Detection of human papillomavirus in small cell carcinomas of the anus and rectum

American Journal of Surgical Pathology

Volumn 36, Issue 7, 2012, Pages 1087-1092

  Cimino Mathews, Ashley ^a   Sharma, Rajni ^a   Illei, Peter B ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

anal carcinoma; HPV; p16; small cell carcinoma

Indexed keywords

CDX2 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; FIXATIVE; FORMALDEHYDE; HOMEODOMAIN PROTEIN; PARAFFIN; TP63 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR MARKER; TUMOR SUPPRESSOR PROTEIN; VIRUS DNA;

ADULT; AGED; ANUS TUMOR; ARTICLE; CHEMISTRY; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; ISOLATION AND PURIFICATION; MALE; METHODOLOGY; MIDDLE AGED; MORTALITY; PAPILLOMA VIRUS; PAPILLOMAVIRUS INFECTION; PATHOLOGY; PREDICTIVE VALUE; RECTUM TUMOR; SMALL CELL CARCINOMA; SURVIVAL; TISSUE FIXATION; UNITED STATES; VIROLOGY;

ADULT; AGED; AGED, 80 AND OVER; ANUS NEOPLASMS; BALTIMORE; CARCINOMA, SMALL CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA, VIRAL; FEMALE; FIXATIVES; FORMALDEHYDE; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PARAFFIN EMBEDDING; PREDICTIVE VALUE OF TESTS; RECTAL NEOPLASMS; SURVIVAL ANALYSIS; TISSUE FIXATION; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 84863307273     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3182549b6d     Document Type: Article

References (43)

