Poorly differentiated tumours of the anal canal: A diagnostic strategy for the surgical pathologist

Histopathology

Volumn 50, Issue 1, 2007, Pages 163-174

  Balachandra, B ^a,b   Marcus, V ^b   Jass, J R ^b  

^a ROYAL ALEXANDRA HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Anus; Carcinoma; Neuroendocrine; Poor differentiation

Indexed keywords

CYTOKERATIN; CYTOKERATIN 20;

ADENOCARCINOMA; ANAL CANAL; ANAL CANAL ADENOCARCINOMA; ANAL CANAL TUMOR; ANUS DISEASE; ANUS TUMOR; CANCER DIAGNOSIS; CELL TYPE; DIFFERENTIAL DIAGNOSIS; HUMAN; IMMUNOHISTOCHEMISTRY; LARGE CELL CARCINOMA; LARGE CELL NEUROENDOCRINE CARCINOMA; LYMPHOMA; MELANOMA; NEUROENDOCRINE CARCINOMA; NEUROENDOCRINE DISEASE; PERIANAL PAGET DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SMALL CELL CARCINOMA; SMALL CELL NEUROENDOCRINE CARCINOMA; SQUAMOUS CELL CARCINOMA; STAINING; TUMOR DIFFERENTIATION; ULTRASTRUCTURE; UNDIFFERENTIATED CARCINOMA;

ADENOCARCINOMA; AGED; ANAL CANAL; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; LYMPHOMA; MALE; MELANOMA; MIDDLE AGED; PATHOLOGY, SURGICAL;

EID: 33845677689     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2006.02550.x     Document Type: Review

References (72)

