Structure-based drug design of a new chemical class of small molecules active against influenza a nucleoprotein in vitro and in vivo

PLoS Currents

Volumn , Issue , 2011, Pages

  Fedichev, Peter ^a   Timakhov, Roman ^a   Pyrkov, Tim ^a   Getmantsev, Evgeny ^a   Vinnik, Andrey ^a  

^a Quantum Pharmaceuticals   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 5 (4 CHLOROPHENYL) 4 (METHYLPHENYL) 1,2,4 TRIAZOLE 3 YLTHIOGLYCOLIC ACID; NUCLEOPROTEIN; OSELTAMIVIR; RIMANTADINE; UNCLASSIFIED DRUG; 3 MERCAPTO 1,2,4 TRIAZOLES DERIVATIVE; ANTIVIRUS AGENT; F 66; INFLUENZA VACCINE; PLACEBO; PROTEIN INHIBITOR; RIBAVIRIN; TRIAZOLE DERIVATIVE; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; COMPUTER MODEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS A; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS A H5N1; MOLECULAR DOCKING; MOUSE; NONHUMAN; VIRUS STRAIN; CYTOPATHOGENIC EFFECT; DRUG DESIGN; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMAGGLUTINATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLUENZA A; LIFE EXPECTANCY; TOXICITY; VIRUS CULTURE;

EID: 84855267788     PISSN: None     EISSN: 21573999     Source Type: Journal    
DOI: 10.1371/currents.RRN1253     Document Type: Article

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