메뉴 건너뛰기




Volumn 29, Issue 1, 2012, Pages 51-62

Genomic and nongenomic signaling induced by 1α,25(OH) 2-vitamin D3 promotes the recovery of amyloid-β phagocytosis by Alzheimer's disease macrophages

Author keywords

Alzheimer's disease; amyloid ; chloride channel; ClC 3; curcumin; hydrogen deuterium exchange; nongenomic; nuclear vitamin D receptor; phagocytosis

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; AMYLOID BETA PROTEIN[1-42]; CALCITRIOL; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; CURCUMIN; DEUTERIUM; HYDROGEN; INOSITOL 3,4,5,6 TETRAPHOSPHATE; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 84863249788     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-110560     Document Type: Article
Times cited : (109)

References (50)
  • 1
    • 77949335521 scopus 로고    scopus 로고
    • The worldwide societal costs of dementia: Estimates for 2009
    • Wimo A, Winblad B, Jonsson L (2010) The worldwide societal costs of dementia: Estimates for 2009. Alzheimers Dement 6, 98-103.
    • (2010) Alzheimers Dement , vol.6 , pp. 98-103
    • Wimo, A.1    Winblad, B.2    Jonsson, L.3
  • 2
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356. (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 3
    • 80052501210 scopus 로고    scopus 로고
    • Resolving controversies on the path to Alzheimer's therapeutics
    • Selkoe DJ (2011) Resolving controversies on the path to Alzheimer's therapeutics. Nat Med 17, 1060-1065.
    • (2011) Nat Med , vol.17 , pp. 1060-1065
    • Selkoe, D.J.1
  • 4
    • 78149488153 scopus 로고    scopus 로고
    • Amyloid-independent mechanisms in Alzheimer's disease pathogenesis
    • Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH (2010) Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci 30, 14946-14954.
    • (2010) J Neurosci , vol.30 , pp. 14946-14954
    • Pimplikar, S.W.1    Nixon, R.A.2    Robakis, N.K.3    Shen, J.4    Tsai, L.H.5
  • 12
    • 33845904135 scopus 로고    scopus 로고
    • Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid
    • DOI 10.1016/j.neuroscience.2006.10.020, PII S0306452206013650
    • Wilcock DM, Jantzen PT, Li Q, Morgan D, Gordon MN (2007) Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid. Neuroscience 144, 950-960. (Pubitemid 46019842)
    • (2007) Neuroscience , vol.144 , Issue.3 , pp. 950-960
    • Wilcock, D.M.1    Jantzen, P.T.2    Li, Q.3    Morgan, D.4    Gordon, M.N.5
  • 15
    • 79951563916 scopus 로고    scopus 로고
    • A novel perspective for Alzheimer's disease: Vitamin D receptor suppression by Amyloid-beta and preventing the Amyloid-beta induced alterations by vitamin D in cortical neurons
    • Dursun E, Gezen-Ak D, Yilmazer S (2011) A novel perspective for Alzheimer's disease: Vitamin D receptor suppression by Amyloid-beta and preventing the Amyloid-beta induced alterations by vitamin D in cortical neurons. J Alzheimers Dis 23, 207-201.
    • (2011) J Alzheimers Dis , vol.23 , pp. 207-1201
    • Dursun, E.1    Gezen-Ak, D.2    Yilmazer, S.3
  • 16
    • 0345874610 scopus 로고    scopus 로고
    • Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
    • Norman AW, Mizwicki MT, Norman DPG (2004) Steroid hormone rapid actions, membrane receptors and a conformational ensemble model. Nat Rev Drug Discov 3, 27-41. (Pubitemid 38088696)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.1 , pp. 27-41
    • Norman, A.W.1    Mizwicki, M.T.2    Norman, D.P.G.3
  • 17
    • 63649121508 scopus 로고    scopus 로고
    • Meeting review: Extra-nuclear steroid receptors-Integration with multiple signaling pathways
    • Carbajal L, Deng J, Dressing GE, Hagan CR, Lange CA, Hammes SR (2009) Meeting review: Extra-nuclear steroid receptors-Integration with multiple signaling pathways. Steroids 74, 551-554.
