Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas

American Journal of Surgical Pathology

Volumn 31, Issue 2, 2007, Pages 285-290

  Owens, Scott R ^a,b   Greenson, Joel K ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Anal intraepithelial neoplasia; Cloacogenic carcinoma; Human papilloma virus; p63; Squamous cell carcinoma

Indexed keywords

PROTEIN P63;

ANUS CARCINOMA; ARTICLE; COLORECTAL CARCINOMA; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PREDICTION; SQUAMOUS CELL CARCINOMA; TISSUE MICROARRAY;

ANAL CANAL; ANUS NEOPLASMS; CARCINOID TUMOR; CARCINOMA IN SITU; CARCINOMA, NEUROENDOCRINE; CARCINOMA, SQUAMOUS CELL; COLORECTAL NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; DNA-BINDING PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; PREDICTIVE VALUE OF TESTS; TISSUE ARRAY ANALYSIS; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 33846606406     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000213362.10756.d3     Document Type: Article

References (15)

1. Cury PM, Butcher DN, Fisher MD, et al. Value of the mesothelium- associated antibodies thrombomodulin, cytokeratin 5/6, calretinin, and CD44H in distinguishing epithelioid pleural mesothelioma from adenocarcinoma metastatic to the pleura. Mod Pathol. 2000;13:107-112.
2. Di Como CJ, Urist MJ, Babayan I, et al. p63 Expression profiles in human normal and tumor tissues. Clin Cancer Res. 2002;8:494-501.
3. Fenger C, Frisch M, Marti MC, et al. Tumours of the anal canal. In: Hamilton SR, Aaltonen LA, eds. Pathology and Genetics of Tumours of the Digestive System. Lyon, France: International Agency for Research on Cancer; 2000:147-155.
4. Fenoglio-Preiser CM, et al. Gastrointestinal Pathology: An Atlas and Text. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1999.
5. Hall PA, Campbell SJ, O'Neill M, et al. Expression of the p53 homologue p63α and ΔNp63α in normal and neoplastic cells. Carcinogenesis. 2000;21:153-160.
6. Kaelin WG. The p53 gene family. Oncogene. 1999;18:7701-7705.
7. Kaufmann O, Fietze E, Mengs J, et al. Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas. Am J Clin Pathol. 2001;116:323-330.
8. Koker MM, Kleer CG. p63 expression in breast cancer: a highly sensitive and specific marker of metaplastic carcinoma. Am J Surg Pathol. 2004;28:1506-1512.
9. Levrero M, De Laurenzi V, Costanzo A, et al. Structure, function and regulation of p63 and p73. Cell Death Differ. 1999;6: 1146-1153.
10. Little NA, Jochemsen AG. Molecules in focus: p63. Int J Biochem Cell Biol. 2002;34:6-9.
11. Reis-Filho JS, Simpson PT, Martins A, et al. Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray. Virchows Arch. 2003;443:122-132.
12. Ryan DP, Compton CC, Mayer RJ. Carcinoma of the anal canal. N Engl J Med. 2000;342:792-800.
13. Tot T. The value of cytokeratins 20 and 7 in discriminating metastatic adenocarcinomas from pleural mesotheliomas. Cancer. 2001;92:2727-2732.
14. Wang BY, Gil J, Kaufman D, et al. p63 in pulmonary epithelium, pulmonary squamous neoplasms, and other pulmonary tumors. Hum Pathol. 2002;33:921-926.
15. Williams GR, Talbot IC, Leigh IM. Keratin expression in anal carcinoma: an Immunohistochemical Study. Histopathology. 1997; 30:443-450.