Quantitative proteomics study on the protective mechanism of phlorizin on hepatic damage in diabetic db/db mice

Molecular Medicine Reports

Volumn 5, Issue 5, 2012, Pages 1285-1294

  Lu, Wei Da ^a   Li, Bao Ying ^a   Yu, Fei ^a   Cai, Qian ^a   Zhang, Zhen ^a   Yin, Mei ^a   Gao, Hai Qing ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

db db mouse; Isobaric tag for relative and absolute quantitation proteomics; Lipid metabolism; Oxidative stress; Phlorizin; Type 2 diabetes

Indexed keywords

PHLORIZIN; SCAVENGER; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CARBOHYDRATE METABOLISM; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DIABETES MELLITUS; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; GLUCOSE BLOOD LEVEL; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WESTERN BLOTTING;

ANIMALS; CARBOHYDRATE METABOLISM; DIABETES MELLITUS; GENE EXPRESSION REGULATION; LIPID METABOLISM; LIVER; MICE; MICE, MUTANT STRAINS; PHLORHIZIN; PROTEOMICS;

MUS;

EID: 84863275757     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.803     Document Type: Article

References (32)

1. Fagot-Campagna A, Bourdel-Marchasson I and Simon D: Burden of diabetes in an aging population: prevalence, incidence, mortality, characteristics and quality of care. Diabetes Metab 31 Spec No 2: 5S35-35S52, 2005.
2. McGarry JD: Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51: 7-18, 2002.
3. LeRoith D: Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities. Am J Med 113 (Suppl 6A): 3S-11S, 2002.
4. Robertson RP, Harmon J, Tran PO, Tanaka Y and Takahashi H: Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52: 581-587, 2003. (Pubitemid 36323562)
5. Stumvoll M, Goldstein BJ and van Haeften TW: Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365: 1333-1346, 2005.
6. Prentki M, Joly E, El-Assaad W and Roduit R: Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. Diabetes 51 (Suppl 3): S405-S413, 2002. (Pubitemid 35403424)
7. Gosch C, Halbwirth H and Stich K: Phloridzin: biosynthesis, distribution and physiological relevance in plants. Phytochemistry 71: 838-843, 2010.
8. Rezk BM, Haenen GR, van der Vijgh WJ and Bast A: The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids. Biochem Biophys Res Commun 295: 9-13, 2002. (Pubitemid 34743766)
9. Wang J, Chung MH, Xue B, Ma H, Ma C and Hattori M: Estrogenic and antiestrogenic activities of phloridzin. Biol Pharm Bull 33: 592-597, 2010.
10. Boccia MM, Kopf SR and Baratti CM: Phlorizin, a competitive inhibitor of glucose transport, facilitates memory storage in mice. Neurobiol Learn Mem 71: 104-112, 1999. (Pubitemid 29393795)
11. Gupte A and Buolamwini JK: Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors. Bioorg Med Chem Lett 19: 917-921, 2009.
12. Burcelin R, Mrejen C, Decaux JF, De Mouzon SH, Girard J and Charron MJ: In vivo and in vitro regulation of hepatic glucagon receptor mRNA concentration by glucose metabolism. J Biol Chem 273: 8088-8093, 1998. (Pubitemid 28168861)
13. Rossetti L, Smith D, Shulman GI, Papachristou D and DeFronzo RA: Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest 79: 1510-1515, 1987. (Pubitemid 17099657)
14. Ross PL, Huang YN, Marchese JN, et al: Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol Cell Proteomics 3: 1154-1169, 2004.
15. Hummel KP, Dickie MM and Coleman DL: Diabetes, a new mutation in the mouse. Science 153: 1127-1128, 1966.
16. Herberg L and Coleman DL: Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 26: 59-99, 1977. (Pubitemid 8027641)
17. Li XL, Li BY, Gao HQ, et al: Proteomics approach to study the mechanism of action of grape seed proanthocyanidin extracts on arterial remodeling in diabetic rats. Int J Mol Med 25: 237-248, 2010.
18. Scott JA and King GL: Oxidative stress and antioxidant treatment in diabetes. Ann NY Acad Sci 1031: 204-213, 2004. (Pubitemid 40361755)
19. Poitout V and Robertson RP: Minireview: secondary beta-cell failure in type 2 diabetes - a convergence of glucotoxicity and lipotoxicity. Endocrinology 143: 339-342, 2002. (Pubitemid 34107184)
20. Savage DB, Choi CS, Samuel VT, et al: Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J Clin Invest 116: 817-824, 2006. (Pubitemid 43326891)
21. Mao J, DeMayo FJ, Li H, et al: Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc Natl Acad Sci USA 103: 8552-8557, 2006. (Pubitemid 43838493)
22. Abu-Elheiga L, Matzuk MM, Abo-Hashema KA and Wakil SJ: Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 291: 2613-2616, 2001. (Pubitemid 32249687)
23. Wakil SJ: Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry 28: 4523-4530, 1989.
24. Ouyang X, Cirillo P, Sautin Y, et al: Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol 48: 993-999, 2008.
25. Akkaoui M, Cohen I, Esnous C, et al: Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids. Biochem J 420: 429-438, 2009.
26. Janssen U, Fink T, Lichter P and Stoffel W: Human mitochondrial 3,2-trans-enoyl-CoA isomerase (DCI): gene structure and localization to chromosome 16p13.3. Genomics 23: 223-228, 1994. (Pubitemid 24296956)
27. Janssen U and Stoffel W: Disruption of mitochondrial beta-oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse. J Biol Chem 277: 19579-19584, 2002. (Pubitemid 34967470)
28. Jung UJ, Lee MK, Park YB, Kang MA and Choi MS: Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol 38: 1134-1145, 2006.
29. Park SA, Choi MS, Kim MJ, et al: Hypoglycemic and hypolipidemic action of Du-zhong (Eucommia ulmoides Oliver) leave water extract in C57BL/KsJ-db/db mice. J Ethnopharmacol 107: 412-417, 2006. (Pubitemid 44363035)
30. Caldas H and Herman GE: NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets. Hum Mol Genet 12: 2981-2991, 2003. (Pubitemid 37442026)
31. Oberley LW: Free radicals and diabetes. Free Radic Biol Med 5: 113-124, 1988.
32. Baynes JW: Role of oxidative stress in development of complications in diabetes. Diabetes 40: 405-412, 1991.