Design and synthesis of benzenesulfonamide derivatives as potent anti-influenza hemagglutinin inhibitors

ACS Medicinal Chemistry Letters

Volumn 2, Issue 8, 2011, Pages 603-607

  Tang, Guozhi ^a   Lin, Xianfeng ^a   Qiu, Zongxing ^a   Li, Wentao ^a   Zhu, Lei ^a   Wang, Lisha ^a   Li, Shaohua ^b   Li, Haodong ^b   Lin, Wenbin ^b   Yang, Mei ^b   Guo, Tao ^b   Chen, Li ^a   Lee, Daniel ^a   Wu, Jim Z ^a   Yang, Wengang ^a  

^a Roche R and D Center China   (China)

^b WUXI APPTEC   (China)

Author keywords

Anti influenza; benzenesulfonamide; hemagglutinin; inhibitor

Indexed keywords

3 (5 HYDROXY 1,3,3 TRIMETHYLCYCLOHEXYLMETHYLAMINO)BENZENESULFONAMIDE; ANTIVIRUS AGENT; BENZENESULFONAMIDE DERIVATIVE; INFLUENZA VIRUS HEMAGGLUTININ; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STABILITY; DRUG SYNTHESIS; ENDOSOME; HEMOLYSIS; INFLUENZA VIRUS A H1N1; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; VIRUS STRAIN;

EID: 80051750533     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml2000627     Document Type: Article

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