    • (2009) Steroids , vol.74 , pp. 551-554
    • Carbajal, L.1    Deng, J.2    Dressing, G.E.3    Hagan, C.R.4    Lange, C.A.5    Hammes, S.R.6
  • 18
    • 68849103260 scopus 로고    scopus 로고
    • The vitamin D sterol-vitamin D receptor ensemble model offers unique insights into both genomic and rapid-response signaling
    • Mizwicki MT, Norman AW (2009) The vitamin D sterol-vitamin D receptor ensemble model offers unique insights into both genomic and rapid-response signaling. Sci Signal 2, re4.
    • (2009) Sci Signal , vol.2
    • Mizwicki, M.T.1    Norman, A.W.2
  • 19
    • 34548202165 scopus 로고    scopus 로고
    • Vitamin D signalling pathways in cancer: Potential for anticancer therapeutics
    • DOI 10.1038/nrc2196, PII NRC2196
    • Deeb KK, Trump DL, Johnson CS (2007) Vitamin D signalling pathways in cancer: Potential for anticancer therapeutics. Nat Rev Cancer 7, 684-700. (Pubitemid 47327412)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.9 , pp. 684-700
    • Deeb, K.K.1    Trump, D.L.2    Johnson, C.S.3
  • 20
    • 0030611087 scopus 로고    scopus 로고
    • 3of whole cell chloride currents in osteoblastic ROS 17/2.8 cells: A structure-function study
    • 3 of whole cell chloride currents in osteoblastic ROS 17/2.8 cells: A structure-function study. J Biol Chem 272, 22617-22622.
    • (1997) J Biol Chem , vol.272 , pp. 22617-22622
    • Zanello, L.P.1    Norman, A.W.2
  • 21
    • 77954761672 scopus 로고    scopus 로고
    • A molecular description of ligand binding to the two overlapping binding pockets of the nuclear vitamin D receptor (VDR): Structure-function implications
    • Mizwicki MT, Menegaz D, Yaghmaei S, Henry HL, Norman AW (2010) A molecular description of ligand binding to the two overlapping binding pockets of the nuclear vitamin D receptor (VDR): Structure-function implications. J Steroid Biochem Mol Biol 121, 98-105.
    • (2010) J Steroid Biochem Mol Biol , vol.121 , pp. 98-105
    • Mizwicki, M.T.1    Menegaz, D.2    Yaghmaei, S.3    Henry, H.L.4    Norman, A.W.5
  • 22
    • 79960978543 scopus 로고    scopus 로고
    • Vitamin D receptor (VDR) regulation of voltage-gated chloride channels by ligands preferring a VDR-alternative pocket (VDR-AP)
    • Menegaz D, Mizwicki MT, Barrientos-Duran A, Chen N, Henry HL, Norman AW (2011) Vitamin D receptor (VDR) regulation of voltage-gated chloride channels by ligands preferring a VDR-alternative pocket (VDR-AP). Mol Endocrinol 25, 1289-1300.
    • (2011) Mol Endocrinol , vol.25 , pp. 1289-1300
    • Menegaz, D.1    Mizwicki, M.T.2    Barrientos-Duran, A.3    Chen, N.4    Henry, H.L.5    Norman, A.W.6
  • 23
    • 68949147935 scopus 로고    scopus 로고
    • 1alpha,25(OH)(2) Vitamin D(3) Induction of ATP Secretion in Osteoblasts
    • Biswas P, Zanello LP (2009) 1alpha,25(OH)(2) Vitamin D(3) Induction of ATP Secretion in Osteoblasts. J Bone Miner Res 24, 1450-1460.
    • (2009) J Bone Miner Res , vol.24 , pp. 1450-1460
    • Biswas, P.1    Zanello, L.P.2
  • 24
    • 34548852606 scopus 로고    scopus 로고
    • CLC chloride channels and transporters: A biophysical and physiological perspective
    • Zifarelli G, Pusch M (2007) CLC chloride channels and transporters: A biophysical and physiological perspective. Rev Physiol Biochem Pharmacol 158, 23-76.