1. Balachandra B, Marcus V, Jass JR. Poorly differentiated tumours of the anal canal: a diagnostic strategy for the surgical pathologist. Histopathology. 2007;50:163-174. (Pubitemid 44953406)
2. Barbieri CE, Pietenpol JA. p63 and epithelial biology. Exp Cell Res. 2006;312:695-706.
3. Bishop JA, Westra WH. Human papillomavirus-related small cell carcinoma of the oropharynx. Am J Surg Pathol. 2011;35:1679-1684.
4. Brenner B, Shah MA, Gonen M, et al. Small-cell carcinoma of the gastrointestinal tract: a retrospective study of 64 cases. Br J Cancer. 2004;90:1720-1726. (Pubitemid 38725641)
5. Buza N, Cohen PJ, Pei H, et al. Inverse p16 and p63 expression in small cell carcinoma and high-grade urothelial cell carcinoma of the urinary bladder. Int J Surg Pathol. 2010;18:94-102.
6. Clark MA, Hartley A, Geh JI. Cancer of the anal canal. Lancet Oncol. 2004;5:149-157. (Pubitemid 38262846)
7. Conner MG, Richter H, Moran CA, et al. Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. Ann Diagn Pathol. 2002;6:345-348. (Pubitemid 36015402)
8. Cooper K, Herrington CS, Stickland JE, et al. Episomal and integrated human papillomavirus in cervical neoplasia shown by non-isotopic in situ hybridisation. J Clin Pathol. 1991;44:990-996.
9. Crum CP, McKeon FD. p63 in epithelial survival, germ cell surveillance, and neoplasia. Annu Rev Pathol. 2010;5:349-371.
10. Damin DC, Caetano MB, Rosito MA, et al. Evidence for an association of human papillomavirus infection and colorectal cancer. Eur J Surg Oncol. 2007;33:569-574. (Pubitemid 46746534)
11. De Vuyst H, Clifford GM, Nascimento MC, et al. Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a metaanalysis. Int J Cancer. 2009;124:1626-1636.
12. Dyson N, Howley PM, Mü nger K, et al. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science. 1989;243:934-937. (Pubitemid 19066153)
13. Frisch M, Fenger C, van den Brule AJ, et al. Variants of squamous cell carcinoma of the anal canal and perianal skin and their relation to human papillomaviruses. Cancer Res. 1999;59:753-757. (Pubitemid 29076078)
14. Frisch M, Melbye M. Anal cancer. In: Schottenfeld D, ed. Cancer Epidemiology and Prevention. 3rd ed. New York, NY: Oxford University Press; 2006:830-840.
15. Giuliani L, Ronci C, Bonifacio D, et al. Detection of oncogenic DNA viruses in colorectal cancer. Anticancer Res. 2008;28(2B):1405-1410. (Pubitemid 351578887)
16. Gornick MC, Castellsague X, Sanchez G, et al. Human papillomavirus is not associated with colorectal cancer in a large international study. Cancer Causes Control. 2010;21:737-743.
17. Horn LC, Lindner K, Szepankiewicz G, et al. p16, p14, p53, and cyclin D1 expression and HPV analysis in small cell carcinomas of the uterine cervix. Int J Gynecol Pathol. 2006;25:182-186. (Pubitemid 44620183)
18. Houghton O, McCluggage WG. The expression and diagnostic utility of p63 in the female genital tract. Adv Anat Pathol. 2009;16:316-321.
19. Huang CC, Qiu JT, Kashima ML, et al. Generation of type-specific probes for the detection of single-copy human papillomavirus by a novel in situ hybridization method. Mod Pathol. 1998;11:971-977. (Pubitemid 28487217)
20. Igarashi T, Jiang SX, Kameya T, et al. Divergent cyclin B1 expression and Rb/p16/cyclin D1 pathway aberrations among pulmonary neuroendocrine tumors. Mod Pathol. 2004;17:1259-1267. (Pubitemid 39312952)
21. Ince TA, Cviko AP, Quade BJ, et al. p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract. Am J Pathol. 2002;161:1111-1117.
22. Jaffee IM, Rahmani M, Singhal MG, et al. Expression of the intestinal transcription factor CDX2 in carcinoid tumors is a marker of midgut origin. Arch Pathol Lab Med. 2006;130:1522-1526. (Pubitemid 44520720)
23. Joseph DA, Miller JW, Wu X, et al. Understanding the burden of human papillomavirus-associated anal cancers in the US. Cancer. 2008;113(suppl):2892- 2900.
24. Kim JJ. Targeted human papillomavirus vaccination of men who have sex with men in the USA: a cost-effectiveness modeling analysis. Lancet Infect Dis. 2010;10:845-852.
25. Klaes R, Friedrich T, Spitkovsky D, et al. Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer. 2001;92:276-284. (Pubitemid 32225381)
26. Li MK, Folpe AL. CDX-2, a new marker for adenocarcinoma of gastrointestinal origin. Adv Anat Pathol. 2004;11:101-105.
27. Licitra L, Bergamini C, Mirabile A, et al. Targeted therapy in head and neck cancer. Curr Opin Otolaryngol Head Neck Surg. 2011; 19:132-137.
28. Longacre TA, Kong CS, Welton ML. Diagnostic problems in anal pathology. Adv Anat Pathol. 2008;15:263-278.
29. Munoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348:518-527. (Pubitemid 36159887)
30. Owens SR, Greenson JK. Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas. Am J Surg Pathol. 2007;31:285-290. (Pubitemid 46175030)
31. Pérez LO, Barbisan G, Ottino A, et al. Human papillomavirus DNA and oncogene alterations in colorectal tumors. Pathol Oncol Res. 2010;16:461-468.
32. Saha A, Kaul R, Murakami M, et al. Tumor viruses and cancer biology: modulating signaling pathways for therapeutic intervention. Cancer Biol Ther. 2010;10:961-978.
33. Salepci T, Yazici H, Dane F, et al. Detection of human papillomavirus DNA by polymerase chain reaction and southern blot hybridization in colorectal cancer patients. J BUON. 2009;14:495-499.
34. Shia J. An update on tumors of the anal canal. Arch Pathol Lab Med. 2010;134:1601-1611.
35. Shia J, Tang LH, Weiser MR, et al. Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity? Am J Surg Pathol. 2008;32:719-731. (Pubitemid 351600819)
36. Srivastava A, Hornick JL. Immunohistochemical staining for CDX-2, PDX-1, NESP-55, and TTF-1 can help distinguish gastrointestinal carcinoid tumors from pancreatic endocrine and pulmonary carcinoid tumors. Am J Surg Pathol. 2009;33:626-632.
37. Stoler MH, Mills SE, Gersell DJ, et al. Small-cell neuroendocrine carcinoma of the cervix. A human papillomavirus type 18-associated cancer. Am J Surg Pathol. 1991;15:28-32.
38. Wang BY, Gil J, Kaufman D, et al. p63 in pulmonary epithelium, pulmonary squamous neoplasms, and other pulmonary tumors. Hum Pathol. 2002;33:921-926.
39. Wang HL, Lu DW. Detection of human papillomavirus DNA and expression of p16, Rb, and p53 proteins in small cell carcinomas of the uterine cervix. Am J Surg Pathol. 2004;28:901-908. (Pubitemid 38856846)
40. Wang TY, Chen BF, Yang YC, et al. Histologic and immunophenotypic classification of cervical carcinomas by expression of the p53 homologue p63: a study of 250 cases. Hum Pathol. 2001;32:479-486.
41. Werling RW, Yaziji H, Bacchi CE, et al. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol. 2003;27:303-310. (Pubitemid 36245795)
42. Wikenheiser-Brokamp KA. Retinoblastoma regulatory pathway in lung cancer. Curr Mol Med. 2006;6:783-793.
43. Zhang H, Liu J, Cagle PT, et al. Distinction of pulmonary small cell carcinoma from poorly differentiated squamous cell carcinoma: an immunohistochemical approach. Mod Pathol. 2005;18:111-118. (Pubitemid 40128103)