Deletion of porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome)

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Liu, Wei ^a   Shaver, Timothy M ^a   Balasa, Alfred ^b   Ljungberg, M Cecilia ^a,c   Wang, Xiaoling ^a   Wen, Shu ^a   Nguyen, Hoang ^a   van den Veyver, Ignatia B ^a,c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b CHILDREN S NUTRITION RESEARCH CENTER   (United States)

^c TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; MEMBRANE PROTEIN; PORCUPINE PROTEIN; UNCLASSIFIED DRUG; WNT3A PROTEIN; PORCN PROTEIN, MOUSE;

ALOPECIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DISEASE MODEL; ECTODERM; EMBRYO; EMBRYO DEATH; FEMALE; GENE; GENE DELETION; GENE INACTIVATION; GENE LOCUS; GOLTZ SYNDROME; INTRON; LIMB MALFORMATION; LOXP SITE; MALE; MESENCHYME; MOUSE; NEOMYCIN GENE; NONHUMAN; PORCN GENE; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SKIN MALFORMATION; TOOTH MALFORMATION; UROGENITAL TRACT MALFORMATION; ANIMAL; BREEDING; C57BL MOUSE; CELL LINE; CHIMERA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; GENETICS; HUMAN; LETHAL GENE; METABOLISM; MOUSE MUTANT; PHENOTYPE; SECRETION; ZYGOTE;

MUS;

ANIMALS; BREEDING; CELL LINE; CHIMERA; DISEASE MODELS, ANIMAL; FOCAL DERMAL HYPOPLASIA; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKOUT TECHNIQUES; GENE SILENCING; GENE TARGETING; GENES, LETHAL; HUMANS; INTRONS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; WNT3A PROTEIN; ZYGOTE;

EID: 84863290593     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032331     Document Type: Article

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