    • (2007) Rev Physiol Biochem Pharmacol , vol.158 , pp. 23-76
    • Zifarelli, G.1    Pusch, M.2
  • 27
    • 33744963881 scopus 로고    scopus 로고
    • Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration
    • DOI 10.1074/jbc.M511030200
    • Moreland JG, Davis AP, Bailey G, Nauseef WM, Lamb FS (2006) Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration. J Biol Chem 281, 12277-12288. (Pubitemid 43855312)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.18 , pp. 12277-12288
    • Moreland, J.G.1    Davis, A.P.2    Bailey, G.3    Nauseef, W.M.4    Lamb, F.S.5
  • 28
    • 0023597394 scopus 로고
    • Cytosolic free calcium increases before and oscillates during frustrated phagocytosis in macrophages
    • DOI 10.1083/jcb.105.6.2685
    • Kruskal BA, Maxfield FR (1987) Cytosolic free calcium increases before and oscillates during frustrated phagocytosis in macrophages. J Cell Biol 105, 2685-2693. (Pubitemid 18017699)
    • (1987) Journal of Cell Biology , vol.105 , Issue.6 I , pp. 2685-2693
    • Kruskal, B.A.1    Maxfield, F.R.2
  • 29
    • 35348944726 scopus 로고    scopus 로고
    • The ClC-3 chloride transport protein traffics through the plasma membrane via interaction of an N-terminal dileucine cluster with clathrin
    • DOI 10.1074/jbc.M703506200
    • Zhao Z, Li X, Hao J, Winston JH, Weinman SA (2007) The ClC-3 chloride transport protein traffics through the plasma membrane via interaction of an N-terminal dileucine cluster with clathrin. J Biol Chem 282, 29022-29031. (Pubitemid 47606048)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.39 , pp. 29022-29031
    • Zhao, Z.1    Li, X.2    Hao, J.3    Winston, J.H.4    Weinman, S.A.5
  • 30
    • 54349128338 scopus 로고    scopus 로고
    • An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function
    • Mitchell J, Wang X, Zhang G, Gentzsch M, Nelson DJ, Shears SB (2008) An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function. Curr Biol 18, 1600-1605.
    • (2008) Curr Biol , vol.18 , pp. 1600-1605
    • Mitchell, J.1    Wang, X.2    Zhang, G.3    Gentzsch, M.4    Nelson, D.J.5    Shears, S.B.6
  • 31
    • 56349137676 scopus 로고    scopus 로고
    • Anion channels: Regulation of ClC-3 by an orphan second messenger
    • Alekov AK, Fahlke C (2008) Anion channels: Regulation of ClC-3 by an orphan second messenger. Curr Biol 18, R1061-R1064.
    • (2008) Curr Biol , vol.18
    • Alekov, A.K.1    Fahlke, C.2
  • 32
    • 0035827526 scopus 로고    scopus 로고
    • Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase
    • Huang P, Liu J, Di A, Robinson NC, Musch MW, Kaetzel MA, Nelson DJ (2001) Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase. J Biol Chem 276, 20093-20100.
    • (2001) J Biol Chem , vol.276 , pp. 20093-20100
    • Huang, P.1    Liu, J.2    Di, A.3    Robinson, N.C.4    Musch, M.W.5    Kaetzel, M.A.6    Nelson, D.J.7
  • 35
    • 62149090281 scopus 로고    scopus 로고
    • HD desktop: An integrated platform for the analysis and visualization of H/D exchange data
    • Pascal BD, Chalmers MJ, Busby SA, Griffin PR (2009) HD desktop: An integrated platform for the analysis and visualization of H/D exchange data. J Am Soc Mass Spectrom 20, 601-610.
    • (2009) J Am Soc Mass Spectrom , vol.20 , pp. 601-610
    • Pascal, B.D.1    Chalmers, M.J.2    Busby, S.A.3    Griffin, P.R.4
  • 36
    • 0034282395 scopus 로고    scopus 로고
    • Myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line
    • Carew MA, Yang X, Schultz C, Shears SB (2000) myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line. J Biol Chem 275, 26906-26913.
    • (2000) J Biol Chem , vol.275 , pp. 26906-26913
    • Carew, M.A.1    Yang, X.2    Schultz, C.3    Shears, S.B.4
  • 38
    • 18944372230 scopus 로고    scopus 로고
    • Rho kinase, a promising drug target for neurological disorders
    • DOI 10.1038/nrd1719
    • Mueller BK, Mack H, Teusch N (2005) Rho kinase, a promising drug target for neurological disorders. Nat Rev Drug Discov 4, 387-398. (Pubitemid 40704122)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.5 , pp. 387-398
    • Mueller, B.K.1    Mack, H.2    Teusch, N.3
  • 40
    • 73649094774 scopus 로고    scopus 로고
    • On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist
    • Mizwicki MT, Bula CM, Mahinthichaichan P, Henry HL, Ishizuka S, Norman AW (2009) On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist. J Biol Chem 284, 36292-36301.