1. The Anal Canal. In Lewin KJ, Riddell RH, Weinstein WM eds. Gastrointestinal pathology and its clinical implications, 1st edn. New York: Igaku-Shoin 1992; 1325.
2. Fenger C. Anal canal. In Sternberg S ed. Histology for pathologists, 2nd edn. Philadelphia: Lippincott Williams and Wilkins 1997; 554-571.
3. Mathur SK, Marwaha N, Arora R, Gupta S, Gupta V, Arora B. Significance of mucin secretion in carcinoma of uterine cervix. Indian J. Pathol. Microbiol. 2002; 45; 261-264.
4. Hameed A, Miller DS, Muller CY, Coleman RL, Albores-Saavedra J. Frequent expression of beta-human chorionic gonadotropin (beta-hCG) in squamous cell carcinoma of the cervix. Int. J. Gynecol. Pathol. 1999; 18; 381-386.
5. Fenger C, Frisch M, Jass JR, Williams GT, Hilden J. Anal cancer subtype reproducibility study. Vrichows Arch. 2000; 463; 229-233.
6. Fenger C, Frish M, Marti MC, Parc R. Tumours of the anal canal. In Hamilton SR, Altonen LA eds. World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system. Lyon: IARC Press 2000; 146-155.
7. Kannan S, Kartha CC, Chandran GJ et al. Ultrastructure of oral squamous cell carcinoma: a comparative analysis of different histological types. Eur. J. Cancer B Oral Oncol. 1994; 30B; 32-42.
8. Williams GR, Talbot IC, Leigh IM. Keratin expression in anal carcinoma: an immunohistochemical study. Histopathology 1997; 30; 443-450.
9. Behrendt GC, Hansmann ML. Carcinomas of the anal canal and anal margin differ in their expression of cadherin, cytokeratins and p53. Virchows Arch. 2001; 439; 782-786.
10. Yamaguchi K, Wu L, Caballero OL et al. Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinomas. Int. J. Cancer 2000; 86; 684-689.
11. Parsa R, Yang A, McKeon F et al. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J. Invest. Dermatol. 1999; 113; 1099-1105.
12. Kaufman O, Fietze E, Mengs J, Dietel M. Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas. Am. J. Clin. Pathol. 2001; 116; 823-830.
13. Frisch M, Fenger C, van den Brule AJC et al. Variants of squamous cell carcinoma of the anal canal and perianal skin and their relation to human papillomaviruses. Cancer Res. 1999; 59; 753-757.
14. Koulos J, Symmans F, Chumas J, Nuovo G. Human papillomavirus detection in adenocarcinoma of the anus. Mod. Pathol. 1991; 4; 58-61.
15. Hobbs CM, Lowry MA, Owen D, Sobin LH. Anal gland carcinoma. Cancer 2001; 92; 2045-2049.
16. Abel ME, Chiu YSY, Russell TR, Volpe PA. Adenocarcinoma of the anal glands. Dis. Colon Rectum 1993; 36; 383-387.
17. Skir I. Mucinous carcinoma associated with fistulas of long standing. Am. J. Surg. 1948; 75; 285-289.
18. Fenger C, Filipe MI. Pathology of the anal glands with special reference to their mucin histochemistry. Acta Path. Microbial Scand. 1977; 85; 273-285.
19. Fenger C, Filipe MI. Mucin histochemistry of the anal canal epithelium. Studies of the normal anal mucosa and mucosa adjacent to carcinoma. Histochem. J. 1981; 13; 921-930.
20. Features of specific human neoplasms with clinicopathologic, immunohistochemical and cytogenetic correlations. In Erlandson RA ed. Diagnositc transmission electron microscopy. New York: Raven Press 1994; 252-261.
21. Kende AL, Carr NJ, Sobin LH. Expression of cytokeratins 7 and 20 in carcinomas of the gastrointestinal tract. Histopathology 2003; 42; 137-140.
22. Kondo R, Hanamura N, Kobayashi M, Seki T, Adachi W, Ishi K. Mucoepidermoid carcinoma of the anal canal: an immunohistochemical study. J. Gastroenterol. 2001; 36; 508-514.
23. Joon DL, Chao MW, Ngan SY, Joon ML, Guiney MJ. Primary adenocarcinoma of the anus: a retrospective analysis. Int. J. Radiat. Oncol. Biol. Phys. 1999; 45; 1199-1205.
24. Li MK, Folpe AL. CDX-2, a new marker for adenocarcinoma of gastrointestinal origin. Adv. Anat. Pathol. 2004; 11; 101-105.
