Imipramine enhances neuroprotective effect of PEP-1-catalase against ischemic neuronal damage

BMB Reports

Volumn 44, Issue 10, 2011, Pages 647-652

  Kim, Dae Won ^a   Kim, Duk Soo ^b   Kim, Mi Jin ^a   Kwon, Soon Won ^a   Ahn, Eun Hee ^a   Jeong, Hoon Jae ^a   Sohn, Eun Jeong ^a   Dutta, Suman ^a   Lim, Soon Sung ^a   Cho, Sung Woo ^c   Lee, Kil Soo ^a   Park, Jinseu ^a   Eum, Won Sik ^a   Hwang, Hyun Sook ^a   Choi, Soo Young ^a  

^a Hallym University   (South Korea)

^b Soonchunhyang University   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

Author keywords

Imipramine; Ischemic damage; PEP 1 CAT; Protein transduction

Indexed keywords

CATALASE; DRUG DERIVATIVE; HYBRID PROTEIN; IMIPRAMINE; MERCAPTAMINE; NEUROPROTECTIVE AGENT; PEP 1 PEPTIDE; PEP-1 PEPTIDE; PEPTIDE; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CELL SURVIVAL; DRUG EFFECT; GENETIC TRANSDUCTION; GENETICS; GERBIL; NERVE CELL; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; ASTROCYTES; BRAIN ISCHEMIA; CATALASE; CELL SURVIVAL; CYSTEAMINE; GERBILLINAE; IMIPRAMINE; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDES; RECOMBINANT FUSION PROTEINS; TRANSDUCTION, GENETIC;

ANIMALIA; GERBILLINAE;

EID: 84863235982     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2011.44.10.647     Document Type: Article

References (29)