    • (2009) J Biol Chem , vol.284 , pp. 36292-36301
    • Mizwicki, M.T.1    Bula, C.M.2    Mahinthichaichan, P.3    Henry, H.L.4    Ishizuka, S.5    Norman, A.W.6
  • 41
    • 0142028937 scopus 로고    scopus 로고
    • Kinases, Homology Models, and High Throughput Docking
    • DOI 10.1021/jm020503a
    • Diller DJ, Li R (2003) Kinases, homology models, and high throughput docking. J Med Chem 46, 4638-4647. (Pubitemid 37271613)
    • (2003) Journal of Medicinal Chemistry , vol.46 , Issue.22 , pp. 4638-4647
    • Diller, D.J.1    Li, R.2
  • 44
    • 33750727091 scopus 로고    scopus 로고
    • P38 MAP-kinase pathway is involved in the production of CLC-3 in nasal epithelial cells with allergic rhinitis induced by interleukin-4
    • DOI 10.1097/01.mlg.0000236078.81313.c8, PII 0000553720061100000007
    • Han D, Zhou B, Cheng L, Oh Y, Li H (2006) P38 MAP-kinase pathway is involved in the production of CLC-3 in nasal epithelial cells with allergic rhinitis induced by interleukin-4. Laryngoscope 116, 1973-1977. (Pubitemid 44704376)
    • (2006) Laryngoscope , vol.116 , Issue.11 , pp. 1973-1977
    • Han, D.1    Zhou, B.2    Cheng, L.3    Oh, Y.4    Li, H.5
  • 45
    • 8744264023 scopus 로고    scopus 로고
    • The functional consequences of cross-talk between the vitamin D receptor and ERK signaling pathways are cell-specific
    • DOI 10.1074/jbc.M404101200
    • Narayanan R, Sepulveda VA, Falzon M, Weigel NL (2004) The functional consequences of cross-talk between the vitamin D receptor and ERK signaling pathways are cell-specific. J Biol Chem 279, 47298-47310. (Pubitemid 39518387)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.45 , pp. 47298-47310
    • Narayanan, R.1    Tovar, S.V.A.2    Falzon, M.3    Weigel, N.L.4
  • 47
    • 0032893076 scopus 로고    scopus 로고
    • AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: Requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation
    • DOI 10.1210/en.140.1.63
    • Aslam F, McCabe L, Frenkel B, Van Wijnen AJ, Stein GS, Lian JB, Stein JL (1999) AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: Requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation. Endocrinology 140, 63-70. (Pubitemid 29011142)
    • (1999) Endocrinology , vol.140 , Issue.1 , pp. 63-70
    • Aslam, F.1    McCabe, L.2    Frenkel, B.3    Van Wijnen, A.J.4    Stein, G.S.5    Lian, J.B.6    Stein, J.L.7
  • 49
    • 0035871888 scopus 로고    scopus 로고
    • 3, that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells
    • DOI 10.1182/blood.V97.8.2427
    • Hisatake J, O'Kelly J, Uskokovic MR, Tomoyasu S, Koeffler HP (2001) Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells. Blood 97, 2427-2433. (Pubitemid 32291490)
    • (2001) Blood , vol.97 , Issue.8 , pp. 2427-2433
    • Hisatake, J.-I.1    O'Kelly, J.2    Uskokovic, M.R.3    Tomoyasu, S.4    Koeffler, H.P.5
  • 50
    • 79952303913 scopus 로고    scopus 로고
    • The effects of vitamin D receptor silencing on the expression of LVSCC-A1C and LVSCC-A1D and the release of NGF in cortical neurons
    • Gezen-Ak D, Dursun E, Yilmazer S (2011) The effects of vitamin D receptor silencing on the expression of LVSCC-A1C and LVSCC-A1D and the release of NGF in cortical neurons. PLoS ONE 6, e17553.
    • (2011) PLoS ONE , vol.6
    • Gezen-Ak, D.1    Dursun, E.2    Yilmazer, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.