Multipotent mesenchymal stromal cells increase tPA expression and concomitantly decrease PAI-1 expression in astrocytes through the sonic hedgehog signaling pathway after stroke (in vitro study)

Journal of Cerebral Blood Flow and Metabolism

Volumn 31, Issue 11, 2011, Pages 2181-2188

  Xin, Hongqi ^a   Li, Yi ^a   Shen, Li Hong ^a   Liu, Xianshuang ^a   Hozeska Solgot, Ann ^a   Zhang, Rui Lan ^a   Zhang, Zheng Gang ^a   Chopp, Michael ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b OAKLAND UNIVERSITY   (United States)

Author keywords

astrocytes; multipotent mesenchymal stromal cells (MSCs); plasminogen activator inhibitor 1 (PAI 1); sonic hedgehog (Shh); stroke; tissue plasminogen activator (tPA)

Indexed keywords

CYCLOPAMINE; GLUCOSE; OXYGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; TISSUE PLASMINOGEN ACTIVATOR; TRANSCRIPTION FACTOR GLI1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CELL THERAPY; COCULTURE; CONTROLLED STUDY; MESENCHYME CELL; MOUSE; NERVE FIBER GROWTH; NONHUMAN; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STROKE; STROMA CELL;

ANIMALS; ASTROCYTES; CELL CULTURE TECHNIQUES; CELL HYPOXIA; COCULTURE TECHNIQUES; CULTURE MEDIA; DOWN-REGULATION; GLUCOSE; HEDGEHOG PROTEINS; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C57BL; MULTIPOTENT STEM CELLS; OXYGEN; RECEPTOR CROSS-TALK; SERPIN E2; SIGNAL TRANSDUCTION; STROKE; TISSUE PLASMINOGEN ACTIVATOR; UP-REGULATION;

EID: 80455174695     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.116     Document Type: Article

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