25. Hinoi T, Tani M, Lucas PC et al. Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon. Am. J. Pathol. 2001; 159; 2239-2248.
26. Drummond F, Putt W, Fox M et al. Cloning and chromosome assignment of the human CDX2 gene. Ann. Hum. Genet. 1997; 61; 393-400.
27. Werling RW, Yaziji H, Bacchi CE, Gown AM. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin. An immunohistochemical survey of 476 primary and metastatic carcinomas. Am. J. Surg. Pathol. 2003; 27; 303-310.
28. Moll R, Robine S, Dudouet B et al. Villin: a cytoskeletal protein and a differentiation marker expressed in some human adenocarcinomas. Virchows Arch. 1987; 54; 155-169.
29. Nakahara H, Moriya Y, Shinkai T, Hiorta T. Small cell carcinoma of the anus in a human HIV carrier: report of a case. Surg. Today 1993; 23; 85-88.
30. Cebrian J, Larach S, Ferrara A et al. Small cell carcinoma of the rectum: report of two cases. Dis. Colon Rectum 1999; 42; 274-277.
31. Mills SE, Allen MS, Cohen AR. Small cell undifferentiated carcinoma of the colon: a clinicopathological study of five cases and their association with colonic adenomas. Am. J. Surg. Pathol. 1983; 7; 643-651.
32. Chu P, Arger DA, Weiss LM. Expression of T/NK-cell and plasma cell antigens in nonhematopoietic epithelioid neoplasms. Am. J. Clin. Pathol. 2003; 120; 64-70.
33. Izuishi K, Arai T, Ochiai A et al. Long-term survival in advanced small cell carcinoma of the colorectum: report of a case. Surg. Today 2002; 32; 72-74.
34. Matsui K, Jin SM, Kitagawa M, Miwa A. Clinocpathologic features of neuroendocrine carcinomas of the stomach. Appraisal of small and large cell variants. Arch. Pathol. Lab. Med. 1998; 122; 1010-1017.
35. Nicholson SA, Beasley MB, Branblilla E et al. Small cell lung carcinoma (SCLC). A clinicopathologic study of 100 cases with surgical specimens. Am. J. Surg. Pathol. 2002; 26; 1184-1197.
36. Dabbs D. Immunohistology of metastatic carcinoma of unknown primary. In Dabbs D ed. Diagnostic immunohistochemistry, 2nd edn. Philadelphia: Churchill Livingstone-Elsevier 2006; 180-227.
37. Wick MR, Weatherby PR, Weiland LH. Small cell neuroendorine carcinoma of the colon and rectum. Hum. Pathol. 1987; 18; 9-21.
38. Brambilla E, Pugatch B, Geisinger K et al. Large cell carcinoma. In Travis WD, Brambilla E, Muller-Hermelink H, Harris CC eds. Pathology and genetics of tumours of the lung, pleura, thymus and heart. Lyon: IARC Press 2004; 45-47.
39. Travis WD, Linnoila RI, Tsokos MG et al. Neuroendocrine tumor of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical and flow cytometric study of 35 cases. Am. J. Surg. Pathol. 1991; 15; 529-553.
40. Cheng SP, Yang TL, Chang KM, Liu CL. Large cell neuroendocrine carcinoma of the ampulla of Vater with glandular differentiation. J. Clin. Pathol. 2004; 57; 1098-1100.
41. Bernick PE, Klimstra DS, Shia J et al. Neuroendocrine carcinomas of the colon and rectum. Dis. Colon Rectum 2004; 47; 163-169.
42. Kato T, Terashima T, Tomida S, Yamaguchi T. Cytokeratin 20-positive large cell neuroendocrine carcinoma of the colon. Pathol. Int. 2005; 55; 524-529.
43. Paterson C, Musselman L, Chorneyko K, Reid S, Rawlinson J. Merkel cell (neuroendocrine) carcinoma of the anal canal. Dis. Colon Rectum 2003; 46; 676-678.
44. Chan JKC, Suster S, Wenig BM, Tsang WYW, Chan JBK, Lau ALW. Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am. J. Surg. Pathol. 1997; 21; 226-234.
45. Sidhu GS, Chandra P, Cassai ND. Merkel cells, normal and neoplastic: an update. Ultrastruct. Pathol. 2005; 29; 287-294.
46. Reyes C, Siddiqui MT. Anaplastic carcinoma of the colon: clinicopathologic study of eight cases of a poorly recognized lesion. Ann. Diagn. Pathol. 1997; 1; 19-25.
47. Clemmensen OJ, Fenger C. Melanocytes in the anal canal epithelium. Histopathology 1991; 18; 237-241.
