Tissue plasminogen activator and plasminogen activator inhibitor 1 contribute to sonic hedgehog-induced in vitro cerebral angiogenesis

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Teng, Hua ^a   Chopp, Michael ^a,b   Hozeska Solgot, Ann ^a   Shen, Lihong ^a   Lu, Mei ^a   Tang, Clark ^a   Zhang, Zheng Gang ^a  

^a HENRY FORD HOSPITAL   (United States)

^b OAKLAND UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; CYCLOPAMINE; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECOMBINANT PROTEIN; SONIC HEDGEHOG PROTEIN; TISSUE PLASMINOGEN ACTIVATOR; VASCULOTROPIN; SHH PROTEIN, HUMAN; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CAPILLARY; BRAIN CELL; CEREBRAL ANGIOGENESIS; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; IN VITRO STUDY; MORPHOGENESIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; UPREGULATION; VASCULAR ENDOTHELIUM; WILD TYPE; ANIMAL; BRAIN; C57BL MOUSE; CAPILLARY; CYTOLOGY; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; SIGNAL TRANSDUCTION; VASCULARIZATION;

ERINACEIDAE;

ANGIOPOIETIN-1; ANIMALS; BRAIN; CAPILLARIES; DOWN-REGULATION; ENDOTHELIAL CELLS; HEDGEHOG PROTEINS; HUMANS; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; PLASMINOGEN ACTIVATOR INHIBITOR 1; SIGNAL TRANSDUCTION; TISSUE PLASMINOGEN ACTIVATOR; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84863281629     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033444     Document Type: Article

References (32)

1. Zhang ZG, Zhang L, Jiang Q, Zhang R, Davies K, et al. (2000) VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest 106: 829-838.
2. Zhang ZG, Zhang L, Tsang W, Soltanian-Zadeh H, Morris D, et al. (2002) Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia. J Cereb Blood Flow Metab 22: 379-392.
3. Krupinski J, Kaluza J, Kumar P, Kumar S, Wang JM, (1994) Role of angiogenesis in patients with cerebral ischemic stroke. Stroke 25: 1794-1798.
4. Slevin M, Krupinski J, Slowik A, Kumar P, Szczudlik A, et al. (2000) Serial measurement of vascular endothelial growth factor and transforming growth factor-beta1 in serum of patients with acute ischemic stroke. Stroke 31: 1863-1870.
5. Carmeliet P, (2005) Angiogenesis in life, disease and medicine. Nature 438: 932-936.
6. Risau W, (1997) Mechanisms of angiogenesis. Nature 386: 671-674.
7. Varjosalo M, Taipale J, (2008) Hedgehog: functions and mechanisms. Genes Dev 22: 2454-2472.
8. Dyer MA, Farrington SM, Mohn D, Munday JR, Baron MH, (2001) Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. Development 128: 1717-1730.
9. Byrd N, Becker S, Maye P, Narasimhaiah R, St-Jacques B, et al. (2002) Hedgehog is required for murine yolk sac angiogenesis. Development 129: 361-372.
10. Pola R, Ling LE, Silver M, Corbley MJ, Kearney M, et al. (2001) The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat Med 7: 706-711.
11. Lee SW, Moskowitz MA, Sims JR, (2007) Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts. Int J Mol Med 19: 445-451.
12. Asai J, Takenaka H, Kusano KF, Ii M, Luedemann C, et al. (2006) Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation 113: 2413-2424.
13. Kanda S, Mochizuki Y, Suematsu T, Miyata Y, Nomata K, et al. (2003) Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase. J Biol Chem 278: 8244-8249.
14. Nagase T, Nagase M, Yoshimura K, Fujita T, Koshima I, (2005) Angiogenesis within the developing mouse neural tube is dependent on sonic hedgehog signaling: possible roles of motor neurons. Genes Cells 10: 595-604.
15. Castellino FJ, Ploplis VA, (2005) Structure and function of the plasminogen/plasmin system. Thromb Haemost 93: 647-654.
16. Adibhatla RM, Hatcher JF, (2008) Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies. CNS Neurol Disord Drug Targets 7: 243-253.
17. Mignatti P, Rifkin DB, (1996) Plasminogen activators and matrix metalloproteinases in angiogenesis. Enzyme Protein 49: 117-137.
18. Bajou K, Masson V, Gerard RD, Schmitt PM, Albert V, et al. (2001) The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies. J Cell Biol 152: 777-784.
19. Devy L, Blacher S, Grignet-Debrus C, Bajou K, Masson V, et al. (2002) The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent. FASEB J 16: 147-154.
20. Labied S, Blacher S, Carmeliet P, Noel A, Frankenne F, et al. (2011) Transient reduction of placental angiogenesis in PAI-1-deficient mice. Physiol Genomics 43: 188-198.
21. Kim JA, Tran ND, Wang SJ, Fisher MJ, (2003) Astrocyte regulation of human brain capillary endothelial fibrinolysis. Thromb Res 112: 159-165.
22. Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, et al. (2011) The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science 334: 1727-1731.
23. Xin H, Li Y, Shen LH, Liu X, Hozeska-Solgot A, et al. (2011) Multipotent mesenchymal stromal cells increase tPA expression and concomitantly decrease PAI-1 expression in astrocytes through the sonic hedgehog signaling pathway after stroke (in vitro study). J Cereb Blood Flow Metab 31: 2181-2188.
24. Dupont DM, Madsen JB, Kristensen T, Bodker JS, Blouse GE, et al. (2009) Biochemical properties of plasminogen activator inhibitor-1. Front Biosci 14: 1337-1361.
25. Li PC, Yang CC, Hsu SP, Chien CT, (2012) Repetitive progressive thermal preconditioning hinders thrombosis by reinforcing phosphatidylinositol 3-kinase/Akt-dependent heat-shock protein/endothelial nitric oxide synthase signaling. J Vasc Surg.
26. Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, et al. (2010) Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Blood 115: 4302-4312.
27. Krishnan V, Pereira FA, Qiu Y, Chen CH, Beachy PA, et al. (1997) Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science 278: 1947-1950.
28. Teng H, Zhang ZG, Wang L, Zhang RL, Zhang L, et al. (2008) Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab 28: 764-771.
29. Liu XS, Zhang ZG, Zhang L, Morris DC, Kapke A, et al. (2006) Atorvastatin downregulates tissue plasminogen activator-aggravated genes mediating coagulation and vascular permeability in single cerebral endothelial cells captured by laser microdissection. J Cereb Blood Flow Metab 26: 787-796.
30. Wang L, Zhang ZG, Zhang RL, Gregg SR, Hozeska-Solgot A, et al. (2006) Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration. J Neurosci 26: 5996-6003.
31. Miskin R, Soreq H, (1981) Sensitive autoradiographic quantification of electrophoretically separated proteases. Anal Biochem 118: 252-258.
32. Ahn MY, Zhang ZG, Tsang W, Chopp M, (1999) Endogenous plasminogen activator expression after embolic focal cerebral ischemia in mice. Brain Res 837: 169-176.