Effects of anandamide on potassium channels in rat ventricular myocytes: A suppression of I to and augmentation of K ATP channels

American Journal of Physiology - Cell Physiology

Volumn 302, Issue 6, 2012, Pages

  Li, Qian ^a   Ma, Hui Jie ^a   Song, Sheng Li ^b   Shi, Min ^a   Ma, Hui Juan ^a   Li, De Pei ^c   Zhang, Yi ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b First Hospital of Baoding City   (China)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

ATP sensitive potassium current; Cardiomyocyte; Electrophysiology; Endocannabinoid; Receptor; Transient outward potassium current

Indexed keywords

ANANDAMIDE; CALCIUM CHANNEL; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENSITY; DOSE RESPONSE; DRUG EFFECT; HEART MUSCLE CELL; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; STEADY STATE;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARACHIDONIC ACIDS; ARRHYTHMIAS, CARDIAC; CARDIAC ELECTROPHYSIOLOGY; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART VENTRICLES; INDOLES; KATP CHANNELS; MALE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2;

RATTUS;

EID: 84863233685     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00228.2011     Document Type: Article

References (42)

1. Amoros I, Barana A, Caballero R, Gomez R, Osuna L, Lillo MP, Tamargo J, Delpon E. Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner. J Mol Cell Cardiol 48: 201-210, 2010.
2. Barana A, Amoros I, Caballero R, Gomez R, Osuna L, Lillo MP, Blazquez C, Guzman M, Delpon E, Tamargo J. Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner. Cardiovasc Res 85: 56-67, 2010.
3. Basavarajappa BS. Critical enzymes involved in endocannabinoid metabolism. Protein Pept Lett 14: 237-246, 2007.
4. Brown AJ. Novel cannabinoid receptors. Br J Pharmacol 152: 567-575, 2007.
5. Chang GJ, Su MJ, Hung LM, Lee SS. Cardiac electrophysiologic and antiarrhythmic actions of a pavine alkaloid derivative, O-methyl-neocaryachine, in rat heart. Br J Pharmacol 136: 459-471, 2002.
6. Choisy SC, Hancox JC, Arberry LA, Reynolds AM, Shattock MJ, James AF. Evidence for a novel K(+) channel modulated by alpha(1A)-adrenoceptors in cardiac myocytes. Mol Pharmacol 66: 735-748, 2004.
7. + channels in rabbit atrial and ventricular cardiomyocytes. Eur J Pharmacol 373: 223-232, 1999.
8. o-induced electrical heterogeneity and extrasystolic activity in isolated canine ventricular epicardium. Phase 2 reentry. Circulation 89: 1839-1850, 1994.
9. Felder CC, Glass M. Cannabinoid receptors and their endogenous agonists. Annu Rev Pharmacol Toxicol 38: 179-200, 1998.
10. Ferrier GR, Moffat MP, Lukas A. Possible mechanisms of ventricular arrhythmias elicited by ischemia followed by reperfusion. Studies on isolated canine ventricular tissues. Circ Res 56: 184-194, 1985.
11. Grover GJ, Garlid KD. ATP-sensitive potassium channels: a review of their cardioprotective pharmacology. J Mol Cell Cardiol 32: 677-695, 2000.
12. Hiley CR. Endocannabinoids and the heart. J Cardiovasc Pharmacol 53: 267-276, 2009.
13. Kass RS, Abriel H, Rivolta I. Ion channels in the heart. In: Heart Physiology and Pathophysiology (4th ed.), edited by Sperelakis N. San Diego, CA: Academic, 2001, p. 1137-1151.
14. Kimura S, Bassett AL, Kohya T, Kozlovskis PL, Myerburg RJ. Simultaneous recording of action potentials from endocardium and epicardium during ischemia in the isolated cat ventricle: relation of temporal electrophysiologic heterogeneities to arrhythmias. Circulation 74: 401-409, 1986.
15. Kochar MS, Hosko MJ. Electrocardiographic effects of marihuana. JAMA 225: 25-27, 1973.