48. Weinstock MA. Epidemiology and prognosis of anorectal melanomas. Gastroenterololgy 1993; 104; 174-178.
49. Longo WE, Vernava AM III, Wade TP, Coplin MA, Virgo KS, Johnson FE. Rare anal canal cancers in the US veteran: patterns of disease and results of treatment. Am. Surg. 1995; 61; 495-500.
50. Cooper PH, Mills ST, Allen S. Malignant melanoma of the anus. Dis. Colon Rectum 1982; 25; 693-703.
51. Ben-Izhak O, Lichtig C. CEA reactivity in amelanotic malignant melanoma of the anal canal. Pathol. Res. Pract. 1993; 189; 1071-1076.
52. Fenger C. Anal neoplasia and its precursors. Facts and controversies. Sem. Diagn. Pathol. 1991; 8; 190-201.
53. Ben-Izhak O, Levy R, Weill S et al. Anorectal malignant melanoma; a clinicopathologic study, including immunohistochemistry and DNA flow cytometry. Cancer 1997; 79; 18-25.
54. Liu V, Mihm MC. Pathology of malignant melanoma. Surg. Clin. North Am. 2003; 83; 31-60.
55. Ioachim HL, Dorsett B, Cronin W et al. Acquired immunodeficiency syndrome-associated lymphomas: clinical, pathologic, immunologic and viral characteristics of 111 cases. Hum. Pathol. 1991; 22; 659-673.
56. Ioachim H, Antonescu C, Giancotti F, Dorsett B, Weinstein M. EBV-associated anorectal lymphomas in patients with acquired immune deficiency syndrome. Am. J. Surg. Pathol. 1997; 21; 997-1006.
57. Chetty R, Hlatswayo N, Muc R, Sabaratnam R, Gatter K. Plasmablastic lymphoma in HIV+ patients: an expanding spectrum. Histopathology 2003; 42; 605-609.
58. Scott NA, Taylor BA, Wolff BG, Lieber MM. Perianal metastasis from a sigmoid carcinoma - objective evidence of a clonal origin. Dis. Colon Rectum 1988; 31; 68-70.
59. Killingback M, Wilson E, Hughes ESR. Anal metastases from carcinoma of the rectum and colon. Aust. NZ J. Surg. 1965; 34; 178-187.
60. Norgren J, Svensson JO. Anal implantation metastasis from carcinoma of the sigmoid colon and rectum - a risk when performing anterior resection with the EEA stapler? Br. J. Surg. 1985; 72; 602.
61. Swah R, Borkowski J, Broaddus R. Metastatic renal cell carcinoma presenting as a hemorrhoid. Arch. Pathol. Lab. Med. 2002; 126; 856-858.
62. Ger R, Reuben J. Squamous-cell carcinoma of the anal canal: a metastatic lesion. Dis. Colon Rectum 1968; 11; 213-219.
63. Kanhouwa S, Burns W, Matthews M et al. Anaplastic carcinoma of the lung with metastasis to the anus: report of a case. Dis. Colon Rectum 1975; 18; 42-48.
64. Dawson PM, Hershman MJ, Wood CB. Metastatic carcinoma of the breast in the anal canal. Postgrad. Med. J. 1985; 61; 1081.
65. Darier J, Coulillaud P. Sur un cas de maladie de Paget de la region perineo-anale et scrotale. Ann. Dermatol. Syphiligr. (Paris) 1893; 4; 25-31.
66. Chanda JJ. Extramammary Paget's disease: prognosis and relationship to internal malignancy. J. Am. Acad. Dermatol. 1985; 13; 1009-1014.
67. Armitage NC, Jass JR, Richman PI, Thompson JPS, Phillips RKS. Paget's disease of the anus: a clinicopathologic study. Br. J. Surg. 1989; 76; 60-63.
68. Goldblum JR, Hart WR. Perianal Paget's disease. A histologic and immunohistochemical study of 11 cases with and without associated rectal adenocarcinoma. Am. J. Surg. Pathol. 1998; 22; 170-179.
69. Ohnishi T, Watanabe S. The use of cytokeratins 7 and 20 in the diagnosis of primary and secondary extramammary Paget's disease. Br. J. Dermatol. 2000; 142; 243-247.
70. Lloyd J, Flanagan AM. Mammary and extramammary Paget's disease. J. Clin. Pathol. 2000; 53; 742-749.
71. Reed W, Oppedal BR, Eeg Larsen T. Immunohistology is valuable in distinguishing between Paget's disease, Bowen's disease and superficial spreading malignant melanoma. Histopathology 1990; 16; 583-588.
72. Cummings BJ. Current management of anal canal cancer. Semin. Oncol. 2005; 32; S123-S128.