delivery of hydrophobic retinoids to photoreceptors. Invest Ophthalmol Vis Sci 2010; 51:5958-64. [PMID: 20574023]
35. Gearhart PM, Gearhart C, Thompson DA, Petersen-Jones SM. Improvement of Visual Performance With Intravitreal Administration of 9-cis-Retinal in Rpe65-Mutant Dogs. Arch Ophthalmol 2010; 128:1442-8. [PMID: 20837787]
36. Umezawa H, Aoyagi T, Morishima H, Matsuzaki M, Hamada M. Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo) 1970; 23:259-62. [PMID: 4912600]
37. Kirschke H, Barrett A. Chemistry of lysosomal protease. London: Academic Press. 1987; pp.193-238.
38. Ueno T, Kominami E. Mechanism and regulation of lysosomal sequestration and proteolysis. Biomed Biochim Acta 1991; 50:365-71. [PMID: 1666280]
39. Tamai M, Matsumoto K, Omura S, Koyama I, Ozawa Y, Hanada K. In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64. J Pharmacobiodyn 1986; 9:672-7. [PMID: 3023601]
40. Tamai M, Yokoo C, Murata M, Oguma K, Sota K, Sato E, Kanaoka Y. Efficient synthetic method for ethyl (+)-(2S,3S)-3-[(S)-3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2-oxiranecarb oxylate (EST), a new inhibitor of cysteine proteinases. Chem Pharm Bull (Tokyo) 1987; 35:1098-104. [PMID: 3301019]
41. McGowan EB, Becker E, Detwiler TC. Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d. Biochem Biophys Res Commun 1989; 158:432-5. [PMID: 2537073]
42. Gallastegui N, Groll M. The 26S proteasome: assembly and function of a destructive machine. Trends Biochem Sci 2010; 35:634-42. [PMID: 20541423]
43. Lee DH, Goldberg AL. Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol 1998; 8:397-403. [PMID: 9789328]
44. Voges D, Zwickl P, Baumeister W. The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem 1999; 68:1015-68. [PMID: 10872471]
45. Miller J, Gordon C. The regulation of proteasome degradation by multi-ubiquitin chain binding proteins. FEBS Lett 2005; 579:3224-30. [PMID: 15943965]
46. Deretic D, Aebersold RH, Morrison HD, Papermaster DS. Alpha A-and alpha B-crystallin in the retina. Association with the post-Golgi compartment of frog retinal photoreceptors. J Biol Chem 1994; 269:16853-61. [PMID: 8207008]
47. Griciuc A, Aron L, Piccoli G, Ueffing M. Clearance of Rhodopsin (P23H) aggregates requires the ERAD effector VCP. Biochim Biophys Acta 2010; 1803:424-34. [PMID: 20097236]
48. Werner ED, Brodsky JL, McCracken AA. Proteasomedependent endoplasmic reticulum-associated protein degeradation: An unconventional route to a familiar fate. Proc Natl Acad Sci USA 1996; 93:13797-801. [PMID: 8943015]