16. Krylatov AV, Uzhachenko RV, Maslov LN, Bernatskaya NA, Makriyannis A, Mechoulam R, Pertwee RG, Sal'nikova OM, Stefano JB, Lishmanov Y. Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism. Bull Exp Biol Med 133: 122-124, 2002.
17. Krylatov AV, Uzhachenko RV, Maslov LN, Ugdyzhekova DS, Bernatskaia NA, Pertwee R, Stefano GB, Makriyannis A. [Anandamide and R-(+)-methanandamide prevent development of ischemic and reperfusion arrhythmia in rats by stimulation of CB2-receptors]. Eksp Klin Farmakol 65: 6-9, 2002.
18. Lepicier P, Bouchard JF, Lagneux C, Lamontagne D. Endocannabinoids protect the rat isolated heart against ischaemia. Br J Pharmacol 139: 805-815, 2003.
19. Lepicier P, Lagneux C, Sirois MG, Lamontagne D. Endothelial CB1-receptors limit infarct size through NO formation in rat isolated hearts. Life Sci 81: 1373-1380, 2007.
20. Li Q, Ma HJ, Zhang H, Qi Z, Guan Y, Zhang Y. Electrophysiological effects of anandamide on rat myocardium. Br J Pharmacol 158: 2022-2029, 2009.
21. Lu T, Ye D, Wang X, Seubert JM, Graves JP, Bradbury JA, Zeldin DC, Lee HC. Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms. J Physiol 575: 627-644, 2006.
22. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564, 1990.
23. Monsuez JJ. Cardiac potassium currents and channels. Part II: Implications for clinical practice and therapy. Int J Cardiol 62: 1-12, 1997.
24. Montecucco F, Lenglet S, Braunersreuther V, Burger F, Pelli G, Bertolotto M, Mach F, Steffens S. CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion. J Mol Cell Cardiol 46: 612-620, 2009.
25. Mouslech Z, Valla V. Endocannabinoid system: an overview of its potential in current medical practice. Neuro Endocrinol Lett 30: 153-179, 2009.
26. Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365: 61-65, 1993.
27. Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ. Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury. Am J Physiol Heart Circ Physiol 291: H537-H542, 2006.
28. Niwa N, Nerbonne JM. Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation. J Mol Cell Cardiol 48: 12-25.
29. Oz M. Receptor-independent actions of cannabinoids on cell membranes: focus on endocannabinoids. Pharmacol Ther 111: 114-144, 2006.
30. Pacher P, Batkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58: 389-462, 2006.
31. Pacher P, Hasko G. Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning. Br J Pharmacol 153: 252-262, 2008.
32. Pertwee RG. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther 74: 129-180, 1997.
33. Randall MD, Harris D, Kendall DA, Ralevic V. Cardiovascular effects of cannabinoids. Pharmacol Ther 95: 191-202, 2002.
34. + channels. Life Sci 88: 653-657, 2011.
35. Roden DM, Balser JR, George AL Jr, Anderson ME. Cardiac ion channels. Annu Rev Physiol 64: 431-475, 2002.
36. Tamargo J, Caballero R, Gomez R, Valenzuela C, Delpon E. Pharmacology of cardiac potassium channels. Cardiovasc Res 62: 9-33, 2004.
37. Ugdyzhekova DS, Bernatskaya NA, Stefano JB, Graier VF, Tam SW, Mekhoulam R. Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of CB(1) and CB(2) receptors. Bull Exp Biol Med 131: 251-253, 2001.
38. Underdown NJ, Hiley CR, Ford WR. Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. Br J Pharmacol 146: 809-816, 2005.
39. Yao JA, Jiang M, Fan JS, Zhou YY, Tseng GN. Heterogeneous changes in K currents in rat ventricles three days after myocardial infarction. Cardiovasc Res 44: 132-145, 1999.
40. Yellen G. The voltage-gated potassium channels and their relatives. Nature 419: 35-42, 2002.
41. + channels in pancreatic, cardiac, and vascular smooth muscle cells. Am J Physiol Cell Physiol 274: C25-C37, 1998.
42. + channel in embryonic chick heart. J Biomed Sci 16: 104, 2009.