1. Koenitzer, J. R. and Freeman, B. A. (2010) Redox signaling in inflammation: interactions of endogenous electrophilies and mitochondria in cardiovascular disease. Ann. N. Y. Acad. Sci. 1203, 45-52.
2. Bickers, D. R. and Athar, F. D. M. (2006) Oxidative stress in the pathogenesis of skin disease. J. Invest. Dermatol. 126, 2565-2575.
3. Mates, J. M. (2000) Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicol. 83, 83-104.
4. Muzykantov, V. R. (2001) Targeting of superoxide dismutase and catalase to vascular endothelium. J. Control. Release 71, 1-21.
5. Kim, D. W., Jeong, H. J., Kang, H. W., Shin, M. J., Sohn, E. J., Kim, M. J., Ahn, E. H., An, J. J., Jang, S. H., Yoo, K. Y., Won, M. H., Kang, T. C., Hwang, I. K., Kwon, O. S., Cho, S. W., Park, J., Eum, W. S. and Choi, S. Y. (2009) Transduced human PEP-1-catalase fusion protein attenuates ischemic neuronal damage. Free Radic. Biol. Med. 47, 941-952.
6. Eum, W. S., Choung, I. S., Li, M. Z., Kang, J. H., Kim, D. W., Park, J., Kwon, H. Y. and Choi, S. Y. (2004) HIV-1 Tat-mediated protein transduction of Cu, Zn-superoxide dismutase into pancreatic beta cells in vitro and in vivo. Free Radic. Biol. Med. 37, 339-349.
7. Ahn, E. H., Kim, D. W., Kang, H. W., Shin, M. J., Won, M. H., Kim, J., Kim, D. J., Kwon, O. S., Kang, T. C., Han, K. H., Park, J., Eum, W. S. and Choi, S. Y. (2010) Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. Toxicol. 276, 192-197.
8. Egleton, R. D. and Davis, T. P. (1997) Bioavailability and transport of peptides and peptide drugs into the brain. Peptides 18, 1431-1439.
9. Behlke, M. A. (2008) Chemical modification of siRNAs for in vivo use. Oligonucleotides 18, 305-320.
10. Dietz, G. P. (2010) Cell-penetrating peptide technology to deliver chaperones and associated factors in diseases and basic research. Curr. Pharm. Biotechol. 11, 167-174.
11. Matsui, H., Tomizawa, K., Lu, Y. F. and Matsushita, M. (2003) Protein therapy: in vivo protein transduction by polyarginine (11R) PTD and subcellular targeting delivery. Curr. Protein Pept. Sci. 4, 151-157.
12. Prochiantz, J. (2000) Messenger proteins: homeoproteins, TAT and others. Curr. Opin. Cell Biol. 12, 400-406.
13. Schwarze, S. R., Ho, A., Vocero-Akbani, A. and Dowdy, S. F. (1999) In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285, 1569-1572.
14. Schwarze, S. R., Hruska, K. A. and Dowdy, S. F. (2000) Protein transduction: unrestricted delivery into all cells? Trends Cell Biol. 10, 290-295.
15. Wadia, J. S. and Dowdy, S. F. (2002) Protein transduction technology. Curr. Opin. Biotechnol. 13, 52-56.
16. Wadia, J. S. and Dowdy, S. F. (2003) Modulation of cellular function by TAT mediated transduction of full length proteins. Curr. Protein Pept. Sci. 4, 97-104.
17. Peng, C. H., Chiou, S. H., Chen, S. J., Chou, Y. C., Ku, H. H., Cheng, C. K., Yen, C. J., Tsai, T. H., Chang, Y. L. and Kao, C. L. (2008) Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampusderived neural stem cells mediated by activation of BDNF and the MAPK pathway. Eur. Neuropsychopharmacol. 18, 128-140.
18. Keilhoff, G., Becker, A., Grecksch, G., Bernstein, H. G. and Wolf, G. (2006) Cell proliferation is influenced by bulbectomy and normalized by imipramine treatment in a region-specific manner. Neuropsychopharmacol. 31, 1165-1176.
19. Schiavon, A. P., Milani, H., Romanini, C. V., Foresti, M. L., Castro, O. W., Garcia-Cairasco, N. and de Oliveira, R. M. (2010) Imipramine enhances cell proliferation and decreases neurodegeneration in the hippocampus after transient global cerebral ischemia in rats. Neurosci. Lett. 470, 43-48.
20. Abdel-Salam, I. M., Nofal, S. M. and El-Shenawy, S. M. (2003) Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. Pharmacol. Res. 48, 157-165.
21. Hashioka, S., Klegeris, A., Monji, A, Kato, T., Sawada, M., McGeer, P. L. and Kanba, S. (2007) Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide. Exp. Neurol. 206, 33-42.
22. Hwang, J., Zheng, L. T., Ock, J., Lee, M. G., Kim, S. H., Lee, H. W., Lee, W. H., Park, H. C. and Suk, K. (2008) Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants. Neuropharmacol. 55, 826-834.
23. Wang, H., Zhong, C. Y., Wu, J. F., Hunag, Y. B. and Liu, C. B. (2010) Enhancement of TAT cell membrane penetration efficiency by dimethyl sulphoxide. J. Control. Rel. 143, 64-70.
24. Lee, S. H., Jeong, H. J., Kim, D. W., Sohn, E. J., Kim, M. J., Kim, D. S., Kang, T. C., Lim, S. S., Kang, I. J., Cho, S. W., Lee, K. S., Park, J., Eum, W. S. and Choi, S. Y. (2010) Enhancement of HIV-1 Tat fusion protein transduction efficiency by bog blueberry anthocyanins. BMB Rep. 43, 561-566.
25. Zhang, D. L., Zhang, Y. T., Yin, J. J. and Zhao, B. L. (2004) Oral administration of Crataegus flavonoids protects against ischemia/reperfusion brain damage in gerbils. J. Neurochem. 90, 211-219.
26. Xia, Z., DePierre, J. W. and Nässberger, L. (1996) Tricyclic antidepressants inhibit IL-6, IL-1 beta and TNF-alpha release in human blood monocytes and IL-2 and interferon-gamma in T cells. Immunopharmacol. 34, 27-37.
27. Kuroda, Y. and Saito, M. (2010) Prediction of phospholipidosis-inducing potential of drugs by in vitro biochemical and physicochemical assays followed by multivariate analysis. Toxicol. In Vitro 24, 661-668.
28. Vistica, D. T., Skehan, P., Scudiero, D., Monks, A., Pittman, A. and Boyd, M. R. (1991) Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production. Cancer Res. 51, 2515-2520.
29. Ahang, D. L., Zhang, Y. T., Yin, J. J. and Zhao, B. L. (2004) Oral administration of Crataegus flavonoids protects against ischemia/reperfusion brain damage in gerbils. J. Neurochem. 90, 211-219.